S Ozme

Hacettepe University, Engüri, Ankara, Turkey

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Publications (82)114.58 Total impact

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    ABSTRACT: The aim of this study was to determine the prevalence and phenotype of metabolic syndrome in Turkish children and adolescents. We adapted the National Cholesterol Education Program Adult Treatment Panel III criteria of metabolic syndrome to children and adolescents. Using the international cutoff points and percentiles, we determined 10- to 17-year-old Turkish children and adolescents with high blood pressure, high triglyceride (TG), low high-density lipoprotein cholesterol (HDL-C), fasting glucose of 100 mg/dL or greater, and elevated body mass index corresponding to overweight or obesity. We examined 1385 apparently healthy students between the ages of 10 to 17 years from Ankara, Turkey: 4.9% of the subjects were overweight or obese; 29.2% had either low HDL-C and/or high TG levels; and 15.7% had either systolic or diastolic blood pressure above the 95th age-, sex-, and height-specific percentile. Thirty students (2.2%) had metabolic syndrome by having 3 or more risk variables. Metabolic syndrome was nearly 10 times more common among overweight and obese students (21%), compared with lean students. Components of metabolic syndrome such as high blood pressure and high TG, and low HDL-C levels were common among Turkish children and adolescents. Strategies should focus on early detection and treatment of these risk variables in Turkish children.
    No preview · Article · Sep 2006 · Metabolism
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    ABSTRACT: Low threshold characteristics and mechanical stability are important features of an ideal pacing lead, especially for children. We report our experience and medium-term results with a steroid-eluting, active-fixation ventricular lead in children. Telectronics Accufix II DEC model 033-212 ventricular leads were implanted in 21 patients. Eighteen patients (11 male / 7 female; 10.6+/-4.0 years), who were followed for a mean period of 6.47 +/-1.13 years, were included in the study. Pacemaker mode was DDDR in three patients, and VVIR in the remaining 15 patients. Mean threshold value was 0.5 volts at implant, which increased to 0.7 volts in the first month (p>0.05). It remained stable (0.62-0.78 V) until 5.5 years (p>0.05), increased significantly at 5.5 years (0.99+/-0.63 V at 5.5 years, p<0.05) and remained significantly high after this time (p<0.05). Pacing lead impedance did not differ significantly throughout the study (p>0.05). Thirteen pulse generators reached end-of-life at > or =4 years. In all the patients whose generators were replaced (11 patients), the leads were kept in place. Steroid-eluting active-fixation ventricular leads have long service lives and low chronic stimulation threshold values, allowing lower outputs. These features may have advantages in pacing therapy of children.
    No preview · Article · Dec 2005 · Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology
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    ABSTRACT: Turkish Heart Study demonstrated that low high density lipoprotein cholesterol levels are prevalent among Turkish adults. We compared body mass index and lipid levels of Turkish children (n = 1525, ages 10-17) with the bi-racial community of Bogalusa Heart Study. Turkish children have lower body mass index than American children (19.0 +/- 3 kg/m(2) for Turkish girls, 20.2 +/- 4 for White American girls, 20.9 +/- 5 for African American girls; and 18.9 +/- 3 kg/m(2) for Turkish boys, 20.2 +/- 4 for White American boys, 20.0 +/- 4 for African American boys, P < 0.01). Turkish children have higher triglyceride and lower high density lipoprotein cholesterol levels despite their lower body mass index. High density lipoprotein cholesterol levels (mmol/L) are 1.3 +/- 0.3 for Turkish girls and boys versus 1.4 +/- 0.5 for White American girls and boys, versus 1.6 +/- 0.5 and 1.7 +/- 0.5 for African American girls and boys, respectively (P < 0.01). Triglyceride levels (mmol/L) are 1.0 +/- 0.6 and 1.0 +/- 0.5 for Turkish girls and boys versus 0.9 +/- 0.5 and 0.8 +/- 0.5 for White American; and 0.7 +/- 0.3 for African American girls and boys, respectively (P < 0.01). Our observation of a lower HDL-C and a higher TG level in Turkish children (despite their lower BMI) is of interest and may indicate that unique characteristics in lipoprotein levels of Turkish adults start early in life.
