Eui Seok Han

Seoul National University, Sŏul, Seoul, South Korea

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Publications (8)13.63 Total impact

  • Eui Seok Han · Won Ryang Wee · Jin Hak Lee · Mee Kum Kim
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    ABSTRACT: To evaluate the long-term results of keratolimbal allograft (KLAL) and elucidate the prognostic factors of KLAL survival. Twenty-four eyes of 22 patients underwent KLAL one or more times, and were followed up more than 1 year postoperatively. Their medical records were reviewed. The success of KLAL and penetrating keratoplasty (PKP) was evaluated. KLAL success was defined as absence of persistent corneal epithelial defect, corneal conjunctivalization, or neovascularization on the corneal edge of the graft. Prognostic factors for survival of KLAL were analyzed, including preoperative diagnosis, history of graft rejection, symblepharon, concurrent surgery, immunosuppressant dose, and interval for full epithelialization time. The prognostic factors were evaluated by univariate survival analysis or multivariate Cox proportional hazards survival regression. KLAL had been successful in 33.3% of the eyes over an average of 47.9 months. Fifteen episodes of KLAL rejection developed in ten eyes (41.7%), but 13 cases (86.7%) were reversible. Of 45 KLAL procedures, eyelid deformity, symblepharon, and the interval of full epithelialization were significantly associated with KLAL success by univariate analysis, and the presence of symblepharon was identified by multivariate Cox regression analysis as the most important prognostic factor to affect KLAL outcome (p = 0.010). KLAL has been partly successful for reconstruction of limbal stem cell deficiency, and symblepharon has been identified as a significant prognostic factor for KLAL survival. Surgical correction of symblepharon is important before KLAL and PKP.
    No preview · Article · Aug 2011 · Albrecht von Graæes Archiv für Ophthalmologie
  • Moon Jung Kim · Eui Seok Han · Jaewoo Kim · Tae-Woo Kim
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    ABSTRACT: To investigate whether bevacizumab may be delivered into the anterior chamber after subconjunctival administration and its pharmacokinetics in aqueous humor. The right eye of 33 rabbits received subconjunctival injection of 2.5 mg of subconjunctival bevacizumab. Three rabbits were sacrificed at each of the following time points: 0.5, 1, 2, 4, 8, 12, 24, 48, 72, 120, 168 h after the injection. Bevacizumab concentrations were measured in aqueous fluid of injected and uninjected eyes and serum using enzyme-linked immunosorbent assay. Bevacizumab was first detected in the aqueous humor of the injected eye at 12 h after the subconjunctival injection. A peak concentration of 70.59 +/- 26.01 ng/mL was achieved at 36 h. Bevacizumab was also detected in the serum and aqueous humor of the uninjected contralateral eye. The concentration in the aqueous humor of the injected eye was lower than in the serum and higher than in the aqueous humor of the uninjected contralateral eye at all time points. Elimination of bevacizumab from the serum and aqueous humor of injected and uninjected eye paralleled with half-life of 57.78 +/- 13.75 h, 27.64 +/- 1.95 h and 28.05 +/- 2.55 h, respectively. We demonstrated that bevacizumab can be delivered into anterior chamber by single subconjunctival injection. Further study is needed to assess whether subconjunctival bevacizumab is clinically useful in patients with neovascular glaucoma.
    No preview · Article · Feb 2010 · Journal of ocular pharmacology and therapeutics: the official journal of the Association for Ocular Pharmacology and Therapeutics
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    Eui Seok Han · Moon Jung Kim · Ki Ho Park
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    ABSTRACT: To investigate the relationship between intraocular pressure (IOP) and visual field defect progression (VFP) in normal-tension glaucoma (NTG).
    Preview · Article · Oct 2009 · Journal of the Korean Ophthalmological Society
  • Eui Seok Han · Won Ryang Wee · Jin Hak Lee · Mee Kum Kim
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    ABSTRACT: Little information is currently available on the long-term safety of eyes following limbal tissue donation. We have therefore evaluated long-term refractive changes, corneal surface stability, and visual outcome following limbal tissue donation of 180 degrees with permanent amniotic membrane transplantation (AMT). Four healthy eyes of four patients underwent limbal keratectomy involving half of the limbal circumference (half limbal) for the purpose of limbal donation with permanent AMT. The best corrected visual acuity (BCVA), astigmatic changes by manifest refraction, and corneal surface changes as assessed by slit-lamp examination and by impression cytology were evaluated. The mean follow-up period was 20.8 months (range: 19-24 months). BCVA remained unchanged in three eyes (75%), but eye one showed a BCVA decrease of two lines due to newly developed filamentary keratitis caused by Sjögren's syndrome. The average astigmatism change was an increase of 0.31 diopters. Conjunctival invasion toward the center beyond the edge of the keratectomy did not occur in any of the eyes, as assessed by impression cytology. Partial conjunctivalization within 2 h on keratectomy sites covered with amniotic membrane developed in three eyes (75%). Limbal donation of 180 degrees with permanent AMT seems to be a safe procedure, demonstrating stable astigmatism and an intact corneal surface for at least 1.5 years following the initial donation.
