You Jin Lee

Ewha Womans University, Sŏul, Seoul, South Korea

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Publications (95)249.62 Total impact

  • You Jin Lee · Ji-Hye Park · Jong-Hee Lee · Dong-Youn Lee
    No preview · Article · May 2016 · International journal of dermatology
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    Preview · Article · May 2016
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    Jin-Mu Yi · Young Ah Kim · You Jin Lee · Ok-Sun Bang · No Soo Kim
    [Show abstract] [Hide abstract] ABSTRACT: Background: Descurainia sophia seeds have a variety of pharmacological functions and been widely used in traditional folk medicine. However, their effects on human drug metabolizing enzyme (DME) activities have not been elucidated. The present study investigated the inhibitory effects of an ethanol extract of D. sophia seeds (EEDS) on human Phase I/II (DMEs) and P-glycoprotein (p-gp) in vitro. Methods: The enzyme activities of human Phase I (cytochrome P450s, CYPs), Phase II (uridine diphosphate glucuronosyltransferases, UGTs) DMEs, and the drug transporter P-gp were determined in the presence of various concentrations of EEDS using commercially available luminogenic assay systems. The mode of enzyme inhibition and the inhibitory constant (Ki) value of EEDS were graphically determined with Lineweaver-Burk double reciprocal plots and secondary plots, respectively. Results: The enzyme activity assays showed that EEDS moderately inhibited the CYP1A2, CYP2C9, and CYP2C19 isoforms with half maximal inhibitory concentrations (IC50) of 47.3, 25.8, and 38.7 μg/mL, respectively. Graphical analyses with Lineweaver-Burk double reciprocal plots and secondary plots indicated that EEDS competitively inhibited CYP2C9 with a Ki value of 19.8 μg/mL; however, it inhibited CYP2C9 and CYP2C19 in a mixed mode with Ki values of 5.2, and 11.9 μg/mL, respectively. Other Phase I (CYP2C8, CYP2D6, and CYP3A4) and Phase II (UGT1A1 and UGT2B7) enzymes as well as P-gp were weakly or negligibly affected by EEDS with concentrations up to 500 μg/mL. Conclusions: EEDS is a selective inhibitor of CYP1A2, CYP2C9, and CYP2C19 with moderate enzymatic inhibition. Clinically, full consideration should be given to a potential toxic adverse effect from a herb-drug interaction when drugs that are particularly susceptible to CYP1A2, CYP2C9, or CYP2C19-mediated metabolism are taken together with EEDS. Characterization of metabolic profiles of specific herbal drugs could help consumers and medical specialists to use them safely as a complementary and alternative medicine.
    Preview · Article · Dec 2015 · BMC Complementary and Alternative Medicine
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    Jun Lee · You Jin Lee · Jinhee Kim · Ok-Sun Bang
    [Show abstract] [Hide abstract] ABSTRACT: In the search for novel herbal-based anticancer agents, we isolated a new angular-type pyranocoumarin, (+)-cis-(3S,4S)-3-angeloyl-4-tigloylkhellactone (1) along with 12 pyranocoumarins (2-13), two furanocoumarins (14, 15), and a polyacetylene (16) were isolated from the roots of Peucedanum praeruptorum using chromatographic separation methods. The structures of the compounds were determined using spectroscopic analysis with nuclear magnetic resonance (NMR) and high-resolution-electrospray ionization-mass spectrometry (HR-ESI-MS). The multidrug-resistance (MDR) reversal and anti-inflammatory effects of all the isolated compounds were evaluated in human sarcoma MES-SA/Dx5 and lipopolysaccharide (LPS)-induced RAW 264.7 cells. Among the 16 tested compounds, two (2 and 16) downregulated nitric oxide (NO) production and five (1, 7, 8, 11, and 13) inhibited the efflux of drugs by MDR protein, indicating the reversal of MDR. Therefore, these compounds may be potential candidates for the development of effective agents against MDR forms of cancer.
