Publications (68)

  • Yigit Akin · Hakan Gulmez · Erhan Ates · [...] · Murat Savas
    [Show abstract] [Hide abstract] ABSTRACT: Objectives: To investigate the impact of neck circumference (NC) in the treatment of bening prostatic hyperplasia (BPH) patients with metabolic syndrome (MtS). Additionally, we determined dose response to alpha-blockers and cut-off values for NC and waist circumference (WC), in these patients. Materials and methods: Non-randomized, open-labelled, and multi-centre study was conducted between March 2014 and September 2015. The BPH patients were enrolled and were divided into 2 groups: with MtS (Group 1; n=94) and without MtS (Group 2; n=103). Demographic data, anthropometric measurements, blood analyses, uroflowmetric parameters, post voiding residual urine (PVR), prostate volume, quality of life (QoL) index, NC and WC were recorded. Both groups were administered oral alphablockers and response to treatment was evaluated. Receiver-operating characteristic (ROC) curves were obtained and significant p was p<0.05. Results: In total, 197 patients were enrolled with mean age of 60.5±8.1 years. Mean NC and WC were higher in MtS patients (p<0.001). Uroflowmetry parameters and QoL indexes were comparable between groups before treatment. International prostate symptom score, uroflowmetry parameters, and QoL significant improved in Group 2 than Group 1, at 1st and 6th months of treatment with alpha-blockers. Success rate of treatment was significant higher in Group 2 than Group 1 (p<0.001). Cut-off values were 42.5cm and 113.5cm for NC and WC respectively, for response to alpha-blockers in BPH patients with MtS. Conclusions: MtS can be related with BPH and can negatively affect the response to alpha-blocker treatment. NC can be used for predicting response to alpha-blocker treatment in BPH patients with MtS.
    Article · Jul 2016 · European Urology Supplements
  • H. Tokgöz · Ö. Tokgöz · K. Karamık · [...] · M. Savaş
    Article · Apr 2016 · Hernia
  • Halil Ciftci · Yigit Akin · Murat Savas · Ercan Yeni
    [Show abstract] [Hide abstract] ABSTRACT: Objective: The aim of this study was to evaluate the long-term functional outcomes of laparoscopic pyeloplasty (LP) in children for consecutive cases of single institute. Materials and methods: Our laparoscopy database was investigated for children in terms of LP between June 2008 and April 2015. All the patients had ureteropelvic junction obstruction (UPJO) and LP was performed. Demographic data including age, gender, side of UPJO, operation time, estimated blood loss (EBL), hospital stay and complications according to Clavien classifications were recorded. Renal ultrasonography and diethylenetriamine penta-acetate (DTPA) scintigraphies were respectively performed 3, 12 and 24 months after surgery. Statistical analyses were performed and p value was accepted as significant at <0.05. Result: Mean follow-up was 34 ± 4.7 months. The mean age was 13 (6-72) months. A total of 153 (110 boys and 43 girls) LP patients enrolled. Of that, 93 (60.78%) LP were in left side and 60 (39.21%) were in right side. Three cases needed open conversation according to difficulties in anastomosis. Aberrant crossing vessel was observed in 12 (7.84%) patients. The mean operation time was 155 ± 21 min and the mean EBL was 22 ± 11.1 ml. The mean hospital stay was 3.4 days. Anastomotic leakage was the common complication (in 13 patients) that was successfully managed conservatively (Clavien 1). Eight patients experienced unsuccessful LP and underwent open pyeloplasty (Clavien 3b). The mean split renal function significantly increased in DTPA scintigraphy in follow-up. The overall success was 91%. Conclusions: The LP procedure can be an effective and safe surgical method for childhood UPJO, specifically in the experienced hands of pioneer centers.