    No preview · Article · Nov 2005 · Preventive Medicine
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    T Karagoz · A Celiker · O Hallioglu · S Ozme
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    ABSTRACT: In this report we describe an asymptomatic paced child with outer coil fracture of the bipolar screw-in steroid eluting ventricular lead without insulation defect, loss of ventricular capture and unexpected increase in lead impedance in the bipolar VVIR pace configuration. A previously unpublished method was performed to retract the helix and the lead. As a result, the fractured lead was successfully retrieved. We suggest that, this unusual extraction method can be tried as an alternative approach in the removal of an active fixation ventricular pacing lead with impaired mechanical function possibly due to fracture.
    Full-text · Article · May 2003 · Europace
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    ABSTRACT: This prospective study aims to investigate the reproducibility of HUTT results in children with typical history of vasovagal syncope. Between October 1996 and October 1999, 58 children with a history of typical vasovagal syncope attacks were evaluated with head up tilt test (HUTT). The table was tilted to 60 degrees and the patients were monitored for heart rate and blood pressure changes during 45 min. No provocative agents were used. The test was repeated a week later at a similar setting. Of 58 patients, 39 had positive and 19 had negative response during the initial test. During the second test, the positive response was reproduced in 29 cases (50%), and the negative response was reproduced in 16 cases (28%). Ten patients (17%) with an initial positive test had a negative second test. A negative test became positive only in three patients (5%). There were 12 vasodepressor, four cardioinhibitor and 23 mixed responses among the initial tests. Only in four patients did the type of the response change from vasodepressor to a mixed type during the second test. The reproducibility of a positive tilt test was 74.4% (29/39), the negative tilt test was 84.2% (16/19), and the overall reproducibility of the HUTT was 77.6% (45/58). Unprovoked HUTT in children is reproducible when repeated on different days and similar settings and the results are comparable to the ones with adult patients.
    No preview · Article · Apr 2003 · International Journal of Cardiology
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    Ozlem M Bostan · Alpay Celiker · Sencan Ozme
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    ABSTRACT: Ventricular tachycardia is rare in children. In the absence of structural heart disease, ventricular tachycardia is known as idiopathic ventricular tachycardia and carries a good prognosis. We report a 14-month-old male child with right bundle branch block incessant ventricular tachycardia without structural heart disease. In this patient ventricular tachycardia was controlled by amiodarone and disappeared during follow-up. We want to stress the benign nature of this tachycardia if the previous treatment protocol had been appropriate.
    Preview · Article · Apr 2003 · The Turkish journal of pediatrics

  • No preview · Article · Apr 2003 · International Journal of Cardiology
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    ABSTRACT: Cardiopathy is an expected finding in X-linked Duchenne and Becker muscular dystrophies. This holds true for some other forms such as autosomal recessive limb-girdle dystrophies. However, data on early-onset and usually severe congenital muscular dystrophies are limited. The purpose of this study was to investigate the presence of cardiac involvement in children with merosin-positive congenital muscular dystrophy. A total of 42 patients and 22 healthy subjects were evaluated by M-mode, 2D, and Doppler echocardiography. Cardiac anatomy, left ventricular dimensions, wall thickness and systolic and diastolic functions were investigated in patients and compared with those of healthy control subjects. Mean left ventricular ejection fraction and shortening fraction were significantly lower in the patient group (P<0.05 and P<0.001, respectively) and in three patients ejection fraction was below 55%. Although some impairments in left ventricular inflow indexes which were suggestive of left ventricular diastolic dysfunction were detected in patients with merosin-positive congenital muscular dystrophy they were not statistically significant. Our results suggest that left ventricular systolic abnormalities may occur in children with merosin-positive congenital muscular dystrophy.