    Full-text · Article · Nov 2015 · Molecules
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    [Show abstract] [Hide abstract] ABSTRACT: The purpose of this study was to evaluate the impact of radioactive iodine therapy (RIT) on vocal function during the early follow-up period after a total thyroidectomy (TT) using perceptive and objective measurements, questionnaires regarding subjective symptoms, and data on vocal function in prospectively enrolled and serially followed thyroid cancer cohort. Of 212 patients who underwent TT and were screened between January and December 2010 at our hospital, 160 patients were included in the final analysis. Patients with the following histories were excluded: 1) lateral neck dissection; 2) organic vocal fold pathologies; 3) external radiotherapy; and 4) voice evaluation during T4 withdrawal. Patients were stratified into 3 groups: TT only; TT with low-dose RIT (30-60 mCi); and high-dose RIT (100-150mCi). Voice evaluations were performed before surgery and at 1 month, 6 months, and 12 months after TT. Vocal characteristics were altered after TT, including changes on the GRBAS scale, increased amplitude perturbation, decreased fundamental frequency, narrowed pitch range, and global disturbances in subjective functional parameters on the voice handicap index. However, the degree of vocal changes between the TT only, TT with low-dose RIT, and high-dose RIT groups did not significantly differ until 1-year postoperative follow-up period. According to the results of subgroup analyses of patients who demonstrated good voice outcomes after TT, there were no significant functional differences between these three groups. RIT at any dose does not affect vocal function within one year of TT. Copyright © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
    Full-text · Article · Aug 2015 · Journal of Nuclear Medicine
  • Eun Kyung Lee · Min Ji Park · You Jin Lee
    No preview · Article · Aug 2015 · Cancer Research
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    [Show abstract] [Hide abstract] ABSTRACT: Angiogenesis is the process of new vessel formation from pre-existing blood vasculature and is critical for continuous tumor growth. We previously reported that an ethanolic extract of Gleditsia sinensis thorns (EEGS) and its active constituent, cytochalasin H, have anti-angiogenic activity in vitro and in vivo via suppression of endothelial cell functions. In the present study, EEGS and cytochalasin H were observed to efficiently inhibit tumor growth in an in ovo xenograft model without significant toxicity. We repeatedly observed the anti-tumor and anti-metastatic effects of EEGS in representative animal models. These results suggest that EEGS and its active constituent, cytochalasin H, are potential candidates for the development of anti-angiogenic cancer drugs.
    Full-text · Article · Jul 2015 · Biological & Pharmaceutical Bulletin
  • [Show abstract] [Hide abstract] ABSTRACT: We undertook this study to estimate an accurate incidence and spread patterns of occult PTC in patients with a preoperative diagnosis of solitary PTC by using whole-specimen mapping of all specimens after total thyroidectomy. Enrolled prospectively in this whole-thyroid mapping study are 82 consecutive patients who underwent total thyroidectomy under a preoperative diagnosis of solitary PTC. All thyroidectomy specimens were serially sectioned in 2-mm thickness and whole-thyroid mapping was carried out for additional foci of occult PTC. The frequencies of occult lesions detected in the whole and contralateral lobe were determined, and clinicopathologic factors associated with multifocality were assessed. Whole-thyroid mapping revealed 66 occult PTC lesions missed by pre-operative ultrasound in 37 (45.1%) of 82 patients. The great majority (92.5%) of the occult PTC was smaller than 3 mm in size and 25 patients (30.5%) had contralateral lesions. We found that male sex was an independent predictor of multifocality (OR 3.00, 95% CI 1.11-8.14), adjusting for preoperative findings. Analysis with pathologic parameters showed that male sex (OR 5.03, 95% CI 1.68-15.08) and extrathyroidal extensions (OR 3.03, 95% CI 1.03-8.95) were associated with multifocal PTC. However, none of the clinicopathologic factors evaluated predicted contralateral PTC. Our study demonstrates the diagnostic limitations of ultrasound for the detection of multifocal PTC, and the need to consider the possibility of occult lesions in the management of solitary PTC, especially in male patients.
