Jihua Li

Sichuan University, Hua-yang, Sichuan, China

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Publications (41)89 Total impact

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    ABSTRACT: Previous research has raised substantial controversy over the synergistic effects of exogenous growth factors, BMP-2 and bFGF, when used together for the treatment of bony defects. Thus, the present study evaluated the effects of BMP-2 and bFGF at specified dose ratio composited with n-HA/PU40, a porous scaffold material, for repairing femoral defect in rats. Four weeks after implantation of this composite system, tissue specimens were collected for histological, immunohistochemical examinations and µ-CT scanning. The results showed that the group DUAL/BMSCs with both the factors had better effect on repairing bone defects than the other four groups in terms of new bone formation and bone-scaffold bonding, suggesting crosstalk between these growth factors during early bone regeneration. This work demonstrates that provided that there is effective contact between cells and active proteins in the defect area, the controlled release of bFGF and BMP-2 have positive synergistic effects on early bone formation in the defect area. This article is protected by copyright. All rights reserved.
    No preview · Article · Oct 2015 · Journal of Biomedical Materials Research Part A
  • Xiang Li · Yubao Li · Yi Zuo · Dan Qu · Yiming Liu · Tao Chen · Nan Jiang · Hui Li · Jihua Li
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    ABSTRACT: A novel bi-layered osteochondral scaffold, including of PVA/Gel/V layer for the cartilage and n-HA/PA6 layer for the subchondral bone, has been proposed to evaluate the potential of the engineered of osteochondral grafts in repairing articular osteochondral defects in rabbits. The two different layers of the scaffolds were seeded with allogenic bone marrow-derived stem cells (BMSCs), which were chondrogenically and osteogenically induced respectively. The critical-size osteochondral defects were created in the knees of adult rabbits. The defects were treated with cell-bi-layered constructs (Group A), bi-layered constructs (Group B) and untreated group C as control group. The adhesion, proliferation and differentiation of BMSCs were demonstrated by immunohistochemical staining and scanning electron microscopy (SEM) in vitro. Cell survival was tracked via fluorescent labeling in vivo. Overall, the porous PVA/Gel/V-n-HA/PA6 scaffold was compatible and had no negative effects on the BMSCs in vitro culture. The cell-bi-layered scaffolds showed superior repair results as compared to the control group using gross examination and histological assessment. With BMSCs implantation, the two different layers of the composite biomimetic scaffolds provided a suitable environment for cells to form respective tissue. Simultaneously, the RT-PCR results confirmed the expression of specific extracellular matrix (ECM) markers for cartilaginous or osteoid tissue. This investigation showed that the porous PVA/Gel/V-n-HA/PA6 scaffold is a potential matrix for treatment of osteochondral defects, and the method of using chondrogenically and osteogenically differentiated BMSCs as seed cells on each layer might be a promising strategy in repair of articular osteochondral defect due to enhanced chondrogenesis and osteogenesis. This article is protected by copyright. All rights reserved. © 2015 Wiley Periodicals, Inc.
    No preview · Article · Mar 2015 · Journal of Biomedical Materials Research Part A
  • Lijun Liao · Yuchun Hsu · Jing Hu · Xiang Li · Hui Li · Jihua Li
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    ABSTRACT: Facial asymmetry is usually due to unbalanced development of the lower jaw and zygoma and often results in esthetically unpleasant appearance. However, reasonable and systematic treatment of such an asymmetric face is rarely reported in the literature. This article aims to evaluate the effectiveness of surgical correction of asymmetric facial deformity and discuss their indications. From July 2006 to November 2010, a total of 52 patients received contour reshaping procedures to correct their asymmetric faces. Those patients in whom the asymmetric facial deformities were initiated by hypertrophy of the mandible and zygoma without occlusion and temporomandibular joint problem were chosen for this study. The authors performed a modified reduction malarplasty to correct asymmetric middle face and mandibular outer cortex splitting ostectomy, mandibular "V-line" ostectomy, and rotation genioplasty to improve asymmetric lower face depending on individual asymmetric facial characteristics. The effectiveness was then evaluated through cephalometric radiographs, three-dimensional computed tomography, and presurgical and postsurgical standard facial photographs. The postoperative results of all 52 cases showed that the asymmetric face was effectively corrected without serious complications and the harmonious facial contour improved significantly. The final esthetic outcomes were quite satisfactory for both surgeons and patients. The results indicate that a variety of contouring techniques for facial asymmetric deformity could be carried out based on characteristics of asymmetric face, so as to acquire a symmetric and harmonious face in accordance with facial esthetics.
