A.Y. Turanli

Hacettepe University, Engüri, Ankara, Turkey

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Publications (47)50.77 Total impact

  • E P Yuksel · F Aydin · N Senturk · M G Ozden · T Canturk · A Y Turanli

    No preview · Article · Sep 2014 · Giornale italiano di dermatologia e venereologia: organo ufficiale, Societa italiana di dermatologia e sifilografia
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    ABSTRACT: Background Nailfold capillaroscopy is used for the identification of microvascular involvement in many rheumatic and extrarheumatic diseases.AimTo determine the nailfold capillary changes in patients with Behçet disease (BD) by videodermoscopy, i.e. nailfold videocapillaroscopy (NVC).Methods We used a videodermatoscope (Molemax II, × 30 magnification) to perform nailfold capillaroscopy on 40 patients with BD and 40 healthy controls (HC). All nailfold images were evaluated for capillary density, distribution and morphology, assessing features such as enlargement or tortuosity of the capillaries, microhaemorrhages and avascular areas.ResultsEnlarged capillaries were detected in 14 patients, microhaemorrhages in 6 patients, and avascular area in 3 patients. There was a statistically significant difference between patients with BD and healthy controls for capillary dilatation and microhaemorrhages (P < 0.05). Capillaroscopic changes were not associated with sex or clinical characteristics.Conclusions Using NVC, nailfold capillary changes were apparent in patients with BD, but not in HC. NVC could be a useful technique for evaluating microvascular damage in BD.
    No preview · Article · Jun 2014 · Clinical and Experimental Dermatology
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    ABSTRACT: Herpes zoster ophthalmicus is rarely seen in children. The incidence of herpes zoster in children is only 1.1 per 1000 person years and especially ophthalmic herpes zoster is even lower. We present a case of herpes zoster ophthalmicus in a 16-month-old male child who had not vaccinated for chickenpox. His cousin had chickenpox 6 months ago but our patient did not develop any rash or fever at that time. There was no history of chickenpox or any other maternal illness during pregnancy. We report this case to document the possibility of herpes zoster ophthalmicus as a rare condition in healthy children with a history of an unrecognized subclinical varicella infection.
    No preview · Article · Jan 2011 · Turkiye Klinikleri Pediatri
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    ABSTRACT: Objective: Dermoscopy is widely used in the differantial diagnosis of melanocytic and non-melanocytic skin lesions and increases the preoperative diagnostic accuracy. Our aim is to evaluate the diagnostic accuracy of dermoscopy by comparing the histopathologic results in the diagnosis of melanocytic and non-melanocytic skin lesions. Material and Methods: In the present study, the data regarding to 1.264 patients with melanocytic and non-melanocytic lessions between 2005-2009 were investigated. The data of 449 lessions of 362 patients among the sepatients who se histopathological examinations were performed because of malignancy or dysplasia suspicion with dermoscopic examination. Results: In the consequence of dermoscopic examination; 328 of 449 lessions were melanocytic and 121 were non-melanocytic. The histopathological examination revealed that 288 lesions were melanocytic and 161 were non-melanocytic. The result of diagnosis confirmation test was shown that either specifity and sensitivity of dermoscopy were high in differentiation of melanocytic and non-melanocytic lesions. Twenty-nine of 84 lesions of dermoscopic diagnosis with dysplastic nevus (DpN) were confirmed as histopathologically. Where as 22 (40.0%) of these patients revealed compound nevus and 1 (1.8%) lesion was malign melanoma (MM). Among 499 patients, MM diagnosis revealed in 38 (8.4%) lesions and in 12 (31.5%) of them the diagnosis was confirmed as histopathologically. Among the lesions with MM diagnosis by dermoscopy were not confirmed as histopathologically, five of these were resulted as DpN and 1 as BCC. Where as the dermoscopic diagnosis of a lesion which had a dermoscopic diagnosis out of MM was DpN and reported as MM. Among 57 (12.7%) BCC lesions, 41 (71.9%) the diagnosis were confirmed as histopathologically. Conclusion: Our results have led us to conclude although this method cannot substitute for histopathologic examination, it is a valuable and non-invasive technique in the diagnosis of pigmented skin lesions.
