[Show abstract][Hide abstract] ABSTRACT: A double-blind clinical comparison of cefadroxil granules (CDX) and a long-acting preparation of cephalexin granules (L-CEX) was conducted in the treatment of impetigo in children. The long-acting cephalexin preparation was composed of 3 parts of granules soluble in the stomach and 7 parts of those soluble in the intestine. Drugs were administered at 3 different doses depending on the body weight of patients (Group I: less than 10 kg, Group II: between 10 kg and 20 kg, Group III: over 20 kg). Overall clinical evaluation by attending doctors: CDX group scored slightly better but not statistically significant results. Evaluation of usefulness: CDX group scored slightly better but not statistically significant results. Partially standardized evaluation: CDX scored statistically significantly higher points in the evaluation of total cases and Group II on Day 5, and Group II on Day 7. Cumulative points through Day 5 and Day 7 were not statistically significant. Follow-up evaluation by attending doctors: CDX group got a better result in total cases and Group II on day 3, and in total cases on days 5 and 7. Otherwise there was no statistically significant difference. Incidence of side effects was not significantly different between the 2 drug groups. As shown in Fig. 1, CDX was administered on rising in the morning, after lunch, and at bed time whereas L-CEX was given on rising and at bed time when the patients were relatively in fasting condition. This may have reduced the expected merit of L-CEX and some reserve is required in the interpretations of the results shown herein.
No preview · Article · Jul 1983 · The Japanese journal of antibiotics
[Show abstract][Hide abstract] ABSTRACT: Cefmetazole was studied experimentally in the field of dermatology. The following results were obtained. 1. The in vitro antibacterial activities of cefmetazole against S. aureus and S. epidermidis were studied. Most strains of both staphylococci were inhibited by 1.56 micrograms/ml or less of cefmetazole. 2. Serum and skin concentrations of cefmetazole in rats were studied after intramuscular administration of 20 mg/kg of cefmetazole. Mean serum concentrations were 40.3, 21.5, 7.1, 0.56 micrograms/ml respectively at 0.25, 0.5, 1 and 2 hours, and the corresponding skin concentrations were 12.5, 6.1, 0.62, 0.61 micrograms/g (n = 4).
No preview · Article · Sep 1982 · The Japanese journal of antibiotics
[Show abstract][Hide abstract] ABSTRACT: 1. Fortimicin (KW-1070) was found to be similar to amikacin in vitro activity against S. aureus of 27 strains and S. epidermidis of 17 strains isolated in dermatological field. 2. Serum and skin levels of the drug were determined in rats. Mean serum levels (n = 4) were 4.91 mcg/ml at 1/4 hour, 2.40 mcg/ml at 1/2 hour, 2.40 mcg/ml at 1 hour and 0.51 mcg/ml at 2 hours. The corresponding skin levels were 2.15 mcg/g, 2.27 mcg/g, 0.83 mcg/g and 0.19 mcg/g. 3. Seven cases with dermatological infections were treated with fortimicin. No side effects were observed both in subjective and in laboratory findings.
No preview · Article · Jul 1982 · The Japanese journal of antibiotics
[Show abstract][Hide abstract] ABSTRACT: C-AMOX was administered to adult patients of acute bacterial skin infection at the dosage of 500 mg 2 times a day after meals in the morning and in the evening. Evaluation was done in 4 grades, i.e. excellent, good, fair and poor. Of 42 cases treated, excellent was marked in 11 cases and good was in 14 cases. Percentage of excellent and good results was 59.5%. Fair results being included, the percentage rises to 83.3%. As subjective side effects, stomach trouble (including stomachache) were observed in 2 cases and diarrhea, perleche, rash, nausea and loss of appetite were each 1 case.
No preview · Article · Mar 1982 · The Japanese journal of antibiotics
[Show abstract][Hide abstract] ABSTRACT: 1. Cefroxadine dry syrup was in principle administered at the dosage of 10 mg per kilogram of body weight 3 times a day. 2. Evaluation was done in 4 grades, i.e. excellent, good, fair and poor. 3. According to subjective judgement by attending doctors, 'excellent' or 'good' was recorded in 90.7%. 4. If the evaluation was partially standardized, 'excellent' or 'good' was obtained in 74.8% of total 163 cases and in 78.7% of 108 impetigo cases. 5. Side effects were observed in 3 cases (diarrhea 1, fever 2). No direct correlation of these complaints with the administration of the present drug was confirmed.
No preview · Article · Jan 1982 · The Japanese journal of antibiotics
[Show abstract][Hide abstract] ABSTRACT: MICs against 91 strains of clinical isolates (S. aureus, 82 strains; S. epidermis, 9 strains) of erythromycin, lincomycin, clindamycin, oxacillin, cephaloridine, cephalothin, cephalexin, doxycycline and minocycline were determined by the standard method of the Japanese Society of Chemotherapy. Serum and skin levels in rats were studied after oral administration of 100 mg/kg of oxacillin and dicloxacillin, 100 mg/kg and 20 mg/kg of doxycycline. From the results we concluded as follows: In moderate skin infections caused by S. aureus, we choose firstly oxacillin, dicloxacillin or cephalexin in oral forms which showed potent antibacterial activity against S. aureus; The resistant strains against macrolides and lincomycins have increased, and minocylcine or doxycycline was considered the drug of second choice, as the resistant strains of staphylococci against these tetracyclines were fewer than macrolides and lincomycins. Longer maintenance of effective serum and skin concentrations was another merit of minocycline and doxycycline; Gram negative bacilli were isolated only rarely from the primary skin infections.
[Show abstract][Hide abstract] ABSTRACT: 1. MIC against 20 strains of staphylococcus isolated from skin infections was studied. MIC was less than or equal to 0.05 mug/ml in 11 strains and greater than 100 mug/ml in 9 strains. 2. Clindamycin-2-phosphate was injected intramuscularly to rats at the dosis of 10 mg/kg in solution of 10 mg/ml. The serum and skin levels of this drug were determined at 0.5, 1, 2, 4 and 7 hours. Mean serum levels of 4 rats were 0.893, 0.578, 0.463, 0.268 and 0.167 mug/ml respectively at 0.5, 1, 2, 4 and 7 hours. The corresponding skin levels were 0.500, 0.707, 0.431, 0.313 and 0.269 mug/g. 3. Clindamycin-2-phosphate was used clinically in 7 patients of skin infection with the following result: excellent in 2 cases, fair in 3 cases and poor in 2 cases. Abdominal pain was complained in one case and loose stool in one case.
No preview · Article · Feb 1977 · The Japanese journal of antibiotics