    No preview · Article · Jun 2015 · Endocrine Related Cancer
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    Full-text · Article · May 2015
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    Full-text · Article · May 2015
  • No preview · Article · May 2015 · Journal of the American Academy of Dermatology
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    [Show abstract] [Hide abstract] ABSTRACT: Thyroid cancer is the most common malignancy in Korea; in 2012, about 44,000 new cases (19.6% of all malignancies) were registered and the estimated age-standardized incidence rate of thyroid cancer was 73.6 per 100,000 (17.3 and 88.6 per 100,000 in men and women, respectively). Despite the steep increase in its incidence, the age-standardized mortality rate of thyroid cancer has remained stable and 10-year relative survival rate is 99.2%. Increased detection using high-resolution ultrasonography may have contributed to the increased incidence of thyroid cancer if not all. However, the effectiveness of thyroid cancer screening using ultrasonography has not been fully evaluated as to whether screening and early diagnosis could decrease the morbidity or mortality of thyroid cancer. A multidisciplinary expert committee for developing a guideline for thyroid cancer screening was organized and established a recommendation for thyroid cancer screening using ultrasonography in Korea based on scientific evidence for the first time. In conclusion, the current evidence is insufficient to assess the balance of benefits and harms of the thyroid cancer screening by ultrasonography and the recommendation is that thyroid ultrasonography is not routinely recommended for healthy subjects.
    Full-text · Article · Apr 2015 · Journal of the Korean Medical Association
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    Full-text · Article · Apr 2015 · Annals of Dermatology
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    You Jin Lee · Yoon Kyoung Yang · You Jin Kim · Oran Kwon
    [Show abstract] [Hide abstract] ABSTRACT: Purpose: Anthocyanins from purple sweet potato (PSP) have been investigated in vitro and in animals and found to have a protective effect against oxidative hepatic damage. In this study, we investigated that aqueous extract of PSP can ameliorate the dysfunction of lipid metabolism in mice fed a high fat/cholesterol diet. Methods: Forty C57BL/6J mice were randomly divided into 5 groups (n = 8) and fed one of the following diets for 8 weeks; normal fat (NF) diet; high fat/ cholesterol (HFC) diet; HFC with 1.25% PSP (HFPL) diet; HFC with 2.5% PSP (HFPM) diet; HFC with 5% PSP (HFPH) diet. Results: Non-alcoholic fatty liver was manifested in the HFC group by showing increased levels in plasma alanine aminotransferase (ALT) activity, total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), increased level of TC and presence of many large lipid droplets in the liver, and increased fat cell size in the HFC group compared with the NF group. However, administration of HFC induced a significant decrease in food intake, resulting in decrease in fat mass. Coadministration of PSP did not lead to reversal of body weight changes, ALT activity, and lipid levels in plasma and the liver, but suppressed excess enlargement of the fat cell size through increasing carnitine palmitoyltransferase-1 (CPT-1) gene expression in the liver. Accordingly, the number of fat droplets in the liver was reduced in PSP administered groups. Conclusion: Taken together, these results suggest that PSP may have a protective effect on the dysfunction of lipid metabolism. Conduct of further studies on the coordinated regulation of PSP for lipid metabolic homeostasis at the liveradipose tissue axis is needed.
    Preview · Article · Feb 2015 · Journal of Nutrition and Health
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    [Show abstract] [Hide abstract] ABSTRACT: To evaluate the effect of gastrectomy on diabetes mellitus (DM) and hypertension (HTN) in non-obese gastric cancer patients. A total of 100000 patients, diagnosed with either type 2 DM or HTN, were randomly selected from the 2004 Korean National Health Insurance System claims. Among them, 360 diabetes and 351 hypertensive patients with gastric cancer who had been regularly treated without chemotherapy from January 2005 to December 2010 were selected. They were divided into three groups according to their treatment methods: total gastrectomy (TG), subtotal gastrectomy (STG) and endoscopic resection (ER). The drug discontinuation rate of anti-diabetic and anti-hypertensive agents after gastric cancer treatment was 9.7% and 11.1% respectively. DM appeared to be improved more frequently (22.8%) and earlier (mean ± SE 28.6 ± 1.8 mo) in TG group than in the two other groups [improved in 9.5% of ER group (37.4 ± 1.1 mo) and 6.4% of STG group (47.0 ± 0.8 mo)]. The proportion of patients treated with multiple drugs decreased more notably in TG group compared to others (P = 0.001 in DM, and P = 0.035 in HTN). In TG group, adjusted hazard ratio for the improvement of DM was 2.87 (95%CI: 1.15-7.17) in a multi-variate analysis and better control of DM was observed with survival analysis (P < 0.001). TG was found to decrease the need for anti-diabetic medications which can be reflective of improved glycemic control, to a greater extent than either ER or STG in non-obese diabetic patients.
