J P Donzeau

Clinique Pasteur, Toulouse, Tolosa de Llenguadoc, Midi-Pyrénées, France

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Publications (34)11.63 Total impact

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    ABSTRACT: The purpose of this study was to determine whether left atrial appendage flow velocity, as determined using trans esophageal echocardiography (TEE), predicts the outcome after catheter ablation of persistent atrial fibrillation (PAF).Method40 PAF patients (85% males, 60 +/− 11 years) underwent a stepwise ablation approach. The procedural end point was termination of persistent AF by catheter ablation, either by conversion directly to sinus rhythm or to atrial tachycardia. Left atrial appendage (LAA) peak flow velocities were measured with transesophageal echography and averaged within each RR interval of 10 consecutive cardiac cycles. Others parameters LA area, left ventricular ejection fraction, duration of continuous AF, Administration of amiodarone, were analyzed to determine the factors associated with procedural termination of arrhythmia.ResultsAmong the 40 patients, all received a circumferential PV isolation, a linear ablation, and a continuous CFE ablation. Atrial fibrillation was terminated in 26 patients (65%) with a mean procedure time of 201 min+/−43 min. The pre-procedural ejection fraction (p = 0.38), duration of continuous AF (p = 0.09) did not differ significantly between patients who had success of catheter ablation compared with those who had not. Peak emptying velocities of the LAA before catheter ablation were significantly higher in patients in whom PAF was terminated during the procedure (0.23 vs. 0.34, p = 0.002). On multivariate logistic regression analysis, only the mean LAA peak emptying velocity > 0.30 cm/s (p = 0.02, odds ratio [OR] = 9, 58 confidence interval [CI] 95% = 1.50 to 61.36), predicted successful catheter ablation for PAF. At 6 months follow-up, patients who underwent continued to have sinus rhythm, were significantly (p = 0, 003) higher in group who have LAA flow velocity > 0, 30.Conclusion High LAA flow velocity assessed by TEE is a clinically useful pre-ablation tool for predicting successful catheter ablation for persistent atrial fibrillation and maintenance of sinus rhythm.
    Full-text · Article · Jan 2011 · Archives of Cardiovascular Diseases Supplements
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    ABSTRACT: The authors underline the importance of carrying out a simple clinical examination to assess the level of two-to-one auriculoventricular block before any invasive electrophysiological procedures are performed. Clinical examination can indeed easily distinguish between the two different prognostic entities, represented by nodal and infra-nodal atrioventricular block. This initial evaluation of the severity of conduction disorders, as soon as the patient arrives at the emergency department or attends a consultation, may be greatly helpful in selecting the most appropriate management of those patients.
    No preview · Article · Dec 2007 · International journal of cardiology
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    ABSTRACT: The authors report the initial experience of an electrophysiological laboratory starting ablation for atrial fibrillation, a promising technique which is not yet widely practiced because of the risks related to the procedure. The incidence of severe complications (tamponade, pulmonary vein stenosis, ischaemic events) did not appear to be different in the first 100 procedures compared with the next 100 procedures: 3% in the two groups. The selection of patients, strict perioperative management and the initial support by confirmed operators seem to be the factors which minimise the complications rate of the procedure.
    No preview · Article · Oct 2006 · Archives des maladies du coeur et des vaisseaux
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    ABSTRACT: The author reports the case of a 46-year old patient diagnosed with idiopathic ventricular fibrillation (Brugada syndrome) further to induction of class Ic antiarrhythmic therapy for the management of paroxystic ventricular fibrillation. It would appear that this diagnosis is increasingly frequent in young patients with Brugada syndrome shown to be minimal or intermittent on electrocardiograms. Atrial arrhythmia was the only rhythmic pathology objectively evidenced in this patient and the author was consequently led to reconsider its prevalence in patients presenting this syndrome both in the literature and according to his personal experience.
    No preview · Article · Jul 2004 · Archives des maladies du coeur et des vaisseaux
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    ABSTRACT: The authors report the case of an asymptomatic 32 year old man with no family history of sudden death but with ECG changes suggesting Brugada's syndrome. He underwent implantation of an automatic defibrillator after inducible syncope ventricular fibrillation had been demonstrated during electrophysiological investigation. The later occurrence of three episodes of ventricular fibrillation treated by the defibrillator confirmed a posteriori the logic of this therapeutic approach.
    No preview · Article · Feb 2001 · Archives des maladies du coeur et des vaisseaux
