T A Korol'kova

Russian Academy of Sciences, Moskva, Moscow, Russia

Are you T A Korol'kova?

Claim your profile

Publications (63)4.09 Total impact

  • I N Knipst · T A Korol'kova · A N Lebedev

    No preview · Article · Sep 2007 · Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
  • [Show abstract] [Hide abstract]
    ABSTRACT: The characteristics of the temporospatial organization of cerebral cortical potentials at different levels of genetically determined emotionality were analyzed by constructing topograms of instantaneous EEG levels in the inbred rat strains MR and MNRA. Two parameters were calculated for each topogram: the total level and the similarity coefficient. Power spectra were calculated for the values and these were found to change in an oscillatory manner. Interstrain differences were found in the correlated changes in total levels and similarity coefficients, in the durations of changes in the total level, which were more marked than those of similarity coefficients, and the nature of interhemisphere asymmetry. In MR rats, the power spectra of both measures showed significant peaks with modes at 2.0, 6.5, and 9.0 Hz. In MNRA rats, peaks in the spectra of these measures both coincided (2.0 Hz) and differed (7.0 Hz in the spectrum of the total level and 3.0, 4.5, and 6.0 Hz in the spectrum of the similarity coefficient). These data suggest different types of functioning of the reticulothalamocortical and hippocampocortical systems in rats of these strains.
    No preview · Article · Aug 2006 · Neuroscience and Behavioral Physiology
  • [Show abstract] [Hide abstract]
    ABSTRACT: With the aim to reveal features of the neocortical spatiotemporal organization of potentials characteristic of different genetically predetermined emotional levels, momentary values of EEG potentials were analyzed in inbred rats of MR and MNRA strains. A topogram was described by a basic parameter such as its general level (the mean of momentary values of potentials derived from 24 symmetrical electrodes bilaterally implanted into the brain cortex) and a similarity coefficient (correlation between the set of its momentary values and that of a standard topogram). The general level and similarity coefficient values were calculated for a series of successive topograms individually for the right and left hemisphere. Also, right- and left-side power spectra of these series were calculated. In rats of MR strain, significant (p < 0.05) peaks in the general level and similarity coefficient spectra were observed in the delta (2.0 Hz), teta (6.5 Hz) and alpha (9 Hz) frequency bands. In this strain, the general level power was higher at the right side, and the similarity coefficient power displayed the left-side dominance. In rats of MNRA strain, peaks in the delta(2.0 Hz) band coinsided in the general level and similarity coefficient spectra, whereas, independently, the general level spectra had peaks in the theta band (7.0 Hz), and similarity coefficient had peaks at frequencies 3.0, 4.5, and 6.0 Hz. The left-side general level spectral power was higher than the right-side general level spectral power in the delta and lower in the high-frequency theta bands. The similarity coefficient power displayed the left-side dominance for the peaks in the delta (2.0 Hz) and theta (3.0 Hz) bands, and it displayed the right-side dominance for the peaks in the theta (4.5 Hz) band. The specific features of the cortical spatiotemporal organization of potentials revealed in rats of MR and MNRA strains suggest different modes of functioning of at least two systems, reticulo-thalamo-corticaland hippocampo-cortical.
    No preview · Article · Jan 2005 · Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
  • [Show abstract] [Hide abstract]
    ABSTRACT: Effect of the new antimigraine drug tropoxin on the EEG profile was studied in MR and MNRA rats with genetically determined high and low levels of emotionality, respectively. In MR rats, tropoxin decreased the number of the bioelectric activity parameters changed by the stressor action (0.9% NaCl, i.p.). The drug reduced the spectral power in the EEG delta band, and increased that in the theta, beta-1, and beta-2 bands. This was evidence of the central stimulating action and the possible enhancement of the exploratory activity. In MNRA rats no changes in bioelectric activity were observed in the low-frequency delta and theta bands, while the spectral power in the beta-1, and beta-2 bands showed a decrease. It was concluded that a neural component is present in the mechanism of the tropoxin action, which may play an important part in the therapeutic effect of the new drug.
    No preview · Article · Sep 2001 · Eksperimental'naia i klinicheskaia farmakologiia
  • [Show abstract] [Hide abstract]
    ABSTRACT: The features of the EEG spatial organization in two rat strains, i.e., with expressed emotional reactions (Maudsley reactive, MR) and less reactive (Maudsley nonreactive, MNR) were compared in two stress situations: during exposure to the action of pain (P) (i.p. injection of 0.9% NaCl solution) and during 24-hour water deprivation (D). Multichannel EEG recording (24 derivations) and their multiparametric estimation (840 signs) made it possible to differentiate characteristic features of the EEG spatial organization in rats with initially increased emotional reactions and passive behavioral strategy during exposure to stress. In both stress-inducing conditions, an increase in crosscorrelation and coherence between cortical potentials in parallel with rise of the spectral power in the range of high-frequency theta and its drop in the range of EEG high-frequency band was observed in the MR rats. The MNR rats showed the opposite changes. Different reactivity of the ratio between the coherence and spectral power of potentials was observed in two strains of rats. This index characterizes the level of the information-energy component of the spatial organization of cortical potentials. It is suggested that different character of the EEG changes reflects the features of interhemispheric relations, information-energy processes, and cortical regulation of autonomic processes in the system of adaptive stress reactions at different levels of emotionality and behavioral strategy.
    No preview · Article · Sep 2001 · Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
  • [Show abstract] [Hide abstract]
    ABSTRACT: Effect of the anxiolytic drugs afobazole, diazepam, and chlordiazepoxide on the cortical biopotential coherency was studied in MR and MNRA rats with increased and decreased level of emotionality, respectively. Afobazole increased a difference in the biopotential coherency between rats of the two lines in the range of EEG theta, alpha, and beta rhythms. In the subrange of dominating theta activity (6.00-7.25 Hz), this effect took place at the expense of reduced coherency in MNRA rats in the absence of changes in the MR line. Afobazole decreased the biopotential coherency in the alpha activity band (7.5-8.25 Hz) in the rats of both lines. This is indicative of the presence of a CNS-stimulating component in the pharmacological activity spectrum of afobazole. The expediency of using afobazole in patients with different levels of anxiety is discussed.
    No preview · Article · Jul 2001 · Eksperimental'naia i klinicheskaia farmakologiia