    No preview · Article · Jan 2015 · Journal of Craniofacial Surgery
  • Hui Li · Jing Hu · En Luo · Songsong Zhu · Jihua Li
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    ABSTRACT: Purpose Osteochondroma is a benign tumor that is rare in the craniofacial region. When it does occur, the condyle and coronoid process have been the most commonly affected sites. The secondary progressive malocclusion and facial asymmetry will be common physical signs in most cases. The traditional surgical treatment of osteochondroma of the mandibular condyle has been condylectomy, with or without reconstruction of the condyle. We believe more attention should be paid to restoring joint function, improving the facial appearance, correcting malocclusion, and re-establishing harmony among them.
    No preview · Article · Nov 2014 · Journal of Oral and Maxillofacial Surgery
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    ABSTRACT: Protrusion of the zygoma is commonly considered undesirable and unattractive among East-Asians, and many try to achieve a harmonious oval midface by having various cosmetic operations. However, effective contouring for a severe protruding zygoma has rarely been reported .The objectives of this study therefore were to investigate the feasibility and effectiveness of a horizontal V-shaped ostectomy for correction of protrusion of the zygoma and zygomatic arch, and to discuss its indications. From January 2008 to December 2011 we treated 27 patients by contouring of the zygoma with a horizontal V-shaped ostectomy through intraoral and preauricular incisions. The effectiveness was then evaluated with cephalometric radiographs, 3-dimensional computed tomography, and standard facial photographs taken before and after operation. The postoperative appearance of all 27 patients showed that the protrusion had been effectively reduced with no serious complications, and the facial contour had improved. The final aesthetic outcomes were satisfactory for both surgeons and patients. The horizontal V-shaped osteotomy is a good technique for the reduction of protrusion of the zygoma and zygomatic arch, and it has the advantages of more convenient multishifting, better results, and fewer complications. It also ensures the integrity of the structure of the malar complex.
    No preview · Article · May 2014 · British Journal of Oral and Maxillofacial Surgery
  • Yunfeng Li · En Luo · Songsong Zhu · Jihua Li · Li Zhang · Jing Hu
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    ABSTRACT: Purpose: The objective of this study was to investigate cancellous bone response to strontium-doped hydroxyapatite (SrHA) in ovariectomized (OVX) rats. Methods: Hydroxyapatite (HA) and 10%SrHA (HA with 10 mol% calcium substituted by strontium) implants were prepared and characterized by scanning electronic microscopy (SEM), energy dispersive microanalysis (EDX) and X-ray diffraction (XRD). Twelve weeks after bilateral ovariectomy, 20 rats randomly received HA or 10%SrHA implants in the right distal femur, with 10 animals in each group. Eight weeks after implantation, specimens were harvested and analyzed by micro-computed tomography (micro-CT) and histology. Results: Compared with HA, 10%SrHA raised the percentage bone volume by 42.6%, bone-to-implant contact by 47.1%, mean trabecular number by 27.3%, mean trabecular thickness by 31.5% and mean connectivity density by 37.4%, while it decreased mean trabecular separation by 20.1% in micro-CT evaluation. 10%SrHA also increased the bone area density by 47.6% in histological analysis. Conclusions: With the HA implants as controls, the 10%SrHA implants were shown to increase bone density and bone-to-implant contact, and improve trabecular architecture in the vicinity of implant surfaces.
