Feza Korkusuz

Hacettepe University, Engüri, Ankara, Turkey

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Publications (107)182.68 Total impact

  • Gürhan Dönmez · Levent Özçakar · Feza Korkusuz
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    ABSTRACT: Reported here is a 20-year-old male suffered a hamstring strain after a prolonged bout of swimming. After ultrasound imaging, the patient's injury was considered to be the result of nearby osteochondromas. Case reports have been previously published concerning anterior cruciate ligament injury, rotator cuff tears, subacromial impingement, or femoroacetabular impingement in multiple osteochondromatosis. However, to the best of our knowledge, this is the first reported case of a hamstring injury secondary to an osteochondroma.
    No preview · Article · Oct 2015 · Clinical journal of sport medicine: official journal of the Canadian Academy of Sport Medicine
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    Dataset: poster

    Full-text · Dataset · Sep 2015
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    Full-text · Patent · Jul 2015
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    ABSTRACT: Loss of bone mineral density (BMD), deterioration of microstructure and increased risk for fracture defines osteoporosis (OP) [2]. Boron (B) containing nano (n) Hydroxyapatite (HAp) was produced, characterized and in vitro tested for adhesion and proliferation of Mesenchymal Stem Cells (MSC) previously [1]. The need of a biologically active medical device that may prevent or treat OP is emerging. We hypothysed that B-n-HAp injected with hyaluronan with or without MSC may improve BMD (g/cm2), bone volume (BV mm3) and bone surface (BS mm2) in overiectomized (OVX) rats. Research questions of this study were whether B-n-HAp with or without MSC can improve (1) BMD measured by dual energy x-ray absorptiometry (DXA) and (2) BV and BS measured by micro computerized tomography (micro-CT).
    Full-text · Conference Paper · Mar 2015
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    Feza Korkusuz