  • No preview · Article · Mar 2001 · Neuroscience and Behavioral Physiology
  • [Show abstract] [Hide abstract]
    ABSTRACT: The influence of scopolamine (1 mg/kg, i.p.) on the spatial organization of the neocortical electrical activity was studied in rats. A decrease in the spectral power and coherence of brain potentials in the range of the dominant theta-rhythm peak (6.00-7.25 Hz) and their increase in the adjacent low-frequency band were observed. Both indices were decreased in the wide beta band (19.00-30.00 Hz). The described changes took place over the whole areas of the right hemisphere and parieto-temporal region of the left hemisphere. The obtained results are discussed with respect to the role of the cholinergic brain system in the higher nervous activity.
    No preview · Article · Jan 2001 · Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
  • [Show abstract] [Hide abstract]
    ABSTRACT: Effect of the anxiolytic drugs afobazole, diazepam, and chlordiazepoxide on the cortical biopotential coherency was studied in MR and MNRA rats with increased and decreased level of emotionality, respectively. Afobazole increased a difference in the biopotential coherency between rats of the two lines in the range of EEG theta, alpha, and beta rhythms. In the subrange of dominating theta activity (6,00 - 7.25 Hz), this effect took place at the expense of reduced coherency in MNRA rats in the absence of changes in the MR line. Afobazole decreased the biopotential coherency in the alpha activity band (7.5 - 8.25 Hz) in the rats of both lines. This is indicative of the presence of a CNS-stimulating component in the pharmacological activity spectrum of afobazole. The expediency of using afobazole in patients with different levels of anxiety is discussed.
    No preview · Article · Jan 2001
  • [Show abstract] [Hide abstract]
    ABSTRACT: Effect of the new antimigraine drug tropoxin on the EEG profile was studied in MR and MNRA rats with genetically determined high and low levels of emotionality, respectively. In MR rats, tropoxin decreased the number of the bioelectric activity parameters changed by the stressor action (0.9 % NaCl, i.p.). The drug reduced the spectral power in the EEG delta band, and increased that in the theta, beta-1, and beta-2 bands. This was evidence of the central stimulating action and the possible enhancement of the exploratory activity. In MNRA rats no changes in bioelectric activity were observed in the low-frequency delta and theta bands, while the spectral power in the beta-1, and beta-2 bands showed a decrease. It was concluded that a neural component is present in the mechanism of the tropoxin action, which may play an important part in the therapeutic effect of the new drug.
    No preview · Article · Jan 2001
  • [Show abstract] [Hide abstract]
    ABSTRACT: Effect of the central M-cholinolytic scopolamine on spatial organization of the rat brain electrical activity was studied under conditions of high and low emotional-stress responses. The EEG changes were estimated by 840 parameters. A possibility of the EEG discrimination by means of interstrain differences in responses to scopolamine, was shown. A more obvious decrease in spectral power and potentials coherence was revealed in Maudsley Reactive rats (MR) as compared with the Maudsley Nonreactive rats (MNRA), in parieto-temporal and occipital areas of the right hemisphere, and the reverse interrelationship occurred in the anterior parts of the right and posterior parts of the left hemisphere. These findings suggest some specifics in the spatial distribution of the maximum scopolamine action foci depending on the initial emotional level. Changes occurring under the scopolamine effect in different EEG frequency bands are different in the MR and the MNRA rats. The findings are discussed in respect to the EEG indices of anxiolytic component of cholinergic regulation of the brain activity.
    No preview · Article · Jun 2000 · Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk
  • [Show abstract] [Hide abstract]
    ABSTRACT: In order to study the possibility of EEG discrimination of genetically determined emotionality (increased propensity to emotional and stress reactions and anxiety) brain electrical activity was recorded in rats of two strains: Maudsley Reactive and Maudsley Nonreactive (24 derivations from the convexital skull surface were used). The program package "Synchro-EEG" was used for EEG processing. It was demonstrated that the two rat strains were significantly different in 120 EEG parameters of 840 ones analyzed. On the basis of 37 parameters, each rat was correctly recognized as belonging to the respective group with the error of 4.89%. The analysis of the detected signs allowed their classification to be performed in accordance with the peculiarities of the emotional and cognitive processes and the level of nonspecific activation. Specific forms of interaction between these components in the system of emotional reactions were revealed.
    No preview · Article · May 2000 · Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova

  • No preview · Article · May 2000 · Doklady Biological Sciences

  • No preview · Article · Dec 1999 · Biulleten' eksperimental'noĭ biologii i meditsiny
  • [Show abstract] [Hide abstract]
    ABSTRACT: The effect of 2-[2-(morpholin)ethylthio]-5-ethoxybenzimidazole (CM-346) on the EEG of MR and MNRA rats was compared with that of diazepam. Both CM-346 and diazepam reversed stress-induced changes in bioelectrical activity after intraperitoneal injection of 0.9% NaCl. In MR and MNRA rats both drugs decreased the EEG spectral power in the high-frequency θ-band (7.5–8.2 Hz). In MR rats, CM-346 increased the power of the low-frequency θ-rhythm (4.8–5.8 Hz) and the dominant activity peak (6.0–7.2 Hz) and decreased the spectral power in the 19–20 Hz band. The data suggest that CM-346 exerts antistressor and anxiolytic effects in animals with passive reactions to emotional stress.
    No preview · Article · Oct 1999 · Bulletin of Experimental Biology and Medicine
  • N E Sviderskaya · T A Korol'kova
    [Show abstract] [Hide abstract]
    ABSTRACT: Theoretical questions of the spatial organization of electrical activity in the brain are discussed in terms of a multilevel realization of the synergetic principle for formation of functional systems underlying behavior and mental function. The role of the spatial-temporal superimposition of coherent structures of biopotentials in generating fields of increased activity in the cerebral cortex is discussed, these being responsible for integrative and associative functions. A hypothesis is proposed regarding the relationship between the energy and information factors of coherent structures as one of the important characteristics describing the efficiency of energy-informational processes. Emphasis is placed on the need for considering not only linear, but also nonlinear associations of biopotentials in considerations of the form and functional sense of their spatial organization.
    No preview · Article · Nov 1998 · Neuroscience and Behavioral Physiology
  • N E Sviderskaia · O I Gorbatov · T A Korol'kova
    [Show abstract] [Hide abstract]
    ABSTRACT: Spatial organization of human EEG was studied by means of topographic mapping methods with the multiparametric data estimations in the state altered by ketamine in terms of the concept of coherent structures of brain electrical activity. Two main features of the altered state of consciousness were reflected in the opposite shifts: an increase in the spatial synchronization in the left hemisphere (especially, in the posterior area) and its decrease in the left frontal and right temporal one. The obtained data are discussed from the viewpoint of dissociative effects of ketamine at the neurochemical and neurophysiological levels.
    No preview · Article · Jan 1998 · Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
  • I N Knipst · T A Korol'kova

    No preview · Article · Sep 1997 · Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
  • N E Sviderskaia · T A Korol'kova
    [Show abstract] [Hide abstract]
    ABSTRACT: In the paper the theoretical problems are discussed of the spatial organization of brain electrical activity. It is considered as a multilevel realization of synergetic principle in formation of functional systems, which underlie behavior and mental activity. The role is discussed of the spatial-temporal superposition of coherent structures of potentials in generation of the cortical fields of increased activity, which realize the integrative and associative functions. A hypothesis is proposed about the alignment of "energy" and "information" factors of coherent structures as one of the important characteristics of efficiency of biological energy-information processes. The necessity is emphasized of taking into account both linear and nonlinear correlations of biopotentials to gain an insight into the forms and functional significance of their spatial organization.
    No preview · Article · Sep 1997 · Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
  • N E Sviderskaia · V R Agaronov · T A Korol'kova
    [Show abstract] [Hide abstract]
    ABSTRACT: The polymorphism of reaction to emotionally significant stimuli is discussed in the context of pathological incentive. Using the "Synchro-EEG" technique 41 patients and 11 healthy volunteers were examined. Analysis of the spatial organization of cortical electrical activity revealed three types of reactions in patients. Intergroup differences were reflected in generalized and local cortical processes (mainly, in the frontal regions of the left and temporo-parieto-occipital regions of the right hemispheres). They were probably related to the sign of emotions, behavioural and autonomic nervous tension and the attitude to the object of motivation ("approach-withdrawal"). This suggestion was substantiated by the finding that the aversive therapy can change the pattern of cortical processes. Intergroup differences were revealed not only in the reactive (to emotionally significant stimulus) but also in the background electrical activity. The groups were different in the dominance of different narrow-frequency processes in one group as compared to the other. These findings suggest determination of emotional reactions by the initial functional state of patients.
    No preview · Article · Nov 1996 · Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova

Publication Stats

160 Citations
4.09 Total Impact Points

Institutions

  • 1983-2006
    • Russian Academy of Sciences
      • Institute of Higher Nervous Activity and Neurophysiology
      Moskva, Moscow, Russia