Chiara Bianchini

University of Ferrara, Ferrare, Emilia-Romagna, Italy

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Publications (45)42.5 Total impact

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    ABSTRACT: The purpose of this study was to evaluate the oncological and functional results of patients affected by laryngeal squamous cell carcinoma (SCC) and surgically treated by supracricoid partial laryngectomy (SCPL) at the ENT Department of the University Hospital of Ferrara. In this retrospective study a total of 155 patients (149 males/l96.1% and 6 females/3.9%), have been included. All patients were treated between January 1st 1998 and December 31st 2010, by SCPL, including 126 cricohyoidopexies (CHP) and 29 cricohyoidoepiglottopexies (CHEP). The overall survival (OS) at 3 and 5 years was 88.77 and 83.24%, respectively and the disease-free survival (DFS) at 3 and 5 years was 84.4 and 81.55%, respectively.The recurrence rate was 17.5%,with local recurrences in 12.1% of the cases, regional in 4.7% and distant metastasis in 0.7% of the cases. Synchronous second primary tumors were 0.7% and metachronous second primary cancers (MSPCs) 5.4%. Removal of nasogastric feeding tube (NGT) or percutaneous endoscopic gastrostomy (PEG) was performed in 98.7% of the patients and lasted 22 days on average after SCPL (range 9-60), while decannulation was performed in all of patients at the 27th day on average after surgery. Oncological outcomes of this series are consistent with those of the literature, showing that SCPL is an effective and safe procedure in terms of survival rate and disease control. Functional outcomes confirmed that SCPL allows a good organ preservation and recovery of laryngeal functions.
    No preview · Article · May 2015 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
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    ABSTRACT: Previous studies have suggested that risk factors for ischaemic vascular disease, such as cigarette smoking, hypertension and hyperlipidaemia, can also be considered risk factors for the development of idiopathic sudden sensorineural hearing loss (ISSNHL). In this study, we have evaluated the hypothesis that these factors can influence hearing threshold recovery in patients affected by ISSNHL. A total of 141 subjects who suffered an episode of ISSNHL were included. All subjects were assessed with tonal audiometry, auditory brainstem responses and MRI to exclude retrocochlear pathology. Hearing tests were conducted at ISSNHL onset (t = 0) and after 30 days. Patients were divided into three classes according to the presence/absence of one or more cardiovascular risk factors including: history of smoking, total serum cholesterol/triglycerides, history of hypertension and diabetes mellitus. Values of hearing threshold recovery were estimated and comparisons were conducted across the three risk factor classes. 75% of patients affected by ISSNHL showed a threshold recovery. However, the threshold recovery was found to be class-independent (average recovery value of 18 dB HL per classes) and also independent of age and gender. Even if cardiovascular risk factors have been found to be involved in the pathogenesis of ISSNHL, the present study suggests that these factors do not have any significant influence on the threshold recovery in ISSNHL.
    Full-text · Article · Apr 2015 · Acta otorhinolaryngologica Italica: organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
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    S Pelucchi · C Bianchini · A Ciorba · F Stomeo · A Ferron · A Pastore
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    ABSTRACT: Herein, a rare case of synchronous cystoadenolymphoma (Warthin's tumour) of the right parotid gland and the nasopharyngeal space is described. Although Warthin's tumour (WT) of the parotid gland is a common benign pathology, the occurrence of extra-parotid cystoadenolymphoma is rare. Extra-parotid WT have been mainly localised in the submandibular gland, periparotid region and occasionally in other sites, such as the oral cavity, hard palate and nasopharynx. The simultaneous occurrence of an intra-parotid and extra-parotid WT localisation, as in the case presented, is extremely uncommon.
    Full-text · Article · Apr 2015 · Acta otorhinolaryngologica Italica: organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
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    ABSTRACT: Presbycusis and presbystasis represent relevant problems of aging, caused by the increase in life expectancy in developed countries. As such, it is advantageous to better understand the physiopathological mechanisms of these age-related inner ear diseases. The hypothesis that presbycusis and presbystasis have a genetic background was proposed some years ago. Several studies (in humans and animals) are available in the literature, and possible genes involved in the physiopathology of both diseases have been identified. The aim of this paper is to present an overview of the information available in the current medical literature on presbycusis and presbystasis. © The Author(s) 2015.
    Full-text · Article · Mar 2015 · International journal of immunopathology and pharmacology
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    Andrea Ciorba · Chiara Bianchini · Michele Zuolo · Carlo Vittorio Feo
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    ABSTRACT: A wide variety of symptoms and diseases of the upper aerodigestive tract are associated to gastro-oesophageal reflux disease (GORD). These disorders comprise a large variety of conditions such as asthma, chronic otitis media and sinusitis, chronic cough, and laryngeal disorders including paroxysmal laryngospasm. Laryngo-pharyngeal reflux disease is an extraoesophageal variant of GORD that can affect the larynx and pharynx. Despite numerous research efforts, the diagnosis of laryngopharyngeal reflux often remains elusive, unproven and controversial, and its treatment is then still empiric. Aim of this paper is to review the current literature on upper aerodigestive tract disorders in relation to pathologic gastro-oesophageal reflux, focusing in particular on the pathophysiology base and results of the surgical treatment of GORD.
    Full-text · Article · Feb 2015
  • C Aimoni · M Malagò · C Bianchini · L Borgatti · A Ciorba

