Chenping Zhang

Shanghai Jiao Tong University, Shanghai, Shanghai Shi, China

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Publications (53)105.5 Total impact

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    Feng Wang · Wei Huang · Chenping Zhang · Jian Sun · Xingzhou Qu · Yiqun Wu
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    ABSTRACT: Objective: Defects of the maxilla caused by tumor resection create high levels of psychological and physical trauma for patients. The application of osseointegrated dental implants using either an obturator prosthesis or a free vascularized flap has tremendously changed the retention and stability of the superstructure. However, no study has been performed to compare the function of the aforementioned two approaches and the quality of life using the subjective assessments of patients. Materials and methods: Eligible patients who were treated with maxillary resection and rehabilitated with implant supported obturator prostheses (group 1) or those who received free vascularized flap transfers with implant supported fixed prostheses (group 2) were enrolled between March 2006 and May 2014. A questionnaire that included the indices of the Obturator Functioning Scale (OFS), EORTC Head and Neck 35 assessment and the Mental Health Inventory (MHI) was used to evaluate the functional rehabilitation and QOL of patients in the study. Results: A total of 42 dental implants, including 25 zygomatic implants, were used in 18 patients (mean age: 56.2 ± 12.3 years) in the obturator prostheses in group 1. Twenty patients (mean age: 45.6 ± 14.1 years) who were treated with a vascularized free flap including the fibula (n = 15) and ilium (n = 5) combined with a total of 71 regular implants for fixed prostheses comprised group 2. No statistically significant median differences in the OFS, EORTC Head and Neck assessment and MHI global scale were observed between the groups. On the MHI subscales item-levels, higher median subscale scores exhibited by group 1 than group 2 and had statistically significant difference between the groups (P = 0.024). Conclusion: Within the limitations of this study, it demonstrated no difference in oral function between patients with implant supported obturators and implant supported fixed prostheses in free vascularized flaps after a maxillectomy. However, patients who received obturator therapy seemed to have poorer mental health than did patients with fixed prostheses, but it should be interpreted prudently with the study's limitation.
    Full-text · Article · Jan 2016 · Clinical Oral Implants Research
  • Zhonglong Liu · Zhuowei Tian · Chenping Zhang · Yue He

    No preview · Article · Dec 2015 · Oncology letters
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    ABSTRACT: To assess the feasibility of superficial circumflex iliac artery perforator (SCIP) flap for oral maxillofacial reconstruction and evaluate computed tomography angiography (CTA) and color Doppler sonography (CDS) in mapping superficial circumflex iliac artery (SCIA) and its perforators.
    No preview · Article · Dec 2015 · Journal of Cranio-Maxillofacial Surgery
  • Shanghui Zhou · Chenping Zhang · Daqing Li
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    ABSTRACT: Robot-assisted surgery is being increasingly used by surgeons because of its enhancement of visualization, precision, and articulation compared with conventional minimally invasive techniques. In recent years, robot-assisted neck dissection (RAND) has begun to be used as an alternative method of neck dissection, one of the classic surgical procedures in the area of head and neck surgery. Currently, there are four kinds of approaches for RAND: (1) modified facelift or retroauricular incision, (2) combined transaxillary and retroauricular incision, (3) transaxillary incision, and (4) transoral incision. RAND may help perform minimally invasive surgery and achieve excellent cosmetic results as well as the desired oncologic outcomes, and this requires selecting an appropriate approach based on the different needs of neck dissections. Although experienced surgeons wishing to avoid large cervical incisions in patients can safely perform RAND, there are still quite a few limitations; in particular, surgical morbidity and oncologic outcomes should be verified by further prospective clinical trials with longer follow-up periods. Also, RAND needs to be standardized and its use disseminated. In this review, we introduce the applications of different approaches for RAND and their indications and determine whether RAND can be more beneficial compared with conventional surgeries.
    No preview · Article · Nov 2015 · Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
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    ABSTRACT: Objectives: With microvascular reconstruction, different perforator flaps have been introduced for the treatment of head and neck defects. In light of this, the superficial circumflex iliac artery perforator (SCIP) flap was assessed for reconstruction after partial and hemiglossectomy. Study design: A total number of nine patients who received SCIP flap reconstruction for tongue defects were included in this study. Details on clinical features were collected, and postoperative functions and esthetic results were analyzed. Results: All the SCIP flaps survived, and postoperative speech and swallowing functions were generally found to be acceptable during follow-up. In addition, subjective questionnaire appraisals from patients were favorable. Conclusion: The SCIP flap may present a good alternative for reconstruction of partial or hemiglossectomy defects.