    Full-text · Article · Feb 2003 · International Journal of Cardiology
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    ABSTRACT: Dual chamber pacemakers (single chamber pacing dual chamber sensing cardiac pacemaker (VDD) and dual chamber pacing and sensing cardiac pacemaker (DDD)) are being used frequently in children and adolescents. The aim of this study was to verify the safety and performance of the VDD and DDD pacing systems, and to evaluate the differences between two pacing modes with regard to atrial sensing and tracking functions. In this study, we evaluated 14 patients with VDD pacing and 15 patients with DDD pacing between 1994 and 2000. In the patient group with VDD pacing, all had congenital or acquired atrioventricular (AV) block. In the patient group with DDD pacing, 11 had congenital or acquired AV block, three had sinus node dysfunction with AV conduction disturbance and one had idiopathic hypertrophic subaortic stenosis. Twenty-eight devices were implanted in the subpectoral area using the transvenous route. After implantation the atrial tracking capabilities of the pacing systems were analyzed by telemetry, Holter monitoring, and treadmill exercise testing. The mean age of patients in the VDD pacing group was younger. The percentage of congenital heart disease was higher in the DDD pacing group. There was no significant difference regarding fluoroscopy time during implantation and follow-up time between the two groups. During implantation, in the VDD pacing group the mean sensed atrial signal was 3.1 +/- 1.3 mV and this decreased to 1.37 +/- 0.68 mV (P < 0.05) during follow-up. This pattern was also observed in DDD group (3 +/- 2 mV vs 1.9 +/- 1.5 mV, P < 0.05). Although the P wave measurement at implantation did not differ between the two groups, it was significantly higher in the DDD pacing group at the last control. Three patients with VDD pacing were reprogrammed to VVI or single chamber pacing and sensing, rate adaptive cardiac pacemaker because of complete loss of AV synchrony. There was no atrial sensing problem in the DDD pacing group. During the follow-up, one patient with VDD pacing developed diaphragmatic stimulation and required lead revision. In one patient with DDD pacing, venous thrombosis occurred in the right subclavian vein and was treated with thrombolytic therapy. During treadmill exercise testing, in one patient with VDD and one patient with DDD pacing temporary failure of atrial sensing occurred. At 24 h Holter monitoring, intermittent loss of atrial sensing was documented in two patients with VDD pacing. Dual chamber pacing in children with DDD or VDD pacemakers is a suitable method for bradycardia treatment. Atrial sensing problems may occur in VDD pacemakers. Therefore, DDD pacing mode should be preferred whenever suitable for the patient to maintain the AV synchrony.
    No preview · Article · Jan 2003 · Pediatrics International
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    Firat Kardelen · Alpay Celiker · Sema Ozer · Sencan Ozme · Ali Oto
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    ABSTRACT: Sinus node dysfunction has been reported rarely in pediatric patients with structurally normal hearts. It has been diagnosed with increasing frequency in children and young adult patients with congenital heart defect, especially in patients who have undergone corrective cardiac surgery related with atrial tissue. Between 1984-1999, 26 patients who were under 22 years of age underwent implantation of a permanent pacemaker for treatment of sinus node dysfunction at our medical center. This subset of patients represents 18.5% of all patients who required permanent pacemakers during this time. The mean age of the 17 male and 9 female patients at initial implantation was 9.2+/-6 years (range, 0.5 to 22 years). Of the 26 patients, 18 (69%) had associated cardiovascular disease and in 11 (34.6%) patients, sinus node dysfunction developed after a cardiac operation. The patients were followed up for a total 1,227 (47+/-45, range 2-176, median 34) pacing months. All symptomatic patients noted a resolution of symptoms after pacing had been performed, and they remained free of symptoms at the latest follow-up examination. Mean acute pacing thresholds and mean latest pacing thresholds for the endocardial atrial and ventricular leads, mean acute impedance and mean latest impedance for the endocardial atrial and ventricular leads and mean acute p wave voltage and the latest p wave voltage did not differ significantly. In this report, we review our experience in children who required implantation of a permanent pacemaker for treatment of sinus node dysfunction during a 15-year period.
