Erhan Varoglu

Selcuk University, Conia, Konya, Turkey

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Publications (68)132.19 Total impact

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    ABSTRACT: Isotretinoin is an effective drug utilized in the management of acne vulgaris and is known to cause dry mouth. In this study, we aimed to evaluate this effect of isotretinoin on the salivary gland function in patients with acne vulgaris using technetium-99m (Tc-99m) pertechnetate imaging of the salivary glands. The study population consisted of 28 patients with acne vulgaris (6 males and 22 females, mean age 20.2 ± 2.3 years), who were treated with isotretinoin for 6 months. We performed radionuclide imaging of the salivary glands pretreatment and at months 3 and 6 of treatment. After 185 MBq (5 mCi) of Tc-99m pertechnetate was intravenously administered, imaging of the salivary glands was performed over a 25-min period. We measured the following glandular function parameters for the parotid and submandibular salivary glands via time-activity curves: uptake ratio, maximum accumulation, and ejection fraction. Statistically significant differences were observed in the values obtained at months 3 and 6 of treatment, compared with the pretreatment values. This study demonstrated that radionuclide imaging of the salivary glands can clearly show the glandular functions that are affected by drugs such as isotretinoin.
    No preview · Article · Aug 2015 · Turkish Journal of Medical Sciences
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    ABSTRACT: Positron emission tomography using fluorodeoxyglucose is a well known diagnostic tool for routine assessment of the patients with carcinoma. Fluorodeoxyglucose uptake, as a marker of glucose metabolism, is increased in malignant conditions as well as infectious and inflammatory processes. In this case report, findings of postoperative changes in the graft on FDG PET/CT were presented in a patient on follow-up for operated renal cell carcinoma and aortic aneurysm graft surgery. The importance of the FDG uptake pattern has been pointed out for differential diagnosis of infectious and non-infectious conditions. Conflict of interest:None declared.
    Full-text · Article · Dec 2012
  • G.K. Gedik · O Sarı · B Kaya · E Varoğlu

    No preview · Article · Oct 2012
  • O Sari · B Kaya · G. Kara Gedik · P. Ozcan Kara · E Varoglu

    No preview · Article · Sep 2012
  • Ayten Kadanali · Hatice Uslu · Rezan Bayraktar · Erhan Varoglu
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    ABSTRACT: Here, we report 1 case of Brucella orchitis detected by 99mTc human immunoglobulin scintigraphy and confirmed by testicular ultrasound. A 29-year-old farmer was admitted to our hospital with fever, fatigue, arthralgia, and painful scrotal swelling that had appeared 12 days before admission. Clinically, right sacroiliitis was recorded through the Fabere test Unilateral sacroiliitis and orchitis were detected by 99mTc human immunoglobulin scintigraphy. Hypoechoic left testicular lesions and swelling of the concurrent epididymis were seen on a testicular ultrasound examination. Wright agglutination test and blood specimen culture for Brucella species were positive.
    No preview · Article · Jul 2012 · Clinical nuclear medicine
  • Z Dostbil · E Varoğlu · M Serdengeçti · B Kaya · H Onder · O Sari
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    ABSTRACT: Objective: The liver has been used as a reference organ for the assessment of abnormal (18)F-fluoro-2-deoxy-d-glucose ((18)FDG) in the body. Some researchers found that hepatosteatosis significantly changed the hepatic (18)FDG uptake, while others did not. This study investigated whether the liver's (18)FDG uptake was affected by the diffuse fatty infiltration of the liver. Material and methods: A total of 156 cases were included in this study. Different patient groups were defined according to the liver Hounsfield unit (HU). The HU was calculated from an unenhanced CT, for all patients, and we calculated the mean standardized uptake value (SUVmean) and maximum standardized uptake value (SUVmax) on an (18)FDG PET scan. For this purpose, we placed regions of interest (ROIs) on the liver image. We statistically compared the SUVmean and SUVmax measured in the fatty liver patients and the control group. Results: The average SUVmean and SUVmax values were calculated as 2.58±0.66 and 3.94±1, respectively, in the patient group and 2.54±0.57 and 3.7±0.88, respectively, in the control group. We found the average SUVmean and SUVmax values in the fatty liver group and its subsets were not significantly different from the values in the control group (p>0.05). We also did not find any statistically significant correlation between average liver density (HU) and the average SUV values (p>0.05). Conclusion: Fatty infiltration may not have a significant effect on the liver's (18)FDG uptake. Thus, the liver may be used as a reference or comparator on (18)FDG PET scans in patients with fatty liver disease.