    No preview · Article · Jan 2011 · Turkiye Klinikleri Dermatoloji
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    ABSTRACT: Objective: Nail fold capillaroscopy has a potential for determining the microvascular disease and following microvascular hearth involvement in autoimmune romatic diseases. In this study, we aimed to describe the capillaroscopic abnormalities observed in patients with Rheumatoid arthritis (RA), associating them with clinical and serologic features. Material and Methods: Fifty-two consecutive patients with RA were studied by clinical evaluation, serology, and proximal nail fold capillaroscopy. Capillaroscopic findings were investigated in 3 categories; normal, nonspecific and scleroderma pattern. Results: Consecutive 52 patients (41 /78.8% female, 11 /21.2% male) patients with a mean age of 50.9±12.48 years were involved in the study. Nail fold capillaroscopy was normal in 67.3% of RA patients; 13.46% had non-specific abnormalities, and 19.2% presented a scleroderma-like pattern. Few enlarged capillaries (n=10), few hemorrhages (n=6) and avascular areas (n=1) were detected among these patients. These findings were consistent with early capillaroscopy pattern except one patient. No association between the presence of rheumatoid factor, Raynaud phenomenon, disease duration, disease activity, erosion or deformity and the localization of the involved joints with nail fold capillaroscopy findings was found. Conclusion: The observation of SD-like pattern on nail fold capillaroscopy in 19% of RA patients has shown that this noninvasive diagnostic technique is very useful in complete evaluation of patients with RA.
    No preview · Article · Jan 2011 · Turkiye Klinikleri Dermatoloji
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    ABSTRACT: Dermatoscopy and videodermatoscopy are methods of skin imaging, which are known for their value in the diagnosis of pigmented skin lesions. Nevertheless, to our knowledge, the der moscopic features of the pigmented lesions in Dyskeratosis congenita (DC) which is a syndrome cha racterized by reticular pigmentation of the skin, nail dystrophy, mucosal leukoplakia, predisposition to cancer and bone marrow failure have not been described previously. The major feature of der matoscopic examination was the delicate pigment network with regularly distributed dots and gb bules, in our case. There was no melanocytic lesion on nail examination. We demonstrate the dermatoscopic findings of DC with this case report.
    No preview · Article · Jan 2011 · Turkiye Klinikleri Dermatoloji
  • M G Ozden · Y Bek · F Aydin · N Senturk · T Canturk · AY Turanli

    No preview · Article · Mar 2010 · Journal of the European Academy of Dermatology and Venereology
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    ABSTRACT: Goltz Syndrome (Focal Dermal Hypoplasia) is a rare congenital mesoectodermal dysplasia with multisystemic involvement. It was first described by Goltz in 1962 and more than 200 cases reported worldwide (Leite et al., 2005). Skin lesions are characterized by athrophic, hyperpigmented linear or reticulated macules, multiple mucocutaneous papillomas, fat herniations or fat tumors. Besides the skin, other structures frequently involved are the skeletal system, eyes, teeth, hair, nails and central nervous system (Kanitakis et al., 2003). The association between Goltz syndrome and anti-HIV serology was not found in the literature. We report 32 year-old woman with typical cutaneous leisons of Goltz Syndrome associated with false positive anti-HIV serology and secondary infertility.
