Hong-Duo Chen

ShenJing Hospital of China Medical University, Feng-t’ien, Liaoning, China

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Publications (133)392.22 Total impact

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    ABSTRACT: Background: Atopic dermatitis (AD) is characterized by defective skin barrier and imbalance in T helper 1/T helper 2 (Th1/Th2) cytokine expression. Filaggrin (FLG) is the key protein to maintaining skin barrier function. Recent studies indicated that Th1/Th2 cytokines influence FLG expression in keratinocytes. However, the role of Th1/Th2 cytokines on FLG processing is not substantially documented. Our aim was to investigate the impact of Th1/Th2 cytokines on FLG processing. Methods: HaCaT cells and normal human keratinocytes were cultured in low and high calcium media and stimulated by either interleukin (IL)-4, 13 or interferon-γ (IFN-γ). FLG, its major processing proteases and key protease inhibitor lymphoepithelial Kazal-type-related inhibitor (LEKTI) were measured by both real-time quantitative polymerase chain reaction and Western blotting. Their expression was also evaluated in acute and chronic AD lesions by immunohistochemistry. Results: IL-4/13 significantly reduced, while IFN-γ significantly up-regulated FLG expression. IL-4/13 significantly increased, whereas IFN-γ significantly decreased the expression of kallikreins 5 and 7, matriptase and channel-activating serine protease 1. On the contrary, IL-4/13 significantly decreased, while IFN-γ increased the expression of LEKTI and caspase-14. Similar trends were observed in AD lesions. Conclusions: Our results suggested that Th1/Th2 cytokines differentially regulated the expression of major FLG processing enzymes. The imbalance between Th1 and Th2 polarized immune response seems to extend to FLG homeostasis, through the network of FLG processing enzymes.
    No preview · Article · Feb 2016 · Chinese medical journal
  • Li Li · Lu Li · Yan Wu · Xing-Hua Gao · Hong-Duo Chen
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    ABSTRACT: Background: Vitiligo is an acquired de-pigmenting disease with uncertain aetiopathogenesis and the treatment modalities need consistently updated. Aim: To evaluate a triple combination treatment with oral α-Lipoic acid (ALA), betamethasone injection and narrowband ultraviolet B (NB-UVB) on vitiligo. Methods: Patients with non-segmental and progressive vitiligo lesions were randomly assigned to two groups. The treatment group and the control group were respectively treated with oral ALA and placebo, in combination with betamethasone injection and NB-UVB. The effectiveness and adverse events were evaluated by investigators and patients pre-treatment and post-treatment. Results: Fifty non-segmental progressive vitiligo patients were enrolled. The treatment period was 6 months. In treatment group, over 40% patients achieved > 50% improvement and ≥5 satisfaction score by 3 months therapy (M3). The patients increased to 90% at M6. Treatment group achieved better efficacy than control group at M3, while no difference was seen at M6. Conclusion: The combined treatment with oral ALA, betamethasone injection, and NB-UVB was effective and safe on non-segmental progressive vitiligo. ALA could accelerate the initial response of re-pigmentation.
    No preview · Article · Jan 2016 · Journal of Cosmetic and Laser Therapy
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    ABSTRACT: Background: Although pulsed dye laser (PDL) has long been regarded as the gold standard in treating port-wine stain (PWS), advanced PWS with deeper coloration may display resistance because of limited penetration depth of 585 or 595-nm light. Recently, a dual-wavelength laser system has been reported to achieve pronounced fading in many patients. OBJECTIVE: The objective was to evaluate the efficacy and safety of a dual-wavelength laser device in treatment of neck and facial PWS in a direct side-by-side comparison. METHODS: Sixteen Chinese patients with neck and/or facial PWSs were enrolled in the study. All lesions were randomly divided into two area, treated area and adjacent untreated area. Five successive treatments using a dual-wavelength laser system (595-nm PDL combined with 1,064-nm Nd:YAG laser) were delivered on treated areas at 4- to 6-week intervals. The adjacent area was not treated as self control. Two blinded dermatologists evaluated the clinical changes by comparing the before and after photos. Erythema index (EI) values were measured with a non-invasive instrument. RESULTS: After five sessions of treatment, over 62.5% (10/16) patients achieved more than 50% (moderate or significant) improvement. The efficacy maintained at the 3-month follow-up visit. The values of EI on treated area showed a significant decrease. Adverse effects of treated area were limited. CONCLUSION: Using this split-face module, the dual-wavelength laser system is proved to be effective and well tolerated in treating neck and facial PWSs in Chinese patients. Adverse effects were minimal and acceptable. J Drugs Dermatol . 2015;14(11):1336-1340.
