Jun Young Lee

Catholic University of Korea, Sŏul, Seoul, South Korea

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Publications (322)698.9 Total impact

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    ABSTRACT: Overproduction of hydrogen peroxide, keeps homeostasis in normal condition, is involved in the pathogenesis of inflammatory diseases such as cancer and arthritis. To image hydrogen peroxide via chemiluminescence energy transfer in near-infrared (NIR) wavelength range, we utilized quantum dots (QDs) functionalized with luminol derivative (L012).
    No preview · Article · Jan 2016 · Chemical Communications
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    ABSTRACT: Purpose: Whether obesity is a risk factor for atopic dermatitis (AD) remains unclear. The aim of the present study was to investigate the association between obesity and AD in Korean young adults. Methods: We included nationally representative data of 5,202 Korean adults aged 19-40 years, obtained from the cross-sectional Korea National Health and Nutrition Examination Survey 2008-2010. Results: Single (unmarried) status was more frequently observed in AD patients (male, [P=0.0002] and female, [P<0.0001]). AD prevalence exhibited a U-shape trend in relation to body mass index (BMI), waist circumference (WC), and total body fat (BF) percentage, especially in young adult women. Women with BMI ≥25 kg/m², WC ≥80 cm, and highest quartile (Q4) of total BF percentage had the highest prevalence of AD. The odds ratio (OR) for participants with both BMI ≥25 kg/m² and WC ≥80 cm was 3.29 (95% confidence interval [CI] 1.71-3.55); therefore, having both general and abdominal obesity was considered a prominent risk factor for AD in young women. After adjustment for confounding factors, including age, smoking, alcohol drinking, exercise, vitamin D, income level, and single status, high BMI (≥30 kg/m²) (OR=4.08, 95% CI: 1.53-10.93), high WC (≥80 cm) (OR=2.05, 95% CI: 1.07-3.94), and high BF percentage (Q4) (OR=2.10, 95% CI: 1.24-3.57) were shown to be significantly associated with AD in young adult women. Conclusions: In this large-scale nation-wide study of Korean adults, obesity was positively related to the presence of AD in women. Our findings suggest that weight management may help prevent AD.
    Preview · Article · Jan 2016 · Allergy, asthma & immunology research
  • Jun Young Lee · Jeong Hoon Park · Sang Wook Kim
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    ABSTRACT: Folate-conjugated fluorescent silica–gold nanoparticles (FSGNs-F) and radioactive gold nanoparticles [S( 198Au)GNs-F] were prepared and evaluated for the detection of folate-receptor-overexpressed cancer. Fluorescence imaging showed that FSGNs-F was targeted successively to mouse colon carcinoma cells (CT-26, folate receptor positive), whereas vague localization was observed in human lung adenocarcinoma epithelial cells (A549, folate receptor negative). S( 198Au)GNs-F also targeted CT-26 cells in a time-dependent manner: 35.2 ± 1.20% at 15 min, 39.3 ± 1.95% at 30 min, 41.6 ± 1.62% at 60 min, and 49.8 ± 1.22% at 120 min. In addition, the biodistribution of S( 198Au)GNs-F showed significant uptake in CT-26 tumors with 0.58 ± 0.02 and 0.42 ± 0.02 %ID/g at 60 and 120 min, respectively. The tumor to blood ratio was 2.18 at 120 min after the injection. These results suggest that S( 198Au)Ns-F has potential as a folate-receptor-targeted agent.
    No preview · Article · Jan 2016 · Bulletin of the Korean Chemical Society
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    Yoon Seob Kim · Ji Hyun Lee · Young Min Park · Jun Young Lee

