Che-Chou Shen

National Taiwan University of Science and Technology, T’ai-pei, Taipei, Taiwan

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Publications (57)52.93 Total impact

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    Che-Chou Shen · Chun-Kai Peng
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    ABSTRACT: Dual-frequency (DF) harmonic imaging simultaneously utilizes the imaging information at both f0and 2f0 frequencies. When phase-coded complementary Golay sequence is combined with DF harmonic imaging to improve signal-to-noise ratio, however, the mutual crosstalk between the f0and 2f0 imaging bands may degrade the image quality. In this study, orthogonal encoding is proposed to suppress the crosstalk artifacts byencoding the f0 and 2f0imaging signals as a1(n) and a2(n) sequence in the first firing and b1(n) and b2(n) sequence in the second firing. The a1(n), b1(n) is one complementary Golay pair and the a2(n), b2(n) is another complementary Golay pair. The two complementary pairs are orthogonal to each other. Both hydrophone measurement and B-mode imaging show that the orthogonal encoding effectively suppresses the mutual crosstalk and restore the resultant main lobe width after Golay decoding.
    Preview · Article · Dec 2015 · Physics Procedia
  • Che-Chou Shen · Jun-Kai Peng · Chi Wu · Chia-Yuan Liu
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    ABSTRACT: Dual-frequency (DF) tissue harmonic imaging has been developed to take advantage of not only harmonic signal at second harmonic (2f0) frequency but also the inter-modulation harmonic signal at fundamental (f0) frequency for simultaneous nonlinear detection. Though phase-encoded Golay pair can improve the signal-to-noise ratio of DF harmonic signal at both f0 and 2f0 frequencies, conventional matched filtering cannot correctly decode the crosstalk from harmonic components at DC and third harmonic (3f0) frequency and will lead to range side lobe artifacts in DF harmonic imaging. For orthogonal Golay pair, however, exchanging the decoding filter will output zero for the signal and keep the crosstalk the same. Therefore, the output of exchanged filtering can be subtracted from that of the original matched filtering to completely remove the spectral crosstalk. Compared to phase inversion method, the proposed orthogonal Golay decoding does not require additional transmits to cancel the unwanted DC and 3f0 harmonic interferences and thus the achievable frame rate remains the same. Various experiments have been performed to verify the efficacy of the proposed orthogonal Golay decoding. Results from hydrophone measurements indicate that the proposed method effectively suppresses the spectral overlap between the harmonic signal and the interference. Corresponding range side lobe level (RSLL) can be suppressed by 10–20 dB when the signal bandwidth is 60%. B-mode harmonic imaging also demonstrates a reduction of side lobe magnitude (SLM) by 8 dB at 2f0 frequencies.
    No preview · Article · Apr 2015 · Biomedical Signal Processing and Control
  • Che-Chou Shen · Chi Wu · Jun-Kai Peng
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    ABSTRACT: Background In dual-frequency (DF) harmonic imaging, the second harmonic signal at second harmonic (2f0) frequency and the inter-modulation harmonic signal at fundamental (f0) frequency are simultaneously imaged for spectral compounding. When the phase-encoded Golay pair is utilized to improve the harmonic signal-to-noise ratio (SNR), however, the DF imaging suffers from range side lobe artifacts due to spectral cross-talk with other harmonic components at DC and third harmonic (3f0) frequency. Methods In this study, a supplementary Golay pair is developed to suppress the range side lobes in combination with the original Golay pair. Since the phase code of the DC interference cannot be manipulated, the supplementary Golay is designed to reverse the polarity of the 3f0 interference and the f0 signal while keeping the 2f0 signal unchanged. For 2f0 imaging, the echo summation of the supplementary and the original Golay can cancel the 3f0 interference. On the contrary, the echo difference between the two Golay pairs can eliminate the DC interference for f0 imaging. Results Hydrophone measurements indicate that the range side lobe level (RSLL) increases with the signal bandwidth of DF harmonic imaging. By using the combination of the two Golay pairs, the achievable suppression of RSLL can be 3 and 14 dB, respectively for the f0 and 2f0 harmonic signal. B-mode phantom imaging also verifies the presence of range side lobe artifacts when only the original Golay pair is utilized. In combination with the supplementary Golay pair, the artifacts are effectively suppressed. The corresponding range side lobe magnitude reduces by about 8 dB in 2f0 imaging but remains unchanged in f0 imaging. Meanwhile, the harmonic SNR improves by 8–10 dB and the contrast-to-noise ratio of harmonic image increases from about 1–1.2 by spectral compounding. Conclusion For DF tissue harmonic imaging, the spectral cross-talk in Golay excitation results in severe range side lobe artifacts. To restore the image quality, two particular phase-encoded Golay pairs are required to perform either echo summation or difference for elimination of unwanted harmonic components.
