Chang Kyu Lee

CHA University, Sŏul, Seoul, South Korea

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Publications (69)145.7 Total impact

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    ABSTRACT: Mosaic variegated aneuploidy (MVA) is a recessive condition characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple chromosomes and tissues. The phenotype of MVA syndrome includes severe microcephaly and growth deficiency, central nervous system anomalies, mental retardation, mild physical anomalies, and predisposition to cancer. We report a case of true fetal mosaicism for variegated aneuploidies detected in amniotic fluid cells. A 33-year-old primigravida woman at 5 weeks 1 day of gestation was referred to our tertiary hospital because of a high-risk pregnancy associated with IgA nephropathy. In a quadruple screening test performed at the 15(th) week of gestation, alpha fetoprotein was 73.4 IU/mL (2.792 MoM), suggesting that she was at high risk of neural tube defect. Following amniocentesis performed at the 17 weeks' gestation, chromosome examination of amniocyte culture showed premature chromatic separation in 63% of the metaphases (58/92) and a high frequency of gain and loss of chromosomes. Repeat amniocentesis at 21 weeks' gestation consistently showed the presence of multiple mosaic autosomal variegated aneuploidies. Ultrasonography at 21 weeks' gestation revealed relatively small head circumference for gestational age (<3%) and vermis defect, suggesting that the fetus would have microcephaly and Dandy-Walker malformation. Cytogenetic analysis with peripheral blood of the parents showed normal karyotype. In summary, we hereby report the cytogenetic analysis and prenatal findings of MVA. © 2015 by the Association of Clinical Scientists, Inc.
    No preview · Article · Dec 2015 · Annals of clinical and laboratory science
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    ABSTRACT: The effect of interleukin (IL)-29, a new therapeutic agent similar to type I interferons (IFNs), on IFN-α secretion of human plasmacytoid dendritic cells (pDCs) has not been studied. Therefore, in this study, we aimed to clarify the effect of IL-29 on IFN-α secretion of pDCs using human peripheral blood mononuclear cells (PBMCs) in the presence of cytosine-phosphate-guanosinemotif-containing oligodeoxy nucleotides (CpG). In this experimental and prospective study, PBMCs were ob- tained from 11 healthy volunteers and divided into four culture conditions: I. control, II. CpG treatment, III. IL-29 treatment and IV. CpG plus IL-29 treatment. The amount of IFN-α secretion was measured from each culture supernatant by flow cytometry using the flowcytomix apparatus (eBioscience, Vienna, Austria). Fractional IFN-α production of the cultured PBMCs was measured by intracellular staining using the cytomics FC 500 system (Beckman Coulter, Brea, CA, USA) with CXP Software. The mean ± standard deviation (SD) of supernatant IFN-α secretion per pDC/μL was 5.7 ± 9.3 pg/mL/count/µL for condition I, 1071.5 ± 1026.6 pg/mL/count/µL for condition II, 14.1 ± 21.1 pg/mL/count/µL for condition III, and 1913.9 ± 1525.9 pg/mL/count/µL for condition IV. There were statistically significant differences between conditions I and II as well as betweenconditions II and IV. Intracellular IFN-α production was only detectable in the pDC fraction from one culture; the production amount was similar between the cells treated with CpG and those treated with CpG plus IL-29. Natural killer (NK) cell production of IFN-α was observed in two out of three cultures and one culture showed IFN- α production in the monocyte fraction. IL-29 alone did not show any effect on IFN-α secretion of PBMCs. However, the addition of CpG along with IL-29 enhanced IFN-α secretion of PBMCs. Given that pDCs are the major secretors of IFN-α in peripheral blood, this result has suggested the possibility that IL-29 has an enhancing effect in human pDC IFN-α secretion. Although the supernatant IFN-α secretion was not directly correlated with pDCs's intracellular IFN-α production in this study, prolonged incubation of pDC and other PB subsets with CpG or IL-29 for over 4 hours could be applied in future studies. These studies would help to elucidate the mechanism of action of IL-29 in human pDCs associated with viral infections.