    No preview · Article · Jan 2015 · Minerva pediatrica
  • L. Crema · F. Maldotti · M. Malagò · A. Ciorba · G. Scanelli · C. Bianchini

    No preview · Article · Oct 2014

  • No preview · Article · Oct 2014
  • A Ciorba · S Savini · F Morolli · M Malagò · C Bianchini · S Pelucchi · A Pastore
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    ABSTRACT: Watt Eagle, firstly described the Elongated Stylohyoid Process Syndrome (ESPS), or Eagle Syndrome, in 1937. Since then, several authors have further studied this syndrome and some classifications have been proposed in relation to signs, symptoms and etiopathogenesis. Aim of this paper was to present the clinical features of a cohort of patients affected by Eagle syndrome that underwent surgical treatment. Retrospective study. A cohort of ten patients that underwent surgical intervention for Eagle syndrome from January 2000 to December 2012 has been selected. For each subject, medical history, clinical features, treatment and follow-up after surgery were evaluated. The surgical treatment resulted effective in 8 of 10 patients. Two patients are still complaining neck pain, although the discomfort has a lower grade and is pharmacologically controllable. Although rare, Eagle's Syndrome should be always considered in the differential diagnosis in patients with chronic orofacial pain refractory to conventional treatments.
    No preview · Article · Oct 2014 · Minerva stomatologica