    Preview · Article · Oct 2002 · The Turkish journal of pediatrics
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    ABSTRACT: This study was designed to evaluate possible interactions between digital cellular telephones and implanted pacemakers in children. The study comprised 95 patients (53 males and 42 females) with a mean age of 11.5 +/- 4.6 years (range 1-22 years). The average time from pacemaker implantation was 2.5 years (range 1 month-12 years). Fourteen (15%) devices were dual chamber and the remaining were single chamber pacemakers. The following companies manufactured the pacemakers tested: Medtronic (n = 42), Telectronics (n = 9), Vitatron (n = 16), Pacesetter (n = 19), CPI (n = 8), and Biotronik (n = 1). All the patients were tested in the supine position during continuous ECG monitoring. After completion of the routine pacemaker check, the effects of the European Global system for mobile communication (GSM) was tested using two cellular telephone models (Ericsson GA 628 and Siemens S 25, 2-W power). For this purpose, atrial and ventricular sensitivity settings were programmed to the most sensitive values, and the tests were carried out in the unipolar and bipolar sensing modes. The evaluation was performed during ringing, switching on/off, and conversation phase with the cellular telephone positioned over the pulse generator and around the pacemaker pocket. A malfunction of the pacemaker was not observed in any patient. Only 1 (1%) of 95 patients showed a brief oversensing problem during calls with the cellular telephone. In this case, an AAIR pacemaker was implanted transvenously in a subcutaneous pocket and the sensing defect occurred only with the unipolar sensing mode and was not reproducible. Once the source of interference was removed, no sensing defect was detected and the patient remained asymptomatic. No symptoms were experienced in this study. The authors believe that pacemaker dependent patients with nonprotected pulse generators manufactured at the beginning of 1990s may be tested by their physicians for possible interferences before they use a digital cellular telephone.
    No preview · Article · Oct 2002 · Pacing and Clinical Electrophysiology
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    ABSTRACT: Arrhythmias are among the malignant causes of syncope. This study has been undertaken to determine the relative incidence and significance of dysrhythmia in the pathogenesis of syncope among patients referred to a pediatric cardiology unit. Between March 1997 and March 1999, 105 consecutive patients (59 female, 46 male) aged 11.5 +/- 3.6 years without neurologic or cardiac morphologic causes were evaluated for at least one episode of syncope. A pediatric cardiologist and a pediatric neurologist evaluated all the patients. Routine chest X-ray, 12-lead electrocardiogram (ECG), electroencephalography (EEG), 24-h Holter monitoring and echocardiography were carried out. When deemed necessary, further tests were undertaken for the cases of syncope which were unexplained by routine tests. The cause of syncope was identified as vasovagal in 25.7% (n = 27) and related to dysrhythmia in 30.5% (n = 32). The cause was migraine-associated syncope in two children, psychogenic syncope in three children and orthostatic hypotension in one patient. The cause was unknown in 36.2% (n = 38). We conclude that dysrhythmia is a significant and frequent cause in children referred to pediatric cardiology units. The combination of ECG, Holter monitoring, electrophysiologic study, transtelephonic ECG and head-up tilt test can identify the underlying cause of syncope in as many as 58% of these patients that present with syncope.