    Preview · Article · Dec 2014 · Clinical Orthopaedics and Related Research
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    Berna Kankilic · Elif Bilgic · Petek Korkusuz · Feza Korkusuz
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    ABSTRACT: Background Implant-related osteomyelitis (IRO) is recently controlled with local antibiotic delivery systems to overcome conventional therapy disadvantages. In vivo evaluation of such systems is however too little.Questions/purposesWe asked whether vancomycin (V)-containing poly-l-lactic acid/ß-tricalcium phosphate (PLLA/ß-TCP) composites control experimental IRO and promote bone healing in vivo.Methods Fifty-six rats were distributed to five groups in this longitudinal controlled study. Experimental IRO was established at tibiae by injecting methicillin-resistant Staphylococcus aureus (MRSA) suspensions with titanium particles in 32 rats. Vancomycin-free PLLA/ß-TCP composites were implanted into the normal and infected tibiae, whereas V-PLLA/ß-TCP composites and coated (C)-V-PLLA/ß-TCP composites were implanted into IRO sites. Sham-operated tibiae established the control group. Radiological and histological scores were quantified with microbiological findings on weeks 1 and 6.ResultsIRO is resolved in the CV- and the V-PLLA/ß-TCP groups but not in the PLLA/ß-TCP group. MRSA was not isolated in the CV- and the V-PLLA/ß-TCP groups at all times whereas the bacteria were present in the PLLA/ß-TCP group. Radiological signs secondary to infection are improved from 10.9¿±¿0.9 to 3.0¿±¿0.3 in the V-PLLA/ß-TCP group but remained constant in the PLLA/ß-TCP group. Histology scores are improved from 24.7¿±¿6.5 to 17.6¿±¿4.8 and from 27.6¿±¿7.9 to 32.4¿±¿8.9 in the CV-PLLA/ß-TCP and the V-PLLA/ß-TCP groups, respectively. New bone was formed in all the PLLA/ß-TCP group at weeks 1 and 6.ConclusionsCV- and V-PLLA/ß-TCP composites controlled experimental IRO and promoted bone healing.Clinical relevanceCV- and V-PLLA/ß-TCP composites have the potential of controlling experimental IRO and promoting bone healing.
    Full-text · Article · Nov 2014 · Journal of Orthopaedic Surgery and Research
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    ABSTRACT: Osteoporosis (OP) is a systemic metabolic disease identified with decrease of bone mineral density and deterioration of microstructure leading to fragility fractures in elderly. Boron (B) is assumed to stimulate osteoblasts. Hydroxyapatite (HAp) is clinically used to conduct bone regeneration and improves implant integration. Nano(n)-HAp expands the surface area for cell adhesion and may improve bone regeneration and tissue integration. The objective of this study was to examine the adhesion, proliferation and differentiation of B-n-HAp with mesenchymal stem cells (MSC’s). Human bone marrow derived MSC’s phenotype was assessed using scanning and transmission electron microscopy after combining with B-n-HAp and n-HAp. Cell adhesion and proliferation potential of these ceramics was examined with the real time cell analysis (xCELLigence, Roche Applied Science and ACEA Bioscience, USA) system and adipogenicosteogenic differentiation was analyzed with morphological and quantitative methods. MSC’s adhesion and proliferation rates (cell index, 4.50) were higher than controls (cell index, 4.00). Adipogenic and osteogenic differentiation potential of MSC’s remained unchanged in the presence of B-n-HAp ceramics. In conclusion, B-n-HAp stimulates MSC’s adhesion, proliferation and differentiation and has a potential to regenerate bone tissue.
    No preview · Conference Paper · Nov 2014
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    ABSTRACT: Osteoarthritis (OA) is a degenerative joint disease, which has no complete treatment with medication yet. Intraarticular hyaluronan (HA) injection can decrease pain and modify the natural course of OA. This study was designed to provide long term delivery of an MMP (matrix-metalloproteinase) inhibitor agent-doxycycline, together with matrix regenerative agent-chondroitin sulfate for treating OA which progress with matrix degenerations. Doxycycline (D) and doxycycline-chondroitin sulfate (D-CS) loaded poly-ɛ-caprolactone (PCL) microspheres (MS) were prepared as intraarticular delivery systems. Bio-effectiveness of developed microspheres was first evaluated with three-dimensional in vitro model of OA where both MS showed significant reduction in MMP-13 levels compared to untreated OA-chondrocytes at 15 and 24 days. Significant decrease was observed in GAG release into the media for both D MS and D-CS MS treated groups at 15 and 24 days. Second, the microspheres were injected to rabbit knee in hyaluronan (HA) to evaluate the effectiveness of the treatment. Radiographic scores of D MS and D-CS MS groups improved after 8 weeks when compared to OA group. Mankin-Pitzker histological scores similarly showed improvement with D MS and D-CSMS groups when compared to OA group. Ex vivo hardness tests of cartilages demonstrated superior hardness values with both doses of D-CSMS compared to OA group. D MS showed promising improvement of OA in histology results. Although, both MS groups had similar effects on cells in the in vitro model, D-CSMS had a positive contribution on all in vivo treatment outcomes and showed potential as a new strategy for treatment when applied to OA knee joints. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2014.
    Full-text · Article · Oct 2014 · Journal of Biomedical Materials Research Part B Applied Biomaterials
