Paweł Nauman

Institute of Psychiatry and Neurology, Warszawa, Masovian Voivodeship, Poland

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Publications (46)77.42 Total impact


  • No preview · Conference Paper · Oct 2015
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    Paweł Nauman
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    ABSTRACT: The present study is aimed to present the potential role of thyroid hormones (TH) in the pathogenesis of glioblastoma multiforme (GBM). In first part of this presentation the effect of general homeostasis of TH on GBM formation and course was shown. Then the evidence concerning present state of the knowledge about active transport of TH to the brain, the role of iodothyronine deiodinase type 2 and 3 in the setting concentration of T3 in the brain and GBM cells, and finally knowledge about the role of genomic (TH nuclear receptors THRA and THRB) and non-genomic modes (membrane integrin receptor αvβ3) of action of TH and its importance for GBM was outlined. The last part of this presentation was devoted to generally approved signalling pathways leading to the formation and the clinical course of GBM, showing at the same time evidence that each of the pathways is affected by particular TH actions. In conclusion it is suggested that TH is one of the pathogenetic factors for GBM and as such can have practical implications for the formation and course and treatment of this tumour. (Endokrynol Pol 2015; 66 (5): 444-459).
    Preview · Article · Oct 2015 · Endokrynologia Polska

  • No preview · Article · Mar 2015 · Brain Stimulation
  • Tomasz Tykocki · Paweł Nauman · Anatol Dow Enko
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    ABSTRACT: Objectives: Intracranial aneurysms (IAs) of the posterior circulation (PC) rupture more frequently and their morbidity and mortality rates are higher compared to anterior circulation. Morphological parameters such as size ratio (SR), inflow angle and parent artery geometry are believed to contribute significantly in determining IA risk rupture. The aim of this study is to establish angiography-based morphometric predictors of PC IA risk rupture. Methods: A retrospective analysis of 58 patients with PC aneurysms was incorporated into the study. The following independent variables were measured: aneurysm dome size, neck size, parent artery size, SR, neck to parent artery ratio, and inflow angle. All aneurysms were divided into ruptured and unruptured groups. The stepwise logistic regression analysis was applied to establish the predictors of PC aneurysm risk rupture. Results: 58 patients with 27 unruptured and 31 ruptured PC cerebral aneurysms were analyzed. The mean aneurysm dome, neck and parent vessel diameters were 8·49±3·5 mm, 2·46±1·4 mm, and 3·92±1·6 mm, respectively. Size ratio was 2·26±0·6; dome/neck 3·45±0·8 and inflow angle 115·2±22°. The relevant difference between unruptured and ruptured groups was: SR (1·91 vs 2·48), aneurysm dome (7·96 vs 8·95 mm), dome/neck (3·77 vs 3·18), and inflow angle (103·7 vs 125·2°). The significant predictive value was reached for inflow angle (OR 1·05; Cl 95% 1·01 to 1·1) and SR (OR 3·53; Cl 95% 1·09 to 11·5). Cut-off value on receiver operating characteristic curve for inflow angle (113·1°; sensitivity 67·7% and specificity 81·5%) and SR (1·99; sensitivity 77·4% and specificity 63%). Discussion: The SR and inflow angle proved to be relevant predictors in estimating the aneurysm risk rupture of the posterior cerebral circulation.
    No preview · Article · Jan 2014 · Neurological Research
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    Full-text · Article · Sep 2013 · Parkinsonism & Related Disorders
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    ABSTRACT: To assess the correlation between quality of life (QoL), depressive symptoms and motor signs in patients with Parkinson disease after subthalamic deep brain stimulation (DBS STN). MATERIAL and 74 patients, average age 55.6 ± 7 and duration of disease 12.3 years± 3.8, treated with l STN DBS for PD were included in the study. All patients were evaluated with (UPDRS III), (PDQ-39) (BDI) at baseline and at 6, 12, and 24-month follow up. All patients were also stratified into three groups depending on UPDRS III improvement ( < 30%, 30-60%, > 60%). Scores in all scales significantly decreased from baseline. The improvement in PDQ-39 was 43.3%, in BDI 25.3 %; UPDRS-III 55.5% at 6 months. At 24 months, motor results and QoL deteriorated by 15.6% and 19.6% respectively. BDI remained unchanged. Mean scores at baseline in PDQ-39 were group I 67.4 ± 29.7; II 64.8±32.0; III 53.4±22.0 and for BDI, group I 17.4±12.04; II 14.0±9.7; III- 15.1±10.55. Scores decreased significantly with DBS at 6-month follow-up and mean change was: PDQ-39, group I 42.7%, II- 40.7%, III 51.6%; BDI group I 23%, II 28.1%, III 23.3 %. Reduction of depressive symptoms, motor signs and improvement of QoL in PD after DBS STN are closely related. Improvement of QoL depends significantly on motor symptoms.
    Full-text · Article · May 2013 · Turkish neurosurgery
