Etem Beskonakli

Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Engüri, Ankara, Turkey

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Publications (63)87.38 Total impact

  • Ö. Okutan · I. Solaroǧlu · M. Karakuş · B. Saygili · E. Beşkonakli
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    ABSTRACT: Spinal cord compression due to the follicular thyroid carcinoma is rare. In this paper, we report 6 unusual cases of isolated vertebrae metastasis of the follicular thyroid carcinoma presenting with spinal cord compression. It is unusual for this neoplasm to begin with present as a single metastasis to the spine. Comprehensive preoperative works up for metastatic tumors of vertebrae is significant. This should include evaluation of the thyroid gland consisting of detailed clinical history and physical examination.
    No preview · Article · Jan 2012
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    ABSTRACT: The major aim of this study was to evaluate the efficiency of chitosan microspheres containing cyclosporine-A (Cs-A) on mitochondrial damage in traumatic brain injury (TBI) animal model. Trauma was introduced to male Sprague-Dawley (SD) rats similar to that of modified Feeney Method. Briefly, after craniectomy in the left parietal region (5 mm). Trauma was performed by dropping 24 g metal sterile rods through a teflon guide tube (9.3 cm) on a foot plate placed over the duramater. Just after the trauma, 20 mg/kg Cs-A (Sandimmune) has been administered to the traumatised SD rats intraperitoneally (i.p.). On the other hand, only chitosan microspheres containing 10 mg/kg was implanted at the craniectomy area locally after trauma in Group E. A small piece of surgicell was placed over the craniectomy hole and the scalp incision was sutured. 24 h after injury and the brain tissues were removed intact. The results were evaluated through lipid peroxidation ratio and ultrastructural grading system. The statistical comparisons were evaluated by using Mann Whitney- U test at the significance level p = 0.05. The lipid peroxidation ratios of sham (78.4  +/-  6.0 nmol/g tissue) and vehicle (80.2  +/- 10.6 nmol/g tissue) were significantly increased 24 h after TBI. However, for treatment groups (i.p. Cs-A; 20 mg/kg) and (10 mg/kg Cs-A in microspheres), statistically significant lower lipid peroxidation ratios were determined as 53.5  +/- 9.7 and 47.9  +/- 8.1 nmol/g tissue, respectively (p < 0.05). The mitochondrial damage scores of the treatment groups were recorded as 21.7  +/-2.6 and 19.4  +/- 3.9 for Group D and Group E, respectively. Both of these scores of the treatment groups were found as significantly different from the sham and vehicle groups' scores individually. The implantation of microsphere formulation has provided a better efficiency in keeping the uniformity of mitochondrial structure in this complex cascade of events after TBI.
    No preview · Article · Oct 2010 · British Journal of Neurosurgery
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    ABSTRACT: Atorvastatin is commonly used as a cholesterol lowering agent in patients. Recently, the neuroprotective effects of atorvastatin became the focus of many research studies. In this study, we have formulated chitosan microspheres containing atorvastatin calcium. In-vitro characterization of chitosan microspheres and quantification of atorvastatin calcium from formulations were also evaluated. The neuroprotective efficiency of atorvastatin calcium was investigated by an experimental spinal cord injury model. Atorvastatin calcium microspheres were implanted at the laminectomy area (1 mg/kg) immediately after trauma. Twenty-four hours after injury, motor functions of animals were scored according to modified Tarlov Scale. In spinal cord tissues tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6 and lipid peroxidation levels were quantified and ultrastructural changes have been investigated. The results of all parameters indicate that microspheres containing atorvastatin calcium were capable of improving functional outcome, attenuating the expression of TNF-alpha, IL-1beta and IL-6; lowering lipid peroxidation levels and maintaining the preservation of the cellular uniformity.