    No preview · Article · May 2012
  • E Varoglu · B Kaya · O Sari
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    ABSTRACT: It is well known that hematopoietic cytokine stimulation can cause increased fluorodeoxyglucose (FDG) accumulation in bone marrow on PET/CT imaging, which simulates that seen in patients with bone marrow metastases. However, increased bone marrow FDG uptake can be caused by other etiologies. We report a patient with operated renal cell carcinoma had no history of hematopoietic cytokine stimulation. The FDG PET/CT images showed increased bone marrow FDG uptake, and the patient was diagnosed as chronic myeloid leukemia. This case revealed that increased FDG uptake on bone marrow may be related to neoplastic disease of the hematopoietic tissues.
    No preview · Article · May 2012
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    ABSTRACT: The differential diagnosis at the inguinal region is very important for hypermetabolic foci because of the possibility of metastasis at this level in cancer patients ongoing PET imaging for detection of metastases. It is important to distinguish this activity from other possible malignant and benign conditions such as lymph node activity, testicular cancer, metastatic disease activity, inflammation and urine skin contamination artefact. A 66-year-old male patient with operated colon cancer and liver metastasis was referred for PET/CT examination for re-staging because of suspicious metastases. Findings of PET/CT imaging with undescended testis detected incidentally was presented.
    No preview · Article · Mar 2012 · Urology
  • Zeki Dostbil · Bugra Kaya · Oktay Sari · Erhan Varoglu
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    ABSTRACT: F-18 FDG PET/CT has been used increasingly in evaluation of pulmonary and mediastinal lesions. However, inflammatory and granulomatous disorders may show increased F-18 FDG uptake on PET scanning. So, some benign conditions may cause false-positive results in cancer investigation. In this case, F-18 FDG PET/CT findings were presented in a patient with sarcoidosis who was investigated for primarily suspected malignancy.
    No preview · Article · Jan 2012 · Healthmed
  • Sinan Yapici · Hayrettin Eroglu · Erhan Varoglu
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    ABSTRACT: This work presents an investigation on the bio-sorption of Tl-201 radionuclide used in nuclear medicine on olive pomace. The experimental parameters were chosen as temperature, the initial pH of the solution, stirring speed, bio-sorbent dose and nominal particle size of bio-sorbent. The initial pH of the solution was found to be the most effective parameter. Thermodynamic analysis gave negative values for ΔG and ΔH. The kinetics of the bio-sorption process fitted very well to the pseudo-second order rate model.
    No preview · Article · Mar 2011 · Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine
  • Hayrettin Eroglu · Erhan Varoglu · Sinan Yapıcı · Ali Sahın
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    ABSTRACT: The radionuclides 67Ga is used in nuclear medicine. This paper presents a bioadsorption study of 67Ga from aqueous solution by solid tea factory waste. The experimental parameters were chosen as temperature, pH, stirring speed, nominal particle size and bioadsorbent dose in the ranges of 10.0–40.0 °C, 2.0–8.0, 300–720 rpm, 0.15–1.4 mm and 1.0–15.0 g/L, respectively. The most effective parameter was determined to be pH, and then temperature, particle size, and bioadsorbent dose in decreasing order. Fourier transform infrared spectroscopy was performed for the characterisation of the bioadsorption of 67Ga on tea waste. The equilibrium results showed that the data exhibited good agreement with the isotherm models of Freundlich, Halsey, and Handerson and Smith. In thermodynamic analysis, ΔG and ΔH values were determined and their values demonstrated that the bioadsorption process was endothermic and spontaneous. Bioadsorption kinetics analysis proved that the rate corresponded to a pseudo second order model, and that the bioadsorption mechanism is governed by intra-particular diffusion.