    No preview · Article · Oct 2014 · Ultrasonics
  • Che-Chou Shen · Jun-Kai Peng · Chi Wu
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    ABSTRACT: Dual-band (DB) harmonic imaging is performed by transmitting and receiving at both fundamental band ( f0) and second-harmonic band (2f0). In our previous work, particular chirp excitation has been developed to increase the signal- to-noise ratio in DB harmonic imaging. However, spectral overlap between the second-order DB harmonic signals results in range side lobes in the pulse compression. In this study, a novel range side lobe inversion (RSI) method is developed to alleviate the level of range side lobes from spectral overlap. The method is implemented by firing an auxiliary chirp to change the polarity of the range side lobes so that the range side lobes can be suppressed in the combination of the original chirp and the auxiliary chirp. Hydrophone measurements show that the RSI method reduces the range side lobe level (RSLL) and thus increases the quality of pulse compression in DB harmonic imaging. With the signal bandwidth of 60%, the RSLL decreases from ¿23 dB to ¿36 dB and the corresponding compression quality improves from 78% to 94%. B-mode images also indicate that the magnitude of range side lobe is suppressed by 7 dB when the RSI method is applied.
    No preview · Article · Feb 2014 · IEEE transactions on ultrasonics, ferroelectrics, and frequency control
  • Che-Chou Shen · Jyun-Gong Yu
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    ABSTRACT: Doppler flow estimation suffers from the weak backscattering from the red blood cells in the vessel. Thus, a novel method is proposed in this study for Doppler detection utilizing Golay-coded excitation to improve signal-to-noise ratio (SNR). Unlike traditional Golay decoding which is limited to low-velocity flow to avoid motion artifact, the proposed decoding is applicable to both high flow velocity and low flow velocity. The analyses show that the main lobe component of Golay code can produce the correct Doppler frequency but the range side lobe counterpart erroneously shifts by half of the pulse-repetition-frequency (PRF). Thus, an optimized decoding filter whose low-pass cut-off frequency is PRF/4 in the slow-time is developed. The PRF/4 filter can retain the main lobe component with Doppler frequency within ±PRF/4 while eliminating the side lobe component outside ±PRF/4. The experimental results demonstrate that the range side lobe level (RSLL) is effectively suppressed by the PRF/4 filter compared to the conventional and the modified methods. In the case of high flow velocity, the color-flow image (CFI) with the PRF/4 filter exhibits accurate estimation of the flow region while the conventional and the modified methods suffer from noticeable side lobe artifacts. In condition, the performance of Golay excitation improves in Doppler detection by using the PRF/4 filter for decoding.
    No preview · Conference Paper · Jul 2013
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    ABSTRACT: In our previous studies we explored the potential of using a combined US/magnetic resonance (MR) multimodality contrast agent, albumin-gadolinium-diethylenetriaminepentacetate (Gd-DTPA) MBs, to induce BBB opening and for distinguishing between FUS-induced BBB opening and intracerebral hemorrhage in MR T1-weighted contrast imaging. According to the previous study in the literature, 1-2 µm bubbles have more pronounced acoustic activity at frequencies above 10 MHz. The present study developed a new targeted US/MR multimodality MB and the acoustic properties were compared with two commercial MBs, SonoVue and Targestar SA. The acoustic activities of these 1.15-2.78 µm MBs with different shells at 10 MHz were investigated. The feasibility of designing a new targeted US/MR multimodality MB was investigated. The lifetime (survival of MBs in the liquid suspension) and attenuation properties of lipid MBs (SonoVue and Targestar SA), albumin-(Gd-DTPA) MBs, and avidin-conjugated albumin (avidin-albumin)-(Gd-DTPA) MBs at 10 MHz were investigated with the pulse-echo substitution method. It was found that incorporating avidin into the albumin MBs and avidin-albumin-(Gd-DTPA) MBs affects the size distribution but does not affect the concentration of MBs produced. The avidin-albumin-shelled MBs had more significant nonlinear activity at 4-18 MHz (p=0.025), while the nonlinear activity of the other MBs peaked at 6-24 MHz (p=0.003-0.044). Moreover, the incorporation of paramagnetic metal ions into the MB shells increased their attenuation coefficients. With regard to the lifetime of these agents, the attenuations of the SonoVue and Targestar SA lipid MBs were 87.96% and 8.74%, respectively, while those of albumin MBs, avidin-albumin MBs, albumin-(Gd-DTPA) MBs, and avidin-albumin-(Gd-DTPA) MBs were 49.52%, 41.38%, 74.69%, and 100%, respectively. Avidin conjugation decreased the lifetime of the albumin MBs, but not that of the lipid MBs. The incorporation of paramagnetic metal ions into the shells of albumin MBs did not decrease the lifetime.