    Full-text · Article · Jan 2015
  • [Show abstract] [Hide abstract] ABSTRACT: Context: With recent technical advances in radiotherapy (RT) planning, simultaneous integrated boost intensity modulated radiotherapy (SIB-IMRT) has made possible the delivery of high radiation dose to the tumor, minimizing surrounding normal tissues. Objective: To evaluate the clinical effectiveness and safety of postoperative SIB-IMRT in patients with locoregionally advanced papillary thyroid cancer (PTC). Design: This was a propensity score matched case control study. Setting: This study was conducted at tertiary referring center. Patients or other Participants: This study included locoregionally advanced PTC (pT4 or N1b) patients who underwent thyroid cancer surgery and radioactive iodine ablation (RIA) followed by postoperative SIB-IMRT (RT group) under a phase II trial or no postoperative RT (Non-RT group) Intervention: Postoperative SIB-IMRT was the intervention. Main Outcome Measures: locoregional relapse free survival (LRFS) was compared between RT group and Non-RT group. Results: Multivariate analysis showed that several factors, including gender, American Thyroid Association risk category and use of postoperative RT, significantly associated with LRFS in all 201 patients (p<0.05 each). In the 118 propensity score matched patients, there were no significant differences in baseline characteristic between the RT and Non-RT groups, but the LRFS rate was significantly higher in the RT than in the Non-RT group (4 years: 100% vs. 84.6%, p = 0.002). Overall, SIB-IMRT was well tolerated, with no grade ≥3 toxicity, and was completed as planned in all patients. Conclusions: Postoperative SIB-IMRT is feasible and effective in improving locoregional control in patients with locally advanced PTC. Large scale randomized studies are warranted.
    No preview · Article · Jan 2015 · Journal of Clinical Endocrinology & Metabolism
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    [Show abstract] [Hide abstract] ABSTRACT: Although preclinical studies suggest that garlic has potential preventive effects on cardiovascular disease (CVD) risk factors, clinical trials and reports from systematic reviews or meta-analyses present inconsistent results. The contradiction might be attributed to variations in the manufacturing process that can markedly influence the composition of garlic products. To investigate this issue further, we performed a meta-analysis of the effects of garlic powder on CVD risk factors. We searched PubMed, Cochrane, Science Direct and EMBASE through May 2014. A random-effects meta-analysis was performed on 22 trials reporting total cholesterol (TC), 17 trials reporting LDL cholesterol (LDL-C), 18 trials reporting HDL cholesterol (HDL-C), 4 trials reporting fasting blood glucose (FBG), 9 trials reporting systolic blood pressure (SBP) and 10 trials reporting diastolic blood pressure (DBP). The overall garlic powder intake significantly reduced blood TC and LDL-C by -0.41 mmol/L (95% confidence interval [CI], -0.69, -0.12) (-15.83 mg/dL [95% CI, -26.64, -4.63]) and -0.21 mmol/L (95% CI, -0.40, -0.03) (-8.11 mg/dL [95% CI, -15.44, -1.16]), respectively. The mean difference in the reduction of FBG levels was -0.96 mmol/L (95% CI, -1.91, -0.01) (-17.30 mg/dL [95% CI, -34.41, -0.18]). Evidence for SBP and DBP reduction in the garlic supplementation group was also demonstrated by decreases of -4.34 mmHg (95% CI, -8.38, -0.29) and -2.36 mmHg (95% CI, -4.56, -0.15), respectively. This meta-analysis provides consistent evidence that garlic powder intake reduces the CVD risk factors of TC, LDL-C, FBG and BP.
