M Oelerich

University of Münster, Muenster, North Rhine-Westphalia, Germany

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Publications (21)55.84 Total impact

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    ABSTRACT: Oculodentodigital dysplasia (ODDD) (MIM 164200) is a rare autosomal dominant inherited disorder affecting the development of the face, eyes, limbs and dentition. Neurological complications are thought to be occasional manifestations of the disorder. This report illustrates the neurological manifestations by a pedigree of two ODDD patients with spastic paraparesis, cerebral white matter hyperintensity and basal ganglia hypointensity. A systematic review of the English, French, German and Italian literature on ODDD is also provided to summarize the neurological manifestations of the disorder. 243 previously described ODDD cases presented a spectrum of neurological manifestation including spasticity (25), subcortical white matter lesions (9) and basal ganglia changes (6) on MRI. Additional findings consisted of gaze palsy and squinting (28), bladder and bowel disturbances (21), visual loss (20) and blindness (4), hearing loss (15), ataxia (11), nystagmus (9), muscle weakness (5) and paresthesias (3). Neurological manifestations, including spasticity associated with MRI changes, are an underrecognized feature in the ODDD phenotype. A clinical guide to the neurological manifestations of ODDD may assist in the assessment of patients with this condition.
    Full-text · Article · Jun 2002 · Journal of Neurology

  • No preview · Article · May 2001 · Journal of Neurology
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    ABSTRACT: In patients infected with human immunodeficiency virus (HIV), the risk of developing non-Hodgkin's lymphoma is over 100 times greater than with noninfected persons. Primary central nervous system lymphoma as a complication of the acquired immunodeficiency syndrome (AIDS) occurs in up to 2.4% of all cases and is strongly associated with the Epstein-Barr virus. The prognosis is very poor, with a mean survival time of 21 to 27 days without therapy and up to 119 days with radiation therapy. We describe the course of seven AIDS patients with histologically proven primary central nervous system lymphoma and present a review of clinical symptoms, diagnosis, and therapy. The main criteria for differential diagnosis from other secondary neuromanifestations such as cerebral toxoplasmosis, progressive multifocal leukoencephalopathy, abscesses, and infarctions are described.
    No preview · Article · Mar 2001 · Der Nervenarzt
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    ABSTRACT: Patienten mit HIV-Infektion weisen ein mehr als 100fach erhöhtes Risiko im Vergleich zu nicht HIV-Infizierten auf, an einem Non-Hodgkin-Lymphom zu erkranken. Das primäre Lymphom des zentralen Nervensystems ist fast immer mit dem Epstein-Barr-Virus assoziiert und tritt mit einer Inzidenz von bis zu 2,4% bei HIV-Infizierten im AIDS-Stadium auf. Die mittlere postdiagnostische Überlebenszeit ohne Therapie beträgt 21–27 Tage, mit Strahlentherapie bis zu 119 Tage, so dass in beiden Fällen eine äußerst ungünstige Prognose vorhanden ist. In dieser Arbeit werden retrospektiv der Krankheitsverlauf und die Therapie von 7 HIV-Infizierten im AIDS-Stadium mit einem histologisch gesicherten primären Lymphom des zentralen Nervensystems analysiert und eine Zusammenfassung Über die klinische Symptomatik, Diagnostik und Therapie gegeben. Wesentliche Kriterien zur differenzialdiagnostischen Abgrenzung gegenüber anderen sekundären Neuromanifestationen wie zerebrale Toxoplasmose, progressive multifokale Leukoenzephalopathie, Abszesse und Infarkte werden dargestellt. In patients infected with human immunodeficiency virus (HIV), the risk of developing non-Hodgkin's lymphoma is over 100 times greater than with noninfected persons. Primary central nervous system lymphoma as a complication of the acquired immunodeficiency syndrome (AIDS) occurs in up to 2.4% of all cases and is strongly associated with the Epstein-Barr virus. The prognosis is very poor, with a mean survival time of 21 to 27 days without therapy and up to 119 days with radiation therapy. We describe the course of seven AIDS patients with histologically proven primary central nervous system lymphoma and present a review of clinical symptoms, diagnosis, and therapy. The main criteria for differential diagnosis from other secondary neuromanifestations such as cerebral toxoplasmosis, progressive multifocal leukoencephalopathy, abscesses, and infarctions are described.
    No preview · Article · Feb 2001 · Der Nervenarzt

