Henk M E Miedema

Nederlandse Organisatie voor Wetenschappelijk Onderzoek, 's-Gravenhage, South Holland, Netherlands

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Publications (55)110.58 Total impact

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    ABSTRACT: Traffic noise and air pollution have been associated with cardiovascular health effects. Until date, only a limited amount of prospective epidemiological studies is available on long-term effects of road traffic noise and combustion related air pollution. This study investigates the relationship between road traffic noise and air pollution and hospital admissions for ischemic heart disease (IHD: International Classification of Diseases (ICD9) 410-414) or cerebrovascular disease (cerebrovascular event [CVE]: ICD9 430-438). We linked baseline questionnaire data to 13 years of follow-up on hospital admissions and road traffic noise and air pollution exposure, for a large random sample (N = 18,213) of inhabitants of the Eindhoven region, Netherlands. Subjects with cardiovascular event during follow-up on average had higher road traffic noise day, evening, night level (L den) and air pollution exposure at the home. After adjustment for confounders (age, sex, body mass index, smoking, education, exercise, marital status, alcohol use, work situation, financial difficulties), increased exposure did not exert a significant increased risk of hospital admission for IHD or cerebrovascular disease. Relative risks (RRs) for a 5 (th) to 95 (th) percentile interval increase were 1.03 (0.88-1.20) for L den; 1.04 (0.90-1.21) for particulate matter (PM 10 ); 1.05 (0.91-1.20) for elemental carbon (EC); and 1.12 (096-1.32) for nitrogen dioxide (NO 2 ) in the full model. While the risk estimate seemed highest for NO 2 , for a 5 (th) to 95 (th) percentile interval increase, expressed as RRs per 1 μg/m 3 increases, hazard ratios seemed highest for EC (RR 1.04 [0.92-1.18]). In the subgroup of study participants with a history of cardiovascular disease, RR estimates seemed highest for noise exposure (1.19 [0.87-1.64] for L den); in the subgroup of elderly RR seemed highest for air pollution exposure (RR 1.24 [0.93-1.66] for NO 2 ).
    No preview · Article · Nov 2013 · Noise and Health
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    Full-text · Dataset · Jan 2013
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    Full-text · Dataset · Jan 2013
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    Full-text · Dataset · Dec 2012