    Preview · Article · Dec 2014 · Nutrition research and practice
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    [Show abstract] [Hide abstract] ABSTRACT: A remarkable increase in the number of thyroid cancer cases has been reported in recent years; however, the markers to predict high-risk groups have not been fully established. We conducted a case-control study (257 cases and 257 controls) that was nested in the Cancer Screenee Cohort Study between August 2002 and December 2010; the mean follow-up time for this study was 3.1 +/- 2.2 years. The levels of total triiodothyronine (TT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroglobulin (Tg), anti-thyroperoxidase antibody (TPOAb), and anti-thyroglobulin antibody (TgAb) were measured using samples with pre-diagnostic status. Logistic regression models were used to examine the association between thyroid function/autoimmunity and thyroid cancer risk. When the markers were categorized by the tertile distributions of the control group, the highest tertile of FT4 (OR = 1.73, 95% CI = 1.11 - 2.69) and the middle tertile of TSH (OR = 1.77, 95% CI = 1.14 - 2.74) were associated with an increased risk of thyroid cancer by multivariate analyses. In addition, an elevated risk for thyroid cancer was found in subjects with TPOAb levels above 30 IU/mL (OR = 8.47, 95% CI = 5.39 - 13.33 for 30-60 IU/mL and OR = 4.48, 95% CI = 2.59 - 7.76 for >=60 IU/mL). Stratified analyses indicated that some of these associations differed by sex, BMI, smoking status, and the duration of follow-up. This study demonstrated that the levels of biomarkers of thyroid function/autoimmunity, particularly the presence of TPOAb, might be used as diagnostic markers for predicting thyroid cancer risk. Our findings suggest that careful monitoring of thyroid biomarkers may be helpful for identifying Korean populations at high-risk for thyroid cancer.
    Full-text · Article · Nov 2014 · BMC Cancer
  • [Show abstract] [Hide abstract] ABSTRACT: Poor electrochemical output of a lithium-ion battery at low temperature is an existing general concern, which restricts their application as energy storage devices. In the current work, low temperature behaviours of coin full cells prepared with specific loading amount, thickness and packing density were investigated. Graphite anode and LiNi0.6Co0.2Mn0.2O2 cathode were prepared with different laminates from low to high loading and thickness. Coin full cell discharge capacity and capacity retention was comparatively investigated both at room temperature (25 °C) and low temperature (−32 °C). The results demonstrated that the cells prepared with low loading and lesser thickness displayed a better low temperature performance in terms of capacity retention. Furthermore, electrochemical impedance spectroscopic analysis determined that at low temperature the electrodes with a lower loading showed a less charge-transfer resistance (Rct) than that of those with a higher loading.
    No preview · Article · Nov 2014 · Physica Status Solidi (A) Applications and Materials
  • No preview · Article · Oct 2014 · The Journal of Dermatology

Publication Stats

847 Citations
249.62 Total Impact Points

Institutions

  • 2015
    • Ewha Womans University
      • Department of Nutritional Science and Food Management
      Sŏul, Seoul, South Korea
    • Korea Institute of Oriental Medicine
      부천시, Gyeonggi-do, South Korea
  • 2014
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2010-2014
    • Korea Research Institute of Chemical Technology
      Daiden, Daejeon, South Korea
  • 2006-2014
    • Hanyang University
      • • Department of Electronic and Electrical Engineering
      • • Department of Electronics and Computer Engineering
      Sŏul, Seoul, South Korea
  • 2012
    • National Cancer Center Korea
      Kōyō, Gyeonggi Province, South Korea
  • 2009
    • Korea Advanced Institute of Science and Technology
      • Department of Chemical and Biomolecular Engineering
      Daiden, Daejeon, South Korea
  • 2008
    • Chonbuk National University
      • School of Medicine
      Tsiuentcheou, Jeollabuk-do, South Korea
  • 2007
    • Yonsei University
      • Center for Bioactive Molecular Hybrids and Department of Chemistry
      Sŏul, Seoul, South Korea
  • 2005
    • University of Ulsan
      • Department of Physics
      Urusan, Ulsan, South Korea
  • 2000-2005
    • Pusan National University
      Busan, Busan, South Korea