    No preview · Article · Jul 2013 · Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
  • Che-Chou Shen · Chun-Kai Peng
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    ABSTRACT: Compared to conventional single-frequency harmonic imaging, dual-frequency harmonic imaging has been proposed by transmitting and receiving at both fundamental frequency (f0) and second harmonic frequency (2f0) to achieve spectral compounding for improved image quality. In our previous work, particular chirp excitation is developed to boost the harmonic generation for dual-frequency harmonic imaging while maintaining the harmonic signal bandwidths. However, spectral overlap between the harmonic imaging bands may lead to marked range side lobes and corresponding image artifacts. In this study, a range side lobe inversion (RSI) method has been developed to change the polarity of the range side lobes by firing an auxiliary chirp. When the original and auxiliary chirps are combined, the range side lobes can be eliminated. The RSI method has been verified using hydrophone measurement and B-mode imaging. When the signal bandwidth is 60 %, the compression quality improves by 16 % which corresponds to a 7-dB decrease of side-lobe-magnitude (SLM) in harmonic imaging. Therefore, the RSI method can effectively eliminate the range side lobes and suppress the image artifacts in DF harmonic imaging.
    No preview · Conference Paper · Jul 2013
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    ABSTRACT: It has been shown that microbubble (MB)-enhanced focused ultrasound (FUS) temporally and locally disrupts the blood-brain barrier (BBB), thereby enhancing drug delivery into brain tumors Imaging tumor angiogenesis with contrast-enhanced ultrasound (US) has been explored with targeted MBs. The BBB opening threshold and BBB opening volume were found to be bubble-size-dependent. However, the relationships between the various components of bubble shells and BBB opening are still unclear. According to a previous study, 1-2 mu m bubbles have the most pronounced acoustic activity at frequencies above 10 MHz. The present study developed targeted US/magnetic resonance (MR) multimodality MBs, whose acoustic properties were compared with two commercial MBs, namely SonoVue and Targestar SA. The acoustic activities of these 1.15-2.78 mu m MBs with different shells at 10 MHz were investigated. The lifetime and attenuation properties of lipid MBs (SonoVue and Targestar SA), albumin-(Gd-DTPA) MBs, and avidin-conjugated albumin (avidin-albumin)-(Gd-DTPA) MBs at 10 MHz were investigated with the pulse-echo substitution method. It was found that incorporating avidin into the albumin MBs and albumin-(Gd-DTPA) MBs affects the size distribution but does not affect the concentration of MBs produced. The avidin-albumin-shelled MBs had more significant nonlinear activity at 4-18 MHz (p = 0.025), whereas the nonlinear activity of the other MBs peaked at 6-24 MHz (p = 0.003-0.044). Moreover, the incorporation of paramagnetic metal ions into the MB shells increased their attenuation coefficients. With regard to the lifetime of these agents, the attenuations of the SonoVue and Targestar SA were 87.96% and 8.74%, respectively, and those of albumin, avidin-albumin, albumin-(Gd-DTPA), and avidin-albumin-(Gd-DTPA) MBs were 49.52%, 41.38%, 74.69%, and 100%, respectively. Avidin conjugation decreased the lifetime of the albumin MBs, but not that of the lipid MBs. The incorporation of paramagnetic metal ions into the shells of albumin MBs did not decrease their lifetime.
