Mustafa Akçetin

Haseki Training and Research Hospital, İstanbul, Istanbul, Turkey

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Publications (10)10.81 Total impact

  • Kadir Kotil · Mustafa Akçetin · Necmettin Güzel · Turgay Bilge

    No preview · Article · Jul 2015 · Journal of pediatric neurology: JPN
  • Kadir Kotil · Mustafa Ali Akçetin · Yildiray Savas
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    ABSTRACT: We rarely use the cervical transpedicular fixation (CPF) technique in the neurosurgery departments of the authors' institutions because the pedicle is thin and there is a risk of neurovascular damage. In this study we investigated postoperative neurovascular injury caused by the transpedicular screws of 210 pedicles in 45 patients on whom we performed CPF for various cervical pathologies. Fixation was performed between C3 and C7, and the iliac crest and lamina were used as autografts for fusion. In 205 of 210 pedicles (97.6%), the screws were in the correct position, while a non-critical lateral orientation was detected in three pedicles (1.4%). Two screws (one in each of two patients) were positioned inappropriately (0.9%, Grade 3), unilaterally and directly in the vertebral foramen, as shown on postoperative CT scans; blood circulation was normal on angiography. The fusion rate was 100%. The average screw length used for C3 to C7 was 32 mm. The patients were followed up for an average of 35.7 months (range: 17-60 months). There was no morbidity or mortality in our study. We concluded that CPF provides very strong cervical spine fixation but also carries a risk of pedicle perforation without neurovascular injury. However, a free-hand technique performed by an experienced surgeon is acceptable for CPF for various cervical pathologies.
    No preview · Article · Apr 2012 · Journal of Clinical Neuroscience
  • Kadir Kotil · Mustafa Ali Akçetin · Yildiray Savaş
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    ABSTRACT: STUDY DESIGN:: Prospective cohort data by merging data from comparative studies. OBJECTIVE:: This study aimed to compare clinical and radiologic outcomes of the transforaminal lumbar interbody fusion (TLIF) procedure with or without pedicle screw support in stable patients with a degenerative disease. SUMMARY OF BACKGROUND DATA:: The unilateral lumbar interbody fusion technique has gained popularity in the management of many lumbar degenerative conditions requiring fusion. TLIF is routinely performed with the support of pedicle screws. The use of the TLIF procedure without pedicle screw support has not yet been reported. METHODS:: Between February 2006 and May 2009, surgical decompression and fusion was performed in patients with lumbar degenerative conditions using the TLIF technique either with (n=30, group A) or without pedicle screw support (n=30, group B). The 2 groups had similar age, sex distribution, pain level, and pain history. In this prospective study, patients were followed for a mean period of 31 months (range, 22 to 38 mo). The mean age was 45.5 years (range, 29 to 78 y), and all patients had a disease involving a single intervertebral space. RESULTS:: The female to male ratio was 19:11 and 18:12 in groups A and B, respectively. Pain and function were evaluated by the Oswestry disability index and visual analog scale. Pseudoarthrosis developed in 2 patients from group A and in 3 patients from group B. Although these 5 patients had insufficient fusion, they did show a clinical improvement. The mean duration of the operation was 110 and 73 minutes in groups A and B, respectively. The mean total amount of bleeding was 410 and 220 mL in groups A and B, respectively. Cage loosening did not occur in group A, but 1 patient in group B developed asymptomatic cage loosening limited to the endplates. Four patients in group A suffered sciatic pain because of the malposition of the screw, and 1 patient in group B had contralateral sciatic pain lasting for 2 months. The visual analog scale and Oswestry disability index scores were higher in group A than in group B 1 month after the operation (P<0.005), but the groups did not significantly differ at 3 months (P<0.89). The cost of the procedure was 3-fold higher in group A compared with group B. CONCLUSIONS:: This study showed that the TLIF procedure without pedicle screw support would be sufficient in the management of preoperatively stable patients with lumbar degenerative spinal disease requiring fusion after single-level decompression. This technique is minimally invasive, requires only unilateral intervention, allows magnetic resonance imaging during the postoperative period and is associated with less costs and complications when compared with pedicle screwing. This study represents the first prospective comparative report on this technique showing several of its advantages.