    Preview · Article · Dec 2015 · Annals of Dermatology
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    ABSTRACT: Population-based studies of atopic dermatitis (AD) in Korean children are lacking. Thus, the purpose of this study was to determine the prevalence, geographic distribution, and risk factors of AD in the Korean pediatric population. We examined AD prevalence using data from the 2008-2011 Korea National Health and Nutrition Examination Survey (KNHANES), which was a cross-sectional survey of 8,947 children up to age 18 throughout the country. Overall, 13.50% of children reported a diagnosis of AD. The age-standardized prevalence ranged from 9.13% to 17.67% between cities and provinces, with the highest prevalence-observed in many of the larger cities at low latitudes, as well as Jeju-do. After adjusting for confounders, high economic status was found to be a significant factor for predicting increased prevalence of AD, with an odds ratio of 1.35 (95% confidence interval of 1.02-1.79, P=0.0034). Urban living (odds ratio 1.24, 95% confidence interval of 1.00-1.53, P=0.0526) was also associated with a higher prevalence of AD. In this first large scale, nationwide study in Korean children, we found that the overall prevalence of AD depends on age, household income, and geographic distribution.
    Preview · Article · Nov 2015 · Allergy, asthma & immunology research
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    Hee Jin Jun · Hyung Ok Kim · Jun Young Lee · Young Min Park
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    ABSTRACT: The cutaneous manifestations of hemophagocytic lymphohistiocytosis (HLH) are variable and nonspecific. A 42-year-old man presented with multiple annular, erythematous patches on the trunk for 3 months. Two months later, he presented with bullae along with high fever. The laboratory examination showed pancytopenia, hypertriglyceridemia, and hypofibrinogenemia. The bone marrow biopsy specimen showed an active hemophagocytosis. On the basis of these findings, a diagnosis of HLH was concluded. After five cycles of chemotherapy, his skin lesion completely resolved. Taking the results together, we suggest that annular skin lesion can be added to the list of cutaneous manifestations of HLH.
    Preview · Article · Oct 2015 · Annals of Dermatology
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    ABSTRACT: While decreasing trend in gender differences in alcohol use disorders was reported in Western countries, the change in Asian countries is unknown. This study aims to explore the shifts in gender difference in alcohol abuse (AA) and dependence (AD) in Korea. We compared the data from two nation-wide community surveys to evaluate gender differences in lifetime AA and AD by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Face-to-face interviews using the Composite International Diagnostic Interview (CIDI) were applied to all subjects in 2001 (n = 6,220) and 2011 (n = 6,022). Male-to-female ratio of odds was decreased from 6.41 (95% CI, 4.81-8.54) to 4.37 (95% CI, 3.35-5.71) for AA and from 3.75 (95% CI, 2.96-4.75) to 2.40 (95% CI, 1.80-3.19) for AD. Among those aged 18-29, gender gap even became statistically insignificant for AA (OR, 1.59; 95% CI, 0.97-2.63) and AD (OR, 1.18; 95% CI, 0.80-2.41) in 2011. Men generally showed decreased odds for AD (0.55; 95% CI, 0.45-0.67) and women aged 30-39 showed increased odds for AA (2.13; 95% CI 1.18-3.84) in 2011 compared to 2001. Decreased AD in men and increased AA in women seem to contribute to the decrease of gender gap. Increased risk for AA in young women suggests needs for interventions.
    Preview · Article · Oct 2015 · Journal of Korean Medical Science
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    ABSTRACT: Silicon (Si) has attracted tremendous attention as a high-capacity anode material for next generation Li-ion batteries (LIB); unfortunately, it suffers from poor cyclic stability due to excessive volume expansion and reduced electrical conductivity after repeated cycles. To circumvent these issues, we propose that Si can be complexed with electrically conductive Ti2O3 to significantly enhance the reversible capacity and cyclic stability of Si-based anodes. We prepared a ternary nanocomposite of Si/Ti2O3/reduced graphene oxide (rGO) using mechanical blending and subsequent thermal reduction of the Si, TiO2 nanoparticles, and rGO nanosheets. As a result, the obtained ternary nanocomposite exhibited a specific capacity of 985 mAh/g and a coulombic efficiency of 98.4% after 100 cycles at a current density of 100 mA/g. Furthermore, these ternary nanocomposite anodes exhibited outstanding rate capability characteristics, even with an increased current density of 10 A/g. This excellent electrochemical performance can be ascribed to the improved electron and ion transport provided by the Ti2O3 phase within the Si domains and the structurally reinforced conductive framework comprised of the rGO nanosheets. Therefore, it is expected that our approach can also be applied to other anode materials to enable large reversible capacity, excellent cyclic stability, and good rate capability for high-performance LIBs.