    No preview · Article · Dec 2010 · The Chemical Engineering Journal
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    ABSTRACT: To prospectively evaluate the regional myocardial deformation changes and viability in anterior acute myocardial infarction (AMI) patients before and after primary coronary intervention (PCI) by strain (S)/strain rate (Sr) imaging. Twenty-one patients presented during the first six hours of an anterior AMI and twenty controls were included in this study. Echocardiographic recordings were obtained from the apical/parasternal images just before PCI, one week and one month after PCI. The S/Sr and velocity (V) were measured from the basal mid and apical segments of the walls supplied by the left anterior descending artery. Myocardial perfusion scintigraphy was performed in the 1st month after PCI. Mann-Whitney U and Wilcoxon tests were used for statistical analysis. Acute myocardial infarction resulted in the reduction of deformation indices (S/Sr/V) in all segments. Deformation indices were increased after successful PCI. The S/Sr values of the normal and ischemic segments after PCI were higher compared to the baseline (ischemic Sr:-1.3 ± 0.3 vs. -1.1 ± 0.3, p=0.04). No difference was noted in the S/Sr values of the necrotic segments during the first week (Sr:-1.1 ± 0.3 vs. -1.0 ± 0.3, p=0.054). For V measurements, no difference was observed between the viability types at the follow-up measurements (p ≤ 0.05). The remedial effect of PCI on the deformation values was observed in the first week and continued during the first month. In the early reperfusion period, S/Sr indices have the potential to differentiate necrotic tissue from other viability types. Strain/Strain rate imaging can be used for determination of myocardial deformation changes and parameters of viability. However, V values were insufficient.
    Preview · Article · Nov 2010 · Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology
  • Hayrettin Eroglu · Sinan Yapici · Erhan Varoglu
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    ABSTRACT: This study investigates the adsorption of gallium-67, routinely used in nuclear medicine laboratories, in aqueous solution by using the waste of a rose-oil processing factory (rose residue). The experimental parameters were determined to be as follows: temperature, (10.0 to 40.0) °C; pH, (2.0 to 10.0); stirring speed, (300 to 720) rpm; particle size, (0.15 to 1.40) mm; and adsorbent dose, (1.0 to 15.0) g·L−1. It was seen that the most important parameters were pH, temperature, particle size, and adsorbent dose. The adsorption mechanism of the rose residue was examined by comparing the Fourier transform infrared (FTIR) spectra before and after adsorption. The ΔG and ΔH values were determined, and it was concluded that the absorption was endothermic and spontaneous. Absorption kinetics was studied, and it was observed that they fit a pseudo second-order model. As a result, it was found that the rose residue was a perfect absorbent for the adsorption of gallium-67.
    No preview · Article · Jun 2010 · Journal of Chemical & Engineering Data
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    ABSTRACT: The inhibitory effects of thallium-201 ((201)Tl) solution on human erythrocyte glucose 6-phosphate dehydrogenase (G6PD) activity were investigated. For this purpose, erythrocyte G6PD was initially purified 835-fold at a yield of 41.7% using 2',5'-Adenosine diphosphate sepharose 4B affinity gel chromatography. The purification was monitored by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, which showed a single band for the final enzyme preparation. The in vitro and in vivo effects of the (201)Tl solution including Tl(+), Fe(+3) and Cu(+2) metals and the in vitro effects of the radiation effect of the (201)Tl solution and non-radioactive Tl(+), Fe(+3) and Cu(+2) metals on human erythrocyte G6PD enzyme were studied. Enzyme activity was determined with the Beutler method at 340 nm using a spectrophotometer. All purification procedures were carried out at +4 degrees C. (201)Tl solution and radiation exposure had inhibitory effects on the enzyme activity. IC(50) value of (201)Tl solution was 36.86 microl ([Tl(+)]: 0.0036 microM, [Cu(+2)]: 0.0116 microM, [Fe(+3)]: 0.0132 microM), of human erythrocytes G6PD. Seven human patients were also used for in vivo studies of (201)Tl solution. Furthermore, non-radioactive Tl(+), Fe(+3) and Cu(+2) were found not to have influenced the enzyme in vitro. Human erythrocyte G6PD activity was inhibited by exposure for up to 10 minutes to 0.057 mCi/kg (201)Tl solution. It was detected in in vitro and in vivo studies that the human erythrocyte G6PD enzyme is inhibited due to the radiation effect of (201)Tl solution.