    No preview · Article · Nov 2015 · Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
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    ABSTRACT: Oral squamous cell carcinoma (OSCC) is a type of head and neck malignancy with a high mortality rate. Oral submucous fibrosis (OSF) is the pre-cancerous lesion of OSCC, whose molecular mechanisms in OSCC tumorigenesis remain largely unclear. Activation of the Wnt/β-catenin signaling pathway plays an important role in oral mucous carcinogenesis, although rare mutations of Wnt signaling molecules are found in OSCC, suggesting an epigenetic mechanism mediating aberrant Wnt/β‑catenin signaling in OSCC. Wnt inhibitory factor-1 (WIF1) is an Wnt antagonist, and its downregulation and methylation have been reported in a number of malignancies. However, the expression and methylation of WIF1 in the development of OSF have yet to be reported. In the present study, we investigated the WIF1 expression level by immuno-histochemical staining and semi‑quantitative RT-PCR in normal oral, OSF and OSCC tissues, as well as the methylation status by methylation-specific PCR and bisulfite genomic sequencing. The results showed that WIF1 was readily expressed in normal oral mucous tissues, but decreased gradually in OSF early, moderately advanced and advanced tissues, and was less expressed in OSCC tissues. Moreover, WIF1 was able to translocate from the nuclear to cytoplasm in OSF and OSCC tissues. Furthermore, WIF1 was frequently methylated in OSCC cases with betel quid chewing habit, but not in normal oral mucous and different stages of OSF tissues, suggesting WIF1 methylation is tumor-specific in the development of OSF. Thus, the results demonstrated that WIF1 is frequently downregulated or silenced by promoter methylation in the carcinogenesis of OSF, which serves as a potential epigenetic biomarker for the early detection of OSCC.
    Full-text · Article · Sep 2015 · Oncology Reports
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    Shuiting Fu · Zhuowei Tian · Chenping Zhang · Yue He
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    ABSTRACT: Mazabraud’s syndrome (MS) is a rare disease that is a combination of fibrous dysplasia and intramuscular myxomas. MS is a benign lesion and there is little data on the disease due to its low incidence. In the present study, the case of a 38-year-old patient who presented with a soft-tissue mass involving the masseter and swelling at the mandibular body and mandibular ramus is reported. Since the mandible is an important aesthetic and functional organ in the oral and maxillofacial region, surgery was primarily aimed at resecting the tumor, with good safety margins, and reconstructing the resultant defect. The lesions were pathologically diagnosed as MS. The unique features of this case included the painless and monostotic fibrous dysplasia, the solitary intramuscular myxomas involving the jaw and the male gender of the patient. MS usually occurs in the lower extremities, with an unusual predilection for the right limb; however, it rarely occurs in the head and neck region. A retrospective analysis of the clinical features and management of MS was also performed in the present study, together with a literature review. From the literature, it was concluded that the incidence of MS is ~2.3-fold greater in female patients than in male patients, and that the age of onset of MS ranges between 17 and 82 years, with an average age of 46.25 years.
    Preview · Article · Aug 2015 · Oncology letters
  • Duohong Zou · Feng Wang · Yiqun Wu · Wei Huang · Chenping Zhang · Zhiyuan Zhang
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    ABSTRACT: To evaluate the performance of dental implant-supported telescopic crown (TC)-retained overdentures to restore the oral function of patients who have insufficient jawbone volume resulting from tumor resection or trauma. From January 2004 to December 2008, implant-supported TC-retained overdentures were used to restore the oral function of patients with severe bony defects resulting from tumor resection or trauma. Clinical data, including implant success and survival rates, biologic and mechanical complications, prosthodontic maintenance efforts, and patient satisfaction, were analyzed annually after delivery of the final prostheses. Twenty-four patients were treated, and a total of 88 implants were inserted to support TC-retained overdentures. The mean modified plaque index of implants remained low (<20%), and the majority of implants (>76.3%) in the study showed the absence of bleeding on probing at follow-up visits. Peri-implant marginal bone loss (MBL) ranged from 0.8 to 1.2 mm. There was no statistically significant difference in the MBL between maxillary and mandibular implants (P = .43). The implant success rate was 100% after 5 years, and the prosthodontic maintenance and complication rate was 0.22 times per year. More than 90% of patients were satisfied with the restoration of their oral function using TCs. Based on our study of 24 patients treated with TC-retained overdentures, it appears that this treatment may be a viable option for patients with insufficient jawbone volume.