    No preview · Article · Sep 2010 · Chemical & pharmaceutical bulletin
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    ABSTRACT: Immunomodulation of acute spinal cord injury may inhibit the activity of specific inflammatory cascades and result in recovery of motor function. In this study, evaluation of the protective effect of a well-known anti-inflammatory immunomodulator, immunoglobulin G (IgG), was conducted in rats after a 50 g/cm contusion spinal cord injury. Following injury, 400 mg/kg of IgG was administered to the treatment group. Twenty-four hours later, animals were assessed functionally via an inclined plane and the Basso-Beattie-Bresnahan motor scale and compared to controls. Tissue was reviewed for myeloperoxidase activiy (MPO) and lipid peroxidation (LPO), and electron microscopy was conducted to assess tissue ultrastructure. Significant functional preservation was observed in the IgG treatment group. In addition, biochemical assays revealed decreased MPO activity, and electron microscopic views of tissue showed preserved ultrastructure. IgG treatment following acute contusion injury to the rat spinal cord confers functional and structural neuroprotection.
    No preview · Article · Mar 2009 · Journal of Clinical Neuroscience
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    ABSTRACT: BackgroundThe aims of this study were to evaluate the efficiency of EPO in the treatment of cold injury–induced brain edema, apoptosis, and inflammation and to compare its effectiveness with DSP.MethodsOne hundred fifteen adult male Sprague-Dawley rats weighing between 280 and 300 g were used for the study. Rats were divided into 5 groups. Controls received craniotomy only. The injury group underwent cold injury and had no medication. In the EPO group, a single dose of 1000 IU/kg body weight of EPO was administered. The DSP group received 0.2 mg/kg body weight of DSP. The vehicle group received a vehicle solution containing human serum albumin, which is the solvent for EPO. Brain edema was formed by cold injury using metal sterile rods with a diameter of 4 mm that were previously cooled at −80°C. Twenty-four hours after the injury, animals were decapitated and brain tissues were investigated for brain edema, tissue MPO and caspase-3 levels, and ultrastructure.ResultsA significant increase in brain water content was revealed in injury group of rats at 24 hours after cold injury. Injury significantly increased tissue MPO and caspase-3 levels and resulted in ultrastructural damage. Both EPO and DSP markedly decreased tissue MPO and caspase-3 levels and preserved ultrastructure of the injured brain cortex.ConclusionsErythropoietin and DSP were found to be neuroprotective in cold injury–induced brain edema model in rats via anti-apoptotic and anti-inflammatory actions.
    No preview · Article · Nov 2008 · Surgical Neurology
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    ABSTRACT: Treatments for brain edema are important and one of the major options is corticosteroids. Cell membrane stabilization and prevention of formation of free radicals are the main mechanisms of action of steroids in edema treatment. As an alternative therapeutic agent, magnesium sulphate has been used for its neuroprotective effect in various injury models. In our animal model of brain injury, cold has been used in Sprague-Dawley rats. After brain injury, magnesium sulphate (600 mg/kg) or dexamethasone sodium phosphate (0.2 mg/kg) were administered to experimental groups. The degree of brain edema and lipid peroxidation was evaluated using the wet-dry weight method, the determination of malondialdehyde (MDA) levels and an ultrastructural grading system. Magnesium sulphate treatment was found to be the most effective choice due to the absence of side effects and comparable efficacy to corticosteroids.
    No preview · Article · Feb 2008 · Journal of Clinical Neuroscience
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    ABSTRACT: A case of a patient with bilateral internal, external, posterior external and anterior jugular vein ligations and excisions performed in the neck due to a larynx tumor is presented. Radical neck dissection is a standard otorhinolaryngological procedure in the management of head and neck cancer patients with bilateral lymph node metastasis to the neck. Sacrifice of both internal and external jugular veins bilaterally has been recognized as a dangerous approach leading to intracranial hypertension with subsequent neurological sequela and death. In this report, we aimed to demonstrate how venous outflow from the brain diverts after jugular venous system obliteration. After bilateral jugular vein ligations, digital subtraction angiography (DSA) showed that the venous drainage route of the brain had been diverted from the jugular veins to the vertebral venous plexus.