    Article · Feb 2016 · Urologia Internationalis
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    Mustafa Yuksel · Serdar Yilmaz · Husnu Tokgoz · [...] · Murat Savas
    [Show abstract] [Hide abstract] ABSTRACT: Purpose: Few studies have investigated the efficacy of silodosin, a recently introduced selective alpha 1-A adrenoceptor antagonist, in medical expulsive therapy (MET) for ureteral calculi. The results of these studies, which all evaluated the efficacy of 8 mg/day, indicate that silodosin is a potential treatment for ureteral calculi. This study investigated the efficacy of 4 mg/day of silodosin for MET of distal ureteral stones 4 to 10 mm in diameter. Material and method: After 70 patients had been randomized into 2 groups of 35 patients each, both the control and experimental groups (groups 1 and 2, respectively) were advised to take 75 mg/day of diclofenacsodiumas needed for pain relief but only the experimental group to take 4 mg/day of silodosin. After 21 days, the groups were compared regarding the stone expulsion rate and duration, number of renalcolicepisodes, and analgesicdosage. Results: The median expulsion rates were 71.4% and 91.4% in groups 1 and 2, respectively, and the difference between them was significant (P=0.031). The median expulsion durations were 12.91±6.14 and 8.03±4.99 days, respectively, and the difference between them was significant (P<0.001). No significant differences were found regarding the median number of renal colic episodes or median analgesic dosage. While no patients in group 1 experienced side effects, 5 patients (14%) in group 2 experienced retrograde ejaculation. Conclusion: These results indicate that 4 mg/day of silodos in facilitates the expulsion of distal ureteral stones 4 to 10 mm in diameter but does not significantly reduce the number of renal colic episodes or analgesic dosage.
    Full-text Article · Oct 2015 · International Journal of Clinical and Experimental Medicine
  • Husnu Tokgoz · Ilkay Soyuncu · Soner Yalcinkaya · [...] · Murat Savas
    Article · May 2015 · International braz j urol: official journal of the Brazilian Society of Urology
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    Yigit Akin · Hakan Gulmez · Murat Savas · [...] · Selcuk Yucel
    [Show abstract] [Hide abstract] ABSTRACT: To investigate relationship between overactive bladder (OAB) and metabolic syndrome (MtS) by using neck circumference (NC). In retrospective view of prospective collected data, 204 women with or without OAB were enrolled into study, between August 2012 and December 2013. All patients were administered OAB validated questionnaires (OAB-V8) and whose score was > 8 were accepted as OAB. Patients were divided into two groups and group 1 consisted of patients with OAB, group 2 consisted of patients without OAB. Demographic data with anthropometric measurements and blood analyses were recorded. Statistical analyses including receiver operating characteristic (ROC) curves were performed; statistically significant p was < 0.05. Mean age was 41.06 ± 9.78 years. There were 115 (56.4 %) patients in group 1, and 89 (43.6 %) patients in group 2. OAB-V8 scores were significant higher in group 1 than group 2 (p < 0.001). Waist circumference (WC) and NC measurements were statistical significant longer in group 1 than group 2 (p < 0.001). In multivariate logistic regression analyses age, body mass index, MtS, WC, and NC were statistical significant associated with OAB. In ROC curves, area under the curve (AUC) was 0.72 cm(2) for relationship between OAB and WC (p < 0.001), and AUC was 0.73 cm(2) for relationship between OAB and NC (p = 0.004). Cut-off NC and WC values for OAB were determined as 35.25 cm and 98.5 cm, respectively. OAB with metabolic syndrome seems like more common in women than in those without. NC may be a novel indicator for OAB in selected female patients with MtS.