    No preview · Article · Jan 2013 · Journal of Medical and Biological Engineering
  • Che-Chou Shen · Hui-Ting Wang
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    ABSTRACT: Background: The presence of tissue harmonic generation during acoustic propagation is one major limitation in nonlinear detection of microbubble contrast agents. However, conventional solutions for tissue harmonic suppression are not applicable in dual-frequency (DF) harmonic imaging. In DF harmonic imaging, the second harmonic signal at second harmonic (2f(0)) frequency and the inter-modulation harmonic signal at fundamental (f(0)) frequency are simultaneously generated for imaging and both need to be suppressed to improve contrast-to-tissue ratio (CTR). In this study, a novel phase-coded pulse sequence is developed to accomplish DF tissue harmonic suppression. Methods: Phase-coded pulse sequence utilizes multiple firings with equidistant transmit phase for harmonic cancellation in the sum of respective echoes. For the f(0) transmit component, the transmit phase comes from the equidistant set of {-2π/3, 0, 2π/3} to suppress the second harmonic signal at 2f(0) frequency. Moreover, in order to provide the inter-modulation harmonic suppression at f(0) frequency, the 2f(0) transmit phase has to be particularly manipulated for the corresponding f(0) transmit phase. Results: The proposed three-pulse sequence can remove not only the second-order harmonic signal but also other higher-order counterparts at both f(0) and 2f(0) frequencies. Measurements were performed at f(0) equal to 2.25 MHz and using hydrophone in water and contrast agents in tissue phantom. Experimental results indicate that the sequence reduces the tissue harmonic magnitude by about 20 dB along the entire axial depths and the corresponding CTR improves at both frequencies. Conclusion: In DF harmonic imaging, the proposed phase-coded sequence can effectively remove the tissue harmonic background at both f(0) and 2f(0) frequencies for improvement of contrast detection.
    No preview · Article · Nov 2012 · Ultrasonics
  • Che-Chou Shen · Chin-Hsiang Lin
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    ABSTRACT: Dual-frequency (DF) transmit waveforms comprise signals at two different frequencies. With a DF transmit waveform operating at both fundamental frequency ( f(0)) and second-harmonic frequency 2f((0)), tissue harmonic imaging can be simultaneously performed using not only the conventional 2f(0) second-harmonic signal but also using the f(0)frequency difference harmonic signal. Nonetheless, when chirp excitation is incorporated into the DF transmit waveform for harmonic SNR improvement, a particular waveform design is required to maintain the bandwidth of the f(0) harmonic signal. In this study, two different DF chirp waveforms are proposed to produce equal harmonic bandwidth at both the f(0) and 2f(0) frequencies to achieve speckle reduction by harmonic spectral compounding and to increase harmonic SNR for enhanced penetration and sensitivity. The UU13 waveform comprises an up-sweeping f(0) chirp and an up-sweeping 2f(0) chirp with triple bandwidth, whereas the UD11 waveform includes an up-sweeping f(0) chirp and a down-sweeping 2f(0) chirp with equal bandwidth. Experimental results indicate that the UU13 tends to suffer from a high range side lobe level resulting from 3f(0) interference. Consequently, the 2f(0) harmonic envelopes of the UD11 and the UU13 waveforms have compression qualities of 87% and 77%, respectively, when the signal bandwidth is 30%. When the bandwidth increases to 50%, the compression quality of the 2f(0) harmonic envelope degrades to 78% and 54%, respectively, for the UD11 and the UU13 waveforms. The compression quality value of the f0 harmonic envelope remains similar between the two DF transmit waveforms for all signal bandwidths. B-mode harmonic images also show that the UD11 is less contaminated by range side lobe artifacts than is the UU13. Compared with a short pulse with equal bandwidth, the UD11 waveform not only preserves the same spatial resolution after compression but also improves the image SNR by about 10 dB. Moreover, the image contrast-to-noise ratio (CNR), defined as the ratio of the mean to the standard deviation of image intensity in the speckle region, can be increased from 1.0 to about 1.2 when DF spectral compounding is performed. Therefore, it is concluded that the UD11 waveform is a potential solution for chirp-encoded DF harmonic imaging.