    No preview · Article · Feb 2012 · Journal of spinal disorders & techniques
  • Kadir Kotil · Mustafa Akçetin · Rabia Tari · Tugrul Ton · Turgay Bilge
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    ABSTRACT: The use of lamina as a graft for fusion in isthmic lumbar spondylolisthesis (LIS) is not known. In the present prospective clinical study, we used the laminoplasty technique and reported on its outcomes. MATERIAL and Twenty cases that have been operated in our clinic due to G1 and G2 ISL between February 2003 and December 2006 were clinically and radiologically examined. The clinical assessment of the patients was carried out with the Prolo Economic and Functional scale. Both interbody fusion and laminoplasty procedures concerning 88 pedicles in total were performed on 20 cases of which 10 were at the L4-5 level, whereas 6 were at the L5-S1 level and 2 were at the L3-4-5 level. Five (25%) cases also had coexisting spinal stenosis. 19 (95%) patients had solid fusion but one (5%) had no solid fusion formation while having posterior fusion along with a clinical neurological examination result similar to the one obtained during the preoperative period. In conclusion, the anterior fusion rate was 95%. The most remarkable finding among the patients was the recovery observed at the 2nd month. The Prolo scale results of the cases were good and the follow-up time was 23.5 months. The laminoplasty technique is a method which presents advantages in isthmic spondylolisthesis cases such as short duration of operation, absence of graft donor site complications, preservation of the osteoligamentous structures of the posterior column and a high probability of achievement of fusion through only a posterior approach at a single session; therefore, we believe it is an alternative surgical technique.
    No preview · Article · Feb 2009 · Turkish neurosurgery
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    Kadir Kotil · Mustafa Eras · Mustafa Akçetin · Turgay Bilge
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    ABSTRACT: Cerebellar mutism is a documented complication of posterior fossa surgery in pediatric ages. Risk factors such as the type of tumor, size, and location of tumor, hyrdrocephalus, postoperative cerebellar swelling for cerebellar mutism were investigated in this study. A consecutive series of 32 children with a cerebellar tumor were operated on at the Haseki Educational and Research Hospital, Department of Neurosurgery, between 1990 and 2005. Their speech and neuroradiological studies were systematically analysed both preoperatively and postoperatively Cerebellar mutism developed in ten children (32%) in the early postoperative period. The type of tumor, midline localization, and vermian incision were significant single independent risk factors. In addition, an interdependency of possible risk factors (tumor > 5 cm, medulloblastoma) was found. The latency for the development of mutism ranged from 0 to 90 days (mean 15.6 d). The speech returned to normal in eight patients. All cases were accompanied by cerebellar ataxia. Mutism after posterior fossa tumor resection is also associated with ataxia. Cerebellar mutism usually has a self-limiting course and a favorable prognosis.