    No preview · Article · Aug 2015 · ACS Applied Materials & Interfaces
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    ABSTRACT: A hybrid structure comprising organic dye molecules (e.g., rhodamine 6G) and graphene was developed for the realization of high-performance optoelectronic devices. The fabricated photodetector offered a broad spectral photo-response across wavelengths in the infrared, visible, and ultraviolet regions, as well as a high responsivity (∼460 A/W at illumination power of 1 μW). The photocurrent generated in the hybrid photodetector (∼mA) was much higher than that generated in a pristine graphene photodetector (<μA). The performance of the dye-sensitized photodetector relied on enhanced photoabsorption and the implementation of a photocurrent gain arising from the photo-excited charges.
    Full-text · Article · Jul 2015 · Carbon
  • Keun‐Sik Hong · Bum Joon Kim · Jun‐Young Lee · Sun U. Kwon
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    ABSTRACT: Prior intracerebral haemorrhage and cerebral microbleeds may increase the risk of haemorrhagic stroke. However, the optimal long-term antiplatelet therapy and lipid management in these patients remain unclear. PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage was designed to compare cilostazol and aspirin and to assess the effect of adding probucol, a lipid-lowering and anti-oxidative agent, in patients at high risk of haemorrhagic stroke. The projected sample size is 1600 patients with at least 12 months of follow-up. PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage is a randomized trial involving 67 institutes from 3 countries. Patients with non-cardioembolic ischemic stroke or transient ischemic attack within 180 days and with prior intracerebral haemorrhage or multiple cerebral microbleeds on gradient echo imaging are eligible. Enrolled patients are simultaneously randomized in a 2 × 2 factorial design: double-blind for cilostazol 200 mg/day vs. aspirin 100 mg/day, and an open-label, blind end-point evaluation for probucol 500 mg/day vs. non-probucol. The co-primary end-points are the safety end-point of haemorrhagic stroke and the efficacy end-point of a composite of stroke, myocardial infarction, or vascular death. Time-to-event will be analyzed separately for each intervention: superiority testing for the safety of cilostazol over aspirin as well as the efficacy of probucol over non-probucol, and non-inferiority testing for the efficacy of cilostazol to aspirin. PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage is the largest secondary stroke prevention trial for informing antiplatelet therapy and lipid management in patients at high risk of haemorrhagic stroke. © 2015 World Stroke Organization.
    No preview · Article · Jul 2015 · International Journal of Stroke
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    ABSTRACT: Copeptin has been considered as a useful marker for diagnosis and prediction of prognosis in heart diseases. However, copeptin has not been investigated sufficiently in hemodialysis patients. This study aimed to investigate the general features of copeptin in hemodialysis and to examine the usefulness of copeptin in hemodialysis patients with left ventricular dysfunction (LV dysfunction). This study included 41 patients on regular hemodialysis. Routine laboratory data and peptides such as the N-terminal of the prohormone brain natriuretic peptide and copeptin were measured on the day of hemodialysis. Body fluid volume was estimated by bioimpedance spectroscopy, and the E/Ea ratio was estimated by echocardiography. Copeptin increased to 171.4 pg/mL before hemodialysis. The copeptin had a positive correlation with pre-dialysis body fluid volume (r=0.314; p=0.04). The copeptin level decreased along with body fluid volume and plasma osmolality during hemodialysis. The copeptin increased in the patients with LV dysfunction more than in those with normal LV function (218.7 pg/mL vs. 77.6 pg/mL; p=0.01). Receiver operating characteristic curve analysis showed that copeptin had a diagnostic value in the hemodialysis patients with LV dysfunction (area under curve 0.737; p=0.02) and that the cut-off value was 125.48 pg/mL (sensitivity 0.7, specificity 0.8, positive predictive value 0.9, negative predictive value 0.6). Copeptin increases in hemodialysis patients and is higher in patients with LV dysfunction. We believe that copeptin can be a useful marker for the diagnosis of LV dysfunction in hemodialysis patients.
    Preview · Article · Jul 2015 · Yonsei medical journal
  • Yoon Seob Kim · Ji Hyun Lee · Jun Young Lee · Young Min Park