  • No preview · Article · Oct 2000 · European Psychiatry
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    ABSTRACT: To compare the diagnostic performance of selenium-based digital radiography with that of conventional screen-film radiography and storage phosphor radiography for the detection of bone lesions simulating osteolyses. Artificial osseous lesions 1.0-3.0 mm in diameter were created in 80 of 160 predefined regions in 16 porcine femoral specimens. Specimens were enclosed in containers filled with paraffin to ensure accurate repositioning and to obtain an absorption condition comparable to that of a human extremity. Imaging was performed with a selenium-based digital radiography system, a conventional screen-film system, and a storage phosphor radiography system with an exposure identical to that used during clinical imaging. The presence of a lesion was assessed with a five-point confidence scale. Receiver operating characteristic (ROC) analysis was performed for a total of 1,440 observations (480 per modality), and diagnostic performance was estimated with the area under the ROC curve (A(z)). Differences in diagnostic performance were assessed with the paired Student t test. ROC analysis results showed A(z) values of 0.656 for selenium-based digital radiography, 0.679 for storage phosphor radiography, and 0.680 for conventional screen-film radiography. Differences between the three modalities were not significant (P =.60-.93). Image quality with selenium-based digital radiography was comparable to that with conventional screen-film radiography and storage phosphor radiography.
    No preview · Article · Aug 2000 · Radiology
  • M Oelerich · F Stögbauer · G Kurlemann · C Schul · G Schuierer
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    ABSTRACT: Dissection of the carotid and vertebral arteries is a not so uncommon cause of stroke and has to be considered as a differential diagnosis especially in younger patients. Therapeutic and prognostic implications are different from those in extracranial atherosclerotic disease. Dissection results from hemorrhage into the vessel wall usually between the layers of the media. Digital subtraction angiography (DSA) depicts the resulting luminal compromise that may reveal some typical, but not specific, findings. The same is true for non-invasive angiographic techniques such as time-of-flight magnetic resonance angiography (MRA) and computed tomography angiography (CTA), which have shown accurate results compared with DSA. The main advantage of these techniques is the direct visualization of the vessel wall confirming the intramural hematoma. This is achieved best with MR imaging due to the high signal of blood degradation products on T1- and T2-weighted images. Therefore, MRI in combination with MRA is presently the method of choice for initial diagnosis and follow-up of craniocervical artery dissection (CCAD). In some questionable cases, CTA is a non-invasive alternative that is independent of flow phenomena.
    No preview · Article · Feb 1999 · European Radiology
  • M Oelerich · S R Stodieck · C Horch · G Schuierer

    No preview · Article · Nov 1998 · RöFo - Fortschritte auf dem Gebiet der R
  • M. Oelerich · S. Stodieck · C. Horch · C. Schuierer