    No preview · Article · Nov 2015 · Journal of drugs in dermatology: JDD
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    ABSTRACT: is missing (Short communication).
    Preview · Article · Nov 2015 · Acta Dermato-Venereologica
  • Junwei Pan · Li Qiu · Ting Xiao · Hong-Duo Chen
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    ABSTRACT: A 8-year-old Chinese boy with generalized pustular psoriasis (GPP) refractory to cyclosporine and methylprednisolone was treated successfully with two infusions of infliximab 3.3 mg/kg. He remained in remission for 21 months. Direct sequencing of IL36RN gene showed a homozygous mutation, c.115 + 6T>C. Juvenile GPP is a rare severe form of psoriasis occasionally associated with life-threatening complications. Like acitretin, cyclosporine and methotrexate, infliximab has been reported to be effective for juvenile GPP in case reports. However, there is a lack of data in the optimal treatment course of infliximab for juvenile GPP. Prolonged administration of these medications may cause toxic or fatal complications. We suggest that short-term infliximab regimen should be recommended as a choice for acute juvenile GPP refractory to traditional systemic therapies. WBC count and CRP are sensitive parameters to reflect the disease activity and evaluate the effectiveness of treatment. Monitoring CD4 T lymphocyte count, preventing and correcting CD4 lymphocytopenia are important in the treatment course of juvenile GPP.
    No preview · Article · Nov 2015 · Dermatologic Therapy
  • Yi-Xiu Bai · Li-Ming Zhang · Ting Xiao · Hong-Duo Chen
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    ABSTRACT: There is a lack of data on treatment and prognosis of pemphigus in China. The aim of this study was to evaluate long-term follow-up and prognosis of pemphigus. Forty-seven inpatients with pemphigus vulgaris (PV) and 22 with pemphigus foliaceus (PF) were recruited in this retrospective study. The average age at onset was 51.6 and 54.9 years in PV and PF, respectively. High-dose systemic steroids were administered in 47 PV and 21 PF, of which 18 PV and 8 PF with adjuvant therapies. CD4 lymphocytopenia was found in 5 PV and 2 PF patients at admission and successfully treated by intravenous thymopentin daily. During a mean follow-up of 37.1 months, 41 PV and 19 PF reached remission, 30 PV and 9 PF relapsed, 4 PV and 2 PF died. Major causes of death were relapse of pemphigus due to discontinuation of oral steroids by the patients themselves (four cases) and severe infections (two cases, one with severe CD4 lymphocytopenia). The 1-year mortality rate of PV and PF was 8.5% and 4.5%, respectively. Cox regression analysis indicated that age at onset of pemphigus was an independent risk factor related to the elevated mortality. Our report confirmed the high mortality rate of pemphigus in a Chinese population and stressed that patient education was urgently needed to prevent relapses and deaths.
    No preview · Article · Oct 2015 · Dermatologic Therapy
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    ABSTRACT: Over the centuries, traditional Chinese medicine (TCM) and Western medicine have traveled along parallel lines with no opportunity for collaboration. In recent decades, while an interest in TCM has been growing among Western clinicians, progress has been made in the comprehension of pathogenic mechanisms of skin disorders, and the communication between Western and Eastern medicines has become more and more intensive. In this paper, the authors discuss TCM remedies used in the treatment of autoimmune bullous disorders (pemphigus and bullous pemphigoid) and lichen planus. Future studies on the active components of the TCM will certainly shed new light on the still obscure aspects of some dermatologic diseases.
    No preview · Article · Sep 2015 · SKINmed
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    Full-text · Article · Jul 2015 · International journal of dermatology
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    Jiu-Hong Li · Hao Guo · Xing-Hua Gao · Hong-Duo Chen

