MW Beckmann

Universitätsklinikum Erlangen, Erlangen, Bavaria, Germany

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Publications (619)977.14 Total impact

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    ABSTRACT: Introduction: To evaluate the influence of the time interval between examination and delivery on the accuracy of sonographic fetal weight estimation (WE). Materials and methods: 8723 singleton pregnancies were included in this retrospective cohort study. Fetuses were divided into eight groups with regard to the time interval between estimation and delivery (group 1: 0 days; group 2: 1-3 days; group 3: 4-7 days; group 4: 8-14 days; group 5: 15-21 days; group 6: 22-28 days; group 7: 29-35 days; group 8: 36-42 days). The accuracy of WE was compared between the different time interval groups and five commonly used formulas using means of percentage errors (MPE), medians of absolute percentage errors, and proportions of estimates within 10 % of actual birth weight. Results: In group one, the Hadlock I and Warsof formula showed a systematic underestimation of fetal weight (negative MPEs). No systematic error was found with the Hadlock II formula and the equations of Merz and Shepard showed a systematic overestimation (positive MPEs). MPE values of the Hadlock I, II and Warsof formulas were closest to zero in WEs of group two. From group three to six, MPE values decreased continuously. With the Merz and Shepard equations MPEs were closest to zero in group four. Discussion: The best accuracy of sonographic WE with most of the commonly used equations is achieved within a scan-to-delivery interval of 1 week.
    No preview · Article · Jan 2016 · Archives of Gynecology and Obstetrics
  • R. Dittrich · M W Beckmann · W. Würfel
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    ABSTRACT: On August 1, 2013, the German Patent and Trademark Office issued a patent for the "Non-embryo-destructive extraction of pluripotent embryonic stem cells, stem cells obtained by this process and their uses" (DE 10 2004 062 184 B4). The patent document describes a non-embryo-destructive process to harvest embryonic stem cells from the inner cell mass (ICM) during the blastocyst development stage. The patent application was filed with the German Patent Office in Munich on December 23, 2004 and the patent claim was published in 2006. The patent was granted on August 1, 2013. Processing the patent application was a lengthy affair due to the fact that, for a long time, the prevailing opinion in Germany was that genetic screening of embryos (preimplantation genetic diagnosis) was prohibited under the German Embryo Protection Act (ESchG). A ruling by the German Federal Court in 2010 proved this opinion to be false. Animal studies have provided the evidence that the described procedure is technically feasible; healthy offspring were born after stem cells were harvested from the blastocyst and stored. We report here on a technique for the non-embryo-destructive extraction of pluripotent embryonic stem cells together with potential future applications for stem cells harvested in this manner.
    No preview · Article · Dec 2015 · Geburtshilfe und Frauenheilkunde
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    ABSTRACT: Protecting the fertility of patients with oncologic disease is becoming more and more important, as fulfilling the wish to have children is increasingly occurring at a later stage in life and long-term survival rates after cancer are continuing to improve. A number of fertility-preserving options exist. In addition to techniques which have been around for some time such as medical ovarian suppression, ovarian transposition, and organ-preserving surgery, there are other, more recent, innovative methods which have developed over the last few years such as cryopreservation of oocytes or ovarian tissue transplantation after completing cancer therapy. As every procedure has its specific advantages and disadvantages, informed patient consent is essential. The physician's aim must be to select the optimal procedure for each patient. The extent of patients' information about the options to preserve fertility in women with oncologic disease remains limited. One of the main reasons for this is that clinicians are not sure how to inform patients about existing procedures and methods. The aim of this review article is to provide help in clinical practice.
    No preview · Article · Dec 2015 · Geburtshilfe und Frauenheilkunde
  • J. Emons · F. Heindl · A. Hein · M. W. Beckmann
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    ABSTRACT: Background Bleeding is a symptom in many gynecologic and obstetric diseases. Perioperative hemorrhage and bleeding in cancer patients are extraordinary situations in gynecological patients. An acute abdomen in oncological patients also requires differential diagnosis of symptoms caused by advanced cancers. Perioperative hemorrhage Perioperative gynecologic hemorrhage is still an acute emergency requiring immediate action. Preoperative identification of patients with increased bleeding risk by thorough anamnesis is essential. Local hemostasis and, if needed, systemic treatment for underlying coagulopathies are essential to treat acute intraabdominal bleeding. Postoperative bleeding is diagnosed by clinical and instrument-based techniques and demands immediate treatment. Tumor bleeding Bleeding occurs in patients with early and end-stage gynecologic cancers and requires – depending on the underlying cancer and clinical stage – surgical, conservative, interventional, or radiotherapeutic treatment. Acute abdomen in cancer patients For gynecologic oncologic patients, both tumor-associated and classic causes for acute abdomen must be taken into account.
    No preview · Article · Nov 2015 · Der Gynäkologe