    Preview · Article · Feb 2008 · Turkish neurosurgery
  • Kadir Kotil · Mustafa Akcetin · Turgay Bilge
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    ABSTRACT: Among all lumbar disc herniations, L5-S1 far-lateral disc herniations are rare entities. Besides, surgical approach may be difficult because of the very narrow passage at this level. For these 2 reasons, most spine surgeons are not experienced in herniations at this level. According to new microanatomic studies, previous lateral approaches at this level often do not allow access to the neuroforamen without partial or total destruction of the L5-S1 facet joint. To preserve the facet joint, an approach was developed. To assess the efficacy of a surgical technique that is a minimally invasive intermuscular approach (MIIMA) for decompression of L5-S1 far-lateral level disc herniation (FLLDH). We present a prospective clinical study analysis of 14 patients with L5-S1 far-lateral disc herniations in a period between 2000 and 2004, treated with microsurgical technique. An imaging study revealed consistency with the patient's clinical presentation. In our department, a total of 580 patients underwent discectomy between 2000 and 2004 for lumbar disc herniation. Twenty-eight patients had foraminal or extraforaminal herniations (4.8%). Fourteen patients had FLLDH at the L4-L5 level (2.4%), whereas the other 14 were cases of FLLDH at the L5-S1 level (2.4%). One patient had FLLDH at both L5-S1 and L4-L5 levels (7.1%). The mean age of patients was 53.6 years, and the male:female ratio was approximately 5:9. All patients failed to recover after at least 6 weeks of conservative therapy. The mean duration of symptoms until the time of surgery was 7.2 months. Using this MIIMA technique, the authors removed the herniated discs compressing the (L5) nerve roots. Clinical outcome was measured using the visual analog scale. Every patient was discharged within 24 hours. Satisfactory (excellent or good) results were demonstrated in 13 patients (92.9%), because, except for 1 (7.1) permanent dysesthesia case, 4 cases (21.3%) were temporary dysesthesia. Postoperatively all patients reported excellent relief of their sciatic pains, and there were no technique-associated complications. No recurrence was observed during the follow-up period ranging from 10 to 60 months (mean, 29 mo). This is one of the major complications of any approach to a far-lateral disc. The authors describe a MIIMA for excising herniated discs that is applicable to all types of far-lateral lumbar herniations. Postoperative dysesthesia is the most important complication and may persist as it did in our cases. Consequently, manipulation of the ganglion should be avoided at all costs, if possible. The MIIMA procedure provides a simple alternative for treating lumbar foraminal or lateral exit zone herniated discs in selected cases. This approach is effective, allowing the preservation of the L5-S1 facet joint, saving the facet joint, preventing postoperative instability, and offering a direct view of the L5-S1 neuroforamen.
    No preview · Article · May 2007 · Journal of Spinal Disorders & Techniques
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    ABSTRACT: No definitive treatment for spinal cord injuries (SCIs) exists, and more research is required. The use of agmatine [4-(aminobutyl)-guanidine-NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)], a guanidinium compound formed by decarboxylation of L-arginine by arginine decarboxylase, is a neurotransmitter-neuromodulator with both N-methyl-D-aspartate receptor (NMDAR)-antagonizing and nitric oxide synthase (NOS)-inhibiting activities. The purpose of this study was to demonstrate the dose-dependent activity of agmatine, an inducible NOS (iNOS) inhibitor and selective NMDAR antagonist, on biochemical and functional recovery in an experimental rat SCI model. This study involved 40 Wistar albino male rats. The rats were subjected to sleep-awake cycles for 7 days before surgery. In each group, general anesthesia was induced by a 60-mg/kg ketamine injection. For the surgical SCI model, a Yaşargil aneurysm clip was placed in the spinal cord. The study was conducted in the following four main groups: Group I (control group) laminectomy only; Group II, trauma-only group and SCI; Group III, laminectomy, SCI and agmatine 50 mg/kg for 10 days; and Group IV, laminectomy, SCI, and agmatine 100 mg/kg for 10 days. On Day 1, no statistical difference was observed in any group (p < 0.005, analysis of variance [ANOVA] and the Fisher protected least significant difference [PLSD]). On Day 2, no statistical difference was noted among Groups II, III, and IV (p = 0.27, p = 0.42, and p = 0.76, respectively; ANOVA and Fisher PLSD). Beginning on Day 3, recovery in Groups III and IV differed significantly from that in Group II (p < 0.005, ANOVA and Fisher PLSD), and a statistically significant difference between Groups III and IV was observed, which also was present on Days 5, 7, and 10 (p = 0.003, p = 0.0024, and p = 0.0036, respectively; ANOVA and Fisher PLSD). Several observations were noteworthy: motor function scores were reduced significantly in the spinal cord-injured rats compared with the controls (p < 0.005); on Day 1, the agreement of motor function scores in rats in each SCI group indicated that the traumatic event had been replicated equally across all groups (p = 0.59, p = 0.59, and p = 0.28); a statistically significant difference in motor function scores developed on Day 3 between the rats subjected to trauma alone (Group II) and those treated with agmatine (Groups III and IV) (p < 0.005); and no statistically significant intergroup difference in motor function existed at any postinjury interval between the 50- and 100-mg/kg/day agmatine-treated rats (p > 0.005). Agmatine administration following SCI was shown to reduce NO levels significantly. No statistically significant intergroup difference in the reduction of NO levels was found between rats treated with 50- and 100-mg/kg/day doses of agmatine. Administration of a 100-mg/kg/day dose of agmatine reduced the NO levels to those measured in controls. The authors conclude that with additional studies into the role of agmatine, this drug may be helpful in the treatment of patients with SCIs.