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    ABSTRACT: Abnormalities in pain perception are a part of the clinical picture in Parkinson's disease (PD) and belong to the category of non-motor symptoms. Two groups of patients were included in this study: (i) an experimental group of 36 patients with PD who were eligible for subthalamic deep brain stimulation (the experimental group [EG]) and (ii) a control group (CG) of 34 patients with a space-occupying lesion who were admitted for a framed stereotactic biopsy. Stereotactic frame fixation was used in both groups as a nociceptive stimulus. All participants were assessed for pain perception with two kinds of visual analogue scales (VAS) (a non-color VAS [ncVAS] and a color VAS [cVAS]) immediately after the stimulus (EG - ncVAS 1 and cVAS 1; CG - ncVAS 3 and cVAS 3) and 24 hours later (EG - ncVAS 2 and cVAS 2; CG - ncVAS 4 and cVAS 4). The means for the two pain scores assessed directly after frame fixation were 3.59 (ncVAS 1) and 3.06 (cVAS 1) for patients in the EG, while the mean ncVAS was 3, and the mean cVAS 3 was 6.1 for those in the CG. The pain intensity was significantly lower for patients with PD (EG) compared to those in the CG for both ncVAS and cVAS (p<0.05 for each measure). The mean pain scores for ncVAS and cVAS measured 24hours after the procedure were 3.18 and 2.79 for patients with PD (EG) and 6.10 and 5.77 for those in the CG, respectively. Pain intensity measured 24hours after the procedure was significantly lower in those with PD (EG) compared to the CG. This study has demonstrated that pain perception in patients with PD is significantly lower than pain perception in non-parkinsonian patients.
    No preview · Article · Feb 2013 · Journal of Clinical Neuroscience
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    ABSTRACT: Complete aneurysm obliteration reduces the risk of rebleeding and is an important goal of the aneurysm treatment. MATERIAL and A retrospective analysis of 63 patients undergoing endovascular treatment of posterior circulation aneurysms. The occlusion rate was stratified to three groups: complete, incomplete and partial. In the analysis compared the influence of the selected characteristics: age, sex, WFNS grade, aneurysm location, size of the aneurysm dome and neck, neck to dome ratio, on the effectiveness of embolization in each group. A multi-factor analysis with probit model and linear regression was applied to assess the impact of all characteristics on the complete occlusion. In the series of 63 single aneurysms, 51 were ruptured and 12 unruptured aneurysms. Complete occlusion was achieved in 36 (57.1%), incomplete in 15 (23.8%), partial in 12 (19%) patients. In patients with the neck size of 1-2 mm the complete occlusion was in 75% (24/32) incomplete in 12,5% (4/32), while when the neck size was 2-4 mm these rates were 38.7% (12/31) and 29% (9/31) respectively. The predictor of total occlusion in probit and linear regression model was only one independent variable, the narrow-neck size. Multi-factor analysis found that the strongest predictor of the complete occlusion is the aneurysm neck size.
    No preview · Article · Jan 2013 · Turkish neurosurgery
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    ABSTRACT: Background and purpose: Despite the rapid development of neuropharmacotherapy, medical treatment of neuropathic pain (NP) still constitutes a significant socioeconomic problem. The authors herein present a group of patients treated with motor cortex stimulation (MCS) for NP of various types and aetiologies. Material and methods: Our cohort included 12 female and 11 male NP patients aged 53 ± 16 treated with MCS. Eleven patients were diagnosed with neuropathic facial pain (NFP), 8 with hemi-body neuropathic pain (HNP), and 4 with deafferentation pain (DP). Prior to surgery, 16 out of 23 patients were treated with repetitive transcranial magnetic stimulation (rTMS), with a positive response in 10 cases. Pain intensity in our group was evaluated with the visual analogue scale (VAS) one month before and three months after MCS implantation. Results: Improvement on the VAS was reported in the whole group of patients (p < 0.001). The best results were reported in the NFP group (p < 0.001) while the worst ones were noted in the DP group (p = 0.04). Anamnesis duration positively correlated with outcome. Infection forced the authors to permanently remove the system in one case. There were no other complications in the group. Conclusions: Minimally invasive, safe neuromodulative treatment with MCS permits neuropathic pain control with good efficacy. The type of neuropathic pain might be a prognostic factor.
    No preview · Article · Nov 2012 · Neurologia i neurochirurgia polska
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    ABSTRACT: Background: Microlesion effect (MLE) is a commonly observed phenomenon after electrode insertion into the subthalamic nucleus (STN) for deep brain stimulation (DBS). Objectives: The aim of this study was to determine the presence of the MLE in the early postoperative period and the relationship between MLE and STN DBS. Methods: 74 patients with Parkinson's disease were included in this study. Motor symptoms were evaluated preoperatively, within 48 h after electrode implantation and at 6 months with United Parkinson's Disease Rating Scale part III (UPDRS-III). According to the improvement level with MLE, all participants were stratified into three groups: (1) less than 20%; (2) 20-40%, and (3) more than 40% in OFF medication states. The degree of improvement in UPDRS-III with DBS ON for each MLE group was assessed at the 6-month follow-up. Regression analysis was applied for the evaluation of the relationship between MLE and improvement with DBS ON. Results: Mean results in UPDRS-III with the MLE in ON and OFF medication states were 22.1 ± 10.5 and 42.1 ± 14 points, respectively. At the 6-month follow-up, with active stimulation, results tended to further ameliorate to 14.6 (59.4%) points in ON and 20.8 (55.3%) in OFF. Mean improvement in MLE groups were: 33.6% group 1, 47.5% group 2 and 61.4% group 3. Regression analysis revealed a positive correlation between the MLE and results at 6 months with DBS ON. Conclusion: Results proved the presence of MLE in the early postoperative period. Furthermore, a positive correlation between MLE and improvement degree with active stimulation was observed.
