Takuo Haruyama

Juntendo University, Edo, Tokyo, Japan

Are you Takuo Haruyama?

Claim your profile

Publications (15)9.09 Total impact

  • Takashi Iizuka · Takuo Haruyama · Keiko Nagaya

    No preview · Article · Aug 2013 · Ear, nose, & throat journal
  • [Show abstract] [Hide abstract]
    ABSTRACT: A young man complained of fever and left-sided neck pain. Computed tomography (CT) scan of the neck showed a round low-density area with enhancement at the margin. We suspected a deep neck abscess, and the antibiotic treatment was started. After 3 days, CT scan showed that the oval low-density area extended to its junction with the left internal jugular vein. We diagnosed him as having Lemierre syndrome of the facial vein thrombosis. CT scan of the chest showed multiple pulmonary embolisms. The patient started to receive intravenous anticoagulant therapy. The swelling and tenderness of the neck gradually resolved, and the patient improved without complications. Lemierre syndrome is potentially fatal. Prompt diagnosis and appropriate therapy are needed. Radiographic findings are characteristic and facilitate the diagnosis of Lemierre syndrome. A positive scan typically shows a filling deficit representing occlusive thrombus in the internal jugular vein. In this case, it was difficult to diagnose because the patient had thrombus involving only a facial vein. Recently, cases of Lemierre syndrome have increased, so it is necessary to know Lemierre syndrome of the facial vein thrombosis.
    No preview · Article · Oct 2012 · The American journal of emergency medicine
  • [Show abstract] [Hide abstract]
    ABSTRACT: A 21-year-old man admitted for idiopathic fever and sore throat was diagnosed with virus-associated hemophagocytic syndrome (VAHS) when bone marrow aspirate showed hemophagocytosis. ELISA for HIV antibodies was negative, although HIV RNA was positive. VAHS is extremely rare as an initial manifestation in HIV infection, being reported, to our knowledge, in only 4 subjects in Japan. Hemophagocytic syndrome (HPS) features fever and hepatosplenomegaly associated with pancytopenia, hypertriglyceridemia, and hypofibrinogemia, due to hypercytokinemia. Physicians should thus be aware that primary HWV infection may involve glandular-fever-like illness and should start prompt diagnosis to contain AIDS spread.
    No preview · Article · Aug 2011 · Nippon Jibiinkoka Gakkai Kaiho
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Clear cell carcinoma is rarely found in the salivary gland. It is classified as a low-grade carcinoma. This case demonstrates a low-grade clear cell carcinoma with myoepithelial features in the submandibular gland which differs from hyalinizing clear cell carcinoma and epithelial-myoepithelial carcinoma. A 32-year-old man presented with a 7 month history of left submandibular swelling. Left submandibular gland excision and left-sided supra-omohyoid neck dissection were performed. Microscopically, the tumor was circumscribed and composed predominantly of cords and nests of clear ovoid cells, set in a densely hyalinizing stroma. These cells are diffusely immunoreactive for cytokeratin AE1/AE3 and focally reactive for vimentin and smooth muscle actin (SMA). Based on these findings, the tumor was diagnosed as "a low-grade clear cell carcinoma with myoepithelial features". The post-operative course was uneventful and the patient is free from disease 21 month after surgery.
    Full-text · Article · Jul 2011 · Indian Journal of Otolaryngology and Head & Neck Surgery
  • [Show abstract] [Hide abstract]
    ABSTRACT: We present herein the imaging and pathological features of a 28-year-old male with a sinonasal hemangiopericytoma-like tumor occupying the left nasal meatus. At the initial visit, a nasal polyp was suspected, but, as the patient was bleeding readily, an angiomatoid lesion was also regarded as a possible diagnosis. Based on a thorough histopathological analysis, a sinonasal hemangiopericytoma-like tumor was diagnosed. Hematoxylin and eosin staining also showed a mild degree of nuclear pleomorphism and a slight increase in mitotic activity, and immunohistochemical studies using anti-CD34, MIB-1, and Vimentin antibodies were useful for distinguishing the hemangiopericytoma-like tumor from true hemangiopericytoma and a solitary fibrous tumor.
    No preview · Article · May 2011 · Auris, nasus, larynx
  • [Show abstract] [Hide abstract]
    ABSTRACT: Meningioma, which usually occurs in the intracranial fossa, occurs only extremely rarely in temporal bone. Tumors extending to the mesotympani are so similar that differentiating between meningioma and paraganglioma is very difficult. We report a case preoperatively diagnosed as glomus jugulare involving radical dissection, but determined postoperatively to be jugular foramen meningioma. Although the subject’s postoperative condition remains satisfactory, follow up must include collaboration with the neurosurgeon. It cannot be emphasized enough that jugular foramen meningioma must be diagnosed from characteristic radiological findings and differentiated from paraganglioma.
    No preview · Article · Jan 2011
  • [Show abstract] [Hide abstract]
    ABSTRACT: Since 1995, we have conducted intra-arterial chemotherapy for advanced head and neck cancer to improve prognosis and to preserve significant organs. Novel approaches have increased the organ preservation rate in spite of frequent distant metastasis. Cimetidine, a kind of H2-blocker, inhibits the development of E-selectin on vascular endothelial cells, and contributes to a decrease in distant metastasis and improvement in prognosis for digestive cancer. Objective: To evaluate the decrease in distant metastasis and its relation to the administration of Cimetidine when used concurrently with intra-arterial chemotherapy for advanced head and neck cancer. Method and Patients: 153 patients treated by intra-arterial chemotherapy for stage IV head and neck cancer from May 2000 to December 2008 were divided into two groups: the Cimetidine group (114 patients) and the non-Cimetidine group (39 patients). Analysis of distant metastasis between the two groups was performed retrospectively. Intra-arterial chemotherapy was administered at 150 mg/m2 of CDDP four times per week. In the Cimetidine group, 800 mg of Cimetidine was administered for a period of more than one year prior to treatment. FDG-PET was performed 2 months after the treatment. Pulmonary CT was performed every 6 months, and chest X-ray examination was conducted every three months. Results: The median period of observation was 45 months for the Cimetidine group and 64 months for the non-Cimetidine group (p < 0.05). Distant metastasis was detected in 10 out of the 39 cases in the non-Cimetidine group and in 6 out of the 114 cases in the Cimetidine group (p < 0.05). Metastatic organs consisted of: 8 cases in lungs, 5 cases in bones, 2 cases in brain, and 1 case in retroperitoneum. The mean time of distant metastasis after treatment was 6.9 months (2-20). Conclusion: Combined intra-arterial chemotherapy and Cimetidine is useful for the treatment of advanced head and neck cancer due to increased loco-regional control and decreased distant metastasis.