    Full-text · Article · Dec 2015 · Cell Journal
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    ABSTRACT: Background: Context Laminoplasty is a major surgical method to treat patients with cervical ossification of the posterior longitudinal ligament (OPLL). Sometimes patients with cervical OPLL demonstrate postoperative kyphosis despite sufficient preoperative lordosis. Recently, the impact of T1 slope has emerged as a predictor of kyphotic alignment change after laminoplasty. However, the relationship between T1 slope and postoperative cervical alignment change is not yet fully established. Purpose: The goals of this study were to investigate the relationship between T1 slope and loss of cervical lordosis (LCL) and to identify the role of T1 slope as a predictor of postoperative kyphosis after laminoplasty in patients with OPLL. Study design: Retrospective case study PATIENT SAMPLE: Between January 2011 and January 2012, 64 consecutive patients who underwent cervical laminoplasty for OPLL were enrolled (male: female ratio = 47:17; mean age = 55.9 years). Cervical spine lateral radiographs in neutral, flexion, and extension were taken before surgery and at 2-year follow-up. Outcome measures: C2-7 Cobb angle, cervical range of motion (ROM), T1 slope, neck tilt, and C2-7 sagittal vertical axis (SVA) were measured from lateral radiographs of the cervical spine preoperatively and postoperatively at the 2-year follow-up. Methods: Patients were divided into two groups according to preoperative T1 slope, and postoperative cervical alignment change was compared between groups. Postoperative kyphosis and LCL incidence were also evaluated at the 2-year follow-up. The relationships between postoperative cervical alignment change and preoperative variables including age, T1 slope, cervical ROM, C2-7 SVA, and T1 slope minus C2-7 Cobb angle (T1S-CL) were investigated. Results: Patients were divided into two groups above and below median preoperative T1 slope (23.2°). There were no differences in age, sex, type of OPLL, or operation level between the 2 groups. Patients with higher preoperative T1 slope demonstrated significantly more lordotic preoperative cervical alignment (p=0.001). Patients with higher preoperative T1 slope were more likely to exhibit postoperative LCL (p=0.03), and when it occurred, the degree of LCL was greater (p=0.06). In multiple linear regression analysis, higher T1 slope (B=0.414, p=0.04), and lower T1S-CL (B=-0.412, p=0.03) were significantly associated with more postoperative LCL. In spite of these results, postoperative kyphosis did not occur more frequently in patients with higher T1 slope (p=0.64). Conclusion: Patients with higher T1 slope had more lordotic curvature before surgery and demonstrated more LCL at the 2-year follow-up. Cervical alignment was compromised after laminoplasty, and the degree of LCL was correlated with preoperative T1 slope. After laminoplasty for cervical OPLL, patients with higher T1 slope tended to exhibit a greater LCL yet did not drift into frank postoperative kyphosis.
    No preview · Article · Nov 2015 · The spine journal: official journal of the North American Spine Society
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    ABSTRACT: Purpose: To evaluate clinical risk factors of disease progression after cataract surgery using phacoemulsification with posterior chamber intraocular lens implantation, in eyes with chronic angle-closure glaucoma (CACG) and coexisting cataract. Design: Retrospective study. Methods: The data of 56 eyes of 45 CACG patients who had undergone uncomplicated phacoemulsification with posterior chamber intraocular lens implantation were retrospectively analyzed. Disease progression was defined as glaucomatous optic nerve change or visual field (VF) deterioration according to the European Glaucoma Society guideline. Correlations between VF progression and various preoperative and postoperative factors were determined by χ and independent t tests. Linear regression analysis [(odds ratio (OR)] was used to determine predictive risk factors for disease progression using univariate and multivariate analyses. Results: The mean postoperative follow-up period was 45.13±17.54 (24 to 84) months. Fourteen eyes (25%) with cataracts diagnosed with CACG progressed after phacoemulsification, but the remaining 42 eyes (75%) did not. According to univariate analysis, disease progression was significantly associated with older age, more number of preoperative/postoperative antiglaucoma drugs, higher scores of preoperative pattern standard deviation, and lower scores of preoperative and postoperative visual field index (VFI) (P<0.05). Using multivariate analysis, a lower score of preoperative VFI (OR: 0.86, P=0.044) and lower postoperative intraocular pressure (IOP) reduction, which was not sustained below 20% less than the preoperative mean IOP, were significantly correlated with disease progression after cataract surgery (OR: 8.44, P=0.048). Conclusions: CACG patients with low preoperative VFI and high postoperative IOP are at risk for disease progression even after uncomplicated cataract surgery.