  • No preview · Conference Paper · May 2012
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    ABSTRACT: Previous studies suggest that pregnant women and children are particularly vulnerable to the adverse effects of air pollution. A prospective cohort study in pregnant women and their children enables identification of the specific effects and critical periods. This paper describes the design of air pollution exposure assessment for participants of the Generation R Study, a population-based prospective cohort study from early pregnancy onwards in 9778 women in The Netherlands. Individual exposures to PM10 and NO2 levels at the home address were estimated for mothers and children, using a combination of advanced dispersion modelling and continuous monitoring data, taking into account the spatial and temporal variation in air pollution concentrations. Full residential history was considered. We observed substantial spatial and temporal variation in air pollution exposure levels. The Generation R Study provides unique possibilities to examine effects of short- and long-term air pollution exposure on various maternal and childhood outcomes and to identify potential critical windows of exposure.
    Full-text · Article · Feb 2012 · Environmental Health
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    ABSTRACT: Exposure to air pollution has been associated with higher C-reactive protein (CRP) levels, suggesting an inflammatory response. Not much is known about this association in pregnancy. We investigated the associations of air pollution exposure during pregnancy with maternal and fetal CRP levels in a population-based cohort study in the Netherlands. Particulate matter (PM) with an aerodynamic diameter ≤ 10 μm (PM10) and nitrogen dioxide (NO2) levels were estimated at the home address using dispersion modeling for different averaging periods preceding the blood sampling (1 week, 2 weeks, 4 weeks, and total pregnancy). High-sensitivity CRP levels were measured in maternal blood samples in early pregnancy (n = 5,067) and in fetal cord blood samples at birth (n = 4,450). Compared with the lowest quartile, higher PM10 exposure levels for the prior 1 and 2 weeks were associated with elevated maternal CRP levels (> 8 mg/L) in the first trimester [fourth PM10 quartile for the prior week: odds ratio (OR), 1.32; 95% confidence interval (CI): 1.08, 1.61; third PM10 quartile for the prior 2 weeks: OR, 1.28; 95% CI: 1.06, 1.56]; however, no clear dose-response relationships were observed. PM10 and NO2 exposure levels for 1, 2, and 4 weeks preceding delivery were not consistently associated with fetal CRP levels at delivery. Higher long-term PM10 and NO2 exposure levels (total pregnancy) were associated with elevated fetal CRP levels (> 1 mg/L) at delivery (fourth quartile PM10: OR, 2.18; 95% CI: 1.08, 4.38; fourth quartile NO2: OR, 3.42; 95% CI: 1.36, 8.58; p-values for trend < 0.05). Our results suggest that exposure to air pollution during pregnancy may lead to maternal and fetal inflammatory responses.
    Full-text · Article · Feb 2012 · Environmental Health Perspectives
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    ABSTRACT: Air pollution exposure during pregnancy might have trimester-specific effects on fetal growth. We prospectively evaluated the associations of maternal air pollution exposure with fetal growth characteristics and adverse birth outcomes in 7,772 subjects in the Netherlands. Particulate matter with an aerodynamic diameter < 10 μm (PM10) and nitrogen dioxide (NO2) levels were estimated using dispersion modeling at the home address. Fetal head circumference, length, and weight were estimated in each trimester by ultrasound. Information on birth outcomes was obtained from medical records. In cross-sectional analyses, NO2 levels were inversely associated with fetal femur length in the second and third trimester, and PM10 and NO2 levels both were associated with smaller fetal head circumference in the third trimester [-0.18 mm, 95% confidence interval (CI): -0.24, -0.12 mm; and -0.12 mm, 95% CI: -0.17, -0.06 mm per 1-μg/m3 increase in PM10 and NO2, respectively]. Average PM10 and NO2 levels during pregnancy were not associated with head circumference and length at birth or neonatally, but were inversely associated with birth weight (-3.6 g, 95% CI: -6.7, -0.4 g; and -3.4 g, 95% CI: -6.2, -0.6 g, respectively). Longitudinal analyses showed similar patterns for head circumference and weight, but no associations with length. The third and fourth quartiles of PM10 exposure were associated with preterm birth [odds ratio (OR) = 1.40, 95% CI: 1.03, 1.89; and OR = 1.32; 95% CI: 0.96, 1.79, relative to the first quartile]. The third quartile of PM10 exposure, but not the fourth, was associated with small size for gestational age at birth (SGA) (OR = 1.38; 95% CI: 1.00, 1.90). No consistent associations were observed for NO2 levels and adverse birth outcomes. Results suggest that maternal air pollution exposure is inversely associated with fetal growth during the second and third trimester and with weight at birth. PM10 exposure was positively associated with preterm birth and SGA.
    Full-text · Article · Jan 2012 · Environmental Health Perspectives