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    ABSTRACT: The object of this study was to assess the feasibility, efficacy and risks of ablation of common atrial flutter using a single catheter electrode. Recent studies have shown that radiofrequency ablation is effective for interrupting atrial flutter but with a variable rate of recurrence. Therefore, the search for a conduction block in the isthmic region has become the reference method for reducing the incidence of recurrence but this requires the use of costly material. The necessity of single usage has incited research to find a less costly method without compromising efficacy. The authors reviewed the results in 70 consecutive patients with common atrial flutter resistant to anti-arrhythmic medication. The site of ablation was located using anatomical landmarks and electrophysiological criteria. The anatomic site was situated either on a lateral isthmus or, to a variable degree, a septal isthmus; the electrophysiological criterion was an endocavitary auriculogramme, the amplitude of which had to decrease by more than 2/3 after application of the radiofrequency. The technique was interrupted not after the interruption of the flutter but after obtaining a microvoltage atrial activity along the isthmus. Radiofrequency energy of 10 to 50 W was delivered at each site for 90 seconds. Atrial flutter was interrupted in all 70 patients (100%). The average number of applications to interrupt the flutter was 12.67 and to create a microvoltage barrier 14.58. The average duration of the radiofrequency procedure was 50.43 minutes. After an average of six months' follow-up, the recurrence rate was 13%: 9 patients, 5 of whom underwent a second session of radiofrequency ablation. There were no immediate complications after this method of ablation.
    No preview · Article · May 1999 · Archives des maladies du coeur et des vaisseaux
  • M Lescure · A M Dechandol · P Lagorce · M Marot · C Goutner · J P Donzeau
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    ABSTRACT: Based on a retrospective study, we report the clinical and electrophysiological characteristics of 62 cases of effort-induced atrio-ventricular block (AVB). The diagnosis of effort-induced AVB was established by stress test and/or Holter ECG. This series consisted of 18 women and 44 men with a mean age of 64 +/- 13 years. AVB presented in the form of poor adaptation to effort in 41 patients (66%), fainting and/or presyncope suggestive of Stokes-Adams attacks in 20 patients (32%), associated with poor adaptation to effort, except in 5 patients. 48 patients (77%) did not have any underlying heart disease. The ECG was normal in 25 patients (40%) or abnormal, demonstrating a 1st degree AVB and/or an intraventricular conduction disorder. On electrophysiological investigation, the AVB was type II (Mobitz II) in 48 patients (77%), generally 2/1. The block was infranodal, either in or below the His bundle, in 56 patients (90%). When it was situated above the His bundle, it was organic and degenerative, situated at the AV node, at the node-His junction, or even proximally in the His bundle. Effort-induced AVB implies DDD atrioventricular stimulation. The presence of this anomaly should be investigated in patients with poor adaptation to effort, but also when the clinical picture is dominated by Stokes-Adam attacks.
    No preview · Article · Dec 1995 · Annales de Cardiologie et d Angéiologie
  • C Goutner · A M Dechandol · J C Bourguet · J P Donzeau
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    ABSTRACT: The authors report the case of a 70 year old woman with frequent attacks of supraventricular tachycardia resistant to antiarrhythmic therapy. The tachycardia was irregular with predominantly normal QRS complexes. Electrophysiological investigation showed dual conduction in the atrioventricular node and tachycardia was induced by atrial extrastimulus. However, reentrant tachycardia could not be induced, the refractory period of the slow pathway being much longer than that of the rapid pathway. The mechanism of the tachycardia was simultaneous conduction of the sinus rhythm through the two nodal conduction pathways. This was successfully treated by radiofrequency ablation of the slow pathway.
    No preview · Article · Dec 1995 · Archives des maladies du coeur et des vaisseaux
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    ABSTRACT: In order to determine the role of tilt testing in the aetiological diagnosis of syncope unexplained by electrophysiological investigation, the authors retrospectively studied the results of this test in 275 patients with a mean age of 64 +/- 16 years. These 275 patients were divided into two groups: group I: 43 patients with a mean age of 50 +/- 19 years presenting with vagal syncopes, group II: 232 patients with unexplained syncope, probably vagal: group IIa (120 patients, mean age: 67 +/- 15 years), sudden syncope: group IIb (112 patients, mean age: 67 +/- 13 years). The electrophysiological investigation was inconclusive in every case. In group II, 50% of tilt tests were positive (19% under basal conditions, 31% after isoproterenol), with 61% of positive tests in group IIa, including 31% on the basal test, and 38% of positive tests in group IIb, including 11% on the basal test. In group I, 84% of tests were positive (33% on the basal test, 51% after isoproterenol), indicating a sensitivity of the test of 84%. In 96 patients with a doubtful electrophysiological investigation, the tilt test was positive in 70% of cases, allowing specific treatment or a pacemaker to be avoided in the majority of cases. 84% of vasovagal syncopes were therefore confirmed by tilt testing; 50% of syncopes unexplained by electrophysiological investigation were demonstrated to be of vasovagal origin. The author emphasize the value of tilt testing in certain discordant situations in which the clinical context is disturbing and/or electrophysiological investigation is not completely reassuring.