    No preview · Article · Nov 2015 · Journal of Glaucoma
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    ABSTRACT: OBJECT The goal of this study was to determine the relationship between cervical spine sagittal alignment and clinical outcomes after cervical laminoplasty in patients with ossification of the posterior longitudinal ligament (OPLL). METHODS Fifty consecutive patients who underwent a cervical laminoplasty for OPLL between January 2012 and January 2013 and who were followed up for at least 1 year were analyzed in this study. Standing plain radiographs of the cervical spine, CT (midsagittal view), and MRI (T2-weighted sagittal view) were obtained (anteroposterior, lateral, flexion, and extension) pre- and postoperatively. Cervical spine alignment was assessed with the following 3 parameters: the C2-7 Cobb angle, C2-7 sagittal vertical axis (SVA), and T-1 slope minus C2-7 Cobb angle. The change in cervical sagittal alignment was defined as the difference between the post- and preoperative C2-7 Cobb angles, C2-7 SVAs, and T-1 slope minus C2-7 Cobb angles. Outcome assessments (visual analog scale [VAS], Oswestry Neck Disability Index [NDI], 36-Item Short-Form Health Survey [SF-36], and Japanese Orthopaedic Association [JOA] scores) were obtained in all patients pre- and postoperatively. RESULTS The average patient age was 56.3 years (range 38-72 years). There were 34 male patients and 16 female patients. Cervical laminoplasty for OPLL helped alleviate radiculomyelopathy. Compared with the preoperative scores, improvement was seen in postoperative VAS and JOA scores. After laminoplasty, 35 patients had kyphotic changes, and 15 had lordotic changes. However, cervical sagittal alignment after laminoplasty was not significantly associated with clinical outcomes in terms of postoperative improvement of the JOA score (C2-7 Cobb angle: p = 0.633; C2-7 SVA: p = 0.817; T-1 slope minus C2-7 lordosis: p = 0.554), the SF-36 score (C2-7 Cobb angle: p = 0.554; C2-7 SVA: p = 0.793; T-1 slope minus C2-7 lordosis: p = 0.829), the VAS neck score (C2-7 Cobb angle: p = 0.263; C2-7 SVA: p = 0.716; T-1 slope minus C2-7 lordosis: p = 0.497), or the NDI score (C2-7 Cobb angle: p = 0.568; C2-7 SVA: p = 0.279; T-1 slope minus C2-7 lordosis: p = 0.966). Similarly, the change in cervical sagittal alignment was not related to the JOA (p = 0.604), SF-36 (p = 0.308), VAS neck (p = 0.832), or NDI (p = 0.608) scores. CONCLUSIONS Cervical laminoplasty for OPLL improved radiculomyelopathy. Cervical laminoplasty increased the probability of cervical kyphotic alignment. However, cervical sagittal alignment and clinical outcomes were not clearly related.