    No preview · Article · Jan 2010 · Ondokuz Mayis Universitesi Tip Dergisi
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    ABSTRACT: Objective: Our aim is to investigate the nail involvement, NAPSI scores and prospectively analyze the correlation of these scores with PASI scores in psoriatic patients. Material and Methods: Seventy-two patients with psoriasis were in enrolled in our study. The severity of nail involvement were scored and calculated with NAPSI system. To find the NAPSI score, each finding in every quadrant of the nails was rated. We have also recorded the severity of skin lesions by using PASI scoring system by the same physician, in the same day. We have also evaluated the information for the treatment, age, sex and disease duration of patients. Results: The frequency of psoriasis and nail involvement according to sex and age was not found statistically significant. We didn't found a relation between the type of psoriasis and psoriatic nail involvement, either. Similarly, there was no correlation between the type of psoriasis and psoriatic arthritis existence. As the disease duration increase the frequency of nail involvement elevated (100/145 months), but this increase was not statistically significant. The average NAPSI score detected for hand-nails was 16.8 ± 20.2, and for toe-nails 13.3 ± 18.0. The average PASI score was significantly higher in the case of arthritis. There was a moderate correlation between the nail involvement that was calculated with NAPSI and PASI scores. Conclusion: As a result, we shown that the nail involvement is a frequent finding in psoriasis patients especially with arthritis and the severity of nail involvement is in correlation with the severity of skin lesions.
    No preview · Article · Jan 2010 · Turkiye Klinikleri Dermatoloji
  • Ö. Yilmaz · M.G. Özden · F. Aydin · N. Sentürk · T. Cantürk · A.Y. Turanli
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    ABSTRACT: Cetuximab, is an IgG1 chimeric monoclonal antibody type of epidermal growth factor receptor (EGFR). It is most commonly prescribed for metastatic colorectal cancer, administered alone or in combination with irinotecan-based chemotherapy regimens (Lee et al., 2008; Segaert et al., 2005; Segaert and Cutsem 2005; Scope et al., 2009). Acneiform eruption is the most common adverse effect with 80% of incidence (Segaert and Cutsem 2005; Lee et al., 2008). We report two cases of severe acneiform eruption induced by cetuximab with metastatic colorectal cancer.
    No preview · Article · Jan 2010
  • F Aydin · G S Pancar · N Senturk · Y Bek · E P Yuksel · T Canturk · A Y Turanli
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    ABSTRACT: Laser-assisted hair removal has become a popular treatment for eradication of body hair. Many studies have been published concerning the safety and efficacy of several laser systems. Adverse events are hyperpigmentation, hypopigmentation, erythema, oedema, scarring, pain and blistering. Changes in sweating have not previously been reported. To investigate the effects on axillary sweating of hair removal by a 1064-nm neodymium:yttrium-aluminium-garnet (Nd:YAG) laser. The sweating function of both axillae was evaluated objectively by the iodine starch test for planimetry measurement and subjectively using a visual analogue scale (VAS) before the treatment, and 1 month and 1 year after the last session. The difference in hyperhidrotic activity before and after treatment was significant (P < 0.05), and these differences persisted 1 year after the last evaluation. The results of this study confirm that treatment of axillary hair using the 1064-nm Nd:YAG laser can cause hyperhidrosis, and this effect is not transient. We did not evaluate the eccrine glands histologically, which is a limitation of the study.
    No preview · Article · Oct 2009 · Clinical and Experimental Dermatology
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    N Senturk · A Bedir · B Bilgici · F Aydin · A Okuyucu · Z C Ozmen · A Y Turanli
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    ABSTRACT: Several different laser types are used in cutaneous surgery. The neodymium:yttrium-aluminium-garnet (Nd:YAG) and frequency-doubled Nd:YAG (KTP, potassium titanyl phosphate) lasers are widely used in dermatology. To investigate the possible genotoxic effects on fibroblasts of irradiation with a 1064-nm Nd:YAG laser and a 532-nm KTP laser. Fibroblast cell cultures were exposed to each of the lasers, using 10-mm spot size at 60 ms pulse duration with 10, 20, 40 J/cm(2) and 3, 6, 12 J/cm(2) fluences, respectively. Fibroblasts in passages 1-6 were used. During laser irradiation, 96-well microplate cultures were kept on a cooling block and transported on ice and in the dark, and processed immediately for single-cell gel electrophoresis (SCGE) assay (also known as a comet assay). DNA damage was determined by computerized assessment of comet assay. There was increasing damage with increasing numbers of passages. For the Nd:YAG laser, the greatest damage occurred on passages 5 and 6, whereas the greatest damage appeared at passages 3 and 4 for KTP and returned to baseline at passages 5 and 6. Damage also increased with each dose increment for both wavelengths. At the highest dose for both wavelengths (Nd:YAG 40 J/cm(2) and KTP 12 J/cm(2)), damage was higher with the Nd:YAG laser. Different patterns of cellular damage were seen for different cell-culture passages, treatment doses, and laser wavelengths. These dose ranges are generally used for the treatment of vascular and pigmented lesions and for rejuvenation purposes. As replicative ageing or cell senescence is one of the critical factors determining the extent of cell damage induced by laser therapy, these results may have important implications for clinical practice.
