J M Frantz

Louisiana State University, Baton Rouge, Louisiana, United States

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Publications (11)39.22 Total impact

  • J M Frantz · B M Gebhardt · J J Reidy · M B McDonald
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    ABSTRACT: The purpose of this study was to compare the survival of epikeratophakia tissue lenses prepared with cryolathing and lyophilization (frozen lenses) and without (fresh lenses) in donor-sensitized recipients with vascularized corneas. Fresh lenses placed in vascularized corneas of immune recipients were subjected to immune attack. Frozen lenses placed in vascularized corneas of immunized recipients did not elicit an immune reaction. Neither fresh nor frozen lenses elicited immune reactions in nonvascularized corneas of immune recipients or in nonvascularized, nonimmune recipients. These results indicate that although the fresh lenses are more antigenic than the lenses in which the cells have been killed by freezing and lyophilization, the fresh lenses prepared using the BKS-1000 technique containing living stromal keratocytes are not likely to stimulate allograft immune reactions in unsensitized patients with avascular graft sites.
    No preview · Article · Jan 1991 · Refractive & corneal surgery
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    ABSTRACT: Prior to undertaking a study in sighted human eyes, we performed photorefractive keratectomy with the 193-nm excimer laser for the correction of myopia in nine legally blind eyes to evaluate safety, efficacy, predictability, and stability. In most cases, reepithelialization was complete by 5 days after surgery; no recurrent erosions were seen. By the end of the 6-month study, all of the corneas had a 0 or 1+ clarity score, on a scale of 0 (clear) to 5+ (opaque). Keratometry and pachometry demonstrated stable flattening of the corneas. One month after surgery, changes in refraction evaluated by retinoscopy showed fair predictability, with no significant increase in refractive or keratometric astigmatism, followed by some regression of effect by the end of the study, possibly caused by anatomical remodeling. The amount of regression appeared to be directly related to the amount of correction intended, suggesting that this effect would not be clinically important in the treatment of mild to moderate myopia.
    No preview · Article · Jul 1990 · Archives of Ophthalmology
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    ABSTRACT: Five patients with Down's syndrome underwent penetrating keratoplasty for keratoconus. In three patients, the indication for surgery was acute corneal hydrops, which had not resolved in the three months before surgery. The other two patients had corneal scars. Two patients had combined penetrating keratoplasty, cataract extraction, and intraocular lens insertion. Four of the five patients maintained clear grafts at their most recent follow-up examination. Two of the five patients had one or more graft reaction episodes; one graft was lost. Good results can be obtained in penetrating keratoplasty for keratoconus in patients with Down's syndrome who do not demonstrate a tendency toward excessive eye rubbing and for whom a single observant caretaker can be relied on to provide consistent postoperative care.
    No preview · Article · Mar 1990 · American Journal of Ophthalmology
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    ABSTRACT: Photorefractive keratectomy for the correction of myopia was performed in 32 eyes of 16 green monkeys. The corneas healed satisfactorily, with normal formation of basal lamina and hemidesmosomal attachments visible in 14-week histologic specimens. No recurrent erosions were observed clinically. After a transient period of faint haze, all corneas were clear at 17 weeks and remained clear through the 1-year follow-up. In terms of accuracy, all corneas demonstrated a significant flattening compared with preoperative values, but no significant difference was seen between the groups with different intended corrections (1.5 and 3 diopters). The changes in corneal shape stabilized by 17 weeks, as measured by keratometry. The clinical results suggest that mechanical removal of the epithelium is preferable to laser ablation of the epithelium. Overall, the results demonstrate that excimer laser ablation of the corneal stroma can produce a stable diptric change in the primate cornea with good healing and long-term corneal clarity.
    No preview · Article · Feb 1990 · Archives of Ophthalmology
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    ABSTRACT: We evaluated the effect of a collagen shield on epithelial healing in keratectomy wounds in rabbit eyes. Superficial keratectomies 6 mm in diameter were created in 12 eyes of six rabbits. Six eyes received collagen shields every eight hours; six eyes received no treatment (control group). Epithelial healing was significantly faster (P less than .01) in corneas treated with collagen shields (47.8 +/- 1.1 microns/hr) compared to untreated control corneas (40.8 +/- 1.6 microns/hr). Regression analysis gave a projected time for closure of treated corneas of 73.96 hours, compared to 83.41 hours for untreated corneas. Scanning electron microscopy of collagen shields after eight hours of wear showed a large number of polymorphonuclear leukocytes entrapped in the collagen matrix. Light microscopy of healed corneas showed that the appearance of the regenerated epithelium in treated and untreated corneas was similar. These results demonstrate that collagen shields speed reepithelialization of keratectomy wounds in the rabbit cornea.