    No preview · Article · Nov 2012 · Stereotactic and Functional Neurosurgery
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    ABSTRACT: Deep brain stimulation (DBS) is a method of treatment utilized to control medically refractory epilepsy (RE). Patients with medically refractory epilepsy who do not achieve satisfactory control of seizures with pharmacological treatment or surgical resection of the epileptic focus and those who do not qualify for surgery could benefit from DBS. The most frequently used stereotactic targets for DBS are the anterior thalamic nucleus, subthalamic nucleus, central-medial thalamic nucleus, hippocampus, amygdala and cerebellum. The DBS is believed to be an effective method of treatment for various types of epilepsy among adults and adolescents. Side effects may be associated with implantation of electrodes and with the stimulation itself. An increasing number of publications and growing interest in DBS application for RE may result in standardization of the qualification and treatment protocol for RE with DBS.
    Full-text · Article · Nov 2012 · Archives of Medical Science
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    ABSTRACT: We present two cases (female and male patients, aged 64 and 38, respectively) of focal mass lesions mimicking a brain tumour: one with cognitive function deficit, memory troubles, behavioral changes and left hemiparesis, the other with difficulty in orientation and right hemiparesis. General physical and neurological examinations, laboratory tests and neuroimaging were used to diagnose the cases. Both of them showed nonspecific changes in the brain tissue and the brain tumour was suspected. In the first case MRI scan revealed two pathological masses in the right frontal region and hemorrhagical focus with destructions inside lesions. Second patient's MRI scan revealed a pathological mass at the interface of the left temporal and occipital regions. The neurosurgical procedure was performed. The final diagnosis was established on the basis of neuropathological examination of postoperative material. On light microscopy examination a severe cerebral amyloid angiopathy (CAA) was revealed. Amyloidoma was excluded due to the absence of amorphous material and eosynophylic masses. Tumefactive CAA is a rare condition. These two cases of focal, tumefactive, masslike lesions of diffuse cerebral amyloid angiopathy are reported because of diagnostic dilemmas. In patients with history of memory disfunction, neurological deterioration and different multiple changes observed in CT and MRI scans, such as hemorrhagic infarcts and ischemic cerebral lesions, CAA should be suspected. The imaging findings make a distinction between tumefactive CAA and brain tumours like gliomas difficult. A differential diagnosis of CAA and amyloidoma plays a significant role in a neuropathological examination.
    Full-text · Article · Jul 2012 · Folia Neuropathologica
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    ABSTRACT: Background and purpose: Quantitative and qualitative analysis of neurosurgical procedures provides important data for assessment of the development and trends in the field of neurosurgery. The authors present statistical data on intracranial procedures (IPs) performed in Poland in 2008-2009. Material and methods: Data on IPs come from reports of the National Health Fund, grouped according to the system of Diagnosis-Related Groups, group A - nervous system diseases. Data concerning the year 2009 include all IPs performed in Poland. Data from the second half of 2008 to 2009 (18 months) come from 35 neurosurgical centers in Poland, divided by provinces. We analyzed the number of IPs, the cost of procedures, duration of hospitalization and deaths. Results: 20 849 IPs were performed in Poland in 2009. The most common procedure was A12 (6807; 32.65%), and the rarest was A04 (96; 0.46%). The annual cost of all IPs was 228 599 956 PLN. Average cost of the procedure ranged from 1578 PLN (A14) to 47 940 PLN (A03). Duration of the hospitalization ranged between 3 days (A14) and 12 days (A12). The highest percentage of deaths was reported for A01 (n = 1050, 19.06%). Reports from 35 neurosurgical centers in the second half of 2008 and 2009 showed the highest number of IPs per 100 000 population in Kujawsko-Pomorskie (93) and the lowest in Wielkopolskie (27) and Podkarpackie (27). The highest number of IPs (1669) was performed in neurosurgical center M1 (Małopolskie), and the lowest (99) in W1 (Wielkopolskie). Conclusions: A significant disparity in the number of IPs performed in different centers in Poland was observed.
    No preview · Article · Jul 2012 · Neurologia i neurochirurgia polska