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    ABSTRACT: Background: Osteoarthritis (OA) is a non-inflammatory, degenerative joint disease, leading to pain, deformity and deterioration of function together with economic loss. Joint cartilage is avascular and systemic medicine may not efficiently reach/retained at the joint fluid. Doxycycline (D), a clinically used antibiotic with a matrix metalloproteinase activity, was combined with chondroitin sulfate (CS) to prevent the progression of OA. For this end, we designed doxycycline loaded and doxycycline-chondroitin sulfate co-loaded poly-ε-caprolactone (PCL) based drug delivery systems that can be applied to treat OA by intra-articular injection [1]. Aim: This study aims to provide a controlled local treatment approach by preventing the progression of OA and enhancing the regeneration of cartilage matrix with the use of two bioactive agents, D and CS. The efficacy of the system was investigated upon injection of the microspheres with hyaluronan (HA) into OA developed knee joints of rabbits. Materials and Methods: Doxycycline loaded (DMS) and doxycycline-chondroitin sulfate co-loaded (D-CSMS) PCL (M w of 14 kDa) microspheres were prepared using polyvinylalcohol (PVA-4%) as emulsifier. Preparation details were described elsewhere [1]. Experimental OA was established by intra-articular collagenase type II (Clostridium histolyticum, Sigma) (4 mg/ml; 456 U/mg solid) injection into the hind knee joints of local albino adult male rabbits at day 1 and 4 [2]. Microspheres (DMS and D-CSMS), sterilized by gamma irradiation, were applied once by dispersing in 0.5 ml of hyaluronan (HA). After the establishment of OA, the treatment injections (HA, DMS and D-CSMS) were performed. Knees were followed for another 8 weeks and the joints were then harvested for radiological, histological and biomechanical evaluations. Results: SEM image showed size and shape distribution of D-CSMS (Fig.1). Radiographic scores of both microsphere groups improved after 8 weeks of microsphere treatments compared to untreated OA joints. Histological scores had similar outcomes for both microsphere groups but also revealed the significance of combined use of D and CS; D-CSMS group significantly improved the Mankin/Pritzker scores when compared with control group. Among treatments, D-CSMS group had the highest hardness value, which was significantly different than OA group, but not different than control group. Figure 1. (A) SEM image of D-CSMS, (B) Front view of D-CSMS injected joint, (C) Descriptive Statistical Data of Mankin Scores (D) D-CSMS treated cartilage section Conclusions and clinical implication: Both DMS and D-CSMS have potential for OA treatment via local controlled release system. However, D-CSMS had more pronounced positive contribution on all treatment outcomes and may be used on OA knee joints.
    Full-text · Conference Paper · Jul 2014
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    ABSTRACT: Background: Osteoarthritis (OA) is a non-inflammatory, degenerative joint disease, leading to pain, deformity and deterioration of function together with economic loss. Joint cartilage is avascular and systemic medicine may not efficiently reach/retained at the joint fluid. Doxycycline (D), a clinically used antibiotic with a matrix metalloproteinase activity, was combined with chondroitin sulfate (CS) to prevent the progression of OA. For this end, we designed doxycycline loaded and doxycycline-chondroitin sulfate co-loaded poly-ε-caprolactone (PCL) based drug delivery systems that can be applied to treat OA by intra-articular injection [1]. Aim: This study aims to provide a controlled local treatment approach by preventing the progression of OA and enhancing the regeneration of cartilage matrix with the use of two bioactive agents, D and CS. The efficacy of the system was investigated upon injection of the microspheres with hyaluronan (HA) into OA developed knee joints of rabbits. Materials and Methods: Doxycycline loaded (DMS) and doxycycline-chondroitin sulfate co-loaded (D-CSMS) PCL (M w of 14 kDa) microspheres were prepared using polyvinylalcohol (PVA-4%) as emulsifier. Preparation details were described elsewhere [1]. Experimental OA was established by intra-articular collagenase type II (Clostridium histolyticum, Sigma) (4 mg/ml; 456 U/mg solid) injection into the hind knee joints of local albino adult male rabbits at day 1 and 4 [2]. Microspheres (DMS and D-CSMS), sterilized by gamma irradiation, were applied once by dispersing in 0.5 ml of hyaluronan (HA). After the establishment of OA, the treatment injections (HA, DMS and D-CSMS) were performed. Knees were followed for another 8 weeks and the joints were then harvested for radiological, histological and biomechanical evaluations. Results: SEM image showed size and shape distribution of D-CSMS (Fig.1). Radiographic scores of both microsphere groups improved after 8 weeks of microsphere treatments compared to untreated OA joints. Histological scores had similar outcomes for both microsphere groups but also revealed the significance of combined use of D and CS; D-CSMS group significantly improved the Mankin/Pritzker scores when compared with control group. Among treatments, D-CSMS group had the highest hardness value, which was significantly different than OA group, but not different than control group. Figure 1. (A) SEM image of D-CSMS, (B) Front view of D-CSMS injected joint, (C) Descriptive Statistical Data of Mankin Scores (D) D-CSMS treated cartilage section Conclusions and clinical implication: Both DMS and D-CSMS have potential for OA treatment via local controlled release system. However, D-CSMS had more pronounced positive contribution on all treatment outcomes and may be used on OA knee joints.
    Full-text · Conference Paper · Jul 2014