    No preview · Article · Apr 2014 · Journal of Applied Biomaterials and Fundamental Materials
  • Xudong Li · Yunfeng Li · Yunmao Liao · Jihua Li · Li Zhang · Jing Hu
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    ABSTRACT: Purpose: This study compared the effect of magnesium-incorporated hydroxyapatite (MgHA) coating with that of HA coating on implant fixation in ovariectomized (OVX) rats. Materials and methods: Coatings of HA and MgHA (10 mol% Ca²⁺ replaced by Mg²⁺) were prepared on the surface of titanium substrates using the sol-gel dip-coating method, and powders of HA and MgHA were produced by the same method. The two kinds of materials were then characterized by scanning electron microscopy and x-ray diffraction. Twelve weeks after bilateral ovariectomy, 18 OVX rats received implants in the distal femora; half of the implants were HA-coated and the other half were MgHA-coated. After 12 weeks of healing, rats were selected randomly for histomorphometry, microcomputed tomography evaluation, and biomechanical testing. Results: Surface characterization analysis demonstrated that the addition of Mg did not dramatically change the surface topography or apatite patterns of the coating. Histomorphometry revealed higher bone-to-implant contact and bone area ratio for MgHA-coated implants than for HA-coated implants. Microcomputed tomographic evaluation revealed improved trabecular parameters and increased osseointegration for MgHA-coated implants. Biomechanical testing revealed that the MgHA coating increased the maximum push-out force and interfacial shear strength compared to the HA coating. Conclusion: Mg incorporated into an HA coating on titanium implants could improve the biologic fixation of implants in osteoporotic bone.
    No preview · Article · Jan 2014 · The International journal of oral & maxillofacial implants
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    ABSTRACT: From an East Asian traditional esthetic viewpoint, a soft facial appearance seems to be more attractive. A prominent mandibular angle, a high zygomatic bone, and an inharmonious chin strongly lessen the attributes of femininity. Attention should be paid to the zygomatic projection and square mandible from the frontal view and the gonial angle and mental region configuration from the lateral view to obtain a slender oval face (melon seed face). From January 2005 through December 2010, 47 patients underwent a combination of 4 operative techniques to reshape a square face: L-shaped osteotomy, V-line osteotomy, mandibular outer cortex splitting ostectomy, and sliding genioplasty. Outcomes in and feedback information from patients showed that these methods made the square face look more harmonious, with significant improvement of the middle and lower facial contours. Asians with a square face have different combinations of facial features; thus, surgeries should be customized and designed comprehensively to achieve optimal results.
    No preview · Article · Jul 2013 · Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons
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    ABSTRACT: Surgical correction of craniosynostosis in children is associated with substantial intraoperative bleeding. Intraoperatively administered tranexamic acid (TXA) can lessen blood loss during orthopedic and cardiovascular surgery, but its efficacy in craniosynostosis surgery is uncertain. Therefore, a meta-analysis performed with published comparative studies was to determine whether TXA could reduce packed red blood cells (or erythrocytes) (PRBCs) transfused and blood loss during pediatric craniosynostosis surgery. Two PubMed and EMBASE electronic databases were searched until June 2012. Eligible studies were restricted in comparative controlled trials. Four studies in 3 articles with 138 patients were included. The results showed that intraoperative administration of TXA can significantly reduce transfusion of PRBCs (weighed mean difference [WMD] = -10.81, 95% confidence interval [CI] = -16.84 to -4.78, P < 0.00001). In the level of blood loss, the meta-analysis on 4 studies showed that the difference was statistically significant (WMD = -20.53, 95% CI = -32.26 to -8.80, P = 0.0006) between the TXA groups and the control groups. However, the subgroup analysis on randomized controlled trials showed that TXA did not significantly reduce blood loss during surgery compared with the placebo group (WMD = -30.79, 95% CIs = -71.72 to 10.14, P = 0.14). Tranexamic acid can significantly reduce the transfusion of PRBCs in children undergoing craniosynostosis surgery. However, there is a controversy on the efficacy of TXA in reducing blood loss. Therefore, new randomized controlled trials to assess the effects of TXA in children with craniosynostosis surgery should be conducted.