    Full-text · Article · Apr 2010 · Nuclear Medicine and Biology
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    ABSTRACT: The purpose of this study was to evaluate the alterations in salivary gland function in patients who receiving continuous ambulatory peritoneal dialysis (CAPD) for chronic renal failure (CRF) using technetium-99m pertechnetate ((99m)Tc-P) salivary gland scintigraphy. The study population consisted of 36 CAPD patients (16 males and 20 females, ranging in age from 19 to 73 years, mean age 44.94+/-15.01 years) and 20 healthy controls (11 males and 9 females, ranging in age from 31 to 51 years, mean age 41.25+/-5.62 years). All patients and healthy controls underwent salivary gland scintigraphy. After the intravenous administration of 185MBq of (99m)Tc-P, dynamic salivary gland scintigraphy was performed for 25min. On the basis of the time-activity curves, the following glandular function parameters were calculated for the parotid and submandibular salivary glands: uptake ratio, maximum accumulation, and ejection fraction. Our results showed: All functional parameters obtained for CAPD patients were significantly lower than for healthy controls (P<0.05). In conclusion, this study demonstrated that salivary gland function, an important determinant of oral health, is impaired among the CRF patients treated with CAPD compared with healthy controls, as evaluated by (99m)Tc-P salivary gland scintigraphy.
    No preview · Article · Jan 2010 · Hellenic journal of nuclear medicine
  • Asuman Orhan Varoglu · Asude Aksoy · Erhan Varoglu
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    ABSTRACT: Parathyroid adenomas (PA) are benign tumors. We report an unusual case of delayed diagnosis of a PA and concomitant Vitamin D deficiency presenting as tetraparesia. A 30-year-woman was admitted to our clinic with an inability to walk. Our examination revealed tetraparesia and common, severe muscular atrophy. Laboratory investigations showed the following: creatinine phosphokinase (CK): 37 IU/L (15-130), calcium (Ca): 11.5 mg/dL (9-11), phosphorus (P): 1.5 mg/dL (2.5-5), parathyroid hormone (PTH): 736.1 pq/mL (15-65), 25-hydroxyvitamin D (25-OHvit D): 4 ng/mL (11-43), and alkaline phosphatase (ALP): 1029.5 lU (64-300). Parathyroid scintigraphy revealed PA. A year after Vitamin D replacement, the patient's neurological status and laboratory findings improved. We suggest that the physicians always keep in mind the primary hyperparathyroidism (HPT) and concomitant Vitamin D deficiency in the differential diagnosis of hypercalcemia when facing atypical neurological symptoms such as tetraparesia.
    No preview · Article · Jan 2010 · Neuro endocrinology letters
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    ABSTRACT: Osteoporosis is a secondary problem in multiple sclerosis (MS) patients. There have been only a few reports about the effect of interferon beta (IFNB) 1b on bone mineral density (BMD). We aimed to determine bone mass in patients using IFNB 1b. We enrolled 17 patients taking IFNB 1b (group I), 15 patients not taking IFNB (group II). We measured the BMD and T scores values and the patients were distinguished as normal, osteopenia and osteoporosis. In the lumbar spine, there was no difference between groups I and II (p=0.3). In the left femur, no significant difference was detected between groups I and II (p=1). There was an inverse correlation between the BMD at the both regions and the Expanded Disability Status Scale score (r= -0.39, p=0.03; r=-0.52, p=0.002, respectively). IFNB 1b may be used safely in MS patients, even in those undergoing pulse steroid therapies, because IFNB 1b has no effect on BMD.