    Full-text Article · Apr 2015 · Wiener klinische Wochenschrift
  • S. Yilmaz · S. Yalcinkaya · E. Islamoglu · [...] · M. Savas
    Article · Nov 2014 · European Urology Supplements
  • S. Bas · E. Islamoglu · S. Yalcinkaya · [...] · M. Savas
    Article · Nov 2014 · European Urology Supplements
  • N. Ates · S. Yalcinkaya · E. Islamoglu · [...] · M. Savas
    Article · Nov 2014 · European Urology Supplements
  • M. Ergun · E. Islamoglu · S. Yalcinkaya · [...] · M. Savas
    Article · Nov 2014 · European Urology Supplements
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    H Ciftci · K Gumuş · İ Yagmur · [...] · M Gulum
    [Show abstract] [Hide abstract] ABSTRACT: Mean platelet (PLT) activation has an important role in the development of vascular diseases. In this study, we aimed to investigate the PLT volume in patients with vasculogenic and nonvasculogenic erectile dysfunction (ED) and compare it with the control group. Mean PLT volume (MPV) levels were measured in 50 patients with vasculogenic ED, in 30 patients who developed ED after radical prostatectomy (nonvasculogenic) and in 40 healthy controls. Ages were similar between the three groups. The diagnosis of ED was based on detailed sexual history, physical examination, laboratory assessment and color Doppler ultrasonography and is defined as the inability to attain or maintain a penile erection that is sufficient for successful vaginal intercourse. The results are given as mean±s.d. of the mean. The mean age of the patients with vasculogenic ED, of patients with ED after radical prostatectomy and of the control group were 53.70±12.39 (range 24-77), 54.60±11.40 (range 43-61) and 53.85±9.5 (range 30-73), respectively (P=0.853). The MPV and PLT values were significantly higher in patients with vasculogenic ED than in patients with ED after radical prostatectomy and in control groups: 7.49±1.4, 6.43±1.19 and 6.85±1.2 for MPV and 262.97±68, 251.77±78 and 252.89±82 for PLT values, respectively (P=0.033). The MPV and PLT values were not statistically significant in postprostatectomy ED patients and in control groups (P=0.663). There was no significant difference among the three groups in terms of white blood cells and hemoglobin levels. PLT count and mean PLT volume were detected to be increased in patients with vasculogenic ED. This finding may suggest a role for PLT volume in the pathogenesis of vasculogenic ED.International Journal of Impotence Research advance online publication, 29 May 2014; doi:10.1038/ijir.2014.17.
    Full-text Article · May 2014 · International Journal of Impotence Research
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    Hakan Gulmez · Yigit Akin · Murat Savas · [...] · Ercan Yeni
    [Show abstract] [Hide abstract] ABSTRACT: Iron deficiency anemia (IDA) is a common micronutrient deficiency worldwide. It is an important health problem especially in women of reproductive age. IDA may cause anxiety, which is the major factor for female sexual dysfunction (FSD). The aim of the present study was to determine the impact of IDA on FSD in women of reproductive age. In total, 207 women were enrolled. Women with IDA who were admitted in an outpatient clinic of family medicine were asked to complete Beck Anxiety Inventory (BAI), Female Sexual Function Index (FSFI), and Quality of Life (QoL) questionnaires. Questionnaires were completed before and after IDA treatments. Blood samples were obtained for measurements of hemoglobin, hematocrit, levels of serum iron, and iron-binding capacity. Outcomes of blood samples were used for diagnosing of IDA. BAI, FSFI, and QoL scores were evaluated. Paired samples t-tests and Pearson correlation analyses were used to assess relationship between findings of IDA treatments and other parameters. The mean age was 33.6 ± 8.4 years. There were statistical significant differences between pre- and posttreatment in terms of hemoglobin, hematocrit, serum iron, and serum iron-binding capacity. BAI scores were decreased and FSFI scores, which were statistically significant, increased after IDA treatments (P < 0.001). However, QoL scores were developed without statistical significance. There is a risk for anxiety as well as FSD in IDA women of reproductive age. Treatment of IDA can significantly improve sexual functions and QoL in these women population in short term. Gulmez H, Akin Y, Savas M, Gulum M, Ciftci H, Yalcinkaya S, and Yeni E. Impact of iron supplementation on sexual dysfunction of women with iron deficiency anemia in short term: A preliminary study. J Sex Med 2014;11:1042-1046.