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    ABSTRACT: Road traffic noise in urban areas is a major source of annoyance. A quiet façade has been hypothesized to beneficially affect annoyance. However, only a limited number of studies investigated this hypothesis, and further quantification is needed. This study investigates the effect of a relatively quiet façade on the annoyance response. Logistic regression was performed in a large population based study (GLOBE, N~18,000), to study the association between road traffic noise exposure at the most exposed dwelling façade (L(den)) and annoyance in: (1) The subgroup with a relatively quiet façade (large difference in road traffic noise level between most and least exposed façade (Q>10 dB); (2) the subgroup without a relatively quiet façade (Q<10 dB). Questionnaire data were linked to individual exposure assessment based on detailed spatial data (GIS) and standard modeling techniques. Annoyance was less likely (OR(Q) (>10)<OR(Q) (<10)) in the subgroup with relatively quiet façade compared to the subgroup without relatively quiet façade. The difference in response between groups seemed to increase with increasing Q and L(den). Results indicate that residents may benefit from a quiet façade to the dwelling.
    No preview · Article · Oct 2011 · The Journal of the Acoustical Society of America
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    ABSTRACT: Recently, it has been suggested that the annoyance of residents at a given aircraft noise exposure level increases over the years. The objective of the present study was to verify the hypothesized trend and to identify its possible causes. To this end, the large database used to establish earlier exposure-response relationships on aircraft noise was updated with original data from several recent surveys, yielding a database with data from 34 separate airports. Multilevel grouped regression was used to determine the annoyance response per airport, after which meta-regression was used to investigate whether study characteristics could explain the heterogeneity in annoyance response between airports. A significant increase over the years was observed in annoyance at a given level of aircraft noise exposure. Furthermore, the type of annoyance scale, the type of contact, and the response percentage were found to be sources of heterogeneity. Of these, only the scale factor could statistically account for the trend, although other findings rule it out as a satisfactory explanation. No evidence was found for increased self-reported noise sensitivity. The results are of importance to the applicability of current exposure-annoyance relationships for aircraft noise and provide a basis for decisions on whether these need to be updated.
    No preview · Article · Apr 2011 · The Journal of the Acoustical Society of America
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    ABSTRACT: Exposure to air pollution is associated with elevated blood pressure and cardiovascular disease. We assessed the associations of exposure to particulate matter (PM(10)) and nitrogen dioxide (NO(2)) levels with blood pressure measured in each trimester of pregnancy and the risks of pregnancy-induced hypertension and preeclampsia in 7006 women participating in a prospective cohort study in the Netherlands. Information on gestational hypertensive disorders was obtained from medical records. PM(10) exposure was not associated with first trimester systolic and diastolic blood pressure, but a 10-μg/m(3) increase in PM(10) levels was associated with a 1.11-mm Hg (95% confidence interval [CI] 0.43 to 1.79) and 2.11-mm Hg (95% CI 1.34 to 2.89) increase in systolic blood pressure in the second and third trimester, respectively. Longitudinal analyses showed that elevated PM(10) exposure levels were associated with a steeper increase in systolic blood pressure throughout pregnancy (P<0.01), but not with diastolic blood pressure patterns. Elevated NO(2) exposure was associated with higher systolic blood pressure levels in the first, second, and third trimester (P<0.05), and with a more gradual increase when analyzed longitudinally (P<0.01). PM(10) exposure, but not NO(2) exposure, was associated with an increased risk of pregnancy-induced hypertension (odds ratio 1.72 [95% CI 1.12 to 2.63] per 10-μg/m(3) increase). In conclusion, our results suggest that air pollution may affect maternal cardiovascular health during pregnancy. The effects might be small but relevant on a population level.
    Full-text · Article · Mar 2011 · Hypertension
  • H.C. Borst · E.M. Salomons · W.J.A. Lohman · R.T. Klerkx · H. Zhou · H.M.E. Miedema
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    ABSTRACT: For management of environmental noise, insight in the current noise situation is needed. An important source of information is provided by strategic noise maps, which can be implemented in a policy cycle on noise. However, the planning of noise measures in an urban environment is complex. Besides noise from different source types, many other aspects play a role, such as traffic air quality and safety. In order to create an integrated overview of these aspects, GIS instruments have been developed and applied. With these instruments, such as Urbis, policy makers gain an overview of the environmental situation in the current situation as well as future scenario's, allowing them to formulate sound environmental policy options. These traditional mapping instruments report in the form of static maps, digitally or on paper. Due to long calculation times, these maps do not allow interaction with the user. In order to support local authorities in their environmental noise planning, TNO has developed an interactive instrument: 'Urban Strategy'. Urban Strategy integrates detailed interactive noise maps and noise impact indicators with other aspects such as traffic calculations, air quality and safety. This allows the assessment of noise exposures as well as the formulation of noise mitigating measures for the reduction of the number of people harmfully affected by environmental noise.
    No preview · Article · Jan 2011