    No preview · Article · Jun 2006 · Journal of Neurosurgery Spine
  • Kadir Kotil · Mustafa Ali Akçetin
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    ABSTRACT: A 6-year-old boy presented with an asymptomatic ossified chronic epidural hematoma. He was neurologically intact and had no complaints. This is the first report with a computed tomography image of cerebral compression due to an asymptomatic ossified epidural hematoma. Computed tomography indicated an ossified epidural hematoma in the left frontal region. In children, surgery for asymptomatic ossified chronic epidural hematoma with significant cerebral compression should be considered to relieve cerebral compression and prevent possible future brain damage.
    No preview · Article · May 2006 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES
  • K. Kotil · M. Eras · M. Akçetin · C. Acar · T. Bilge
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    ABSTRACT: Objective: To the best of our knowledge, a clinical study of lumbar disc pathologies associated with other spinal pathologies has never been published before. We determined clinical, radiological, surgical data, and long term results for cauda equina and conus medullaris syndromes (CCES) due to prolapsed lumbar intervertebral disc with spinal pathology. The relationship between time and surgery has been reported in many articles. The aim of our study was to study the relationship between the surgical effect of CCES and lumbar disc herniation with spinal pathologies. Methods: Between 1990 and 2005, 20 patients (12 males and 8 females) with ages ranging from 13 to 75 years (mean 45 years), presented with CCES due to herniated lumbar discs (group A) and lumbar disc with other spinal pathologies (group B). Five (25%) patients had upper lumbar disc herniation (conus medullaris syndrome) and 15 (75%) also had low lumbar disc herniation, both leading to cauda equina syndrome (CES). Results: The herniation levels were L5-S1 in 5 (25%), L4-L5 in 5 (25%), L3-L4 in 3 (15%), L2-L3 in 2 (10%), L1-L2 in 3 (15%), and Th12-L1 in 2 (10%) patients. Nine (45%) patients had only lumbar disc herniations (group A), while 11 (55%) patients had other spinal pathologies (group B) including high thecal sack in 1, multilevel disc herniations in 5, stenosis in 3, and tethered cord in 2 patients. Eighteen patients had complete, and 2 patients had incomplete incontinence of urine, stool, or both. At presentation, all were urgently examined with conventional myelography, computed tomography (CT) and magnetic resonance imaging (MRI). All patients had been admitted as emergencies with CCES, and underwent laminectomy and discectomy. Follow-ups ranged from 10 months to 6 years. Postoperatively, only 3 cases (33.3%) improved in Group A. Both sensory and motor symptoms were improved in 2 cases. One case had full motor recovery and minor sensory recovery. Group B patients (n=11) with CCES did not improve. The results of this group were unsatisfactory. Although 3 CCES cases undergoing early surgery showed improvement, cases operated on later did not. Conclusion: If there are additional spinal pathologies, the prognosis is very poor. This unique study had a long follow-up duration. We review the current literature on major neurological deficits (conus medullaris and cauda equina syndromes) and available treatment options.
    No preview · Article · Jan 2006
  • Kadir Kotil · Mustafa Akçetin · Turgay Bilge
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    ABSTRACT: Introduction Cauda equina syndrome with sphincter dysfunction is an uncommon and feared complication of lumbar disc herniation. Case report Lumbar disc disease in the pediatric age has been reported infrequently, but to the best of our knowledge, this is the first pediatric case of acute lumber disc herniation presenting with caudal compression.
    No preview · Article · Jul 2004 · Child s Nervous System