    No preview · Article · Jun 2015 · The Journal of Dermatology
  • Yeon Soo Kang · Ji Hyun Lee · Young Min Park · Jun Young Lee

    No preview · Article · May 2015 · Pediatric Dermatology
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    Ji Yoon Choo · Ji Hyun Lee · Jun Young Lee · Young Min Park

    Preview · Article · Mar 2015

  • No preview · Article · Mar 2015
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    ABSTRACT: We devised a simple transparent metal oxide thin film transistor architecture composed of only two component materials, an amorphous metal oxide and ion gel gate dielectric, which could be entirely assembled using room temperature processes on a plastic substrate. The geometry cleverly takes advantages of the unique characteristics of the two components. An oxide layer is metallized upon exposure to plasma, leading to the formation of a monolithic source-channel-drain oxide layer, and the ion gel gate dielectric is used to gate the transistor channel effectively at low voltages through a coplanar gate. We confirmed that the method is generally applicable to a variety of sol-gel processed amorphous metal oxides, including indium oxide, indium zinc oxide, and indium gallium zinc oxide. An inverter NOT logic device was assembled using the resulting devices as a proof of concept demonstration of the applicability of the devices to logic circuits. The favorable characteristics of these devices, including i) the simplicity of the device structure with only two components, ii) the benign fabrication processes at room temperature, iii) the low-voltage operation under 2 V, and iv) the excellent and stable electrical performances, together support the application of these devices to low-cost portable gadgets, i.e., cheap electronics.
    No preview · Article · Mar 2015 · ACS Nano
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    ABSTRACT: The influence of processing conditions, such as ink concentration and coating method, on the thermoelectric properties of SWCNT/P3HT nanocomposite films was investigated systematically. Using simple wire-bar-coating, SWCNT/P3HT nanocomposite films with high thermoelectric performance could be obtained without additional P3HT doping. The wire-bar-coated SWCNT/P3HT nanocomposite films exhibited power factors of up to 105 µW m-1K-2 at room temperature. The SWCNT bundles with diameters in the range of 6 - 23 nm formed an interconnected network in the wire-bar-coated nanocomposite films. Network formation in these nanocomposite films was expected to be strongly related to the development of electrical pathways due to inter-SWCNT bundle connections. This study suggests that the thermoelectric performance of SWCNT/P3HT nanocomposite films could be optimized by controlling their processing conditions and morphology.
    No preview · Article · Mar 2015 · ACS Applied Materials & Interfaces
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    ABSTRACT: Patients with atopic dermatitis (AD) should be relatively well informed about the disorder to control their condition and prevent flare-ups. Thus far, there is no accurate information about the disease awareness levels and therapeutic behavior of AD patients. To collect data on patients' knowledge about AD and their behavior in relation to seeking information about the disease and its treatment. We performed a questionnaire survey on the disease awareness and self-management behavior of AD patients. A total of 313 patients and parents of patients with AD who had visited the The Catholic University of Korea, Catholic Medical Center between November 2011 and October 2012 were recruited. We compared the percentage of correct answers from all collected questionnaires according to the demographic and disease characteristics of the patients. Although dermatologists were the most frequent disease information sources and treatment providers for the AD patients, a significant proportion of participants obtained information from the Internet, which carries a huge amount of false medical information. A considerable number of participants perceived false online information as genuine, especially concerning complementary and alternative medicine treatments of AD, and the adverse effects of steroids. Some questions on AD knowledge had significantly different answers according to sex, marriage status, educational level, type of residence and living area, disease duration, disease severity, and treatment history with dermatologists. Dermatologists should pay more attention to correcting the common misunderstandings about AD to reduce unnecessary social/economic losses and improve treatment compliance.
    Full-text · Article · Feb 2015 · Annals of Dermatology
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    Bo In Lee · Young Min Park · Hyung Ok Kim · Jun Young Lee

    Preview · Article · Feb 2015 · Annals of Dermatology
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    ABSTRACT: We investigated the heterojunction effects of perylene tetracarboxylic diimide (PTCDI) derivatives on the pentacene-based field-effect transistors (FETs). Three PTCDI derivatives with different substituents were deposited onto pentacene layers, and served as charge transfer dopants. The deposited PTCDI layer, which had a nominal thickness of a few layers, formed discontinuous patches on the pentacene layers, and dramatically enhanced the hole mobility in the pentacene FET. Among the three PTCDI molecules tested, the octyl substitut-ed PTCDI, PTCDI-C8, provided the most efficient hole doping characteristics (p-type) relative to the fluoro-phenyl substituted PTCDIs, 4-FPEPTC and 2,4-FPEPTC. The organic heterojunction and doping characteristics were systematically investigated using atomic force microscopy (AFM), 2D grazing incidence X-ray diffraction (2D GIXD) studies, and ultraviolet photoelectron spectroscopy (UPS). PTCDI-C8, bearing octyl substituents, grew laterally on the pentacene layer (2D growth), whereas 2,4-FPEPTC, with fluorophenyl substituents, un-derwent 3D growth. The different growth modes resulted in different contact areas and relative orientations between the pentacene and PTCDI molecules, which significantly affected the doping efficiency of the deposited adlayer. The differences between the growth modes and the thin-film microstructures in the different PTCDI patches were attributed to mismatch between the surface energies of the patches and the underlying pentacene layer. The film morphology-dependent doping effects observed here offer practical guidelines for achieving more effective charge transfer doping in thin film transistors.
    No preview · Article · Jan 2015 · ACS Applied Materials & Interfaces