    No preview · Article · Jul 2015 · The International journal of oral & maxillofacial implants
  • Kailiu Wu · Xi Yang · Liwen Li · Min Ruan · Wei Liu · Wei Lu · Chenping Zhang · Siyi Li
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    ABSTRACT: The objectives of this study were to analyze the regional characteristics of the cervical lymph node metastasis and to investigate the factors associated with the risk of lymph node involvement. One hundred seventy-one patients suffering from early primary squamous cell carcinoma (SCC) of the tongue (cT1-2N0) were enrolled. Gender, age, growth site, T stage, histological grade, and neurovascular invasion were statistically analyzed by K-M survival analysis and Cox multivariate analysis to evaluate the relationship between the factors and the neck lymph node metastasis. Of the 171 cases divided into the neck dissection group and observation group, 40 ended up with lymph node metastasis, of which 17 were metastasized to level I, 27 to level II, 10 to level III, 2 to level IV, and 1 to level V. Histological grade and neurovascular invasion were significantly associated with lymph node involvement in univariate and multivariate analyses. Age distribution was found to be significantly associated with the lymph node metastasis in multivariate analysis. The metastasis of early tongue SCC has a certain regularity at different sites. Age was not a critical risk factor for cervical lymph node metastasis after surgery. Tumor size was suspected to exert a negative effect on metastasis by influencing tumor invasion. Histological grade and neurovascular invasion were significantly associated with the risk of cervical lymph node metastasis of early tongue SCC.
    No preview · Article · Apr 2015 · Molecular Neurobiology
  • Source
    Yiqun Wu · Chenping Zhang · Cristiane H. Squarize · Duohong Zou
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    ABSTRACT: The oral conditions of adult edentulous patients with ectodermal dysplasia (ED) often lead to decreased physical and psychological health, and the negative effects can become as extreme as social and psychological isolation. However, restoring oral function of adult edentulous patients with ED using zygomatic implants (ZIs) or conventional implants (CIs) remains challenging for dentists because of the severe atrophy of these patients' alveolar ridges. This report describes 2 cases of adult edentulous siblings with ED; they exhibited severe alveolar bone atrophy and were treated with ZIs and CIs as bases to augment the bone in their anterior jaws. For these patients, bone augmentation was completed with an autogenous fibular graft. Although there was mild evidence of bone graft resorption in the maxilla, the bone augmentation procedures were successful in the 2 patients. Effective osseointegration of the implants was obtained. After placement, the functional and esthetic results of the oral rehabilitation were acceptable. More importantly, restoration of the patients' oral function enhanced their self-confidence and self-esteem. Therefore, restoring oral function in adult patients with ED and edentulous jaws using ZIs and CIs as the bases for bone augmentation is an effective approach. Crown Copyright © 2015. Published by Elsevier Inc. All rights reserved.
    Full-text · Article · Apr 2015 · Journal of Oral and Maxillofacial Surgery
  • Zhonglong Liu · Zao Fang · Tianguo Dai · Chenping Zhang · Jian Sun · Yue He
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    ABSTRACT: Extensive studies have been conducted to analyze adenoid cystic carcinoma (ACC) in the head and neck region. No research has been published focusing on ACC patients with cervical lymph node (LN) metastasis. The aims of current investigation were to summarize the clinical characteristics of ACC patients with LN metastasis (ACC-LNM) and to identify prognostic factors for tumor-related outcomes. A retrospective review was conducted with respect to ACC patients with nodal involvement between 2000 and 2013. The clinical variables and outcomes of these special cases were recorded and further analyzed. Metastasis-free survival and overall survival rate were calculated using the Kaplan-Meier method, and the log-rank test and Cox regression analysis were applied to identify the prognostic factors. A total of 47 patients (34 male and 13 female) 32-77 years of age (mean: 54.6 years; median: 54 years) were analyzed in the current protocol. The recurrence-free survival (RFS), distant metastasis-free survival (MFS), and overall survival (OS) rate in all patients were 90.1%, 55.6%, and 60.1%, respectively. In univariate analysis, T stage, positive LN ratio, LN-involved section, and extracapsular spread were strongly associated with poorer MFS rate. The predictive roles of LN-involved section and surgical margin on the OS rate were also identified. In multivariate analysis, positive LN ratio and surgical margin were predictors for MFS and OS rate, respectively. Positive LN ratio was strongly associated with distant metastasis. Comprehensive treatment should be performed in ACC patients with higher positive LN ratios. In addition, ideal surgical margin should be achieved to acquire better overall survival rate. Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
    No preview · Article · Apr 2015 · Journal of Cranio-Maxillofacial Surgery
  • Yiqun Wu · Baohua Fan · Huayi Cheng · Chenping Zhang · Tong Ji · Zhiyuan Zhang

    No preview · Article · Feb 2015 · Journal of Neurological Surgery, Part B: Skull Base
  • Yue He · Huawei Yang · Jian Sun · Chenping Zhang · Hanguang Zhu · Zhonglong Liu
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    ABSTRACT: To elucidate the clinical characteristics of malignancies involving the pterygopalatine and infratemporal fossa and identify the outcome-related predictors. A retrospective review of the patients diagnosed with malignancies involving these spaces between 2006 and 2013 was conducted. We investigated the 5-year recurrence free survival, metastasis free survival and overall survival, and univariate and multivariate analysis were used to identify the outcome-related factors. A total of 80 patients (46 male and 34 female) aged from 1 to 82 years were retrospectively analysed. The most frequent location for involved malignancies included the pterygopalatine fossa (n = 35, 43.8%), followed by the infratemporal fossa (n = 25, 31.2%) and the pterygopalatine and infratemporal fossa together (n = 20, 25%). In multivariate analysis, gender (HR: 2.59, 95% CI: 1.034-6.488, p = 0.042), margin status (HR: 6.158, 95% CI: 2.115-17.932, p = 0.001) and adjuvant radiotherapy (HR: 3.116, 95% CI: 1.057-9.191, p = 0.039) were predictors for the 5-year recurrence-free survival rate, and brain invasion (HR: 6.218, 95% CI: 1.375-28.115, p = 0.018) and surgical margin (HR: 21.961, 95% CI: 2.383-202.418, p = 0.006) were predictors for the 5-year overall survival rate. These results indicate that malignancies involving the pterygopalatine and infratemporal fossa have a poor prognosis. Brain invasion is a dangerous sign for decreased survival. An ideal surgical margin is associated with a lower recurrence and higher survival rate. Adjuvant radiotherapy should be performed to achieve better local control. Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
    No preview · Article · Feb 2015 · Journal of Cranio-Maxillofacial Surgery
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    ABSTRACT: The use of vascularized nerve graft models has been limited because of the complexity of the operation. The authors sought to develop a simple and effective rabbit model for facial nerve repair and evaluated its advantages over conventional nerve grafts. Rabbits were divided into three groups consisting of six rabbits each. The central auricular nerve and its nutrient vessels were used as a vascularized graft. Rabbits were grafted with a vascularized facial nerve graft (vascularized nerve graft group), with a free nerve graft (free nerve graft group), or with a vascularized nerve graft and a free nerve graft on each side of the face (vascularized nerve graft/free nerve graft group). Four months after surgery, facial performance and electrophysiologic monitoring were evaluated. The rabbits were then killed to prepare the nerve specimens for histologic, immunohistochemical, and transmission electron microscope study. At 4 months after the facial nerve repair, the functional recovery of the facial nerve was observed and analyzed. The side grafted with vascularized nerve graft was superior to the side grafted with free nerve graft. Regenerated nerve fibers were observed in all groups, and rabbits grafted with vascularized nerve grafts had more regenerated axons than those that underwent free nerve grafting, although the regenerated nerves were not as good as the natural nerves. This study demonstrates that it is feasible to establish a vascularized nerve graft model in rabbits. The model offers the obvious advantages of operability and reliability. The vascularized nerve graft is demonstrated to have a superior value for facial nerve repair.