    Full-text · Article · Oct 2009 · Clinical and Experimental Dermatology
  • M G Ozden · L Yildiz · F Aydin · N Senturk · T Canturk · A Y Turanli

    No preview · Article · Mar 2009 · Clinical and Experimental Dermatology

  • No preview · Article · Jun 2008 · International journal of dermatology
  • F Aydin · N Senturk · E Sabanciler · M T Canturk · AY Turanli
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    ABSTRACT: Keratoacanthoma centrifugum marginatum (KCM) is a rare entity, usually classified as solitary keratoacanthoma (KA). The Ferguson-Smith type is the most common form of multiple KAs. Because development of multiple KAs and KCM in a single patient has rarely been reported, this association presents a therapeutic challenge. We report a 46-year-old man with Ferguson-Smith multiple KAs and KCM, who was successfully treated with acitretin.
    No preview · Article · Dec 2007 · Clinical and Experimental Dermatology
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    F Aydin · N Kara · N Senturk · S Gunes · M T Canturk · H Bagci · Y Bek · AY Turanli
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    ABSTRACT: Behçet's disease is a chronic, multisystem, inflammatory disease characterized by the predominance of T-helper 1 cytokines. The disease is also characterized by infiltration of lymphocytes and neutrophils into the affected tissues. Because cytokines are involved in the regulation of lymphocyte and phagocyte functions, they may play an important role in the pathogenesis of Behçet's disease. Leptin, a member of the gp 130 family of cytokines, induces a strong T-helper 1 response and is regarded as a proinflammatory inducer. Recent studies have shown that serum leptin concentration was increased in patients with Behçet's disease and correlated with disease activity. We aimed to investigate the role of G2548A polymorphism of leptin gene in patients with Behçet's disease and compare the results with healthy controls. A total of 93 subjects with Behçet's disease and 125 healthy controls were included in this study. Analyses of G-2548A polymorphism of the LEP gene were performed using the PCR-restriction fragment length polymorphism technique. The genotypes (GG, GA, and AA of leptin G2548A) and alleles (G and A of leptin 2548) were scored and the frequency was estimated. The frequencies of the alleles and genotypes in patients and controls were compared. We analysed the correlation between leptin gene polymorphism and the clinical features of BD. Both genotype and allele frequencies were not significantly different between controls and Behçet's disease patients [OR=0.67, 95% CI (0.35-1.29), P=0.197 and OR=0.77, 95% CI (0.52-1.15), P=0.184]. We did not find any significant relationship between leptin gene polymorphism and the clinical features of BD (P>0.05). In the present case-control study, we found no evidence of an association between the G-2548A variant of the leptin gene and BD among Turks. Further studies are needed to investigate serum leptin level to explain the mechanisms behind the lack of association between leptin G2548A gene polymorphism and BD.