  • No preview · Article · Sep 2014 · Neurogastroenterology and Motility
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    ABSTRACT: Carcinosarcoma is an extremely rare malignant neoplasm, with both a malignant epithelial and mesenchymal component, that rarely affects the larynx. Aim. Aim of this paper is to describe the case of a patient affected by a larynx carcinosarcoma treated by endoscopic horizontal partial laryngectomy with CO(2) laser and particularly discuss the histogenetic hypothesis as well as the possible treatment modalities of this rare lesion. Methods. Case report and literature review. Discussion and Conclusion. Still little is known about the biology of carcinosarcoma and there is still no consensus in the literature on the treatment of these tumors. Endoscopic horizontal partial laryngectomy could represent another treatment option in selected cases.
    Full-text · Article · Jul 2014
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    ABSTRACT: The purpose of this article was to review the main aspects of pain and its prevalence among head and neck cancer patients, as well as to identify the presence of possible pain predictive factors. For an integrated presentation of this topic a Pubmed database systematic search for relevant published studies was performed. When considering the prevalence of pain in head and neck cancer patients the studies available in this field show great variations in relation to the number of patients included, surgical procedures performed, and established approaches to analgesia. Despite the recognized association between cancer and pain, insufficient attention is paid in the head and neck pain problem, and to date, only few studies in the literature address the diagnosis of head and neck pain or its management. Further efforts are necessary in order to understand the real dimension of this problem in head and neck cancer patients, and therefore to recognize pain predictive factors and/or pain genetic factors aiming (i) to identify those subjects most at risk for pain, and (ii) to tailor, in a near future, 'targeted' analgesic interventions.
    No preview · Article · Jul 2014 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • A. Ciorba · L. Crema · F. Maldotti · C. Bianchini
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    ABSTRACT: Over the past years, researchers have identified reactive oxygen species (ROS) as major factors mediating sensorineural hearing loss (SNHL). SNHL is caused by loss of cochlear hair cells or neurons and this damage is irreversible. SNHL is a common disorder as it is reported to affect millions of people, of any age, around the world; SNHL also has different presentations, from mild to profound, including low and high frequencies patterns. ROS can damage inner ear directly by injuring cellular DNA or indirectly by inducing apoptosis of the inner ear sensory cells (hair cells or spiral ganglion neurons). Recent observations also link oxidative stress to further damage in the inner ear by causing endothelial dysfunction in the cochlear microcirculation. Since the role of endothelial cells in microcirculation is crucial as they control and regulate the local blood flow (i.e. through the expression of several adhesion molecules), their injury can induce relevant damages to cochlear hair cells or spiral ganglion neurons. The cochlea, in fact, is particularly vulnerable to hypoxic or ischaemic damage as: (i) it is provided with a terminal capillary bed and it is not supplied by collateral vessels which could restore blood flow in ischaemic regions; (ii) cochlear hair cells have a high metabolic activity. Understanding the aethiopathogenetic mechanisms of SNHL is crucial also in order to indentify possible innovative therapeutic approaches.
    No preview · Chapter · Jan 2014
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    ABSTRACT: Aims: The aim of this retrospective study is to review the experience in performing head and neck reconstruction surgery between 1989 and 2009 at the ENT Department of the University Hospital of Ferrara, Italy, considering the oncological as well as the functional and psychological outcome. Methods and study design: Thirty-three consecutive patients were enrolled. Patients underwent flap reconstruction following primary or salvage surgery for squamous cell carcinoma of the oral cavity or oropharynx. Oncological results in terms of survival rate and disease-free interval, as well as functional and psychological results were evaluated. Results: The oncological results, i.e. survival rate related to cancer stage and disease-free interval, were in agreement with those of the literature. Functional assessment, swallowing function and speech intelligibility were statistically poorer in patients affected by oropharyngeal malignancies than in patients affected by oral cancer. Quality of life was compromised in terms of reduced relationships and onset of depression or irritability. Conclusions: Reconstructive surgery can be considered a relatively standard procedure in the treatment of head and neck cancer. The main drawback is still related to the major impact on patients' quality of life and functional status.
    No preview · Article · Dec 2013
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    ABSTRACT: Fine-needle aspiration cytology (FNAC) is a minimally invasive procedure usually well tolerated, easy to perform, quick, cheap and easy to repeat in case of doubts or non-diagnostic results. Echography is also a fast, cheap and non-invasive tool; however, the role of FNAC and echography in the diagnosis of salivary gland pathology is not universally recognised. Three hundred and fifty-seven patients with a cytological diagnosis at FNAC, and 247 of these who were also studied with echography, were enrolled for this retrospective study. The final histopathological diagnoses, obtained after surgery, were then compared to the preoperative FNAC diagnoses and echographic findings. From the analysis of our data, the overall FNAC specificity resulted 93 percent, sensitivity 83 percent, and diagnostic accuracy 92 percent. Echography sensibility was 57.1 percent specificity 98.2 percent, while positive and negative predictive value were respectively 80 percent and 94.8 percent. While echography can be useful in order to provide a better characterization of salivary gland lesions, FNAC can then be considered a safe diagnostic tool with reliable sensitivity and specificity for the assessment of salivary gland pathology and thus for selecting patients and indicating the best surgical treatment.