    Full-text · Article · Jul 2015 · The Lancet
  • Yuxiao Hong · Bing Song · Hong-Duo Chen · Xing-Hua Gao
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    ABSTRACT: The Journal of Investigative Dermatology Symposium Proceedings publishes basic and clinical research in cutaneous biology and skin disease.
    No preview · Article · Jul 2015 · Journal of Investigative Dermatology Symposium Proceedings

  • No preview · Article · Jun 2015
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    Hao Guo · Xing-Hua Gao · Hong-Duo Chen · Jiu-Hong Li

    Full-text · Article · May 2015 · Indian journal of dermatology, venereology and leprology
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    ABSTRACT: Traditional Chinese medicine (TCM) is increasingly being used in the Western world particularly in specialty areas such as gynecology, pediatrics, nutrition, and dermatology. TCM is an alternative method of therapy that proposes to treat symptoms that Western medicine is unable to manage by treating the underlying causes of disease. The authors provide a general overview of TCM remedies used in the treatment of various dermatologic disorders (acne, psoriasis, atopic dermatitis) for dermatologists interested in this unconventional therapeutic approach.
    No preview · Article · Apr 2015 · SKINmed
  • Yan Sun · Yan Wu · Bihuan Xiao · Lu Li · Li Li · Hong-Duo Chen · Xing-Hua Gao
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    ABSTRACT: Abstract Background: Vitiligo is an acquired cutaneous hypopigmentary disorder which characterized by solitary or multiple depigmented maculae or patches. The 308-nm excimer laser has been used as phototherapy on vitiligo. Objective: To evaluate the efficacy and safety of 308-nm excimer laser on vitiligo. Methods: Randomized Controlled Trials (RCTs) were searched to conduct a systematic review. The keywords were identified as laser/ excimer laser/ quasimolecule/ XeCl" and "vitiligo". Results: Seven studies with 390 vitiligo patients were included. No significant differences were seen between 308-nm excimer laser and 308-nm excimer lamp on either ≥75% or ≥50% re-pigmentation rate, or between 308-nm excimer laser and narrow band-ultraviolet B (NB-UVB) on either 100% or ≥75% re-pigmentation rate. More patients or lesions achieved ≥50% re-pigmentation rate by 308-nm excimer laser treatment than by NB-UVB treatment. The side effects of 308-nm excimer laser were slight and tolerable. Conclusions: The 308-nm excimer laser showed equivalent efficacies to 308-nm excimer lamp control and NB-UVB control concerning of ≥75% re-pigmentation rate of vitiligo patches. More studies with high methodological quality, low risk of bias and more sample size are needed to confirm the conclusion.
    No preview · Article · Nov 2014 · Journal of Dermatological Treatment
  • Bin Wei · Le Qu · Hong Zhu · Ting Xiao · Hua-Chen Wei · Hong-Duo Chen · Chundi He
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    ABSTRACT: Background: The relationship between serum hormone levels and adolescent acne is not fully clarified. Objective: To determine the relationship between levels of androstenedione, dehydroepiandrosterone sulfate (DHEA-S), testosterone, estradiol and 17α-hydroxyprogesterone (17-OHP) with adolescent acne in Northeast China. Methods: A transversal study included 242 acne cases and 188 controls. All data were analyzed using SPSS version 17.0. Results: Androstenedione and testosterone levels were significantly higher (p < 0.0001) in the cases than in the control group. In males, the difference in 17-OHP levels was statistically significant (p < 0.0001), as well as between mild and severe acne cases (p = 0.002). The estradiol level was significantly different (p < 0.0001) between cases and controls in females. Conclusion: Higher androstenedione and testosterone levels are significant risk factors in the occurrence of adolescent acne. A higher 17-OHP level aggravates the severity of male adolescent acne, while a higher estradiol level protects females against the onset of adolescent acne. © 2014 S. Karger AG, Basel.
    No preview · Article · Nov 2014 · Dermatology
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    Jiu-Hong Li · Hao Guo · Song Zheng · Bo Li · Xing-Hua Gao · Hong-Duo Chen
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    ABSTRACT: Abstract is missing (Quiz).
    Full-text · Article · Nov 2014 · Acta Dermato Venereologica
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    ABSTRACT: This study aims to assess the impact of childhood vitiligo on the psychological status and quality of life of their parents, and to determine how this varies according to their children's disease condition. The study included 50 families of children with vitiligo (a total of 75 participants) and 50 families of normal children (a total of 79 participants). The psychosocial impact of the disease on parents was measured using the Self-rated Health Measurement Scale (SRHMS) and the Dermatitis Family Impact Questionnaire (DFI). SRHMS scores for parents of children with vitiligo were significantly lower than for parents with normal children. In addition, women had lower scores than men in the study group. The mean DFI score in affected families was higher than in unaffected families. Parents of children with vitiligo have significant psychological problems, and their quality of life is poorer than for parents of normal children. In conclusion, parents of children with vitiligo need as much care and attention as their affected children.