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    ABSTRACT: This study assesses the effects of aircraft noise on residential satisfaction, an important indicator of subjective well-being. A structural equation model is specified that estimates the relationships between objective variables, noise annoyance variables and residential satisfaction. Secondary data-analysis is used to estimate the model. The survey was conducted in 1996/1997 among the population living within a 25-km radius of Amsterdam Schiphol, the largest airport in the Netherlands. The effect of aircraft noise annoyance is found to be relatively small. In addition, the objective level of aircraft noise exposure is found to be a better predictor of residential satisfaction than its subjective counterpart. The most important determinants of residential satisfaction are found to be road traffic noise annoyance, age and neighbor noise annoyance.
    Full-text · Article · May 2010 · Transportation Research Part D Transport and Environment
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    ABSTRACT: Annoyance is usually predicted from the noise levels at the most exposed façade of the dwelling. This relationship may be refined by also taking into account the noise level at the least exposed façade, assuming that a quiet façade may have benefits. Questionnaire data from a large population based cohort study (GLOBE) in the Netherlands were linked to individual exposure assessment, for which detailed spatial data were used together with geographical information systems (GIS) and state of the art modeling techniques. Logistic regression was used to study the association between exposure at the most exposed façade of the dwelling (L den) and annoyance, taking into account the exposure at the least exposed façade. Annoyance was measured by asking if subjects were disturbed by environmental noise. The results suggest that residents may benefit from having a quiet façade.
    No preview · Article · Jan 2010
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    ABSTRACT: It has long been recognized that fear contributes to the annoyance response by aircraft noise. The present study focuses on the role of fear in the path from aircraft noise exposure to self-reported effects of noise, including both annoyance and specific disturbances. Analyses are done on original data from two large surveys in the vicinity of a large international airport (Amsterdam Schiphol airport). The effect of aircraft noise exposure on annoyance was found to be mediated by self-reported concern about one's safety due to living underneath an aircraft flight path (fear) as well as by specific disturbances. Furthermore, it was found that fear increased sleep disturbance, concentration disturbance and conversation disturbance due to aircraft noise. The results suggest that fear is a very important factor in the response to aircraft noise, reflecting the important function of fear in the regulation of behaviour.
    No preview · Article · Jan 2010
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    ABSTRACT: The effects of ambient air pollution on pregnancy outcomes are under debate. Previous studies have used different air pollution exposure assessment methods. The considerable traffic-related intra-urban spatial variation needs to be considered in exposure assessment. Residential proximity to traffic is a proxy for traffic-related exposures that takes into account within-city contrasts. We investigated the association between residential proximity to traffic and various birth and pregnancy outcomes in 7,339 pregnant women and their children participating in a population-based cohort study. Residential proximity to traffic was defined as 1) distance-weighted traffic density in a 150 meter radius, and 2) proximity to a major road. We estimated associations of these exposures with birth weight, and with the risks of preterm birth and small size for gestational age at birth. Additionally, we examined associations with pregnancy-induced hypertension, (pre)eclampsia, and gestational diabetes. There was considerable variation in distance-weighted traffic density. Almost fifteen percent of the participants lived within 50 m of a major road. Residential proximity to traffic was not associated with birth and pregnancy outcomes in the main analysis and in various sensitivity analyses. Mothers exposed to residential traffic had no higher risk of adverse birth outcomes or pregnancy complications in this study. Future studies may be refined by taking both temporal and spatial variation in air pollution exposure into account.
    Full-text · Article · Dec 2009 · Environmental Health
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    ABSTRACT: Walking is an important source of outdoor physical activity among elderly people. In order to devise measures aimed at encouraging walking among the elderly it is important to understand how the local environment influences the walking behaviour of elderly people. Here, a model describing the influence of environmental street characteristics on the walking route choice of elderly people is presented. Techniques adapted from the field of transportation research were employed within the model. Data concerning the walking route choice to specific destinations reported by 364 independently living elderly residents (55–80 years) from three Dutch urban districts were collected. Route choice was modelled within a ‘Geographic Information System’ (GIS) database by using ‘resistance factors’ to describe the resistance to walking of street sections (i.e. links) within the street network. These factors were optimized by minimizing the difference between the estimated and the reported number of trips along each link. This is, to the authors' knowledge the first time that this technique has been applied within this context. The influence of link characteristics on link resistance was investigated by multivariate linear regression. The first results of the route choice model and the influence of street characteristics on route choice are reported and discussed.
    Full-text · Article · Dec 2009 · Journal of Environmental Psychology