    No preview · Article · Nov 2012 · IEEE transactions on ultrasonics, ferroelectrics, and frequency control
  • Po-Wen Cheng · Che-Chou Shen · Pai-Chi Li
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    ABSTRACT: Using software for beamforming in ultrasound systems provides high flexibility, and the large number of computations required in a software-based system can be performed in real time on a PC. However, the very large data transfer rate required from the ultrasound front-end to the PC host for real-time operation is a bottleneck which cannot be overcome without appropriate compression. Previous studies have examined JPEG compression of ultrasound RF channel data, but the schemes do not exploit temporal redundancy between adjacent frames. This study utilized MPEG technology to process the ultrasound RF data to increase the compression efficiency. Our results indicate that MPEG compression generally provides a better compression ratio than does JPEG compression. As an example, the compression ratio of MPEG compression in an 8-bit channel A/D data under 5 μm interframe displacement is smaller than 0.13, thus allowing real-time data transfer requirements to be met. Moreover, the compression efficiency for motions in different directions is shown to be highly dependent on the frame-to-frame correlation.
    No preview · Article · Jul 2012 · IEEE transactions on ultrasonics, ferroelectrics, and frequency control
  • Hui-Ting Wang · Che-Chou Shen
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    ABSTRACT: The presence of tissue harmonic generation during acoustic propagation is one major limitation in nonlinear detection of microbubble contrast agents. However, conventional solutions for suppression of tissue harmonic background are not directly applicable when dual-frequency (DF) waveform is utilize for transmit. In DF harmonic imaging, the second harmonic signal at second harmonic frequency (2f0) and the inter-modulation harmonic signal at fundamental frequency (f0) are simultaneously produced and both need to be suppressed for imaging of contrast agents. In this study, novel phase-coded pulse sequences are developed to accomplish DF harmonic suppression. The proposed three-pulse sequence can effectively remove the second-order harmonic signal by producing equidistant phases for cancellation in the sum of different firings. Therefore, the tissue background in DF harmonic imaging can be mostly suppressed. Experiments have been performed to validate the efficacy of the proposed sequence. It is shown that the sequence effectively suppresses the tissue harmonic signal at both f0 and 2f0 frequencies to improve CTR.
    No preview · Conference Paper · Jan 2012
  • Tai-yu Shi · Che-chou Shen
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    ABSTRACT: Ultrasound tissue harmonic signal generally provides superior image quality as compared to the linear signal but with limited penetration and the sensitivity due to low signal-to-noise ratio (SNR). The method of third harmonic (3f0) transmit phasing can improve the tissue harmonic SNR by transmitting at both the fundamental and the 3f0 frequencies to provide mutual enhancement between the second harmonic components. To further increase the SNR without excessive transmit pressure, the phase-encoded Golay excitation can be incorporated in 3f0 transmit phasing to boost the tissue harmonic generation. The resultant frequency-sum and frequency-difference components of tissue harmonic signal can be simultaneously Golay-encoded for SNR improvement. Results indicate that the tissue harmonic SNR increases by about 11 dB without noticeable compression artifacts.
    No preview · Article · Jan 2012
  • Chin-Hsiang Lin · Che-Chou Shen
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    ABSTRACT: Dual-frequency (DF) transmit waveform comprises of signals at both fundamental frequency (f0) and second harmonic frequency (2f0). With the DF transmit waveform, tissue harmonic imaging can be simultaneously performed not only using the conventional 2f0 second harmonic signal but also the f0 frequencydifference harmonic signal. Nonetheless, when chirp excitation is incorporated into the DF transmit waveform for improvement of harmonic SNR, particular waveform design is required to maintain the bandwidth of the f0 harmonic signal. In this study, two different chirp waveforms (i.e., UD11 and UU13) are proposed to provide the desired signal bandwidth. Experimental results indicate that the UU13 tends to suffer from high range side lobe level due to severe 3f0 interference. Consequently, the 2f0 harmonic envelope of the UD11 is consistently superior to that of the UU13 while the quality of the f0 harmonic envelope remains similar between the two DF transmit waveforms. B-mode harmonic images also show that the UD11 is less susceptible to range side lobe artifacts than the UU13. Therefore, it is concluded that the UD11 waveform is a better solution for chirp-encoded DF harmonic imaging.
