[Show abstract][Hide abstract] ABSTRACT: In 30 human volunteers who performed operator activity for 25 min on the stand trainer there have been determined the pre- and post-operation magnitude of beta-adrenoception of the cellular membranes (beta-APM) by applying the author's method (Russian Federation Patent), hemodynamic indices, osmoresistance of erythrocytes and the content of total bilirubin in the blood. The quality of operator activity was determined from the amount of erroneous actions and from time (T) spent for their clearing. There exists the direct correlation between the magnitudes of beta-APM and T within the mean ranges of their magnitudes (on evidence derived from histograms). The moderately increased magnitudes of beta-APM (10-16 units) which are in the limits of the norm (10-16 units) determined by us are the criterion of high working capacity of an operator. Magnitudes of beta-APM which are higher than 16 units mesh perfectly with the high quality of operator activity, however, on the screening examination remain, to be considered as the risk factor of developing the stressor-induced diseases.
No preview · Article · Jan 1997 · Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine
[Show abstract][Hide abstract] ABSTRACT: A new method of individual determination of sympathoadrenal activity (SAA) uses the parameter of beta-adrenoreception in cell membranes (beta-ARM) based on the erythrocyte model. Correlation of an individual reference beta-ARM value with specific features of hypertension states, and CVS responses to psychoemotional stress was studied. Described are the method, and normal distribution of individual beta-ARM values in healthy flyers, aviation students, non-flyers, and aviators with diagnosed the neurocirculatory dystonia of hypertensive type and patients with the hypertonic disease of 2nd stage (the overall numbers of subjects = 221). Another group of healthy subjects and patients with the hypertonic disease of 1st stage and different reference beta-ARM values (n = 39) participated in determination of HR and BP levels during the verbal count test. On the evidence of individual beta-ARM distribution in the test groups, the upper limit of the beta-ARM physiological norm (16.0 arbitrary units) was suggested to be a critical parameter in diagnosis of a hyperadrenergic state. Analysis of hemodynamics and the quality of verbal count during performance of a psychoemotional test by subjects with varying reference beta-ARM values revealed hyperreactive cardiovascular systems in and less successful fulfillment of the count test by subjects with high beta-ARM.
No preview · Article · Feb 1996 · Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine
[Show abstract][Hide abstract] ABSTRACT: The study covered 226 individuals including 40 apparently healthy subjects, 30 patients with vasoneurosis accompanied by arterial hypertension, 23 patients with I stage arterial hypertension and 83 patients with II stage arterial hypertension. The aim was to evaluate some parameters of myocardium and response of cardiovascular system exposed to modified psychoemotional Kreppelin test. Basic value of beta-adrenoreactivity in cellular membranes appeared to be important in manifold evaluation of cardiovascular strain. Higher values of beta-adrenoreactivity in cellular membranes induce inadequate hemodynamic responses to physical load, resulting in progress of morphologic and functional disorders of myocardium.
No preview · Article · Feb 1996 · Meditsina truda i promyshlennaia ekologiia
[Show abstract][Hide abstract] ABSTRACT: Dynamics of correlations between the absolute values and individual changes in adrenoception of erythrocytes and insulinemia was studied in 17 patients with hypertension (II stage) prior to and after 2-month treatment by calcium antagonists. Clear correlation is observed between the sensitivity of alpha- and beta- adrenoceptors and reduction of insulinemia after treatment with calcium antagonists (r = -0.77, p < 0.05). The effect of heterologous sensitization of cell membranes on metabolism in patients suffered with hypertonia after their treatment with calcium antagonists are discussed.
No preview · Article · Jan 1995 · Eksperimental'naia i klinicheskaia farmakologiia
[Show abstract][Hide abstract] ABSTRACT: The immunological and biochemical parameters were studied in patients with Stage II hypertensive disease (HD) before and 2 months after course treatment with calcium antagonists of the dihydropyridine series (siscor and nitrepine). The metabolic mechanisms of the therapeutical action of these drugs were found to affect all specific features of the immune and biochemical status typical of hypertensives. One should identify the priority links which are unambiguously positive and the next links which rank to them, i. e. those manifested themselves in impaired adaptive processes whereby the sick body ensures protection from the disease. The priority links include reduction of hypercortisole- and insulinemia, increase in incretion of testosterone to the reference values, stabilization and sensitization of cellular membranes, decrease of beta 2-microglobulinemia, as well as moderate activation of the immune system and mechanisms of protein synthesis in the cells. The latter links comprise a drop of alpha-cholesterol (HDL) in persistent hypertriglyceridemia, additional tension of hepato- and cardiomyocytic functions, a tendency to cell aging and, partially, reversion of the established sexual hormone ratio.
No preview · Article · Mar 1994 · Eksperimental'naia i klinicheskaia farmakologiia