    No preview · Article · Sep 2002 · Pediatrics International
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    ABSTRACT: We reviewed hospital records of 45 children with corrected transposition of the great arteries (c-TGA) to determine the incidence and outcome of congenital and postoperative dysrhythmias seen in this congenital anomaly. Our study comprised 45 patients (12 girls, 33 boys). The mean age of the patients at initial evaluation was 3.4 +/- 3.7 years, and they were followed for a mean period of 3.5 +/- 4 years. Forty-three patients (95%) with c-TGA had associated intracardiac defects. Two patients (5%) did not have any cardiac defects. In 31 (69%) of the 45 patients, ventricular septal defect (VSD) was present, while the remaining 14 patients (31%) had intact ventricular septum. VSD repair was done in 17 of 31 patients. Different types of dysrhythmias were detected in 19 of 45 patients. Six patients (13%) presented initially with congenital complete atrioventricular block (AVB) and five patients with postoperative complete ve AVB. Pacemaker implantation was required for 11 patients with complete AVB. In eight patients, ventricular and supraventricular ectopic beats, left bundle-branch block (LBBB) and first-degree AVB were determined but therapy was not required. TWenty-five (58%) of 43 patients with intracardiac defects underwent different surgical procedures. Permanent pacemaker implantation was required for five patients (29%) after VSD repair (17 patients) due to postoperative complete AVB. The incidence of congenital AVB in 14 patients with intact ventricular septum was found to be high (29%) in comparison to the group with VSD (6%). Patients diagnosed as c-TGA with or without cardiac defects should be followed carefully during their clinical course to identify and treat different types of dysrhythmias that can appear at any time.
    No preview · Article · Jul 2002 · The Turkish journal of pediatrics
  • Alpay Celiker · Canan Ayabakan · Sema Ozer · Sencan Ozme
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    ABSTRACT: There is limited experience on sotalol use in the management of childhood arrhythmias. This study reviews the results of our experience with oral sotalol for treatment and prevention of tachyarrhythmias in children. The records of 62 patients (27 female, 35 male, mean age: 8.5+/-5.3 years) treated with sotalol for supraventricular or ventricular arrhythmias from 1994 to 1999 at our institution were reviewed. Demographic, clinical, echocardiographic, electrocardiographic (ECG), ambulatory ECG and electrophysiologic variables were collected. Forty-two (63.6%) patients had re-entrant supraventricular tachycardia, eight patients (12.9%) had atrial tachycardia, one patient (1.6%) had junctional ectopic tachycardia, four patients (6.5%) had ventricular tachycardia, and seven patients (11.3%) had complex ventricular arrhythmias, as evidenced by surface or ambulatory ECG records; or revealed during the electrophysiological study. The mean sotalol dose was 3.9+/-1.2 mg/kg per day. In 15.5+/-13.9 months of sotalol use 50% (n=31) had complete relief of symptoms and/or arrhythmia and 29% (n=18) had partial relief. Sotalol was ineffective in 20% (n=13). Sotalol was more effective in re-entrant type supraventricular tachycardias (P=0.012). Sotalol was the first choice in 35.5% of patients. The sotalol therapy was initiated in inpatient settings in 40.3% (25 patients). Complications due to sotalol were seen in six patients (five patients developed bradycardia/pauses, and one patient had torsades de pointes) for which the sotalol dose was modified. In patients with sick sinus syndrome, a pacemaker was implanted and in another patient sotalol was stopped. Sotalol, being an effective and safe drug particularly in children, is a good therapeutic alternative for the preventive treatment of childhood tachyarrhythmias.
    No preview · Article · Jan 2002 · Pediatrics International
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    ABSTRACT: We retrospectively assessed the clinical course and outcome of left-sided endocarditis in pediatric patients to find out the prognostic significance of the presence and size of echocardiographically detected vegetations. Among the children admitted to our institution with endocarditis between January 1987 and October 1999, 16 patients (mean age 9.03 +/- 4.95 years) who met the Duke criteria for the diagnosis of infective endocarditis (IE) were included in this study. Rheumatic valvular disease was the most frequent underlying heart disease (10 patients: 62.5%). Five patients were operated at a mean of 13.9 months before endocarditis, and all had residual defects. Vegetation was detected in 11 cases (69%). Ten patients had major complications (within 2 weeks in 6 patients). Three patients developed congestive heart failure (CHF), six had intracranial and one had lower extremity emboli. Among them four were operated because of complications (CHF: 3 cases, intracranial emboli: 1 case). All the operated cases are doing well. The association between intracranial embolic events and echocardiographically detected vegetations was determined by calculating specificity (40%), sensitivity (100%), positive predictive value (50%), and negative predictive value (100%). No intracranial embolism occurred in patients without vegetations. All vegetations were < or = 6 mm in patients with systemic embolism. There were four deaths, three of which were because of intracranial embolism. This study suggests that intracranial emboli have a major risk of mortality in left-sided endocarditis. The larger size of the vegetation is not a predictor of complications; furthermore, the absence of vegetations predicts that the patient is safe from embolic events. Therefore all patients with left-sided IE should be considered for earlier surgical intervention.