    No preview · Article · Jan 2013 · The Journal of craniofacial surgery
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    ABSTRACT: Introduction: For East Asians, correction of square jaw has become one of the commonly performed procedures in aesthetic surgery. While reviewing unsatisfactory cases of mandibular reduction, the authors discovered that failure was largely due to surgeons generally focussing too much on treatment of the posterior part of the mandible, and ignoring the aesthetic significance of the harmonious and smooth overall curve from the anterior mandible to the inferior margin of the mandible. Thus, our group proposes that a coordinated, balanced and smooth jaw line is considered a key factor in Oriental mandibular contouring. Patients and methods: A total of 128 patients accepted jaw line reshaping by 'V-line' ostectomy, mandibular outer cortex split ostectomy, narrowing and/or sliding genioplasty and porous polyethylene implantation to achieve the desired cosmetic effects. Results: All patients obtained satisfactory cosmetic results, and their square jaw was corrected. After the operation, a natural, harmonised and balanced jaw line was achieved. Lower third of the facial contour was significantly improved. Conclusion: Based on different facial features of square jaw deformity, a variety of plastic surgical methods for mandibular contouring were integrated and applied to achieve a balanced and delicate jaw line.
    No preview · Article · Aug 2012 · Journal of Plastic Reconstructive & Aesthetic Surgery
  • Xudong Li · Ge Feng · Songsong Zhu · Jihua Li · En Luo · Jing Hu
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    ABSTRACT: Orthopedic surgeons and dentists often implant materials to repair bone tissue defects and restore physiological functions of bone organs. The clinical success depends on adequate bone formation in operation sites. However, the real cause of osteogenesis has not yet been fully elucidated. To investigate the bone response to implanted materials, this study examined the bone tissue reaction in rat femoral medullary canal, which received gelatin and collagen as foreign-body materials. A total of 36 six-month-old Sprague-Dawley rats were randomly and meanly divided into three groups. In the gelatin group, the bilateral femora received gelatin material; in the collagen group, they were implanted with type I collagen, and in the control group, the femora suffered from sham operation with no materials inserted. After 2, 4, 8, and 12 weeks, specimens were harvested and subjected to a series of examinations. After 2 weeks of healing, a significant upregulation of both alkaline phosphatase and osteocalcin by both kinds of implanted materials relative to the control (sham implantation group) was seen in gene expression analysis. Strong reactivity of osteoprotegerin and receptor activator of NFκB ligand was detected in the two test groups in immunohistochemistry at 4 weeks of healing. Also, micro-CT revealed an increase in cortical bone thickness in the two test groups as compared to the control group. Densitometry showed increased bone mineral density in the bone receiving materials after 12 weeks, leading to the enhanced maximum load in the test groups. These results indicated that the implanted materials led to an osteogenesis response in rat femoral medullary canal. Thus, we probably should reconsider the potential cascades of tissue reaction when utilizing orthopedic and dental implants and other materials to recover bone related-organ function and repair bone defects.