    Full-text · Article · Feb 2008 · Turkish neurosurgery
  • Ozerk Okutan · Ihsan Solaroglu · Etem Beskonakli · Yamac Taskin
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    ABSTRACT: Inflammatory response and apoptosis have been proposed as mechanisms of secondary injury of the spinal cord after primary insult. Recent studies have shown that erythropoietin (EPO) has neuroprotective properties. In this study, we assessed the efficacy of recombinant human erythropoietin (r-Hu-EPO) in the treatment of acute spinal cord injury (SCI) in rats. Rats were divided into five groups of eight rats each. Controls (Group 1) received laminectomy only. The trauma-only group (Group 2) underwent 40 g/cm contusion injury and had no medication. In group 3, 30 mg/kg of methylprednisolone (MPSS) was administered. Group 4 received 1000 IU/kg body weight of r-Hu-EPO. The vehicle group (Group 5) received a vehicle solution containing human serum albumin, which is the solvent for r-Hu-EPO. Twenty-four hours after trauma, animals were functionally evaluated and a spinal cord samples were obtained for the assessment of caspase-3 and myeloperoxidase (MPO) activities. The results showed that MPO and caspase-3 activities increased to statistically significant higher levels in the spinal cord after contusion injury comparing to the control group. MPO and caspase-3 enzyme activity levels were significantly reduced in animals treated either with r-Hu-EPO or MPSS. In addition, we observed significant early functional recovery in EPO-treated rats. EPO has anti-apoptotic and anti-inflammatory effects, and improves early clinical results after SCI.
    No preview · Article · May 2007 · Journal of Clinical Neuroscience
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    Beril Gok · Ozerk Okutan · Etem Beskonakli · Kamer Kilinc
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    ABSTRACT: Neutrophil infiltration has been implicated in the secondary destructive pathomechanisms after initial mechanical injury to the spinal cord. Tissue myeloperoxidase (MPO) activity has been shown to be an exclusive indicator of the extent of post-traumatic neutrophil infiltration. We have studied the effect of magnesium sulphate on MPO activity after spinal cord injury in rats. Rats were randomly allocated into 5 groups. Group 1 was control and normal spinal cord samples were obtained after clinical examination. Forty g-cm contusion injury was introduced to Group 2. Group 3 was vehicle, 1 ml of physiological saline was injected post-trauma. Group 4 was given 30 mg/kg methylprednisolone sodium succinate (MPSS) immediately after trauma. Group 5 was given 600 mg/kg magnesium sulphate immediately after trauma. Animals were examined by inclined plane technique of Rivlin and Tator 24 h after trauma. Spinal cord samples obtained following clinical evaluations. Magnesium sulphate treatment improved early functional scores and decreased MPO activity. These findings revealed that magnesium sulphate treatment possesses neuroprotection on early clinical results and on neutrophil infiltration after acute contusion injury to the rat spinal cord.
    Full-text · Article · May 2007 · The Chinese journal of physiology
  • Ihsan Solaroğlu · Erkan Kaptanoğlu · Ozerk Okutan · Etem Beşkonakli
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    ABSTRACT: Fractures of isolated spinous processes of cervical and thoracic vertebrae are called as Clay shoveler's fracture. In this report, a case of 32-year-old male with multiple isolated spinous process fracture of cervical spine is reported. The patient treated conservatively with a cervical collar. These fractures may be a warning sign of more severe spinal injuries.