    No preview · Article · Jan 2002 · The Turkish journal of pediatrics
  • C Ayabakan · S Ozer · A Celiker · S Ozme
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    ABSTRACT: Holter monitoring (HM) is widely used in arrhythmic disorders of adult patients; however, studies in the pediatric age group are limited. This study aims to determine the value of HM in diagnosis and treatment of disorders related to arrhythmias in pediatric patients. We examined 2,017 Holter records of 1,500 children who applied to our institution between November 1994 and October 1998. The age ranged from 0-24 years (52% male, 48% female). The indications for HM were screening for arrhythmic symptoms (palpitation, chest pain, syncope) in 67 percent, monitoring dysrhythmic therapy in 17 percent, postoperative control in five percent, and pacemaker control in four percent. Palpitation is the leading presenting symptom, with more frequent findings of supraventricular extrasystole (SVE), supraventricular tachycardia (SVT), ventricular extrasystole (VE) and complete heart block (CHB) when compared to other symptoms. Only 5.3 percent of the patients had arrhythmic symptoms during monitoring and asymptomatic patients had more frequent arrhythmias. SVT, VE, and CHB are more frequent findings in the abnormal heart with previous cardiac operations. The diagnostic yield is low with arrhythmic symptoms in the pediatric age group; however, HM enables cumulative evaluation of heart rhythm and rhythm variability, which is important in diagnosing silent arrhythmias in high risk groups (abnormal heart, postoperative heart).
    No preview · Article · Oct 2000 · The Turkish journal of pediatrics
  • T Karagöz · A Celiker · S Ozer · S Ozme · M Saraçlar
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    ABSTRACT: Sick sinus syndrome is a rare cause of bradycardia in children without structural heart disease. A case of profound sinus bradycardia, sinus arrest with junctional escape, and pauses in a two-year-old infant with breath-holding and syncope episodes is presented. As a result of these clinical symptoms and electrocardiographic findings, the patient with sick sinus syndrome underwent implantation of transvenous ventricular pacemaker. He has been well and asymptomatic since the insertion of the pacemaker. In the differential diagnosis of an infant with breath-holding and syncope episodes, when these symptoms in particular cannot be explained by other common reasons, sick sinus syndrome should be kept in mind. This case also illustrates the importance of electrocardiographic studies for the diagnosis.
    No preview · Article · Oct 2000 · The Turkish journal of pediatrics
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    ABSTRACT: Although active fixation ventricular leads seem to have advantages over passive fixation leads, this study compares the follow-up results of active and passive fixation leads in children. We evaluated the implantation and follow-up data of 41 children with active (Accufix II DEC, group 1) (n = 20) or passive (Membrane E, group 2) (n = 21) fixation, steroid-eluting ventricular leads. All but one of the patients in group 1 completed the 12-month follow-up. The mean follow-up period in group 2 was 10.4 +/- 2.9 months (range 3-12 months, median 12 months). In both groups the mean pacing threshold was measured as 0.51 +/- 0.09 V versus 0.48 +/- 0.15 V (P > 0.05) at 0.5-ms pulse width, mean R wave amplitude as 9.9 +/- 2.5 mV versus 9.4 +/- 3.2 mV (P > 0.05), and mean impedance as 557 +/- 92 omega versus 664 +/- 160 omega (P < 0.05), respectively, at implantation. After the first week of pacing, mean threshold values in group 1 were significantly lower than those of group 2 (P < 0.01 and P < 0.05, respectively). During the follow-up period, lead impedance measurements did not show a significant difference between the two groups. In one patient from group 1, the lead (by unscrewing) was removed easily because of pacemaker pocket infection. No lead dislodgement or helix deformation occurred in group 1. Nevertheless, in one patient from group 2, the lead was extracted at 4-month postimplantation because of lead displacement. We conclude that the steroid-eluting active fixation lead (Accufix II DEC) have advantages of easier implantation and lower acute and chronic stimulation thresholds compared to the passive fixation lead (Membrane E). Therefore, Accufix II DEC is superior to Membrane E, and it is a better first choice in children with an implanted single chamber ventricular pacemaker.