    No preview · Article · Dec 1994 · Annales de Cardiologie et d Angéiologie
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    ABSTRACT: The authors report four observations: three are essentially clinical cases where sustained rate dependent left bundle branch block can induce syncope, where as there is no syncope when the same supraventricular tachycardia at the same frequency has narrow QRS complexes. The fourth case demonstrates the dramatic decrease of arterial electrophysiological slowly accelerated atrial pacing in a patient investigated for a loss of consciousness of unknown origin. The hemodynamic impairment due to intermittent left bundle branch block has been demonstrated even in patients with normal ventricular function. If there are critical hemodynamic events such as during fast supraventricular rhythms occurrence of a left bundle branch block may determinate a dramatic decrease of arterial pressure with syncope. Syncope of supraventricular tachycardias might be induced not only by very fast rate but also by functional left bundle branch block. It might have some interesting applications in the diagnosis of syncope when coexist electrophysiological data of supraventricular arrhythmia substrate and frequency dependent left bundle branch block.
    No preview · Article · Jun 1994 · Annales de Cardiologie et d Angéiologie
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    ABSTRACT: The aim of this study was to compare the electrophysiologic properties of asymptomatic Wolff-Parkinson-White (WPW) syndromes with those of symptomatic WPW, and in particular the anterograde refractory period of the accessory tract and atrial vulnerability. This retrospective study involved 171 patients with WPW seen in their surface electrocardiogram, untreated, having undergone standard invasive electrophysiologic investigation. These patients were divided into two groups: group I consisting of 42 asymptomatic patients and group II consisting of 129 asymptomatic patients. 1) The mean anterograde refractory period (mean ARP) did not differ statistically between group I (330 +/- 97 msec) and group II (311 +/- 110 msec). The mean minimum interval between two preexcited complexes during atrial fibrillation (mean RR min) did not differ statistically between group I (313 +/- 80 msec) and II (300 +/- 105 msec). The mean retrograde refractory period (mean RRP) was significantly (p < 0.001) longer in group I (416 +/- 126 msec) than in group II (307 +/- 75 msec). 2) A reciprocal tachycardia was induced in 95% of cases in group II (122 patients) as compared with 9.5% of cases in group I (4 patients), with a very significant (p < 0.001) difference. Atrial fibrillation was induced in 24% of cases in group I (10 patients) and 34% of cases in group II (44 patients), the difference not being significant. 3) The incidence of potentially serious forms did not differ statistically between groups I and II. Nine patients in group I (21.4%) and 49 patients in group II (38%) had rapid anterograde conduction in the accessory tract (ARP or RR < or = 250 msec).(ABSTRACT TRUNCATED AT 250 WORDS)
    No preview · Article · Mar 1993 · Annales de Cardiologie et d Angéiologie
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    ABSTRACT: Thirty-two complete bundle branch blocks were observed during 16,500 exercise stress tests between 1973 and 1988: there were 7 right bundle branch blocks and 25 left bundle branch blocks. Exercise stress testing was indicated in 15 cases for stable angina, in 15 cases for different functional disturbances and in 2 cases as a systematic investigation. All patients underwent coronary angiography and selective left ventriculography. Right bundle branch block occurring at a heart rate of 105 +/- 25/mn were associated with typical anginal pain at the time of apparition in 5 patients. Coronary angiography showed triple vessel disease in 3 cases, double vessel disease in 2 cases and an isolated proximal lesion of the left anterior descending artery in 2 cases. Left bundle branch block occurring at a heart rate of 125 +/- 12/mn was associated with normal coronary angiography in 7 cases. Eighteen patients had pathological coronary angiogrammes with severe lesions of the left anterior descending artery. Two women suffered from chest pain when the block developed and coronary angiography was normal in one of them. During follow-up (average 62 months), 16 coronary events were observed including 2 infarcts, and 6 patients developed cardiac failure. In conclusion, complete right bundle branch block appearing during exercise stress testing was constantly associated with atherosclerotic coronary artery disease. The predictive value of complete left bundle branch block on effort was 72%. Complete left bundle branch block occurring at heart rates of less than 120/mn was frequently associated with a proximal stenosis of the left anterior descending artery.
    No preview · Article · Mar 1991 · Archives des maladies du coeur et des vaisseaux
  • J P Donzeau · H Aristouy · J P Bounhoure