  • No preview · Article · Jun 2012 · Journal of Neurological Surgery, Part B: Skull Base

  • No preview · Article · Jan 2012 · Parkinsonism & Related Disorders

  • No preview · Article · Jan 2012 · Parkinsonism & Related Disorders

  • No preview · Article · Jan 2012 · Parkinsonism & Related Disorders
  • T. Mandat · H. Koziara · R. Rola · T. Tykocki · W. Bonicki · P. Nauman

    No preview · Article · Jan 2012 · Parkinsonism & Related Disorders
  • T. Mandat · M. Tutaj · H. Koziara · P. Nauman · W. Bonicki · R. Rola

    No preview · Article · Jan 2012 · Parkinsonism & Related Disorders
  • T. Tykocki · T. Mandat · P. Nauman

    No preview · Article · Jan 2012 · Parkinsonism & Related Disorders

Publication Stats

163 Citations
77.42 Total Impact Points

Institutions

  • 2010-2015
    • Institute of Psychiatry and Neurology
      Warszawa, Masovian Voivodeship, Poland
    • Medical University of Warsaw
      Warszawa, Masovian Voivodeship, Poland
    • Centrum Onkologii-Instytut im. Marii Skłodowskiej-Curie
      • Department of Molecular Biology
      Warszawa, Masovian Voivodeship, Poland
  • 2011
    • Maria Skłodowska-Curie Institute of Oncology
      Cracovia, Lesser Poland Voivodeship, Poland
  • 2009-2011
    • Maria Sklodowska Curie Memorial Cancer Centre
      Gleiwitz, Silesian Voivodeship, Poland