    No preview · Article · Jun 2012 · Journal of Orthopaedic Science
  • Jihua Li · Songsong Zhu · Tao Wang · En Luo · Lin Xiao · Jing Hu
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    ABSTRACT: PURPOSE: Distraction osteogenesis can be used to correct micrognathia after temporomandibular joint (TMJ) ankylosis. However, there is still some controversy over the proper sequencing of management for the ankylosed patients. The objective of the present study was to evaluate a staged treatment of TMJ ankylosis accompanied by micrognathia using arthroplasty, mandibular distraction osteogenesis, and advancement genioplasty. PATIENTS AND METHODS: A total of 12 bilateral TMJ ankylosis patients with micrognathia (aged 17 to 27 years) underwent arthroplasty as the initial surgical procedure, followed by orthodontic treatment and correction of mandibular micrognathia by osteodistraction and advancement genioplasty as the second surgical procedure. The clinical results were evaluated by mouth opening, radiography, medical photography, and respiratory function. RESULTS: The patients were followed up for a minimum of 8 months to a maximum of 36 months. The TMJ ankylosis was released successfully in all the patients, showing an increase in average mouth opening from 3.3 mm preoperatively to 35.8 mm postoperatively. Micrognathia was corrected, and, remarkably, the obstructive sleep apnea and hypopnea syndrome was cured. Satisfactory occlusion was achieved with orthodontic treatment. CONCLUSIONS: Our data suggest that a staged and surgical orthodontic treatment might be a better approach to manage TMJ ankylosis accompanied by mandibular hypoplasia. In addition to mandibular osteodistraction, advancement genioplasty should be considered for better improvement in facial esthetics and respiratory function.
    No preview · Article · May 2012 · Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons
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    ABSTRACT: Currently, investigating an optimal method to deal with midface hypoplasia has become a significant issue in the field of facial aesthetic surgery. Traditional ways to address this problem primarily include segmental osteotomies and using autogenous bone or cartilage grafts or synthetic implants. For the patients with paranasal hypoplasia but without malocclusion, autogenous bone grafts or implants are recommended. However, some of these patients have a flattened nose and protrusive malar, especially in the Eastern Asian; the nose will seem more flattened after augmentation the paranasal area. Hence, osteotomy is necessary in these patients to bring the flattened nose forward to get a more satisfying contour of the midface. We propose a novel osteotomy through the application of model surgery to solve the problem of midface hypoplasia combined with flattened nose but without malocclusion. When compared with other techniques, this novel method not only allows the augmentation to be performed on a broader scale composed of different segments of the midface skeleton, but also results in a lower surgical risk and maintenance of the stability of occlusion. This novel osteotomy can bring the premaxilla in combination with the nasal bone forward to solve the problem of midface hypoplasia combined with flattened nose in patients with normal occlusion. Through simultaneous augmentation of the different segments of the midface through this novel osteotomy, a more pleasing contour of the midface in all 3 dimensions can be achieved.
    No preview · Article · May 2012 · The Journal of craniofacial surgery
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    ABSTRACT: Fracture or defect of the mandible is a serious complication of mandibular angleplasty, and precise reconstruction for such defect is still a huge challenge. This case report provides a new method based on CAD/CAM and rapid prototyped titanium for individual design, fabrication, and implantation of a mandibular ramus and angle. A 25-year-old woman with a square-shaped face, who had undergone mandibular outer cortex split ostectomy (MOCSO) 3 months earlier, was afflicted by a series of symptoms: asymmetric face, collapse of the right face, masticatory problems, deviation during mouth opening, malocclusion, and TMJ clicks. These symptoms were caused by unintentional removal of the fractured ramus during MOCSO. By means of CT scan data, rapid prototyping, reverse engineering, 3D display, and CAD/CAM, the individualized titanium implant was designed and fabricated. The 3D demo system of operative scheme demonstrated the operative procedure, and determined the position of the implant so as to obtain a perfect fit. Postoperatively, the patient regained satisfactory morphologic symmetry, facial appearance, occlusion, and TMJ functions.