    No preview · Article · Oct 2013 · International journal of immunopathology and pharmacology
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    ABSTRACT: The aetiopathogenetic mechanism of sudden sensorineural hearing loss (SSNHL) is still unclear. Microvascular impairment is one of the possible reported causes of SSNHL; nonetheless, few studies in the literature have investigated the association between SSHNL and vascular disease and a cause-effect relationship still has to be demonstrated. Two cases of SSNHL are presented and the possible role of vascular disorders in the pathogenesis of this disease is discussed.
    No preview · Article · Jun 2013
  • C. Bianchini · V. Iannini · A. Ciorba · R. Rinaldi · R. Merlo · A. Pastore
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    ABSTRACT: The aim of this paper was to describe the case of a patient affected by a neoplastic cervical mass, discussing about the diagnostic workup and the possible differential diagnosis, focusing on the diagnosis of a cancerization of an amygdaliod cyst through a case report and literature review. The differential diagnosis of a neoplastic neck mass covers a broad spectrum of diseases; an adequate diagnostic workup through the evaluation of clinical, instrumental and radiological data is always crucial, in order to understand if the lesion has a primitive or a metastatic origin. In the presented case, the histological pattern and the absence of any other primary T, allowed to consider the cervical neoplastic lesion as a primitive carcinoma arising from an amygdaloid cyst.
    No preview · Article · Jun 2013
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    ABSTRACT: Enhanced recovery after surgery (ERAS) programs have recently been developed in order to reduce morbidity, improve recovery, and shorten hospital stays of surgical patients. Since the 1990s, ERAS programs have been successfully applied in many centres, especially in northern Europe and America, to perioperative management for colorectal surgery, vascular surgery, thoracic surgery, and then also to urological and gynaecologic surgery. Purpose of this paper is to evaluate and discuss the very recent introduction of ERAS programs also in head and neck surgery. Embase and Pubmed database searches were performed for relevant published studies. There are still no reports concerning the results of the application of ERAS protocols in the head and neck field. ERAS programs, however, could offer also to head and neck surgery patients an advantage in terms of fastening recovery, reducing hospital stay, and favouring early return to daily activities after hospital discharge. Therefore, the investigation of specific ERAS protocol in head and neck surgery patients should be encouraged.
    No preview · Article · Apr 2013 · Archives of Oto-Rhino-Laryngology
  • F Stomeo · E Tosin · F Morolli · C Bianchini · A Ciorba · A Pastore · S Pelucchi
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    ABSTRACT: Several studies in recent years have already reported good oncologic results with laser microsurgery in the treatment of early glottic carcinoma. We conducted a longitudinal voice evaluation, in patients with early glottic cancer who underwent transoral laser cordectomy, in order to assess the voice quality outcome and its relationship with objective and subjective (voice handicap index questionnaire and GIRBAS scale) means. Twenty-four previously untreated patients underwent transoral laser cordectomy for early glottic cancer. All patients underwent subjective and objective voice assessment according to the multidimensional voice protocol recommended by the European Laryngological Society including acoustic, perceptual and stroboscopic analysis combined to patient self assessment of voice (voice handicap index-VHI). These evaluations were performed before treatment and 6 months after the treatment. Vocal fold healing was complete in all cases by 6 months following surgery. Main voice parameters (subjective and objective) resulted improved at the 6-month control after surgery. In particular, voice handicap index (VHI) and GIRBAS scale resulted reliable for voice assessment and for the postoperative follow-up. In conclusion, VHI, GIRBAS, multidimensional voice program (MDVP) and spectroacoustic parameters showed a close trend in the present study, and this confirms the validity of the voice analysis performed by each tool.
    No preview · Article · Apr 2013 · International journal of immunopathology and pharmacology
  • A. Ciorba · C. Bianchini · A. Pastore · M. Mazzoli
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    ABSTRACT: Background: Tinnitus is one of the most prevalent disabilities in developed countries, nonetheless understanding the mechanisms of its generation still remains a challenge for physiologists, otolaryngologists and audiologists. Several authors have already claimed the possible role of oxidative stress in its pathogenesis and have therefore advocated the use of antioxidants in its treatment. Methods: A systematic review of the English literature among tinnitus and oxidative stress has been performed through Medline searches. Results and Conclusions: While oxidative stress could have an implication in the pathogenesis of tinnitus secondary to some cochlear pathologies, its role in idiopathic tinnitus is still unclear. Consequently, treatment with antioxidants might be suitable for tinnitus secondary to cochlear pathology induced by oxidative stress; instead concerning idiopathic tinnitus, it is still necessary to understand the etiopathologic mechanism underlying this disease, in order to then develop a causal approach.
    No preview · Article · Jan 2013 · Journal of International Advanced Otology