    No preview · Article · Oct 1998 · RöFo - Fortschritte auf dem Gebiet der R
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    ABSTRACT: We compared the value of 3D time-of-flight (TOF) and phase-contrast (PC) MR angiography (MRA) for detection and grading of intracranial vascular steno-occlusive disease. Unenhanced 3D-TOF MRA and 3D-PC MRA (30-60 cm/s velocity encoding) were performed at the level of the circle of Willis in 18 patients, mean age 56 +/- 10 years. Postprocessed images using a maximum-intensity projection reconstruction with multiple targetted projections were analysed. A total of 126 vessels was assessed by PC MRA and 143 by TOF MRA, with digital subtraction angiography (DSA) in 15 patients and/or transcranial Doppler sonography (TCD) in 18 as a standard. Two blinded readers reviewed the MRA, DSA and TCD examinations retrospectively. On DSA and/or TCD the two observers found 32 and 28 steno-occlusive lesions. 3D-TOF MRA was more sensitive than 3D-PC MRA (87% and 86% vs. 65% and 60%) and had a higher negative predictive value (96% vs. 89%). Correct grading of stenoses was achieved in 78 % by 3D-TOF and 65% by 3D-PC MRA.
    No preview · Article · Oct 1998 · Neuroradiology
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    ABSTRACT: To find the appropriate contrast agent dose for gadolinium-enhanced magnetic resonance (MR) angiography by using individual measurement of contrast agent transit times in a randomized study. A total of 34 patients with disease of the aorta or its major branches or both were randomly assigned to receive a dose of 0.1, 0.2, or 0.3 mmol of gadopentetate dimeglumine per kilogram of body weight. Initially, contrast agent transit times were measured with use of a turbo fast-low-angle-shot sequence. Subsequently, a three-dimensional fast imaging with steady-state precession sequence (7.3-msec repetition time, 2.8-msec echo time) was used for breath-hold MR angiography. Gadopentetate dimeglumine was injected with an MR-compatible power injector. Efficacy was evaluated by measurement of vessel enhancement and by clinical correlation of MR angiograms with x-ray angiograms. Evaluation of contrast agent transit time was possible in all patients with the test doses, which provided contrast-enhanced MR angiograms of constant quality. Neither vessel enhancement nor diagnostic information was significantly different across the these study groups. The clinical gadolinium dose of 0.1 mmol/kg is sufficient for diagnostic assessment of the aorta and its major branches at contrast-enhanced MR angiography. High-dose studies appear not to be required for these large vessels.
    No preview · Article · Sep 1998 · Radiology
  • K Ludwig · U Bick · M Oelerich · G Schuierer · Z Puskas · K Nicolas · A Koch · H Lenzen
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    ABSTRACT: This study examines the suitability of working with a selection of images in a teleradiology consulting system in neurological or neurosurgical emergency situations. The teleradiology system was based on IBM-compatible personal computers, video digitization for data acquisition, and data transmission by Integrated System Digital Network. Forty normal and 60 abnormal emergency cranial computed tomograms were shown to a radiologist on call who presented all cases he regarded as pathologic to a neuroradiologic expert by teleradiology. To reduce transmission time, only a selection of images from the CT study was presented (up to four images per case). For each case the on-call radiologist's diagnosis (D(on-call)), the expert's diagnosis on the teleradiology screen (D(monitor)), and the expert's diagnosis on the original film (D(original)) was documented, together with an estimation of the agreement between those diagnoses. There was clinically relevant disagreement between the on-call radiologist's diagnosis and the neuroradiologist's diagnosis based on the image selection on the teleradiology monitor in 23% of cases. A clinically important discrepancy between the neuroradiologist's diagnosis based on the image selection and his diagnosis using the original films was found in 30% of cases. This was due to the presence of clinically relevant information on images not transferred by the on-call radiologist. Image quality of the transferred images was sufficient in all cases. Drastic selection of images from a complete CT study leads to a high rate of incorrect diagnoses and is not appropriate to reduce transmission time in teleradiology.
    No preview · Article · Feb 1998 · European Radiology
  • Michael Oelerich · Florian Stögbauer · Christoph Schul
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    ABSTRACT: Neurinomas are the most common intradural extramedullary tumors of the spine. Together with meningeoma they account for 80% to 90% of all tumors in this compartment. Radicular pain is the initial symptom in the majority of cases while motor disorders are less common and occur later in the course of the disease. We report a patient with spinal neurinoma and calf pain as the only presenting complaint. The differential diagnosis in this case required an interdisciplinary approach. (C) Elsevier Science Inc., 1998.
    No preview · Article · Jan 1998 · Clinical Imaging
  • M Oelerich · G Schuierer
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    ABSTRACT: The primitive hypoglossal artery (PHA) is a rare persistent carotid-basilar anastomosis. Usually it is found incidentally on angiography, but detection may be of importance for patient management. In the presented case MR- and CT angiography, which to our knowledge have not yet been reported in PHA, provided important additional information.
    No preview · Article · Feb 1997 · European Radiology
  • M Oelerich · M G Lentschig · T Vestring · P E Peters
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    ABSTRACT: The common use of interventional angiographic techniques and the sensitive detection of this vascular complication by ultrasound are major factors contributing to the increasing incidence of femoral artery pseudoaneurysms. ultrasound-guided compression repair of femoral artery pseudoaneurysms was prospectively evaluated. 11 femoral artery pseudoaneurysms were detected in 10 patients who ranged from 45 to 79 years of age. In one patient two ipsilateral pseudoaneurysms occurred. All patients were considered to be candidates for ultrasound-guided compression repair. Successful compression repair was achieved in 9 of 11 pseudoaneurysms (82%) with a mean diameter of 2.2 +/- 1.0 cm. In two recurrent lesions (22%) definitive thrombosis required a second treatment. Compression was maintained between 10 and 40 minutes (mean 22 +/- 11 minutes). No complications have been observed. Ultrasound-guided compression repair provides an efficient, noninvasive and safe treatment of femoral artery pseudoaneurysms. More than 80% of pseudoaneurysms can be occluded successfully. In recurrent lesions a second attempt is valuable.
    No preview · Article · Dec 1996 · RöFo - Fortschritte auf dem Gebiet der R
  • M. Oelerich · M. Lentschig · Th. Vestring · P. Peters