Publication Stats

3k Citations
698.90 Total Impact Points

Institutions

  • 2001-2016
    • Catholic University of Korea
      • Department of Dermatology
      Sŏul, Seoul, South Korea
  • 2015
    • Korea University
      • College of Medicine
      Sŏul, Seoul, South Korea
  • 2003-2015
    • Seoul National University
      • • College of Medicine
      • • Department of Neuropsychiatry
      Sŏul, Seoul, South Korea
  • 2000-2015
    • Sungkyunkwan University
      • • Department of Chemical Engineering
      • • Institute of Science and Technology Law
      • • Department of Polymer Science and Engineering
      Sŏul, Seoul, South Korea
  • 1970-2015
    • Yonsei University
      • • Department of Internal Medicine
      • • Department of Materials Science and Engineering
      • • Department of Chemical and Biomolecular Engineering
      • • College of Medicine
      Sŏul, Seoul, South Korea
  • 2014
    • Gyeongju University
      Gyeongju, Gyeongsangbuk-do, South Korea
    • Soongsil University
      • Department of Chemical Engineering
      Sŏul, Seoul, South Korea
  • 2004-2014
    • Chosun University
      • • Division of Natural Medical Sciences
      • • College of Medicine
      Gwangju, Gwangju, South Korea
  • 2013
    • International St. Mary's Hospitals
      Chemulpo, Incheon, South Korea
    • Daegu Fatima Hospital
      연천군, South Korea
    • Yonsei University Hospital
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
    • Korea Centers for Disease Control and Prevention
      Daiden, Daejeon, South Korea
  • 2012-2013
    • Kookmin University
      • Graduate School of Automotive Engineering
      Sŏul, Seoul, South Korea
    • Seoul Medical Center
      Sŏul, Seoul, South Korea
    • Chonbuk National University Hospital
      Sŏul, Seoul, South Korea
    • Wonkwang University School of Medicine and Hospital
      Riri, North Jeolla, South Korea
    • Dongguk University
      • College of Science and Technology
      Sŏul, Seoul, South Korea
  • 2009-2012
    • Korea Institute of Industrial Technology
      Anzan, Gyeonggi Province, South Korea
  • 2001-2012
    • Korea Advanced Institute of Science and Technology
      • • Department of Chemistry
      • • Department of Chemical and Biomolecular Engineering
      Sŏul, Seoul, South Korea
  • 2011
    • University of Seoul
      Sŏul, Seoul, South Korea
    • Fukushima Medical University
      • Department of Gastroenterology and Rheumatology
      Hukusima, Fukushima, Japan
    • Wonkwang University
      • Department of Medicine
      Riri, North Jeolla, South Korea
  • 2007-2011
    • Electronics and Telecommunications Research Institute
      Sŏul, Seoul, South Korea
    • Soonchunhyang University
      • College of Medicine
      Onyang, Chungcheongnam-do, South Korea
  • 1999-2010
    • Yeungnam University
      • • Division of Internal Medicine
      • • Department of Urology
      Gyeongsan, Gyeongsangbuk-do, South Korea
  • 2008
    • Kyung Hee University
      • Pharmaceutical Science Division
      Sŏul, Seoul, South Korea
  • 2006
    • Keimyung University
      • Department of Chemical System Engineering
      Sŏul, Seoul, South Korea
  • 2005-2006
    • Sejong University
      • Department of Physics
      Sŏul, Seoul, South Korea
  • 1999-2003
    • University of Suwon
      Suigen, Gyeonggi Province, South Korea
  • 2002
    • University of Ulsan
      • College of Medicine
      Urusan, Ulsan, South Korea
    • Catholic University of Daegu
      • Department of Food Science and Nutrition
      Kayō, Gyeongsangbuk-do, South Korea
  • 1997
    • Korea Institute of Science and Technology
      • Electronic Materials Research Center
      Sŏul, Seoul, South Korea