    No preview · Article · Jun 2007 · Albrecht von Graæes Archiv für Ophthalmologie
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    Eui Seok Han · Won Ryang Wee · Jin Hak Lee · Mee Kum Kim
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    ABSTRACT: To evaluate visual outcome and the changes of contrast sensitivity (CS) after diffuse lamellar keratitis (DLK). Using retrospective chart review, 48 eyes of 25 patients who underwent laser in situ keratomileusis (LASIK) with Visx S4 (VISX Inc., Santa Clara, CA) and M2 (Moria, France) and who were followed for at least six months were included. They were divided into two groups: DLK and non-DLK, by diagnosis of DLK or its absence after LASIK. Postoperative logMAR visual acuities and logCS measured using the VCTS 6500 (Vistech Consultants, Inc., Dayton, OH) were compared with preoperative values in the DLK and non-DLK groups at three and six months after LASIK. There was no difference in logMAR visual acuity between the DLK and non-DLK groups until the sixth postoperative month. However, CS was significantly decreased at 12 and 18 cycle/degree compared with preoperative values (p=0.043 and p=0.045, respectively) in the DLK group, whereas CS was significantly increased at 12 cycle/degree in the non-DLK group (p=0.042) at six months. DLK seemed to be strongly associated with a postoperative decrease of CS.
    Preview · Article · Apr 2007 · Korean Journal of Ophthalmology
  • Eui Seok Han · Ki Ho Park
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    ABSTRACT: To compare three types of digital images for assessment of retinal nerve fiber layer (RNFL) defects: red-free RNFL images, color nonmydriatic images, and digitally converted nonmydriatic red-free fundus images. Diagnostic test comparison. Ninety-five image sets of three type images were evaluated. Converted images were acquired from nonmydriatic digital images by converting them into red-free, monochromatic images with graphics software. Taking RNFL images as standards, the sensitivities/specificities of nonmydriatic digital color and converted images were evaluated for detecting wedge-shaped defect (WSD) or diffuse atrophy. In terms of WSD, the sensitivity/specificity of converted images were 85.7%/95.5%, and those of nonmydriatic were 83.9%/91.0%. Regarding diffuse atrophy, the sensitivity/specificity of converted images were 60.0%/97.8%, and those of nonmydriatic were 60.0%/98.9%. Intragrader/intergrader agreements for converted images were 0.849/0.793 (WSD) and 0.417/0.614 (diffuse atrophy). Converted nonmydriatic fundus images without pupillary dilation are as effective as conventional red-free RNFL images for detecting WSD.
    No preview · Article · Mar 2007 · American Journal of Ophthalmology
  • Eui Seok Han · Jin Hak Lee
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    ABSTRACT: To determine an accurate method of intraocular lens (IOL) power calculation in highly myopic eyes with previous radial keratotomy (RK). Five eyes that had undergone RK with preoperative myopia >-14.0 diopters (D) were studied retrospectively. The keratometric values obtained with the clinical history method, contact lens over-refraction method, conventional keratometry, adjusted keratometry, and Orbscan II were compared to the true keratometric value calculated retrospectively with the SRK/T formula. The true keratometric value was closest to that from the contact lens over-refraction method in one eye and to the flatter keratometric value between simulated keratometry (Sim K) and the 3-mm diameter central zone mean keratometric value obtained with axial keratometric power map of Orbscan II in four eyes. The flatter keratometric value between Sim K and the 3-mm zone mean keratometric value from Orbscan II was closest to the true postoperative RK keratometric value of the central cornea.
    No preview · Article · Oct 2006 · Journal of refractive surgery (Thorofare, N.J.: 1995)
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    ABSTRACT: We sought to investigate the effect of external subretinal fluid drainage (SRFD) on secondary or impending secondary glaucoma caused by bullous exudative retinal detachment for saving eyes with Coats' disease. By retrospective chart review, we collected the treatment results of 56 patients younger than 15 years of age with Coats' disease. External SRFD was performed when exudative retinal detachment became bullous enough to cause anterior displacement of the lens-iris diaphragm or when secondary angle-closure glaucoma occurred. Treatment results were regarded as successful when secondary angle-closure glaucoma was prevented or responded to treatment. The mean age of those who underwent external SRFD was 3.1+/-1.8 years. Exudative retinal detachment was found in 48 eyes (86%), and external SRFD was needed initially in 19 (28%). External SRFD initially was performed in 19 eyes (28%) and in 2 (3%) after initial cryotherapy. Of these 21 eyes, no definite neovascular glaucoma was detected, and it took on average 1.2 SRFDs to treat or prevent secondary angle-closure glaucoma. All treatments were successful, and no eye was enucleated. External SRFD should be considered early as a treatment for secondary angle-closure glaucoma associated with bullous exudative retinal detachment in Coats' disease.
    No preview · Article · May 2006 · Journal of American Association for Pediatric Ophthalmology and Strabismus

Publication Stats

45 Citations
13.63 Total Impact Points


  • 2006-2011
    • Seoul National University
      • Department of Ophthalmology
      Sŏul, Seoul, South Korea
  • 2006-2007
    • Seoul National University Hospital
      • Department of Ophthalmology
      Sŏul, Seoul, South Korea