    No preview · Article · Nov 1996 · RöFo - Fortschritte auf dem Gebiet der R
  • J Alberty · M Oelerich
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    ABSTRACT: Globus pharyngis is a frequent symptom in patients who consult an otolaryngologist. In many cases, routine diagnostic work-up including history, clinical examination, and barium swallow fail to revealing the underlying pathogenesis. In a retrospective study, we present 51 selected patients suffering from globus pharyngis of unknown origin who were investigated by high-speed cineradiography in a standardized manner. Twenty-four of the patients enrolled in the study (47.1%) showed functional and/or structural swallowing disorders. In 13 cases (25.5%) dyskinesias of the superior esophagus sphincter muscle were found. Five of these patients (9.8%) also had an inconstant hypopharyngeal diverticulum. Six cases (11.8%) showed laryngeal penetration or tracheal aspiration. In four cases (7.8%) functional disorders of pharyngeal, and in three cases (5.9%) functional disorders of oral bolus transport were found. Furthermore one hypopharyngeal web (1.9%) and two benign tumors (3.9%) were detected. In many cases, varying combinations of these findings occurred. Using high-speed cineradiography for evaluation of globus pharyngis results in an increased incidence of pathologic findings, and thus is an important method for interdisciplinary diagnostic work up of patients suffering from this symptom.
    No preview · Article · Oct 1996 · Laryngo-Rhino-Otologie
  • J. Alberty · M. Oelerich

    No preview · Article · Sep 1996 · Laryngo-Rhino-Otologie
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    ABSTRACT: To compare the accuracy of detection of artificial spine fractures with helical computed tomography (CT) versus conventional CT. Twenty-six motion segments from 15 human cadaver thoracolumbar spines were imaged with helical and conventional CT both before and after fractures were artificially induced. The vertebrae were scanned with different collimations, reconstruction indexes, and exposure doses. A total of 900 images were analyzed by four radiologists, and a receiver operating characteristic (ROC) analysis was performed. ROC analysis showed a large area under the curve for conventional CT (0.913) than for helical CT (0.844) when 3-mm collimation was used. The ability to detect fractures with helical CT increased when collimation was decreased and exposure dose was increased. Conventional CT allows more accurate detection of artificial spine fractures than does helical CT. Helical CT requires thinner collimation for fracture detection comparable with that of conventional CT.
    No preview · Article · Mar 1996 · Radiology
  • M Oelerich · R Mai · H Müller-Miny · P E Peters
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    ABSTRACT: Dysphagia is a common symptom in clinical practice. Due to the broad spectrum of underlying diseases many disciplines are involved in the therapy and diagnosis of dysphagia, where radiology plays a central role. The radiologist is confronted with different diagnostic problems and has to choose the most appropriate type of investigation. In many cases no organic disorder can be demonstrated by clinical examination, endoscopy or conventional radiological techniques. In this setting cineradiography is an outstanding tool for finding functional or structural changes in the swallowing chain. This study underlines the efficiency of cineradiography in the diagnosis of dysphagia.
    No preview · Article · Nov 1995 · Der Radiologe

Publication Stats

317 Citations
55.84 Total Impact Points


  • 1995-2002
    • University of Münster
      • • Department of Neurology
      • • Department of Clinical Radiology
      • • Clinic for Ear, Nose and Throat
      Muenster, North Rhine-Westphalia, Germany