    No preview · Article · Aug 2000 · Pacing and Clinical Electrophysiology
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    ABSTRACT: Although active fixation ventricular leads seem to have advantages over passive fixation leads, this study compares the follow-up results of active and passive fixation leads in children. We evaluated the implantation and follow-up data of 41 children with active (Ac-cufix II DEC, group 1) (n = 20) or passive (Membrane E, group 2) (n = 21) fixation, steroid-eluting ventricular leads. All but one of the patients in group 1 completed the 12-month follow-up. The mean follow-up period in group 2 was 10.4 ± 2.9 months (range 3–12 months, median 12 months). In both groups the mean pacing threshold was measured as 0.51 ± 0.09 V versus 0.48 ± 0.15 V (P > 0.05) at 0.5-ms pulse width, mean R wave amplitude as 9.9 ± 2.5 m V versus 9.4 ± 3.2 mV (P > 0.05), and mean impedance as 557 ± 92 Ω versus 664 ± 160 Ω (P < 0.05), respectively, at implantation. After the first week of pacing, mean threshold values in group 1 were significantly lower than those of group 2 (P < 0.01 and P < 0.05, respectively). During the follow-up period, lead impedance measurements did not show a significant difference between the two groups. In one patient from group 1, the lead (by unscrewing) was removed easily because of pacemaker pocket infection. No lead dislodgement or helix deformation occurred in group 1. Nevertheless, in one patient from group 2, the lead was extracted at 4-month postimplantation because of lead displacement. We conclude that the steroid-eluting active fixation lead (Accufix II DEC) have advantages of easier implantation and lower acute and chronic stimulation thresholds compared to the passive fixation lead (Membrane E). Therefore, Accufix II DEC is superior to Membrane E, and it is a better first choice in children with an implanted single chamber ventricular pacemaker.
    No preview · Article · Aug 2000 · Pacing and Clinical Electrophysiology
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    ABSTRACT: CATCH 22 is a medical acronym for cardiac defects, abnormal facies, thymic hypoplasia, cleft palate, and hypocalcemia, and a variable deletion on chromosome 22q11. The deletion within the chromosome region of 22q11 may occur in patients with dysmorphologic and cardiological syndromes: DiGeorge syndrome (DGS), velocardiofacial syndrome (VCFS), and conotruncal anomaly face syndrome (CAFS). In this study, using N25 (D22S75) DiGeorge chromosome region probe. fluorescence in situ hybridization (FISH) analyses were performed on 32 patients with congenital heart diseases. Twenty-nine of 32 patients had conotruncal heart disease. A 22q11 deletion was detected in two patients (6.9%) of the 29 patients with conotruncal heart disease. One of our 22qdel (+) patients had unilateral facial nerve palsy. Although it is not a frequent finding, unilateral facial nerve palsy will be included among the symptoms of CATCH 22 syndrome. After careful clinical evaluation of patients with conotruncal cardiac anomalies, only syndromic cases should be screened for this deletion.
    No preview · Article · Jul 2000 · The Turkish journal of pediatrics

Publication Stats

801 Citations
114.58 Total Impact Points

Institutions

  • 1977-2006
    • Hacettepe University
      • • Department of Pediatrics
      • • Department of Pediatric Cardiology
      • • Department of Cardiology
      • • Department of Cardiovascular Surgery
      • • Faculty of Medicine
      Engüri, Ankara, Turkey
  • 2003
    • Uludag University
      • Faculty of Medicine
      Boursa, Bursa, Turkey