  • No preview · Article · Nov 2015 · Zeitschrift für Geburtshilfe und Neonatologie

  • No preview · Article · Nov 2015 · Zeitschrift für Geburtshilfe und Neonatologie
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    Full-text · Article · Nov 2015 · Geburtshilfe und Frauenheilkunde
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    ABSTRACT: Purpose: Official guideline published and coordinated by the German Society of Gynecology and Obstetrics (DGGG). Due to their rarity and their heterogeneous histopathology uterine sarcomas remain challenging tumors to manage and need a multidisciplinary approach. To our knowledge so far there is no evidence-based guideline on the appropiate management of these heterogeneous tumors. Methods: This S2k-guideline is the work of an representative committee of experts from a variety of different professions who were commissioned by the DGGG to carry out a systematic literature review of uterine sarcoma. Members of the participating scientific societies developed a structured consensus in a formal procedure. Recommendations: 1. The incidence and histopathologic classification of uterine sarcoma. 2. The clinical manifestations, diagnosis and staging of uterine sarcoma. 3. The management of leiomyosarcoma. 4. The management of endometrial stromal sarcoma and undifferentiated uterine sarcoma. 5. The management of adenosarcoma as well as carcinosarcomas. 6. The management of morcellated uterine sarcoma.
    Full-text · Article · Nov 2015 · Geburtshilfe und Frauenheilkunde
  • L-C Horn · M W Beckmann · M Follmann · M C Koch · P Mallmann · S Marnitz · D Schmidt
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    ABSTRACT: Between 2011 and the end of 2014 the former consensus S2k guidelines for the diagnostics and treatment of cervical cancer were updated and upgraded to S3 level, methodologically based on the regulations of the German Cancer Society (DKG). The present article summarizes the relevant aspects for the sectioning, histopathological workup, diagnostics and reporting for the pathology of invasive cancer of the uterine cervix. The recommendations are based on the most recent World Health Organization (WHO) and TNM classification systems and consider the needs of the clinician for appropriate surgical and radiotherapeutic treatment of patients. Detailed processing rules of colposcopy-guided diagnostic biopsies, conization and trachelectomy as well as for radical hysterectomy specimens and lymph node resection (including sentinel lymph node resection) are given. In the guidelines deep stromal invasion in macroinvasive cervical cancer is defined for the first time as tumor infiltration of > 66 % of the cervical stromal wall. Furthermore, morphological prognostic factors for microinvasive and macroinvasive cervical cancer are summarized.
    No preview · Article · Oct 2015 · Der Pathologe
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    ABSTRACT: The goal of this study was to compare a traditional slow-freeze method (TF) with an open unidirectional slow freeze cooling system (UF) for whole ovary cryopreservation. Therefore, whole pig ovaries were randomly assigned to (A) fresh control, (B) traditional slow freeze (TF) or (C) unidirectional slow freeze (UF). Ovaries were perfused with 10% DMSO in Krebs-Ringer. For TF, whole ovaries were placed in specimen jars containing 10% DMSO and placed into a specialized container for freezing filled with propan-2-ol. For UF, whole ovaries were placed within a specially designed container containing 10% DMSO and transferred to a specialized freezing machine (CTE 920). Histological evaluation demonstrated intact morphology of follicles in all groups; however, an overall decrease of follicle numbers in TF (46%) and UF (50%) compared to fresh control. Live/dead assay indicated significantly lower populations of live cells in both TF (60%) and UF (58%) compared to fresh tissue (74%). TUNEL assay confirmed a difference in percentage of apoptotic follicles between fresh and TF, but there was no significant difference between fresh and UF. To improve the structural and functional integrity of whole ovaries, further investigation, especially into directional freezing, is needed. Whole ovary cryopreservation could provide opportunities for women facing fertility loss due to chemo- or radiotherapy treatment.
    No preview · Article · Oct 2015 · Reproduction in Domestic Animals
  • A Dietl · S Cupisti · M W Beckmann · M Schwab · U Zollner
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    ABSTRACT: Introduction: Delayed childbearing is increasing, and advanced maternal age has been associated with an increased risk of obstetrical complications. The purpose of this study was to evaluate pregnancy outcomes in women with advanced maternal age (≥ 40 years). Methods: Maternal and obstetrical data were collected from the Department of Obstetrics and Gynecology of the University of Wuerzburg for the period from 2006 to 2011. In this retrospective analysis we compared the outcomes for women aged ≥ 40 years (n = 405) with those of three younger subgroups (I: < 30 y; II: 30-34 y; III: 35-39 y). Results: Pregnant women older than 40 years had more chronic diseases such as hypertension, needed medical treatment more frequently and had a higher thrombosis risk. Pregnancy-induced diseases such as gestational diabetes, preeclampsia and pregnancy-associated hypertension occurred more often in women ≥ 40 years of age. Compared to mothers who were younger than 30 years, primiparous women ≥ 40 years had a more than four times higher overall cesarean section rate and four times higher elective cesarean section rate. Furthermore, they required longer hospital stays, both after cesarean section and after vaginal delivery. The preterm birth rate (≤ 32 weeks of gestation) was similar across the different age groups. Conclusions: The outcomes of pregnancy and childbirth and for newborns born to women ≥ 40 years did not vary significantly from those of younger women if the following conditions were met: a) pre-existing chronic diseases were treated medically and dietetically; b) pregnancy-induced morbidity was monitored regularly and controlled medically; c) women attended regular prenatal check-ups; d) a healthy lifestyle was adhered to during pregnancy, and e) delivery occurred in a perinatal center.
    No preview · Article · Sep 2015 · Geburtshilfe und Frauenheilkunde