    Full-text Article · Apr 2014 · Journal of Sexual Medicine
  • [Show abstract] [Hide abstract] ABSTRACT: The majority of renal injury secondary to blunt abdominal trauma can be successfully treated conservatively. In the present study, the clinical features and outcomes of children who presented with renal injury secondary to blunt abdominal trauma were evaluated. This study was carried out retrospectively using data from children at the Department of Pediatric Surgery who were hospitalized for renal injury due to blunt abdominal trauma between 2000 and 2012. Patient characteristics, clinical presentation, management strategy, and outcome were evaluated. Forty-one patients were hospitalized. The mean age of the patients was 10±4.85 years. The majority of renal injuries were grade 1 and 2. Falling was the cause of most renal injuries. All patients were initially treated conservatively. Three patients underwent acute surgical exploration for life-threatening renal bleeding (grade 4-5 injury). Nephrectomy was performed in 3 patients due to injury to the pedicle. The conservative treatment of pediatric renal parenchymal injuries is safe and effective in children. Although the vast majority of renal injuries do not require surgical intervention, life-threatening renal bleeding, regardless of the grade of injury, should be treated surgically.
    Article · Mar 2014 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES
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    Adem Altunkol · Murat Savas · Halil Ciftci · [...] · Muharrem Bitiren
    [Show abstract] [Hide abstract] ABSTRACT: Malignant fibrous histiocytomas (MFH) are the most commonly seen soft tissue sarcomas in adults. It is rarely seen in some visceral organs. Kidneys are the parenchymal organs in which MFHs are most frequently seen. More than 50 cases of primary renal MFH have been reported. Among these cases, only 1 was reported as primary giant cell subtype in association with urolithiasis. This case report is the second such case with the these characteristics.
    Full-text Article · Mar 2014 · Canadian Urological Association journal = Journal de l'Association des urologues du Canada
  • Y. Akin · H. Gulmez · M. Savas · [...] · S. Yalcinkaya
    Article · Jan 2014 · Journal of Sexual Medicine
  • M. Gulum · E. Yeni · M. Savas · [...] · K. Gumus
    Article · Jan 2014 · Journal of Sexual Medicine
  • H. Ciftci · K. Gumus · I Yamur · [...] · M. Gulum
    Article · Jan 2014 · Journal of Sexual Medicine
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    [Show abstract] [Hide abstract] ABSTRACT: The mean platelet volume (MPV) is a marker of the platelet activity and is reported to increase in vascular diseases. We aimed to investigate the association between MPV and vasculogenic erectile dysfunction (ED). MPV and platelet (PLT) levels were measured in 50 cases of ED and 40 healthy controls. The diagnosis of vasculogenic ED was based on a detailed sexual history, physical examination, laboratory assessment, and color Doppler ultrasonography. The results are given as mean±standard deviation of the mean. The mean ages of the patient and the control groups were 53.70±12.39 years (range 24~77 years) and 53.85±9.5 years (range 30~73 years), respectively (p=0.947). The MPV and PLT values were significantly higher in the patients with ED than those of the controls (7.49±1.4), (6.85±1.2), (262.97±68), (252.89±82) respectively, p<0.001). However, the MPV values were not statistically significantly different in the patients with severe ED according to the International Index of Erectile Function than in those with mild ED, p>0.05), and there was no correlation between MPV and either age of patients (p=0.905) or duration of ED (p=0.583). The platelet count and MPV was detected to be increased in patients with vasculogenic ED. This finding suggests a role for platelets in the pathogenesis of vascular complications and that the MPV would be useful in monitoring disease progression.
    Full-text Article · Dec 2013
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    Full-text Dataset · Oct 2013
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    Mehmet Gülüm · Yavuz Yeşilova · Murat Savaş · [...] · Fadile Yıldız Zeyrek
    [Show abstract] [Hide abstract] ABSTRACT: Cutaneous leishmaniasis is a protozoan disease caused by leishmanias, which results in deformations of the skin. Cutaneous leishmaniasis is endemic in the southeastern parts of Turkey. Cutaneous leishmaniasis is the most common form and is often observed in open regions of the body. Involvement of the penis was rarely reported. In this paper, we present a case of a giant hyperkeratotic form of cutaneous leishmaniasis in the glans penis. (Turkiye Parazitol Derg 2013; 37: 53-4).
    Full-text Article · Aug 2013 · Turkiye parazitolojii dergisi / Turkiye Parazitoloji Dernegi = Acta parasitologica Turcica / Turkish Society for Parasitology