    No preview · Article · May 2007 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES
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    ABSTRACT: Electron and light microscopic changes, neutrophil infiltration, and lipid peroxidation in the spinal cord and early neurologic examination were studied in rats. To examine the effects of immunomodulator treatment with recombinant human interferon-beta after spinal cord contusion injury. Immunomodulator treatment with interferon-beta has been the subject of extensive studies, but mainly in relation to multiple sclerosis. Recently, it was reported that interferon-beta possessed significant neuroprotection after experimental transient ischemic stroke. However, to our knowledge, there have been no previous reports about the neuroprotective effect of interferon-beta after spinal cord injury. Rats were randomly allocated into 5 groups. Group 1 was control and after clinical examination, normal spinal cord samples were obtained. Group 2 was introduced 50 g/cm contusion injury. Group 3 was vehicle, immediately after trauma 1 mL of physiologic saline was injected. Group 4 was given 30 mg/kg methylprednisolone sodium succinate intraperitoneally immediately after trauma. Group 5 was given 1 x 10(7) IU interferon-beta immediately and 0.5 x 10(7) IU interferon-beta 4 hours after trauma. Animals were examined by inclined plane and Basso-Beattie-Bresnahan scale 24 hours after trauma. Spinal cord samples obtained following clinical evaluations. Neutrophil infiltration was evaluated by myeloperoxidase activity and lipid peroxidation was estimated by thiobarbituric acid test. Electron and light microscopic results were also performed to determine the effects of interferon-beta on tissue structure. Interferon-beta treatment improved neurologic outcome, which was supported by decreased myeloperoxidase activity and lipid peroxidation. Electron and light microscopic results also showed preservation of tissue structure in the treatment group. Immunomodulator treatment with interferon-beta possesses obvious neuroprotection after acute contusion injury to the rat spinal cord.
    No preview · Article · Apr 2007 · Spine
  • Ozerk Okutan · Ihsan Solaroglu · Erkan Kaptanoglu · Etem Beskonakli
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    ABSTRACT: A patient with intracranial lung adenocarcinoma metastasis mimicking a colloid cyst of the third ventricle is reported. These tumours may be associated with excessive bleeding and may infiltrate into surrounding structures. Open microsurgery rather than endoscopic surgery should be considered for these cases, particularly a transcortical-transventricular or transcallosal approach, in order to avoid serious complications.
    No preview · Article · Jun 2006 · Journal of Clinical Neuroscience
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    ABSTRACT: In this study, film formulations containing dexamethasone sodium phosphate were prepared by using a natural polymer chitosan. The in vivo efficiency of film formulations were evaluated by the animal model in which the brain edema was formed on Sprague Dawley rats. The evaluation of the efficiency for film formulations were investigated through the parameters such as wet-dry weight method, determination of the lipid peroxidation ratio, ultrastructural grading system and Transmission Electron Microscopy. The statistical evaluation of te experimental results revealed no significant difference between the experimental groups (p>0.05) which is probably due to the insufficient release medium in the craniectomy area, the movements of the film formulation as a result of the natural movements of the animals after surgery.
    No preview · Article · Mar 2006 · Fabad Journal of Pharmaceutical Sciences
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    ABSTRACT: Foot drop has been known to occur in peripheral and spinal lesions and in muscular dystrophy as well as with central lesions. Insufficient neurological examination may result in an unnecessary investigation and delayed diagnosis. In this case report, the foot drop due to parasagittal meningioma was the first clinical presentation.
    No preview · Article · Jan 2006
  • Ihsan Solaroglu · Ozerk Okutan · Etem Beskonakli
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    ABSTRACT: Although lumboperitoneal shunts have some advantages over other shunt types, they are also associated with unique complications, including scoliosis, back pain, and sciatica. We report a case of foraminal migration of a lumboperitoneal shunt catheter tip, which resulted in radicular pain and neurological deficit.
    No preview · Article · Dec 2005 · Journal of Clinical Neuroscience
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    ABSTRACT: Introduction Brain involvement in hydatid disease occurs in 1–2% of all Echinococcus granulosus infections. Secondary infection of intracranial hydatid cysts is extremely rare. Case report and discussion In this case report, we present a secondary infection of an intracranial hydatid cyst due to Clostridium ramosum, which is an extremely rare infectious pathogen in neurosurgical practice, and a potential pitfall in neuroradiological investigations.