    No preview · Article · Dec 1989 · American Journal of Ophthalmology
  • Jonathan M. Frantz · Marguerite B. McDonald · Herbert E. Kaufman
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    ABSTRACT: In the Nationwide Study of Epikeratophakia, 22 eyes underwent penetrating keratoplasty (PKP) after epikeratophakia for keratoconus. Reasons for PKP included visual acuity unsatisfactory to the patients (6 eyes), recipient corneal scarring (4 eyes), recipient Descemet's folds (3 eyes), scarring in the tissue lens (2 eyes), vascularization of the tissue lens (2 eyes), astigmatism (2 eyes), failure of the tissue lens to reepithelialize (1 eye), corneal ulcer (1 eye), and scarring of the donor and recipient cornea (1 eye). After PKP, all patients had clear grafts and 20/40 or better visual acuity. Average follow-up was 17 months. Three of the 22 patients (13.6%) had graft reaction episodes, all of which were treated successfully, resulting in clear grafts. The authors conclude that previous epikeratophakia does not adversely affect the outcome of subsequent PKP for keratoconus.
    No preview · Article · Sep 1989 · Ophthalmology
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    ABSTRACT: We report a case of a patient who received excimer laser ablation that was designed to flatten the cornea in a putatively blind eye. This was performed as part of the early human safety and efficacy 'blind eye' trials under the aegis of the Investigational Device Exemption granted by the Food and Drug Administration to Dr Trokel. Within 7 weeks of laser ablation, the patient, who had apparently been suffering from functional rather than physiologic blindness, had a visual acuity of 20/25 and then 20/20 without correction. After 6 months of follow-up, the cornea remained clear and the visual acuity appeared to be stable. This is, to our knowledge, the first report of good visual results in a human eye from central photorefractive keratectomy with the excimer laser for the correction of myopia.
    No preview · Article · Jun 1989 · Archives of Ophthalmology
  • J M Frantz · J J Reidy · M B McDonald
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    ABSTRACT: Surgical keratometers were conceived as an aid that would help anterior segment surgeons minimize postoperative astigmatism, a major obstacle along the road to rapid visual rehabilitation. Two classes of surgical keratometers are commercially available at present. The first class of devices produces a keratoscopic image from which the surgeon must make a qualitative assessment of both the amount and location of astigmatism based upon distortion present in the keratoscopic image. The second class of devices quantitates corneal power at a chosen meridian and providing the surgeon with either an analogue or digital readout. Usually it is up to the surgeon to identify the meridian of greatest corneal power based on qualitative alterations of the keratoscopic image. These keratoscopes are based either on the optical principles of the von Helmholtz keratometer, or on nonparallel electronic image digitization. In this article we critically review commercially available surgical keratometers emphasizing their attributes and limitations.
    No preview · Article · Jan 1989 · Refractive & corneal surgery
  • Jonathan M. Frantz · Donald R. Bergsma

    No preview · Article · Dec 1988 · American Journal of Ophthalmology
  • J M Frantz · M B Limberg · H E Kaufman · M B McDonald
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    ABSTRACT: Seven patients underwent penetrating keratoplasty after epikeratophakia for keratoconus. All seven patients achieved clear grafts and 20/40 or better best corrected visual acuity after penetrating keratoplasty. Three of the seven patients had one or more episodes of rejection after penetrating keratoplasty; all were treated successfully. No grafts were lost. The results in terms of graft clarity and visual acuity are comparable with those in patients undergoing penetrating keratoplasty for keratoconus with no previous ocular surgery. Whether the relatively high rate of rejection episodes (three [43%]) seen in this small number of patients indicates some relationship between previous epikeratophakia and subsequent rejection after penetrating keratoplasty remains to be seen.
    No preview · Article · Oct 1988 · Archives of Ophthalmology

  • No preview · Article · Oct 1987 · American Journal of Ophthalmology

Publication Stats

220 Citations
39.22 Total Impact Points


  • 1989-1991
    • Louisiana State University
      Baton Rouge, Louisiana, United States
    • Louisiana State University Health Sciences Center New Orleans
      • Eye Center
      New Orleans, Louisiana, United States