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    ABSTRACT: Background: Osteoarthritis (OA) is a non-inflammatory, degenerative joint disease, leading to pain, deformity and deterioration of function together with economic loss. Joint cartilage is avascular and systemic medicine may not efficiently reach/retained at the joint fluid. Doxycycline (D), a clinically used antibiotic with a matrix metalloproteinase activity, was combined with chondroitin sulfate (CS) to prevent the progression of OA. For this end, we designed doxycycline loaded and doxycycline-chondroitin sulfate co-loaded poly-ε-caprolactone (PCL) based drug delivery systems that can be applied to treat OA by intra-articular injection [1]. Aim: This study aims to provide a controlled local treatment approach by preventing the progression of OA and enhancing the regeneration of cartilage matrix with the use of two bioactive agents, D and CS. The efficacy of the system was investigated upon injection of the microspheres with hyaluronan (HA) into OA developed knee joints of rabbits. Materials and Methods: Doxycycline loaded (DMS) and doxycycline-chondroitin sulfate co-loaded (D-CSMS) PCL (M w of 14 kDa) microspheres were prepared using polyvinylalcohol (PVA-4%) as emulsifier. Preparation details were described elsewhere [1]. Experimental OA was established by intra-articular collagenase type II (Clostridium histolyticum, Sigma) (4 mg/ml; 456 U/mg solid) injection into the hind knee joints of local albino adult male rabbits at day 1 and 4 [2]. Microspheres (DMS and D-CSMS), sterilized by gamma irradiation, were applied once by dispersing in 0.5 ml of hyaluronan (HA). After the establishment of OA, the treatment injections (HA, DMS and D-CSMS) were performed. Knees were followed for another 8 weeks and the joints were then harvested for radiological, histological and biomechanical evaluations. Results: SEM image showed size and shape distribution of D-CSMS (Fig.1). Radiographic scores of both microsphere groups improved after 8 weeks of microsphere treatments compared to untreated OA joints. Histological scores had similar outcomes for both microsphere groups but also revealed the significance of combined use of D and CS; D-CSMS group significantly improved the Mankin/Pritzker scores when compared with control group. Among treatments, D-CSMS group had the highest hardness value, which was significantly different than OA group, but not different than control group. Figure 1. (A) SEM image of D-CSMS, (B) Front view of D-CSMS injected joint, (C) Descriptive Statistical Data of Mankin Scores (D) D-CSMS treated cartilage section Conclusions and clinical implication: Both DMS and D-CSMS have potential for OA treatment via local controlled release system. However, D-CSMS had more pronounced positive contribution on all treatment outcomes and may be used on OA knee joints.
    Full-text · Conference Paper · Jul 2014
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    ABSTRACT: PRP preparations contain high concentrations of platelets that, once activated, undergo degranulation to release growth factors with healing properties. Due to its autogenous origin, easy preparation, inexpensiveness, and excellent safety profile, the use of PRP technologies has opened a gait to the treatment of soft-tissue injuries. PRP has been increasingly used in sports-related injuries for therapeutic applications. Since sports medicine patients desire earlier return to training and competition, PRP may have certain applications that will speed recovery in cases of tendon, ligament, muscle, and cartilage disorders. There is still an ongoing debate about the positive clinical and experimental outcomes. Despite the lack of hard evidence through randomized clinical trials, clinical observations and opinions suggest that pain relief and return to function occur more rapidly than expected for some healing orthopedic problems after the use of PRP. This chapter will focus on the laboratory studies about the effects of PRP on the most common sports-related injury areas and thus the brief review of the clinical studies.
    No preview · Chapter · Jan 2014
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    ABSTRACT: The purpose of this study was to examine outcomes following arthroscopic Bankart repair with the focus on strength after the repair. 56 shoulders with Bankart lesion were operated on arthroscopically. Gender, mechanism of the first dislocation, number of dislocations, dominant side, operated side and the number of anchors used for surgery were recorded. DASH and Oxford instability scoring systems were applied preoperatively and compared to scores at the 24-month follow-up. The scoring systems were also applied to contralateral shoulders at the 24th month of follow-up. Range of motion was measured with a goniometer. Muscle strength was analyzed with a dynamometer simultaneously with the muscle activity of four perishoulder muscles. The data were recorded with surface EMG. Range of motion, muscle strength and activity were evaluated according to the contralateral shoulder at the 24th month of follow-up. Male/female ratio was 42/14 with a mean age of 32 years. The mean number of dislocations was 3 ± 1 and all were traumatic dislocations. The number of mean anchors used was 3.1 and the mean follow-up period was 24 months. In clinical evaluation, the preoperative and postoperative results of the DASH and Oxford instability scores of the unstable shoulders were significantly different. In the comparison between the operated and contralateral shoulders, there was no significant difference in DASH and Oxford instability scores at the 24th month of follow-up. There was no significant loss of range of motion. Only internal rotation strength was significantly reduced and there was no significant change in the EMG patterns. Although good clinical results can be achieved, internal rotation strength is reduced after arthroscopic surgery, but daily activities are not affected. There is no guarantee for patients of excellent recovery. Level III cohort study.
    Full-text · Article · Oct 2013 · Archives of Orthopaedic and Trauma Surgery
  • Feza Korkusuz