    No preview · Article · Feb 2015 · Plastic & Reconstructive Surgery
  • Weimin Ye · Jingzhou Hu · Hanguang Zhu · Chenping Zhang · Zhiyuan Zhang
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    ABSTRACT: Purpose Reconstruction of lower lip defect with Karapandzic flap often leads to greater rounding of commissure. The aim of this study was to provide a new design of bilateral Karapandzic flap, which is useful in large lower lip defect reconstruction. Methods In this retrospective study of case series, a modification of the Karapandzic lip reconstruction technique was used with an additional incision to recruit more tissue. The esthetic outcome of the reconstruction was assessed in a 4 point scale with regard to the shape of commissure, lip symmetry, appearance of the scar and lip projection. The functional outcome were assessed in terms of speech, preservation of oral competence, lip sensory, facial expression, diet and denture usage. Results Seventeen lower lip squamous cell carcinoma patients underwent single-stage lip reconstruction (13 males, 4 females) with an age range of 52 to 82 years. The lip defects post tumor resection ranged from 50 to 90% of the lower lips. All patients achieved oral competence, without leading to greater rounding of the commissure. The esthetic outcome was considered excellent/good in 88% of cases and the reconstruction did not lead to functional impairments of speech, oral competence, lip sensory, facial expression, diet or denture usage. Conclusions Modified bilateral Karapandzic flap is a reliable technique to reconstruct large lip defects without leading to rounding of the commissure. With this technique, good esthetic and functional outcomes could be achieved.
    No preview · Article · Oct 2014 · Journal of Oral and Maxillofacial Surgery
  • Xuelai Yin · Chenping Zhang · Eugene Poh Hze-Khoong · Yang Wang · Liqun Xu
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    ABSTRACT: Purposes The continuity and integrity of the enveloping nutritive periosteum may be compromised during the installation of the dental implant distractor (DID) device. This novel animal experiment aims to study the influence of the periosteum on the bony regenerate in 3 scenarios of periosteal coverage: whole periosteum (WP), half periosteum (HP) and no periosteum (NP). Materials and methods Twelve goat tibias were vertically osteotomised into two segments each and divided into the three groups of WP, HP and NP. A DID device was surgically installed onto each segment, followed by 10 days of distraction at a rate of 0.35mm twice daily. Fluorescence-labeling and trabeculae count per high powered field (TBC/HPF) measurements were performed and statistically compared across the various groups. Implant stability quotients (ISQ) of all fixtures were also done. Results New bone formation of WP and HP groups were found to be faster than the NP group under fluoroscopy. The TBC/HPF values had no statistically significant differences across all three groups. All WP groups showed significantly higher ISQ values (0.93) compared to the HP (0.85) and NP (0.84) groups. Conclusion Vertical distraction osteogenesis can be successfully performed with the dental implant distractor to obtain bone of adequate stock and density. However, the enveloping periosteum should be preserved as much as possible during the installation of the DID device.
    No preview · Article · Oct 2014 · Journal of Oral and Maxillofacial Surgery
  • Zhonglong Liu · Zhuowei Tian · Chenping Zhang · Jian Sun · Zhiyuan Zhang · Yue He
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    ABSTRACT: Flap complications still present challenges in the field of microsurgical reconstruction. The aim of this study was to explore the role of diabetes mellitus in free flap prognosis in elderly patients (≥60 years) after oral tumor resection. The data of aged oral cancer patients who had undergone reconstructions with free flaps in our institution were gathered in this retrospective cohort study. The samples were classified into diabetic and nondiabetic groups. The predictive roles of diabetes status and other factors in free flap prognosis were analyzed. The primary outcome variable was the presence of flap complications, which was subdivided into major (requiring re-exploration or local surgery) and minor (dressing or drug treatment) groups. Major complications were defined as the second outcome variable. Univariate and multivariable analyses were used for data statistics. A total of 309 patients (176 men [57%] and 133 women [43%]) aged 60 years or older were included in this study. There were 105 diabetic patients (34%) and 204 nondiabetic patients (66%). A total of 75 flap complications occurred during the perioperative period, with an overall incidence of 24.3% (44 diabetic patients [41.9%] and 31 nondiabetic patients [15.2%], P ≤ .001). The odds of susceptibility for flap complication development in elderly diabetic patients was 3.413 times that of nondiabetic patients (odds ratio, 3.413; P ≤ .001). Of 75 flap complications, 43 (13.9%) were deemed major complications (24 diabetic patients [22.9%] and 19 nondiabetic patients [9.3%], P ≤ .001). This statistical association was further confirmed by multivariate analysis (odds ratio, 2.885; P = .002). Diabetes mellitus increases the risk of the development of free flap complications in elderly patients when dealing with oral reconstruction after tumor removal. Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
    No preview · Article · Aug 2014 · Journal of Oral and Maxillofacial Surgery
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    ABSTRACT: Purpose To evaluate the use of the buccal fat pad (BFP) in theimmediate reconstruction of oncological palate defects and the influence of postoperative radiotherapy on reconstruction. Methods Patients who were diagnosed with moderate- to high- grade malignancies of palate underwent partial maxillectomy. BFP was used as a pedicled flap to reconstruct the defects. All patients received postoperative radiotherapy 4-5 weeks after surgery. Results Eighteen patients (9 males, 9 females) with an age range of 37 to 81 years underwent surgery and subsequent radiotherapy. The size of all defects ranged from 7.5-19.2cm2. Adequate closure of the defects was achieved during surgery and all the flaps were epithelialized within 3 weeks after operation with no complications of dehiscence or flap failure. Furthermore, there were no complications derived from the postoperative radiotherapy. Conclusions Our study suggests that the BFP is an effective and reliable method for the reconstruction of small to medium sized palate defects. Furthermore, postoperative radiotherapy doesn’t influence the success of the reconstruction.
