Yuka Satsuki

Osaka Prefectural Institute of Public Health, Ōsaka, Ōsaka, Japan

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Publications (6)14.43 Total impact

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    ABSTRACT: Recently, thienyl derivatives of cathinones have appeared on the market as new psychoactive substances (NPS). In this study, identification and characterization of 2-(pyrrolidin-1-yl)-1-(thiophen-2-yl)pentan-1-one (α-PVT), 2-(pyrrolidin-1-yl)-1-(thiophen-2-yl)butan-1-one (α-PBT), and their bromothienyl analogs disclosed in illicit products are described. In our analysis, some analogous compounds of α-PVT, which had a bromine substitution on the thiophene ring, were identified in the samples containing α-PVT; 1-(4-bromothiophen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one, 1-(5-bromothiophen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one, and 1-(4,5-dibromothiophen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one by comparing the analytical data with synthetic reference standards. We also observed 1-(4-bromothiophen-2-yl)-2-(pyrrolidin-1-yl)butan-1-one and 1-(5-bromothiophen-2-yl)-2-(pyrrolidin-1-yl)butan-1-one from a powder product, in which α-PBT was detected. The brominated α-PVTs were also found when overbrominated 1-(thiophen-2-yl)pentan-1-one reacted with pyrrolidine, and they are suspected to be the by-products of α-PVT synthesis. In Japan, cathinone derivatives with a phenyl group as the aromatic ring have been widely controlled by generic scheduling. To escape from such a regulation, analogs with different aromatic groups such as α-PVT and α-PBT appeared on the illicit market of psychoactive compounds. To our knowledge, this is the first report describing identification of α-PBT, and bromothienyl analogs of both α-PVT and α-PBT in illicit drug products. The synthetic method and analytical data shown in this study will be useful for identification of the thienyl derivatives of cathinone analogs. © 2015 Japanese Association of Forensic Toxicology and Springer Japan
    No preview · Article · Aug 2015 · Forensic Toxicology
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    ABSTRACT: LY2183240 and the LY2183240 2′-isomer inhibit cellular reuptake and enzymatic hydrolysis of endocannabinoids. These compounds were detected in herbal blend products as designer drugs. Simultaneously, two analogs of LY2183240 and LY2183240 2′-isomer were also detected; (A) 5-[(biphenyl-4-yl)methyl]-1H-tetrazole and (B) 2-(N,N-dimethylamino)-5-[(biphenyl-4-yl)methyl]-1,3,4-oxadiazole. The structure of compound B was identified by nuclear magnetic resonance spectroscopy and X-ray crystallography. To reveal the mechanism of production of these compounds in herbal products, we analyzed the reference standard solution of LY2183240 or the LY2183240 2′-isomer after treatment under various conditions. Compound A was easily formed as a decomposition product of both LY2183240 and the LY2183240 2′-isomer under hydrolysis conditions. Compound B was only detected from the solution of the LY2183240 2′-isomer. These findings suggest that compound B was produced by elimination of N2 from the tetrazole structure; LY2183240 and the LY2183240 2′-isomer may be decomposed at the step of producing herbal blend products, extraction procedure, and/or instrumental analysis. This is the first report to reveal the presence of two analogs of LY2183240 or the LY2183240 2′-isomer in herbal blend products.
    No preview · Article · Apr 2015 · Forensic Toxicology
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    ABSTRACT: Many methods for determining pesticide residues in food have been reported. Although natural medicines should be confirmed to be as safe as food, few methods for determining pesticide residues in natural medicines have been reported. In this study, 56 pesticides were detected in natural medicines with a simple, rapid sample preparation method. This study indicates that the proposed method is useful for analyzing pesticides in natural medicines.
    No preview · Article · Feb 2008 · Journal of Natural Medicines
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    ABSTRACT: Many methods for the determination of pesticide residues in food have been reported. Although natural medicines should be confirmed to be as safe as food, few methods for the determination of pesticide residues in natural medicines have been reported. In this study, 17 organochlorine pesticides were detected in natural medicines using GC/MS with negative chemical ionization (NCI). GC/MS with NCI can detect halogenated pesticides selectively and thus is suitable for the detection of organochlorine pesticides. This study indicates that GC/MS with NCI is useful for analyzing organochlorine pesticides in natural medicines.
    Full-text · Article · Aug 2007 · Yakugaku zasshi journal of the Pharmaceutical Society of Japan
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    ABSTRACT: Many methods for the determination of pesticides residues in food have been reported. Although natural medicines should be confirmed as safe as food, only a few methods for the determination of pesticide residues in natural medicines have been reported. In this study, 10 pyrethroid pesticides were detected in natural medicines by GC/MS with negative chemical ionization (NCI). GC/MS with NCI can detect halogenated pesticides selectively, and thus is suitable for the detection of pyrethroid pesticides. This study indicates that GC/MS with NCI is useful for analyzing pyrethroid pesticides in natural medicines.
    No preview · Article · Nov 2006 · Yakugaku zasshi journal of the Pharmaceutical Society of Japan
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    Takaomi Tagami · Keiji Kajimura · Yuka Satsuki · Takao Kawai
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    ABSTRACT: Dried thyroid added to dietary supplements was analyzed using liquid chromatographyl mass spectroscopy (LC/MS). However, rapid analysis of many dietary supplements on the market is difficult because the analysis uses expensive instruments (LC/MS) and requires a long time for pretreatment. The enzyme-linked immunosorbent assay (ELISA) is rapid, simple, and lowcost and thus suitable for processing many samples. In this study, we investigated rapid analysis of dried thyroid contained in dietary supplements with ELISA using commercial anti-thyroglobulin antibody. The analytical method using ELISA established in this study may be useful for the screening of dried thyroid added to dietary supplements.
    Preview · Article · Jan 2005 · Journal of health science