  • No preview · Article · Nov 2009 · Epidemiology
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    ABSTRACT: A computational study of road traffic noise in cities is presented. Based on numerical boundary-element calculations of canyon-to-canyon propagation, an efficient engineering algorithm is developed to calculate the effect of multiple reflections in street canyons. The algorithm is supported by a room-acoustical analysis of the reverberant sound fields in the source and receiver canyons. Using the algorithm, a simple model for traffic noise in cities is developed. Noise maps and exposure distributions of the city of Amsterdam are calculated with the model, and for comparison also with an engineering model that is currently used for traffic noise impact assessments in cities. Considerable differences between the two model predictions are found for shielded buildings with day-evening-night levels of 40-60 dB at the facades. Further, an analysis is presented of level differences between the most and the least exposed facades of buildings. Large level differences are found for buildings directly exposed to traffic noise from nearby roads. It is shown that by a redistribution of traffic flow around these buildings, one can achieve low sound levels at quiet sides and a corresponding reduction in the percentage of highly annoyed inhabitants from typically 23% to 18%.
    No preview · Article · Nov 2009 · The Journal of the Acoustical Society of America
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    ABSTRACT: To investigate and explain sex differences in subjective and actigraphic sleep parameters in community-dwelling elderly persons. Cross-sectional study. The study was embedded in the Rotterdam Study, a population-based study. Nine hundred fifty-six participants aged 59 to 97 years. N/A. Participants wore an actigraph and kept a sleep diary for an average of 6 consecutive nights. Subjective sleep quality was assessed with the Pittsburgh Sleep Quality Index. Unadjusted sex differences in sleep parameters were assessed with t tests. Women reported shorter total sleep time, a less favorable sleep-onset latency, lower sleep efficiency, and worse global sleep quality, as compared with men. When assessed with actigraphy, however, women were found to have longer and less-fragmented sleep than men. Sex differences in diary-reported sleep duration and other subjective sleep parameters were attenuated by adjustment for marital status, the use of sleep medication, and other covariates, but all sex differences remained significant in a multivariate-adjusted model. Sex differences in actigraphic sleep parameters were barely attenuated by multivariate adjustment, although the shorter actigraphically measured sleep duration in men was partly explained by their higher alcohol consumption. Some covariates (eg, sleep medication) had a different relationship with diary-reported or actigraphic total sleep time in men and women. If assessed by diary or interview, elderly women consistently reported shorter and poorer sleep than elderly men. In contrast, actigraphic sleep measures showed poorer sleep in men. These discrepancies are partly explained by determinants of sleep duration, such as sleep medication use and alcohol consumption.
    Full-text · Article · Oct 2009 · Sleep

Publication Stats

2k Citations
110.58 Total Impact Points

Institutions

  • 2008-2012
    • Nederlandse Organisatie voor Wetenschappelijk Onderzoek
      's-Gravenhage, South Holland, Netherlands
    • Erasmus MC
      Rotterdam, South Holland, Netherlands
  • 2000-2012
    • TNO
      's-Gravenhage, South Holland, Netherlands
  • 2007
    • Leiden University
      Leyden, South Holland, Netherlands