    No preview · Article · Oct 2015 · Journal of neurosurgery. Spine
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    ABSTRACT: In pus and wound samples collected from the right second toe of a 61-year-old woman with diabetes mellitus (DM), gram-negative diplococci bacterium was observed. However, the bacterium could not be identified by conventional microbiological methods and mass spectrometry. In the partial 16S rRNA gene sequence analysis, the bacterium showed a 100% identity match with GenBank sequence FJ0763637.1 (Neisseria skkuensis). N. skkuensis, SMC-A9199 strain, was reported as a novel species in 2010 based on its phenotypic characteristics and the 16S rRNA gene sequence, which was isolated from the blood and wound pus of a DM patient with a foot ulcer. The second reported N. skkuensis was identified from the blood cultures of a patient with endocarditis. To the best of our knowledge, this is only the third report of N. skkuensis. © 2015 by the Association of Clinical Scientists, Inc.
    No preview · Article · Jul 2015 · Annals of clinical and laboratory science

  • No preview · Article · May 2015 · Annals of clinical and laboratory science
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    ABSTRACT: In the present study we used an empty zona pellucida derived from hatched blastocysts as an alternative source for embryo aggregation and compared results with the conventional microwell method. Denuded 4-cell stage porcine embryos were aggregated by introduction into an empty zona or placement within a concave microwell. The present study showed that although the rate of aggregate formation was similar, the blastocyst rates and allocation of more cells to the inner cell mass (ICM) in the resultant aggregates were increased significantly more in the empty zona than in the microwell. Notably, using an empty zona showed no limitations with regards to the increased number of embryos aggregated or embryonic stages for aggregation, while partial or no aggregation frequently occurred in the microwell. The discrepancy may be due to the difference of microenvironments where the embryos were placed namely, the presence/absence of zona pellucida. We hypothesize the success of the empty zona in generating aggregates is due to the physical aggregation of individual embryos allowing closer contact between the blastomeres and/or embryos compared with a concave microwell. These results indicate that aggregation conditions could influence overall production efficiency and developmental potential of aggregates, suggesting physical restraint via empty zona that provide three-dimensional pressures is an important factor for successful embryo aggregation.
    Full-text · Article · Apr 2015 · PLoS ONE
  • Chan Yun Kim · Seungsoo Rho · Naeun Lee · Chang‐Kyu Lee · Youngje Sung
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    ABSTRACT: Objective To evaluate the accuracy of a new semi-automated method for counting axons in transmission electron microscopic (TEM) images.ProceduresOptic nerve cross sections were obtained from both eyes of Sprague Dawley rats after unilateral induction of chronic ocular hypertension. TEM images (3000× magnification) of cross sections were evaluated by both semi-automated and manual counting methods. The semi-automated counting method was performed using ImageJ software after simple image optimization, and the resulting estimate of axon damage was compared with semiquantitative damage grading scale from light microscopic (LM) images.ResultsAxon counts obtained from the semi-automated method were strongly correlated with those obtained from the manual counting method (Pearson's correlation coefficient r = 0.996, P < 0.001) and from the full manual count from LM images (Spearman's ρ = 0.973, P < 0.001). The semi-automated method measured axonal damage with an error of 0.94 ± 3.16% (mean ± standard deviation), with worse axonal damage associated with greater error. Interobserver and intra-observer variability in axons counts were low (Spearman's ρ = 0.999, P < 0.005). The results of the semi-automated counting method were highly correlated with semiquantitative damage grading scale (Spearman's ρ = 0.965, P < 0.001).Conclusion Results of our semi-automated method for counting axons in TEM images were strongly correlated with those of conventional counting methods and showed excellent reproducibility.
    No preview · Article · Jan 2015 · Veterinary Ophthalmology
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    Seung Hwan Jo · Chang Kyu Lee
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    ABSTRACT: Several energy drinks containing a high content of caffeine are widely consumed among young adults. We examined the effects of caffeinated energy drinks on intraocular pressure (IOP) and blood pressure (BP) in healthy young subjects.