  • No preview · Article · Sep 2015 · Journal of Reproductive Immunology
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    ABSTRACT: Purpose: Aim of this study was to determine the rate of complications following femoral placement of totally implantable venous access ports (f-TIVAP) in women with bilateral breast cancer, with a special focus on long-term function, deep vein thrombosis (DVT), and port infection. Methods: 73 patients with bilateral breast cancer treated between October 2000 and January 2013 with placement of an f-TIVAP using a transfemoral approach were retrospectively reviewed. All patients were followed up, and all complications of f-TIVAP were recorded. Results: The median age was 62.5 years (range: 35–86 years). Four patients received f-TIVAP under local anesthesia, and 69 underwent placement under general anesthesia. Mean follow-up was 33.7 months (SD 25.9; range: 0.2–93.5 months). Complications over the entire period of observation included infections in 21%, DVT in 19% and catheter occlusion in 12%. Patients receiving chemotherapy who developed leukopenia were more likely to experience DVT at the access site (p = 0.037). There was a trend towards a higher infection rate when the device was used more often (p = 0.084). Conclusion: Although the rates of complications in the longer term, especially device infections and DVTs, appeared to be relatively high, TIVAP implantation using femoral vein access is recommended in patients with bilateral breast cancer not suitable for cephalic vein cut-down.
    Full-text · Article · Aug 2015 · Geburtshilfe und Frauenheilkunde
  • Almasi-Sperling V · Hieber S · Lermann J · Strahl O · M W Beckmann · Lang W · Sagban TA
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    ABSTRACT: Purpose: Aim of this study was to determine the rate of complications following femoral placement of totally implantable venous access ports (f-TIVAP) in women with bilateral breast cancer, with a special focus on long-term function, deep vein thrombosis (DVT), and port infection. Methods: 73 patients with bilateral breast cancer treated between October 2000 and January 2013 with placement of an f-TIVAP using a transfemoral approach were retrospectively reviewed. All patients were followed up, and all complications of f-TIVAP were recorded. Results: The median age was 62.5 years (range: 35-86 years). Four patients received f-TIVAP under local anesthesia, and 69 underwent placement under general anesthesia. Mean follow-up was 33.7 months (SD 25.9; range: 0.2-93.5 months). Complications over the entire period of observation included infections in 21 %, DVT in 19 % and catheter occlusion in 12 %. Patients receiving chemotherapy who developed leukopenia were more likely to experience DVT at the access site (p = 0.037). There was a trend towards a higher infection rate when the device was used more often (p = 0.084). Conclusion: Although the rates of complications in the longer term, especially device infections and DVTs, appeared to be relatively high, TIVAP implantation using femoral vein access is recommended in patients with bilateral breast cancer not suitable for cephalic vein cut-down.
    No preview · Article · Aug 2015 · Geburtshilfe und Frauenheilkunde