    No preview · Article · Mar 2012
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    ABSTRACT: Strontium ranelate (SrR) was an effective anti-osteoporotic drug to increase bone formation and decrease bone resorption. However, reports about the effect of SR on osteoblastic and adipocytic differentiation from bone marrow mesenchymal stem cells (BMMSCs) are limited. The purpose of this study is to evaluate whether SrR affects the ability of BMMSCs to differentiate into osteoblasts or adipocytes. Rat BMMSCs were identified by flow cytometry and exposed to SR (0.1 and 1.0mMSr(2+)) under osteogenic or adipogenic medium for 1 and 2weeks. The proliferation and differentiation of BMMSCs were analyzed by MTT, alkaline phosphatase (ALP), Oil red O staining, quantitative real-time RT-PCR and Western blot assays. SrR significantly inhibited the proliferation, increased osteoblastic but decreased adipocytic differentiation of rat BMMSCs dose-dependently. In osteogenic medium, SrR increased the expression of ALP, the mRNA levels of Cbfa1/Runx2, bone sialoprotein, and osteocalcin by RT-PCR, and the protein levels of Cbfa1/Runx2 by Western blot. In adipogenic medium, SrR decreased the mRNA levels of PPARγ2, adipocyte lipid-binding protein 2 (aP2/ALBP), and lipoprotein lipase (LPL) by RT-PCR, and the protein expression of PPARγ in Western blot analysis. These results indicated that the effects of SrR to promote osteoblastic but inhibit adipocytic differentiation of BMMSCs might contribute to its effect on osteoporosis treatment.
    No preview · Article · Feb 2012 · Biochemical and Biophysical Research Communications
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    ABSTRACT: Among the East Asian population, a long or square face produces a characteristic coarse and masculine appearance and is therefore considered undesirable and unattractive. Because of this many Orientals seek to achieve a harmonious contour of their face by undergoing various cosmetic surgical procedures. Mandibular contouring for a long or asymmetrical face with/without square jaw is rarely reported in the literature and the objective of this study was to investigate the effectiveness of total or partial inferior border ostectomy for mandibular contouring and to discuss its indications. From July 2005 to November 2009, 74 patients in this study received mandibular contouring by total or partial inferior border ostectomy procedure to correct a disharmonious facial contour. Postoperatively the appearance of all 74 cases showed that the length of the lower 3rd of the face and the width of the mandible were decreased effectively, and the mandibular contour was improved. The final aesthetic outcomes were satisfactory for both the surgeons and the patients. The results suggest that facial contour could be improved by using total or partial inferior border ostectomy of the mandible thus achieving a harmonious facial outline based on East Asian aesthetics.
    No preview · Article · Feb 2012 · Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • Songsong Zhu · Jihua Li · En Luo · Ge Feng · Yongqing Ma · Jing Hu
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    ABSTRACT: Treatment of adult patients with temporomandibular joint (TMJ) ankylosis and secondary deformities is a challenging problem. Although various techniques, including arthroplasties, orthognathic surgery, autogenous bone graft, and distraction osteogenesis, have been described for the management of patients with this condition, an appropriate treatment protocol has not been established. The purpose of this report is to describe a 2-stage treatment protocol, comprising TMJ reconstruction as the initial surgery, followed by orthodontic treatment, and correction of secondary deformities as the second surgery, for the management of TMJ ankylosis with secondary deformities in adults. From January 2003 to December 2009, 24 adult patients (30 joints) with TMJ ankylosis and secondary deformities underwent TMJ reconstruction as the initial surgery, followed by orthodontic treatment and correction of secondary deformities as the second surgery. Clinical outcome was assessed based on oral function, radiography, and medical photography. Patients were followed up for a minimum of 12 months to a maximum of 32 months (mean, 18.6 months). No relapse of TMJ ankylosis occurred in any patient during the follow-up period. Oral function and skeletal deformities were significantly improved in all patients. Satisfactory occlusion was achieved with the help of orthodontic treatment. Most of the patients were satisfied with the final outcome. The 2-stage treatment protocol described not only restores oral function but also improves the patient's esthetic appearance. We believe that it is a good approach for management of TMJ ankylosis with secondary deformities in adult patients.