    Preview · Article · Jan 2015 · Journal of the Korean Ophthalmological Society
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    ABSTRACT: Quantitation of cytomegalovirus (CMV) DNA using real-time PCR has been utilized for monitoring CMV infection. However, the CMV antigenemia assay is still the 'gold standard' assay. There are only a few studies in Korea that compared the efficacy of use of real-time PCR for quantitation of CMV DNA in whole blood with the antigenemia assay, and most of these studies have been limited to transplant recipients. 479 whole blood samples from 79 patients, falling under different disease groups, were tested by real-time CMV DNA PCR using the Q-CMV real-time complete kit (Nanogen Advanced Diagnostic S.r.L., Italy) and CMV antigenemia assay (CINA Kit, ArgeneBiosoft, France), and the results were compared. Repeatedly tested patients were selected and their charts were reviewed for ganciclovir therapy. The concordance rate of the two assays was 86.4% (Cohen's kappa coefficient value=0.659). Quantitative correlation between the two assays was a moderate (r=0.5504, P<0.0001). Among 20 patients tested repeatedly with the two assays, 13 patients were transplant recipients and treated with ganciclovir. Before treatment, CMV was detected earlier by real-time CMV DNA PCR than the antigenemia assay, with a median difference of 8 days. After treatment, the antigenemia assay achieved negative results earlier than real-time CMV DNA PCR with a median difference of 10.5 days. Q-CMV real-time complete kit is a useful tool for early detection of CMV infection in whole blood samples in transplant recipients.
    Preview · Article · Jan 2015 · Annals of Laboratory Medicine
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    ABSTRACT: A recently introduced Sofia RSV FIA was evaluated comparatively with the BinaxNow® RSV Card and the SD Bioline RSV test using 348 respiratory samples. The Sofia, BinaxNow and SD Bioline kits showed sensitivities of 66%, 65%, and 64% for RSV A, and 71%, 63%, and 65% for RSV B, respectively. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
    Full-text · Article · Nov 2014 · Journal of Clinical Microbiology
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    ABSTRACT: OCT4 encoded by POU5F1 has a crucial role of maintaining pluripotency in embryonic stem cells during early embryonic development and several OCT4 variants have been identified in mouse and human studies. The objective of the present study was to identify different variants of OCT4 and analyze their expression patterns in preimplantation porcine embryos and in various tissues. Here, we showed that POU5F1 transcribes its three variants, namely OCT4A, OCT4B, and OCT4B1. The OCT4B transcript consists of exons identical to the major form of the OCT4 variant, OCT4A, with a differential N-terminal domain coding exon. The structure of OCT4B1 mRNA was same as that of OCT4B mRNA, but harbored a cryptic exon. Based on these findings, the transcription levels was investigated and found that OCT4B and OCT4B1 made up approximately 20% among the variants in embryonic stage and this indicates OCT4A mRNA is dominantly expressed during preimplantation embryos development. Also, OCT4B mRNA was detected in all tissues examined, while OCT4A and OCT4B1 were detected only in testis but not in other tissues examined. OCT4B1 showed inversely correlated expression with SOX2 and NANOG expression. OCT4A protein was specifically localized in the nuclei, whereas OCT4B was mainly localized in the cytoplasm of the porcine embryos at the blastocyst stage. The findings of this study reveal that the porcine OCT4 gene can potentially encode three variants (OCT4A, OCT4B, and OCT4B1), and they are differentially expressed and would have dissimilar roles each other in preimplantation embryos and various adult tissues.