  • No preview · Article · Aug 2015 · Zeitschrift für Geburtshilfe und Neonatologie
  • R. Schulz-Wendtland · M.W. Beckmann · P.A. Fasching · M. Uder
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    ABSTRACT: Full field digital mammography (FFDM) is the most important method for early diagnosis of breast cancer. The typical overlapping of normal and pathological tissue during the standard 2D projection, however, often reduces the specificity and sensitivity of the mammographic investigation. Digital breast tomosynthesis (DBT) provides on the basis of a limited number of single images with different projection angles not superimposed tomograms and may remove the unwanted masking by superimposed structures. Clinical studies show that the digital tomosynthesis has the real potential to reduce the recall rate and simultaneously increase the cancer detection rate, especially in women with dense breasts (detection and volumetry). The use of tomosynthesis seems to be superior to full field digital mammography in mammography screening. Other possibilities of the tomosynthesis are the dual energy mammography, contrast medium-enhanced mammography and intervention.
    No preview · Article · Aug 2015
  • J Hackl · S Burghaus · T Hildebrandt · J Lermann · MW Beckmann · SP Renner

    No preview · Article · Jul 2015 · Geburtshilfe und Frauenheilkunde

  • No preview · Article · Jul 2015 · Ultraschall in der Medizin
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    ABSTRACT: Observational studies have reported a modest association between obesity and risk of ovarian cancer; however, whether it is also associated with survival and whether this association varies for the different histologic subtypes are not clear. We undertook an international collaborative analysis to assess the association between body mass index (BMI), assessed shortly before diagnosis, progression-free survival (PFS), ovarian cancer-specific survival and overall survival (OS) among women with invasive ovarian cancer. We used original data from 21 studies, which included 12 390 women with ovarian carcinoma. We combined study-specific adjusted hazard ratios (HRs) using random-effects models to estimate pooled HRs (pHR). We further explored associations by histologic subtype. Overall, 6715 (54%) deaths occurred during follow-up. A significant OS disadvantage was observed for women who were obese (BMI: 30-34.9, pHR: 1.10 (95% confidence intervals (CIs): 0.99-1.23); BMI: ⩾35, pHR: 1.12 (95% CI: 1.01-1.25)). Results were similar for PFS and ovarian cancer-specific survival. In analyses stratified by histologic subtype, associations were strongest for women with low-grade serous (pHR: 1.12 per 5 kg m(-2)) and endometrioid subtypes (pHR: 1.08 per 5 kg m(-2)), and more modest for the high-grade serous (pHR: 1.04 per 5 kg m(-2)) subtype, but only the association with high-grade serous cancers was significant. Higher BMI is associated with adverse survival among the majority of women with ovarian cancer.British Journal of Cancer advance online publication, 7 July 2015; doi:10.1038/bjc.2015.245 www.bjcancer.com.
    No preview · Article · Jul 2015 · British Journal of Cancer

  • No preview · Article · Jul 2015 · Geburtshilfe und Frauenheilkunde

Publication Stats

3k Citations
977.14 Total Impact Points

Institutions

  • 1999-2016
    • Universitätsklinikum Erlangen
      • Department of Obstetrics and Gynaecology
      Erlangen, Bavaria, Germany
    • University of Bonn
      Bonn, North Rhine-Westphalia, Germany
  • 2001-2015
    • Friedrich-Alexander Universität Erlangen-Nürnberg
      • Department of Obstetrics and Gynaecology, School of Midwifery
      Erlangen, Bavaria, Germany
  • 1993-2012
    • Heinrich-Heine-Universität Düsseldorf
      • Frauenklinik
      Düsseldorf, North Rhine-Westphalia, Germany
  • 2011
    • Deutsche Gesellschaft für Gynäkologie und Geburtshilfe e.V.
      Erlangen, Bavaria, Germany
  • 2004
    • Universität Regensburg
      Ratisbon, Bavaria, Germany
    • Edel&weiss Clinic, Germany, Nuremberg
      Nuremberg, Bavaria, Germany
  • 2003
    • Universität zu Lübeck
      • Klinik für Augenheilkunde
      Lübeck Hansestadt, Schleswig-Holstein, Germany
  • 1991-2003
    • University of Chicago
      • Department of Obstetrics & Gynecology
      Chicago, Illinois, United States
    • Washington University in St. Louis
      • Department of Medicine
      San Luis, Missouri, United States
  • 1992
    • Goethe-Universität Frankfurt am Main
      Frankfurt, Hesse, Germany