    No preview · Conference Paper · Jan 2012
  • Che-Chou Shen · Hsin-Hsien Wu · Chih-Kuang Yeh
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    ABSTRACT: In high-frequency swept-scan Doppler system, the spectral broadening of tissue clutter limits the detectability of low-velocity flow signal. Conventionally, the scanning speed of transducer has to be reduced to alleviate the clutter interference but at the cost of imaging frame rate. With third harmonic (3f0) transmit phasing, the tissue harmonic clutter is suppressed and the cut-off frequency of wall filtering can be reduced to preserve low-velocity flow without compromising the frame rate. Our results indicate that the 3f0 transmit phasing effectively reduces the harmonic clutter magnitude and thus improves the flow signal-to-clutter ratio. Compared to the conventional counterpart, the clutter-suppressed color flow and power Doppler images show fewer clutter artifacts and is capable of detecting more low-velocity flow of microbubbles. The resultant color-pixel-density also improves with clutter suppression. For the swept-scan high-frequency system, 3f0 transmit phasing is capable of providing effective clutter suppression. With the same achievable scanning speed, the resultant Doppler image has higher sensitivity for low-velocity flow and is less susceptible to clutter artifacts.
    No preview · Conference Paper · Oct 2011
  • Che-Chou Shen · Hsin-Hsien Wu
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    ABSTRACT: High-frequency Doppler imaging is highly potential for detection of blood flow in microcirculation. In a swept-scan system, however, the spectral broadening of tissue clutter limits the detectability of low-velocity flow signal. Conventionally, the scanning speed of transducer has to be reduced to alleviate the clutter interference but at the cost of imaging frame rate. For example, the blood velocity of 0.5mm/s becomes detectable only with a scanning speed lower than 1mm/s. In this study, an alternative method is examined by suppressing the clutter magnitude to reduce the interference to flow signal without sacrificing scanning speed. The method of third harmonic (3f(0)) transmit phasing can suppress the tissue harmonic clutter by transmitting at the fundamental and the additional 3f(0) frequencies to achieve mutual cancellation between the frequency-sum and the frequency-difference components of the second harmonic signal. With 3f(0) transmit phasing, the cut-off frequency of wall filtering can be reduced to preserve low-velocity flow without compromising the frame rate. Our results indicate that the 3f(0) transmit phasing effectively reduces the harmonic clutter magnitude and thus improves the flow signal-to-clutter ratio. Compared to the conventional counterpart, the clutter-suppressed color flow and power Doppler images show fewer clutter artifacts and is capable of detecting more low-velocity flow of microbubbles. The resultant color-pixel-density also improves with clutter suppression. For the swept-scan high-frequency (>20MHz) system, 3f(0) transmit phasing is capable of providing effective clutter suppression. With the same achievable scanning speed, the resultant Doppler image has higher sensitivity for low-velocity flow and is less susceptible to clutter artifacts.
    No preview · Article · Aug 2011 · Ultrasonics
  • Che-Chou Shen · Shin-Yuan Su · Chih-Hao Cheng · Chih-Kuang Yeh
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    ABSTRACT: The goal of this work is to examine the effects of pulse-inversion (PI) technique in combination with dual-frequency (DF) excitation method to separate the high-order nonlinear responses from microbubble contrast agents for improvement of image contrast. DF excitation method has been previously developed to induce the low-frequency ultrasound nonlinear responses from bubbles by using the composition of two high-frequency sinusoids (f(1) and f(2)). Although the simple filtering was conventionally utilized to provide signal separation, the PI approach is better in the sense that it minimizes the mutual interferences among these high-order nonlinear responses in the presence of spectral overlap. The novelty of the work is that, in addition to the common PI summation, the PI subtraction was also applied in DF excitation method. DF excitation pulses having an envelope frequency of 3MHz (i.e., f(1)=8.5MHz and f(2)=11.5MHz) with pulse lengths of 3-10μs and the pressure amplitudes from 0.5 to 1.5MPa were used to interrogate the nonlinear responses of SonoVue™ microbubbles in the phantom experiments. The high-order nonlinear responses in the DF excitation were extracted for contrast imaging using PI summation for even-order nonlinear components or PI subtraction for odd-order nonlinear ones. Our results indicated that, as compared to the conventional filtering technique, the PI processing effectively increases the contrast-to-tissue ratio (CTR) of the third-order nonlinear response at 5.5MHz and the fourth-order nonlinear response at 6MHz by 2-5dB. For these high-order nonlinear components, the CTR increase varies with the transmission pressures from 0.5 to 1.5MPa due to the microbubbles' displacement induced by the radiation force of DF excitation. For DF excitation technique, the PI processing can help to extract either the odd-order or the even-order nonlinear components for higher CTR estimates.