    Full-text · Article · Oct 2014 · Reproduction (Cambridge, England)
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    Jiehyun Jeon · Joo Ha Kim · Chang Kyu Lee · Chil Hwan Oh · Hae Jun Song
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    ABSTRACT: Background: Skin infections with Gram-negative bacteria are sometimes challenging to treat, because these bacteria show multidrug resistance against commonly used antibiotics and patients with Gram-negative bacterial infection overall have deteriorated in conditions in many cases. Studies have shown that epigallocatechin gallate (EGCG) and green tea extracts (GTE) inhibit the growth of several Gram-positive bacteria species. Objective: The purpose of this study was to investigate the minimum inhibitory concentrations (MICs) of EGCG and GTE in Pseudomonas aeruginosa and Escherichia coil, and assess the use of these chemicals as an alternative or adjunct topical antimicrobial agent against P. aeruginosa and E. coil with multidrug resistance. Methods: The MICs of EGCG, GTE, and other tested antibiotics were measured and compared to determine the antibacterial efficacy and the differences in pattern of resistance. Results: The P. aeruginosa and E. coil strains used in this study showed multidrug resistance. EGCG inhibited the growth of P. aeruginosa at a MIC level of 200 similar to 400 mu g/ml. The MIC of GTE was a 1:16 dilution for P. aeruginosa. EGCG showed antimicrobial activity against E. coil at a MIC of 400 mu g/ml. In the case of GTE, the MIC was a dilution between 1: 8 and 1:4 for E. coli. Conclusion: EGCG and GTE showed potential as alternative or adjunct topical antimicrobial agents for infections that are resistant to traditional antibiotic therapy.
    Preview · Article · Oct 2014 · Annals of Dermatology
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    ABSTRACT: Background This study aimed to investigate the impact of preceding respiratory viral infections (RVI) on the clinical severity of pneumococcal pneumonia patients. MethodsA retrospective observational study was conducted at a university hospital from January 2009 to March 2013. Study subjects included adults (aged 18years) with pneumococcal pneumonia who had undergone laboratory tests for RVI. Multivariate logistic regression analysis was performed to identify risk factors associated with severe pneumococcal pneumonia, defined as severity with the Pneumonia Severity Index (PSI) score 91. ResultsIn total, 191 patients with pneumococcal pneumonia were included for analysis and stratified into 2 groups: the severe group with a PSI score 91 (n=99) and the non-severe group with a PSI score <91 (n=92). Preceding RVIs were detected in 48 patients, including influenza A virus (n=20), influenza B virus (n=4), parainfluenza viruses (n=5), metapneumovirus (n=4), rhinovirus (n=4), respiratory syncytial viruses (n=6), coronaviruses (n=2), and mixed viral infections (n=3). In the multivariate logistic regression analysis, preceding RVIs (odds ratio [OR], 249; 95% confidence interval [CI], 110-560), male sex (OR, 258; 95% CI, 124-538), old age (OR, 292; 95% CI, 137-624), hypoalbuminemia (OR, 326; 95% CI, 156-684)], and azotemia (OR, 224; 95% CI, 108-467) were significantly associated with severe pneumococcal pneumonia. Conclusion This study suggests that preceding RVIs might be one of the risk factors affecting the clinical severity of pneumococcal pneumonia.
    Preview · Article · Jun 2014 · Influenza and Other Respiratory Viruses
  • Kwang Sook Park · Mi Hwa Yang · Chang Kyu Lee · Ki-Joon Song
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    ABSTRACT: Human parainfluenza viruses (HPIV) are important causes of respiratory tract infections in young children. To characterize the molecular epidemiology of an HPIV outbreak occurring in Korea during 2006, genetic analysis of 269 cell culture isolates from HPIV-infected children, was conducted using nested reverse transcription-PCR (RT-PCR). HPIV-1 was detected in 70.3% of tested samples (189/269). The detection rate of HPIV-2 and HPIV-3 was 1.5% (4/269) and 9.3% (25/269), respectively. Mixed HPIV-1, -2 and -3 infections were detected in 19.0% (51/269): HPIV-1 and HPIV-2 in 15, HPIV-1 and HPIV-3 in 26, HPIV-2 and HPIV-3 in 6, and HPIV-1, -2 and -3 in 4. Of these positive samples for three different types HIPV-1, -2, and -3, two each representative strains were selected, the full length of hemagglutinin-neuraminidase (HN) gene for HPIV was amplified by RT-PCR, and sequenced. Multiple alignment analysis, based on reference sequence of HPIV-1, -2, and -3 strains available in GenBank, showed that the identity of nucleotide and deduced amino acid sequences was 92.4-97.6% and 92.7-97.9%, respectively, for HPIV-1, 88.5-99.8% and 88.6-100% for HPIV-2, and 96.3-99.5% and 95.0-99.3% for HPIV-3, respectively. Phylogenetic analysis showed that HPIV-1, -2, and -3 strains identified in this study were closely related among the strains in the same type with no significant genetic variability. These results show that HPIV of multiple imported sources was circulating in Korea. J. Med. Virol. © 2014 Wiley Periodicals, Inc.