    Full-text · Article · Feb 2007 · Journal of the European Academy of Dermatology and Venereology
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    ABSTRACT: Patients with lupus erythematous may develop an acute eruption clinically similar to toxic epidermal necrolysis or erythema multiforme. The presence of erythema multiforme-like lesions and characteristic pattern of immunological abnormalities including antinuclear antibody (speckled pattern), anti-Ro antibody or anti-La antibody and positive rheumatoid factor in lupus patients has been termed as Rowell′s syndrome. Although diagnostic criteria of this syndrome have been reviewed recently, definite mechanisms of pathogenesis is still unknown. Here we reported a 29-year-old female patient who had systemic lupus erythematosus developed erythema multiforme-like lesions.
    No preview · Article · Jan 2007 · Indian Journal of Dermatology
  • F Aydin · T Canturk · N Senturk · AY Turanli
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    ABSTRACT: Psoriasis is a chronic skin disease that often requires long-term therapy to control the symptoms. Combination therapies for severe psoriasis have advantages for disease control and are thought to reduce long-term side-effects. To assess the efficacy and side-effects of methotrexate plus ciclosporin used in combination for the treatment of severe psoriasis. In this prospective study, 20 patients were treated with the combination of methotrexate and ciclosporin. Methotrexate was given intramuscularly as a single weekly dose of 10 mg and ciclosporin at a dose of 3.5 mg/kg/day in two equally divided doses. Clinical response was assessed according to clinical outcome and the Psoriasis Area and Severity Index which were evaluated at the beginning of therapy (PASI1), after cessation of one agent (PASI2), and at the end of therapy (PASI3). All the patients had previously received one or more systemic treatment. There were 10 women and 10 men (mean age 44 years). The median (minimum to maximum) duration of methotrexate and ciclosporin treatments were 12.5 (4-55) and 14.0 (4-80) weeks, respectively. Median duration of combination therapy was 9.5 weeks (range 4-50). The median of previously used and end-of-study cumulative doses of methotrexate were 181.8 mg (range 0-785) and 330.8 mg (range 50-845), respectively. The median PASI scores were decreased by 77.4% (range 51.2-90.2) and 75.9% (range 10.1-100) at PASI2 and PASI3, respectively. Patients with severe psoriasis had clinically significant improvement after the initiation of combination therapy. Healing rate was decreased upon cessation of one of the medications. Short-term side-effects were minor, transient and manageable. Long-term follow-up of patients treated with this combination is needed.
    No preview · Article · Aug 2006 · Clinical and Experimental Dermatology
  • N Senturk · L Yýldiz · F Aydin · L Eroglu · T Canturk · AY Turanli

    No preview · Article · Jun 2006 · Journal of the European Academy of Dermatology and Venereology
  • E O Goktas · F Aydin · N Senturk · M T Canturk · AY Turanli
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    ABSTRACT: Narrow band ultraviolet B (NB-UVB) phototherapy has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been claimed to be effective, either as monotherapy or as a part of combination therapies. The aim of the present study was to compare the clinical efficacy of NB-UVB and NB-UVB plus topical calcipotriol in the treatment of vitiligo. NB-UVB treatment was given to 24 patients with generalized vitiligo three times weekly. Topical calcipotriol cream was only applied to the lesions located on the right side of the body. Treatment was continued for 6 months. Treatment efficacy was evaluated by determining the average response rates of the lesions at 3-month intervals. The average response rates of patients receiving combination of NB-UVB plus calcipotriol and NB-UVB alone were 51 +/- 19.6% and 39 +/- 18.9%, respectively. The median cumulative UVB dose and number of UVB exposures for initial repigmentation were 6345 mj/cm(2) (range; 2930-30980) and 18 (range; 12-67) for the combination therapy, and 8867.5 mj/cm(2) (range; 2500-30980) and 24 (range; 15-67) for the narrow band UVB therapy, respectively. These findings indicate that concurrent topical calcipotriol potentates the efficacy of NB-UVB in the treatment of vitiligo. This combination not only provides earlier pigmentation with lower total UVB dosage and less adverse UVB effects, but also reduces the duration and cost of treatment as well.
    No preview · Article · Jun 2006 · Journal of the European Academy of Dermatology and Venereology