    No preview · Article · Dec 2005 · Child s Nervous System
  • Ihsan Solaroğlu · Ozerk Okutan · Erkan Kaptanoğlu · Etem Beşkonakli
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    ABSTRACT: This 4-year-old boy presented with an ectopic lacrimal gland in the right orbit. Computerized tomography scans revealed a well-encapsulated mass lesion in the right orbit with lateral wall destruction and extension to the subcutaneous tissue. A lateral orbital approach was performed. Although ectopic lacrimal gland tissue is rare in the orbit, this lesion can cause proptosis and orbital bone destruction in childhood.
    No preview · Article · Oct 2005 · Journal of Neurosurgery
  • E Beskonakli · I Solaroglu · K Tun · L Albayrak
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    ABSTRACT: Cerebral involvement in hydatid disease occurs in 1-4% of cases. There are few documented cases in the literature of intracranial hydatid cysts in unusual locations such as pons and thalamus. In this report, a case of 33-year-old male with primary intracranial hydatid cyst in the interpeduncular cistern is reported. This is the first such case in the literature.
    No preview · Article · Aug 2005 · Acta Neurochirurgica
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    ABSTRACT: Oxidative stress may contribute to many of the pathophysiologic changes that occur after traumatic brain injury (TBI). There are a number of potential sources and mechanisms for oxygen free radical (OFR) production and lipid peroxidation after TBI. In this study, we investigate the time-dependent changes in xanthine oxidase (XO) activity and lipid peroxidation using a focal TBI animal model. We demonstrate that there is an immediate increase in lipid peroxidation by-products and in XO enzyme activity after TBI.
    No preview · Article · May 2005 · Journal of Clinical Neuroscience
  • E Kaptanoglu · I Solaroglu · H S Surucu · F Akbiyik · E Beskonakli
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    ABSTRACT: Spinal cord injury (SCI) involves a series of pathological events. Abnormal sodium influx has been implicated as one of the key events in the pathophysiology of the SCI. Pharmacological blockade of sodium channels can reduce secondary injury and increase recovery from trauma. The aim of the present study was to show the neuroprotective effect of phenytoin, a sodium channel blocker, after experimental SCI. Control and laminectomy-only groups were not injured. 50 g-cm weight drop injury was produced in the trauma group. In the treatment groups, methylprednisolone (30 mg/kg) and phenytoin (1 mg/kg, 10 mg/kg, or 30 mg/kg) were given intraperitoneally immediately after injury. Malondialdehyde (MDA) levels in the spinal cord samples were examined for lipid peroxidation. Spinal cord ultrastructure was evaluated and grading system was used for quantitative evaluation. Trauma increased tissue MDA levels. Treatment with methylprednisolone and phenytoin decreased MDA levels compared to trauma in all doses. Significant ultrastructural neuroprotection was observed with 30 mg/kg of phenytoin treatment according to general neural score. This ultrastructural neuroprotection of phenytoin was not different from methylprednisolone. Phenytoin appears to protect spinal cord against injury by decreasing lipid peroxidation and lessening neuronal damage associated with SCI in rats.
    No preview · Article · May 2005 · Acta Neurochirurgica

Publication Stats

936 Citations
87.38 Total Impact Points


  • 2007-2009
    • Ataturk Chest Diseases and Chest Surgery Education and Research Hospital
      Engüri, Ankara, Turkey
  • 2007-2008
    • Ankara Atatürk Training and Research Hospital
      Engüri, Ankara, Turkey
  • 1997-2008
    • Ankara Numune Training and Research Hospital
      Engüri, Ankara, Turkey
  • 2004
    • Hacettepe University
      • Department of Biochemistry of Cancer
      Engüri, Ankara, Turkey
  • 1990-1996
    • Konya Numune State Hospital
      Conia, Konya, Turkey