    No preview · Article · Dec 2011 · Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons
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    ABSTRACT: In East Asian population, a square face is considered unappealing as it imparts a coarse and masculine look. Therefore, Oriental women prefer to have an ovoid and slender facial contour, which is thought to be more feminine and attractive. Nowadays, mandibular contouring surgery has become a commonly performed procedure. Clinical data show that majority of patients who have severe form are characterised by a definite square-shaped face with low gonial angle. A square face is usually visualised in frontal view but the lateral view provides additional information regarding gonial angle, mandibular plane steepness, chin deficiency and more importantly, length of the ramus. These factors are the key points for a precise categorisation, design, selection of surgical methods and choosing the ostectomy line for contouring on a square face with low angle. From 2005 to 2009, 94 women were diagnosed as square face with low angle. Three types of surgical design based on procedures such as mandibular 'V-Line' ostectomy, mandibular outer cortex split ostectomy, sliding genioplasty and inlay bone graft in various combinations were constructed, depending upon the presenting facial features. Precise categorisation, designs and techniques resulted in higher satisfaction as these procedures provided an overall narrowing and harmonising effect on the lower facial contour postoperatively. Patients with square face and low gonial angle come with multitude of features so that design and technique applied should be tailored to each individual to achieve perfection.
    No preview · Article · Sep 2011 · Journal of Plastic Reconstructive & Aesthetic Surgery
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    ABSTRACT: Nano-hydroxyapatite/polyamide 6 (n-HA/PA6) composite scaffolds were prepared by a combined method of phase separation and particle leaching processing technique. The porous matrices were seeded with allogenic bone marrow-derived stem cells (BMSCs) and implanted in the critical-size calvarial defect (8-mm diameter) in rats. The adhesion, proliferation, and differentiation of BMSCs were demonstrated by (3-{4,5-dimethylthiazol-2yl}-2,5-diphenyl-2H-tetrazoliumbromide) assay, immunohistochemical staining, and scanning electron microscopy in vitro. Cell survival was tracked via fluorescent labeling in vivo. The regeneration process was evaluated by several techniques at 4, 8, and 16 weeks after implantation. According to the results, the porous n-HA/PA6 scaffolds are biocompatible and have no negative effects on the BMSCs in vitro. Nano-hydroxyapatite/polyamide 6 composite combined with BMSCs exhibited good biocompatibility and osteoconductivity and enhanced osteogenesis at the initial stage after implantation. The results demonstrated that porous n-HA/PA6 scaffold is a potential matrix for bone tissue engineering, and using BMSCs as seed cells on porous n-HA/PA6 might be an alternative procedure in repair of large defect due to enhanced osteogenesis and osteointegration.
    No preview · Article · Sep 2011 · The Journal of craniofacial surgery
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    ABSTRACT: A square face is considered unattractive in Orientals; thus, it has become a frequently encountered reason for patients undergoing face contouring surgery. While reviewing the unsatisfactory cases of mandibular reduction, the authors discovered that some failed cases were related to a square jaw on a short face. The conventional procedures fix only the posterior region of the mandible, resulting in increased prominence of the stunted or square chin and short face. Thus, the authors applied a narrowing and sliding genioplasty procedure combined with a mandibular outer cortex ostectomy technique to reshape a wide, weak chin, and a square jaw on a short lower facial contour into a slender and attractive oval face. From July of 2005 to October of 2009, there were a total of 57 patients in this study who underwent a narrowing and sliding genioplasty combined with a mandibular outer cortex ostectomy procedure to correct a square jaw on a short face. The postoperative appearance of all 57 cases showed that the lower face had narrowed and had become softer, slender, and oval, with a slick mental region. Narrowing and sliding genioplasty combined with a mandibular outer cortex ostectomy procedure could efficiently adjust the shape and position of the chin to obtain a good proportion of the lower face and change a square, short face to a slender, oval one in a single operation in accordance with fashionable aesthetics in Orientals.
    No preview · Article · May 2011 · Plastic and Reconstructive Surgery