    No preview · Article · Jun 2011 · Ultrasonics
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    ABSTRACT: This report describes a system that utilizes a single high-intensity focused ultrasound (HIFU) transducer for both the localization and ablation of arteries with internal diameters of 0.5 and 1.3 mm. In vitro and in vivo tests were performed to demonstrate both the imaging and ablation functionalities of this system. For imaging mode, pulsed acoustic waves (3 cycles for in vitro and 10 cycles for in vivo tests, 2 MPa peak pressure) were emitted from the 2-MHz HIFU transducer, and the backscattered ultrasonic signal was collected by the same transducer to calculate Doppler shifts in the target region. The maximum signal amplitude of the Doppler shift was used to determine the location of the target vessel. The operation mode was then switched to the therapeutic mode and vessel occlusion was successfully produced by high-intensity continuous HIFU waves (12 MPa) for 60 s. The system was then switched back to imaging mode for residual flow to determine the need for a second ablation treatment. The new system might be used to target and occlude unwanted vessels such as vasculature around tumors, and to help with tumor destruction.
    Full-text · Article · May 2011 · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control
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    Chih-Hao Cheng · Che-Chou Shen · Chih-Kuang Yeh
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    ABSTRACT: The method of dual-frequency (DF) difference excitation is capable of generating a low-frequency envelope component as the driving force of commercial contrast microbubbles by using a high-frequency pulse. Although the DF difference excitation method provides good lateral resolution in high-frequency contrast imaging, it suffers from degraded axial resolution because a longer-than-usual envelope component is required to induce the oscillation of microbubbles. In this study, a coded excitation technique (i.e. chirp waveform) is combined with the DF difference excitation method (also referred to as the DF chirp excitation method) to improve the axial resolution of contrast imaging while maintaining the impinging insonation energy. B-mode images were constructed to compare the performance of the DF chirp excitation method with the conventional tone-burst pulse method. Results indicate that the proposed DF chirp excitation method can provide better axial resolution after pulse compression. Moreover, as compared to the tone-burst pulse with the same pulse duration, the pulse compression results in a higher signal-to-noise ratio because of the temporal concentration of the received energy. Nevertheless, images with the DF chirp excitation method demonstrated noticeable image artefacts resulting from the range sidelobes. The DF chirp excitation method also produced obvious tissue harmonic generation that could degrade the contrast-to-tissue ratio at higher acoustic pressures.
    Preview · Article · Apr 2011 · Physics in Medicine and Biology
  • Che-Chou Shen · Tai-Yu Shi
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    ABSTRACT: Golay-encoded excitation in combination with the third harmonic (3f<sub>0</sub>) transmit phasing is examined for both signal-to-noise ratio (SNR) and contrast-to-tissue ratio (CTR) improvements in harmonic imaging of contrast microbubbles. To produce the cancellation pair of tissue harmonic signal in 3f<sub>0</sub> transmit phasing, the phase of the bit waveform is properly designed for both the fundamental and the 3f<sub>0</sub> transmit signals to provide the Golay encoding of the received harmonic responses. Results indicate that the proposed Golay excitation can effectively suppress the tissue harmonic amplitude to increase CTR. Meanwhile, the SNR of the contrast harmonic signal also improves because of the elongated waveform of Golay excitation. Nevertheless, the generation of marked range side-lobes of the bubble region would degrade the achievable SNR improvement and the image contrast, especially when the bit of Golay excitation increases. The range side-lobes could result from the nonlinear resonance of the microbubbles that interferes with the phase modulation of the Golay encoding.
    No preview · Article · Mar 2011 · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control

Publication Stats

286 Citations
52.93 Total Impact Points

Institutions

  • 2007-2015
    • National Taiwan University of Science and Technology
      • Department of Electrical Engineering
      T’ai-pei, Taipei, Taiwan
  • 2000-2010
    • National Taiwan University
      • Department of Electrical Engineering
      T’ai-pei, Taipei, Taiwan
  • 2008
    • National Tsing Hua University
      • Department of Biomedical Engineering and Environmental Sciences
      Hsinchu, Taiwan, Taiwan