    No preview · Article · Jun 2014 · Journal of Medical Virology
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    ABSTRACT: Recently, AdvanSureTM kit based on multiplex real-time PCR was developed for simultaneous detection of 14 respiratory viruses. We compared the performance of AdvanSure with those of Seeplex® RV 15 ACE and culture by determining their sensitivity and specificity against a composite reference standard. Four hundred and thirty seven respiratory samples were tested by modified shell vial culture method, RV 15 ACE and AdvanSure. One hundred and fourteen samples (26.2%) out of 437 samples were positive by culture, while additional 91 (20.8%) were positive by AdvanSure or RV15. One hundred twelve of 114 culture positive samples were positive by AdvanSure except 2 samples (1 adenovirus, 1 RSV). Overall, the sensitivities of culture, RV15 and AdvanSure were 74.5%, 89.8%, and 95.1%, respectively. Sensitivities of culture, RV15 and AdvanSure for each virus tested were as follows; 91/100/96% for influenza A, 60/0/100% for influenza B, 63/95/97% for RSV, 69/81/89% for adenovirus, and 87/93/93% for PIV. For viruses not covered by culture, sensitivities of RV15 and AdvanSure were as follows; 77/88% for rhinovirus, 100/100% for coronavirus OC43, 40/100% for coronavirus 229E/NL63, 13/100% for metapneumovirus, and 44/100% for bocavirus. The overall specificities of culture, RV15 and AdvanSure were 100/98.9/99.5%, respectively. Of 45 co-infected specimens, AdvanSure detected 41 specimens (91.1%) as co-infected, while RV15 detected 27 specimens (60.0%) as co-infected. AdvanSure assay demonstrated exquisite performance for the detection of respiratory viruses and will be a valuable tool for the management of respiratory virus infection.
    No preview · Article · May 2014 · Diagnostic microbiology and infectious disease
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    Full-text · Article · Mar 2014 · Annals of Laboratory Medicine
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    Myeong In Yeom · Sang Soo Kim · Chang Kyu Lee

    Preview · Article · Jan 2014 · Journal of the Korean Ophthalmological Society
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    ABSTRACT: The aim of this study was to compare the analytical sensitivity and specificity of the recently updated 4th generation Elecsys HIV combi PT assay (Roche Diagnostics GmbH, Germany) to those of the ARCHITECT HIV Ag/Ab Combo assay (Abbott Laboratories, Germany).
    Full-text · Article · Jan 2014

Publication Stats

729 Citations
145.70 Total Impact Points

Institutions

  • 2015
    • CHA University
      Sŏul, Seoul, South Korea
  • 2010-2015
    • Yonsei University
      • The Spine and Spinal Cord Institute
      Sŏul, Seoul, South Korea
    • Inje University
      Kŭmhae, Gyeongsangnam-do, South Korea
    • Korea University Medical Center
      Sŏul, Seoul, South Korea
  • 2007-2015
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2006-2015
    • Korea University
      • • Department of Laboratory Medicine
      • • Department of Biomedical Science
      Sŏul, Seoul, South Korea
  • 2005-2015
    • Seoul National University
      • Department of Agricultural Biotechnology
      Sŏul, Seoul, South Korea
  • 2014
    • Maryknoll Medical Center
      Busan, Busan, South Korea
  • 2012
    • Hanyang University
      • Division of Mechanical Engineering
      Sŏul, Seoul, South Korea