    No preview · Article · May 2013 · Clinical Orthopaedics and Related Research
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    Dataset: JCLB3075
    Bekir Bediz · H Nevzat Ozgüven · Feza Korkusuz

    Full-text · Dataset · Dec 2012
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    ABSTRACT: Aim: The purpose of this study was to investigate proliferation, morphology, mineralization and mRNA expressions of mineralized tissue associated proteins of PDL cells on smooth (S), sandblasted small-grit (SSG), sandblasted large-grit (SLG) and sodium titanate (NaTi) coated titanium alloys, in vitro. Methods and materials: PDL cells were cultured with DMEM media containing 10% FBS on the S, SSG, SLG and NaTi titanium surfaces. PDL cell proliferation, mineralization and immunohistochemistry experiments for Bone Sialoprotein (BSP) were performed. The morphology of the PDL cells was examined using confocal and scanning electron microscopy (SEM). Gene expression profiles of cells were evaluated using a quantitative-polymerase chain reaction (Q-PCR) for type I collagen (COL I), Osteocalcin (OCN), osteopontin (OPN) and Runt-related transcription factor-2 (Runx2) on days 7 and 14. Results: Proliferation results on days 6 and 10 were similar in groups, while those of day 13 revealed a decrease in the NaTi group when compared to the S group. NaTi surface induced BSP mRNA expression which was correlated with mineralization tests and BSP immunostaining results. Increased Runx2 mRNA expression was also noted in the NaTi surface when compared to other surfaces. Conclusions: This study considers the NaTi surface as a potential alternative to SSG and SLG surfaces. This surface might provide a promising environment for PDL ligament-anchored implants.
    No preview · Article · Oct 2012 · Acta odontologica Scandinavica