    No preview · Article · Feb 1982 · Archives des maladies du coeur et des vaisseaux
  • P Bernadet · J C Auvergnat · J P Donzeau · C Suc · G Sabot · J L Sassi
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    ABSTRACT: Bacterial endocarditis due to Staphylococcus epermidis is rare and severe. In a first patient, a 58-year-old-man, it developed 40 days after the insertion of a double prosthesis (mitral and aortic). Cure was obtained by medical treatment using a combination of vancomycin and gentamicin, followed by pristinamycin and tobramycin. The second patient, a 50-year-old-woman, suffering from cirrhogenic hepatitis and treated with corticosteroids. Staphylococcus epidermidis endocarditis developed without any portal of entry being discovered. After the failure of various antibiotic combinations (even though bactericidal in vitro), a mitral Starr valve was inserted which resulted in cure. None of the patients showed any sign of valvular mutilations or disinsertion of prosthesis.
    No preview · Article · Jun 1979 · La Nouvelle presse médicale
  • B Mazières · R Constans · J P Donzeau · P Sacau · P Dardenne · J Arlet

    No preview · Article · Mar 1979 · Revue du rhumatisme et des maladies ostéo-articulaires
  • J P Donzeau · P Bernadet · J P Bounhoure · P Calazel
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    ABSTRACT: His bundle electrocardiograms were recorded from a patient with previously unexplained PR prolongations or shortenings suggestive of both type I and II second degree AV block. The conduction disturbances were due to the association of concealed His bundle depolarizations (H') not propagated to atria or ventricles with first degree AV block in the His bundle. These data strongly suggest that frequent spontaneous His bundle depolarizations are another manifestation of a disease process involving the His bundle, a kind of "Sick--His bundle syndrome".
    No preview · Article · Feb 1979 · European journal of cardiology
  • J P Donzeau · A Birmacker · P Bernadet · J P Bounhoure

    No preview · Article · Nov 1978 · Annales de Cardiologie et d Angéiologie
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    ABSTRACT: From a study of 34 cases, the authors have tried to define the characteristic features of this very specialised type of coronary artery disease. From the clinical standpoint, if the common combination of uncontrolled angina and a past history of myocardial infarction are taken as representative, the basal ECG can in no way differentiate the diagnosis; on the other hand tests on the bicycle ergometer appear to have a good indicative value. Coronary arteriography shows the sharply isolated character of the stenosis of the trunk which is part of the picture of diffuse coronary disease, and the frequency (2 cases out of 3) of total coronary occlusion. The haemodynamic findings are even more variable and unpredictable, and bear no relationship to the degree of trunk stenosis, to the index of the lesion, and to the number of occlusions. However, joint analysis of the index of the lesion and of the degree to which the coronary circulation is compensated or de-compensated allows a better interpretation of the haemodynamic picture.
    No preview · Article · Dec 1977 · Archives des maladies du coeur et des vaisseaux
  • J P Donzeau · R Constans · M Delpont

    No preview · Article · Nov 1977 · La Nouvelle presse médicale
  • J P Donzeau · R Constans · P Bernadet · J P Bounhoure · P Calazel
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    ABSTRACT: The authors describe a case of regular 200/minute tachycardia with atrio-ventricular dissociation. In sinus rhythm and in tachycardia, the ventriculogram assumes the appearance of a left bundle branch block. The His potential makes it possible to link this case with nodal tachycardias. Ventricular electrostimulation administered during tachycardia was followed by a premature beat with no change in the HV interval. This argues in favour of the existence of a re-entry circuit making anterograde use of the His system and retrograde use of Mahaim's bundle.
    No preview · Article · Nov 1977 · Annales de Cardiologie et d Angéiologie