    No preview · Article · Jan 2010 · Journal of Back and Musculoskeletal Rehabilitation
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    ABSTRACT: The aim of this research was to test the removal of Ga-67 radionuclides from aqueous solutions by biosorption onto waste pomace of an olive oil factory (WPOOF). Batch adsorption studies were performed in order to investigate the temperature, the initial pH of the solution, the stirring speed, the biosorbent dose, and the nominal particle size of the biosorbent in the experimental work. The most effective parameter was found to be the initial pH. A high biosorption yield of 98 was obtained. The equilibrium values were fitted to the isotherm models. The values of DeltaG and DeltaH were calculated to be negative. The adsorption kinetics calculations showed that the kinetics of the biosorption process fitted well to the pseudo-second order rate model.
    No preview · Article · Aug 2009 · Journal of hazardous materials
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    ABSTRACT: Nuclear medicine workers are occupationally exposed to chronic ionizing radiation. It is known that ionizing radiation may have damaging effects on chromosomes. In the present study, we investigated the genotoxic effects of ionizing radiation on nuclear medicine workers. We used two different indicators of genotoxicity methods: sister chromatid exchange (SCE) and micronucleus (MN). The present research was carried out using 21 nuclear medicine workers (11 females and 10 males) during two periods: during normal working conditions and after a 1-month vacation. The radiation dose varied from 1.20 to 48.56 mSv, which accumulated during the occupational exposure time between two vacations. Peripheral blood samples were taken from each subject for two distinct lymphocyte cultures (SCE and MN) in each period. In nearly all subjects, SCE values increased significantly during radiation exposure compared to the postvacation period (P<.05). Similarly, MN frequencies in most of the subjects increased significantly during radiation exposure compared to the postvacation period (P<.05). This study revealed that both SCE and MN frequencies in most of the subjects were significantly higher during exposure to ionizing radiation than after a 1-month vacation period. However, this genotoxic effect was reversible in most of the subjects.
    No preview · Article · Jul 2009 · Nuclear Medicine and Biology
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    ABSTRACT: The aim of the present experimental study was to determine and compare the effect of Hippophae rhamnoides L. extract (HRe-1) and of dexpanthenol on the blood flow of a wound region, in rats using xenon-133 ((133)Xe) clearance technique. METHODS: Burn wounds were made on both thighs of rats and, HRe-1 and dexpanthenol were applied topically on the wound region only in the right thigh for a period of 8 days. The effect of HRe-1 and of dexpanthenol on blood flow of the wound region was assessed before and after their topical application by using the (133)Xe clearance technique. RESULTS: HRe-1 increased significantly blood flow of the wound region (P<0.05). Dexpanthenol showed a smaller increase in blood flow. In conclusion, our results in rats suggest that HRe-1 increases blood flow of the wound area and can be used for the treatment of skin wound healing, preferably than dexpanthenol.
    Full-text · Article · Jun 2009 · Hellenic journal of nuclear medicine

Publication Stats

364 Citations
132.19 Total Impact Points


  • 2012
    • Selcuk University
      Conia, Konya, Turkey
    • Necmettin Erbakan Üniversitesi
      • Meram Faculty of Medicine
      Conia, Konya, Turkey
  • 2001-2012
    • Ataturk University
      • • Department of Nuclear Medicine
      • • Faculty of Medicine
      Kalikala, Erzurum, Turkey
  • 2001-2006
    • Yuzuncu Yil University
      • Faculty of Medicine
      Thospia, Van, Turkey