  • No preview · Article · Sep 2012 · New Biotechnology
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    Ozgur Celik · Yasar Salci · Emre Ak · Aydiner Kalaci · Feza Korkusuz
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    ABSTRACT: BACKGROUND: Acute effects of physical exercise on the deformational behaviour of articular cartilage and changes in cartilage oligomeric matrix protein (COMP) are definite. However, conclusive positive effects of fitness exercise on functional adaptation of articular cartilage have not been proved. AIM: Therefore, in this parallel-group randomised controlled trial, we tested the hypothesis that adequate amount of physical exercise with enough impact would be able to stimulate the functional behaviour of articular cartilage. METHODS: We evaluated 44 healthy males for their physical-fitness levels and their blood samples were obtained before, immediately after and 0.5h after a 30-min walking exercise. Thereafter, participants were assigned to the running, the cycling, the swimming and the control groups. At the end of 12weeks of intervention, the same measurement procedures were applied. Mixed repeated-measures analysis of variance (ANOVA) design was used for statistics. (Level of evidence: 2). RESULTS: Pre-test measurements showed that 30min of walking significantly increased serum-COMP levels in all groups. The post-tests revealed that the COMP level of all groups, except running, showed an increase after a 30-min walking activity. CONCLUSION: Overall, it was concluded that, 12weeks of regular, weight-bearing, high-impact physical exercise (i.e., running) decreases the deformational effect of walking activity. This finding is an evidence of functional adaptation of articular cartilage to specific environmental requirements.
    Full-text · Article · Jul 2012 · The Knee
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    ABSTRACT: Purpose: Bioceramics are currently in use to cover bone defects in orthopedics and craniofacial surgery. But their compatibility and efficacy in cranium were not investigated in detail. The aims of this study were to produce, characterize, and assess the biocompatibility and osteointegration of Si-HA, Si-Sr-HA, HA-Wollastonite, and HA-Wollastonite-Frit bioceramics. Methods: Bioceramics were implanted into the burr holes of 14 craniotomy patients who were followed up from three to 24 months. Radiologic and scintigraphic examinations were performed. Results: Osteoblastic activity quantified by scintigraphy increased from 6.865 to 22.991±1.682 from four to eight months in the HA-Woll group. Adding fritt into HA-Woll decreased osteoblastic activity at 10 months. Si-Sr-HA displayed significantly higher osteoblastic activity when compared to the craniotomy site at 12 months. The scintigraphic ratio of the bioceramic implanted regions to the craniotomy sites varied between 1.10 and 1.57. Osteoblast formation and establishment of the trabecular pattern of bone was observed in the surroundings of bioceramics in two patients. Conclusion: These bioceramics can be safely used to cover the burr holes of craniotomy patients, as well as to close the cranial bone defects.
    No preview · Article · Jun 2012 · Journal of Applied Biomaterials and Fundamental Materials
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    Mustafa Söğüt · Sadettin Kirazci · Feza Korkusuz
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    ABSTRACT: Rhythm training is an integral part of sports. The purposes of the study were to analyze the effects of rhythm training on tennis performance and rhytmic competence of tennis players, to compare the improvement levels of tennis specific and general rhythm training and to examine the effects of shorter and longer tempos on rhythmic competence. Thirty university students whose mean score of International Tennis Number (ITN) was 7.3 (±0.9) were divided randomly into three sub-groups: Tennis Group, General Rhythm Training Group and Tennis-Specific Rhythm Training Group. The experimental procedure lasted 8 weeks. During this period, all groups had the same tennis training twice a week. The Tennis Group had regular tennis training sessions. In addition to regular tennis training sessions, the General Rhythm Training Group followed the general rhythm training sessions and the Tennis-Specific Rhythm Training Group had tennis-specific rhythm training. The measurement instruments were ITN, Rhythmic Competence Analysis Test and Untimed Consecutive Rally Test. The results indicated that participation in tennis-specific or general rhythm training resulted in progress in tennis playing levels, forehand consistency performance and rhythmic competence of the participants. On the other hand, attendance to the regular 8-week tennis training was enough to solely increase the tennis playing level but not sufficient to develop forehand consistency performance and rhythmic competence. Although the participants in the TRTG had better improvement scores than the ones in the GRTG, no significant difference was found between the rhythm training groups. The results also revealed that participants exhibited higher rhythmic competence scores on fast tempo compared to slow tempo.
    Full-text · Article · Jun 2012 · Journal of Human Kinetics

Publication Stats

2k Citations
182.68 Total Impact Points

Institutions

  • 2013-2014
    • Hacettepe University
      • Department of Sports Medicine
      Engüri, Ankara, Turkey
  • 1995-2013
    • Middle East Technical University
      • • Department of Physical Education and Sports
      • • Department of Biotechnology
      • • Department of Biomedical Engineering
      • • METU Medical Center
      • • Department of Engineering Sciences
      Engüri, Ankara, Turkey