    No preview · Article · Jul 2014 · Journal of Oral and Maxillofacial Surgery
  • Jiannan Liu · Wei Cao · Wantao Chen · Liqun Xu · Chenping Zhang
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    ABSTRACT: Background Kallmann syndrome 1 sequence gene (KAL1) protein is an extracellular matrix associated protein which plays vital roles in neurons development and cell migration. However, its biological functions and clinical implications have yet not been revealed in oral carcinogenesis. The objective of the study was to evaluate the role of KAL1 in oral cancer and determine clinical significance of KAL1 in oral squamous cell carcinomas (OSCCs).Methods The expression pattern of KAL1 was examined in a testing cohort including OSCCs (n = 42) and paired adjacent tissues (PATs) (n = 14) by real-time PCR. The result was further validated in a validating cohort of OSCCs (n = 32). Correlation between clinicopathological parameters and KAL1 mRNA levels was analyzed by Kruskal–Wallis test. In vitro, the effects of KAL1 ablation through siRNA-mediated knockdown on the proliferation of OSCC cells were determined by CCK-8, BrdU, and colonies formation assays, respectively. In addition, cell cycle distribution was further evaluated by cytometry.ResultsWe observed that remarkably decreased expression of KAL1 mRNA in two independent cohorts (P = 0.0002 and P = 0.033, respectively). Furthermore, downregulated KAL1 mRNA was significantly associated with worse pathological grade (P = 0.013 and P = 0.035, respectively). Upon KAL1 silencing, the proliferation and colonies formation potentials of OSCC cells were notably promoted by accelerating G1 to M phase transition.Conclusion These data indicated that KAL1 plays a potential suppressive role on OSCC initiation and progression, and KAL1 gene may serve as an adjuvant biomarker for the identification of pathological grade.
    No preview · Article · Jul 2014 · Journal of Oral Pathology and Medicine
  • Mingming Lv · Yi Shen · Jun Li · Chenping Zhang · Hanguang Zhu · Jian Sun
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    ABSTRACT: Purpose The aim of the study is to estimate the impact of different defect size and used flaps on post-operative soft palate functional outcomes. Methods The study included 45 consecutive patients who were treated by three different reconstructive flaps for their soft palate defect. Post-operative speech and swallowing functions were assessed to measure the relationships between the defect size and postoperative function of soft palate, the different flap reconstructed and postoperative function. The one-way ANOVA test was computed. P <.05 was considered significant. Results Postoperative evaluation revealed that both speech and swallowing functions were normal or near normal in patients with type II defects but poor in the patients of type III and IV defects. No significant changes in postoperative soft palate functions using different flap sizes for the same defect type. Conclusions The study confirms that the size of defect, rather than the type of the flap, has the most critical influence on the soft palate post-operative functions. Defect size of 50% or less has a better outcomes than those with a defect of more than 50%.
    No preview · Article · Jul 2014 · Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons

Publication Stats

232 Citations
105.50 Total Impact Points

Institutions

  • 2008-2016
    • Shanghai Jiao Tong University
      • • Lab of Oral Pathology
      • • Department of Oral and Maxillofacial Surgery
      Shanghai, Shanghai Shi, China
    • Shanghai Medical University
      Shanghai, Shanghai Shi, China
  • 2015
    • University of Michigan
      Ann Arbor, Michigan, United States
  • 2013
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
  • 2005-2012
    • Shanghai University
      Shanghai, Shanghai Shi, China
  • 2003-2006
    • Second Military Medical University, Shanghai
      Shanghai, Shanghai Shi, China