    No preview · Article · Aug 2014 · Acta Dermato Venereologica
  • Bi-Huan Xiao · Yan Wu · Yan Sun · Hong-Duo Chen · Xing-Hua Gao
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    ABSTRACT: Objective: To assess the effect and safety of NB-UVB for vitiligo using an evidence-based approach. Methods: Randomized controlled trials (RCTs) on the treatment of vitiligo with NB-UVB were identified by searching PubMed and the Cochrane Library. The primary outcome was re-pigmentation degree. Results: A total of seven RCTs involving 232 participants with vitiligo were included in this systematic review. The methodological qualities of included studies were generally moderate. Two trials compared narrow-band ultraviolet B (NB-UVB) with UVA control, showing no significant differences between two methods on the number of patients who achieved >60% re-pigmentation [relative risk (RR) = 2.50, 95% confidence interval (CI): 0.11-56.97, p > 0.05]. Two trials compared NB-UVB with psoralens plus UVA (PUVA) control, and no difference was seen between the two treatments on the number of patients who achieved >50 re-pigmentation (RR = 1.16, 95% CI: 0.64-2.11, p > 0.05) or >75% re-pigmentation (RR = 2.00, 95% CI: 0.89-4.48, p > 0.05). Three trials compared NB-UVB with 308-nm excimer light/laser (EL) control, and again no significant difference was found between the two methods (p > 0.05). The adverse events of NB-UVB in the included studies were slight and tolerated. Conclusion: NB-UVB showed equivalent efficacies to UVA, PUVA or 308-nm EL control in the treatment of vitiligo. Side effects of NB-UVB were acceptable. More RCTs were needed to validate the results.
    No preview · Article · Aug 2014 · Journal of Dermatological Treatment
  • Weifeng Zheng · Yan Wu · Xuegang Xu · Xinghua Gao · Hong-Duo Chen · Yuanhong Li
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    ABSTRACT: Background Photodynamic therapy (PDT) has been used for acne, however, the efficacy and safety need to be determined. Objective To assess the effects and safety of PDT for acne using an evidence-based approach. Methods Randomized controlled trials (RCTs) on the treatment of acne with PDT were identified by searching PubMed, CNKI and the Cochrane Library. Results A total of 14 RCTs involving 492 patients were included. Photosensitizers included aminolevulinic acid (ALA), methylaminolevulinate (MAL), and indole-3-acetic acid (IAA). Light sources included red light, pulsed dye laser (PDL), intense pulsed light (IPL), long-pulsed dye laser (LPDL) and green light. The PDT protocols, including ALA + red light, ALA + PDL, ALA + IPL, MAL + red light, and MAL + LPDL, all showed great efficacy on inflammatory lesions. ALA + red light also had effects on non-inflammatory lesions and sebum secretion. ALA + IPL and IAA + green light significantly decreased sebum secretion. Triple treatment protocols showed great improvement on inflammatory and non-inflammatory lesions. Increasing ALA concentration, ALA incubation time, PDT sessions, dose of light source or using occlusion for photosensitizers, or a combination of other treatments with PDT may achieve greater efficacy. The common side effects of PDT were tolerable and transient. Conclusion Limited evidence indicates that PDT shows good efficacy in the treatment of acne with acceptable side effects. ALA + red light was shown to be the optimal choice. However, more RCTs are needed to determine the types and concentrations of photosensitizers and light sources, and the duration of light activation and incubation.
    No preview · Article · Jun 2014 · European journal of dermatology: EJD
  • Yi-Lei Li · Yao-Jia Luo · Yan Wu · Bo Li · Xing-Hua Gao · Hong-Duo Chen · Jiu-Hong Li
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    ABSTRACT: Adult colloid milium is a rare cutaneous deposition disorder that frequently involves areas of chronic sun exposure. The most common clinical presentation exhibits multiple, firm, and amber-colored papules that cluster to form large plaques. Histologically, there are masses of amorphous, eosinophilic material expanding the papillary dermis, and at times extending into the mid-dermis, with adjacent solar elastosis. When this disorder affects the face, disfiguring is of great concern and treatment is often sought. Attempts to safely remove colloid milium are generally unsuccessful. Dermabrasion has been reported to be effective. The present authors present a case with extensive facial colloid milium successfully ablated by the fractionated CO2 laser.
    No preview · Article · Mar 2014 · Dermatologic Therapy

Publication Stats

907 Citations
392.22 Total Impact Points

Institutions

  • 2007-2015
    • ShenJing Hospital of China Medical University
      Feng-t’ien, Liaoning, China
  • 2004-2015
    • China Medical University (PRC)
      • Department of Dermatology
      Feng-t’ien, Liaoning, China
  • 2004-2014
    • Southern Medical University
      Shengcheng, Guangdong, China
  • 2012-2013
    • Northeastern University (Shenyang, China)
      Feng-t’ien, Liaoning, China
  • 2011
    • General Hospital of the Air Force, PLA
      Peping, Beijing, China
  • 2009
    • Mount Sinai Medical Center
      • Department of Dermatology
      New York City, New York, United States
  • 2008
    • China Medical University (ROC)
      臺中市, Taiwan, Taiwan