    No preview · Article · Jan 2011 · Japanese Journal of Head and Neck Cancer
  • [Show abstract] [Hide abstract]
    ABSTRACT: The present study was designed to elucidate the immunoreactivity and protein level of IL-17 in human cholesteatomas. The expression and localization of IL-17 and receptor activator of nuclear factor κB ligand (RANKL) were examined by immunohistochemistry in tissue specimens collected from 24 patients with cholesteatomas. The cellular sources of IL-17 were assessed by double staining with CD4. The level of IL-17 protein was determined using an enzyme-linked immunosorbent assay. The degree of bone destruction was compared with the IL-17 immunoreactivity. IL-17 immunoreactivity was detected in the inflammatory cells in the granulation tissues and there were increased levels of IL-17 protein. The localization of IL-17 expression coincided with CD4-positive lymphocytes. IL-17 was correlated with the cells positive for RANKL. The degree of bone destruction was dependent on the number of infiltrated IL-17-positive cells. IL-17-driven pathology was observed in the congenital type as compared with the acquired type. The present study suggests that IL-17 is related to the pathogenesis of the disease.
    No preview · Article · Oct 2010 · ORL
  • [Show abstract] [Hide abstract]
    ABSTRACT: We investigated the effectiveness of Lipo-prostaglandin El (Lipo-PGEl) into patients with idiopathic sudden hearing loss. Thirty three patients were treated with steroids only (steroids group) and 40 patients were treated with steroids plus Lipo-PGEl (steroids plus Lipo-PGEl group). There was no significant difference in sex, age, initial hearing level, and period between the onset of the disease and the start of the treatment between the two groups. The rate of complete recovery and marked improvement was 45. 4% in the steroids group and 65. 0% in the steroids plus Lipo-PGEl group at the final examination. There was no significant difference in the rate between the two groups. For patients under 60 years of age and those with vertigo in the steroids and Lipo-PGEl group a significantly better outcome was seen in the rate of complete recovery and marked improvement. These results suggest that the Lipo-PGEl may be effective as a concomitant drug with the steroids regardless of the age and hearing level of the patient for the treatment of idiopathic sudden hearing loss.
    No preview · Article · Jan 2010
  • [Show abstract] [Hide abstract]
    ABSTRACT: Paragangliomas are highly vascular, slow growing neoplasms that can occur within the temporal bone, as well as other sites in the head and neck. Preoperative angiography showed no feeding artery of the tumor in our case, but Zellenballen and hypervasularity were observed histologically. Tympanic paragangliomas confined to the middle ear cavity do not need preoperative embolization.
    No preview · Article · Jan 2010 · Practica Otologica, Supplement
  • [Show abstract] [Hide abstract]
    ABSTRACT: Cervical cystic lymphangioma usually develops in subjects less than two years old, but we report a case in an adults 23-year-old woman reporting cervical swelling continuing for three years had been diagnosed as having a relativery soft cervical tumor. Bloody liquid was aspirated twice from the tumor and we conducted angiography for suspected hemangioma, but no tumor staining was seen. Under a clinical diagnosis of lymphangioma indicated by computed tomography (CT), magnetic resonance imageing (MRI), and cervical echo graphic findings, the tumor was surgically extirpated. The definitive pathological diagnosis was lymphangioma. No recurrence has been seen 5 years since surgery.
    No preview · Article · Dec 2009 · Practica oto-rhino-laryngologica
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Before performing transnasal fiberscopy to observe the nasal cavity, pharynx and larynx in outpatient clinics, nasal anesthetics and vasoconstrictive agents are routinely sprayed into the nares in order to improve patients' comfort. Bacterial contamination of the nozzles of Venturi principle atomizer barrels and their solutions after being used for multiple patients over a long-term period without cleaning is controversial. We evaluated the potential risk of atomizer-associated cross-infection by using atomizers commonly available in Japan that use compressed air to atomize medication. Eighteen of the 23 samples (78.3%) from the external nozzle tips of the atomizers resulted in positive bacterial cultures. These detected bacteria are suggested to be colonized in the nares and to cause bacterial contamination of the atomizer. Of the 25 samples obtained from the spray of the drug solutions, 11 samples showed positive bacterial culture, whereas 16 control samples produced no growth of bacteria. The present study demonstrated that the atomizer widely used in the outpatient ENT clinics in Japan has a potential risk of causing cross-infection of patients.
    Full-text · Article · Sep 2009 · Indian Journal of Otolaryngology and Head & Neck Surgery
  • [Show abstract] [Hide abstract]
    ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) otorrhea has become an increasing problem with regard to infection through the tympanic membrane perforation and postsurgical infection. In particular, dry ear, at the preoperative stage, is considered to be a crucial factor in surgery. We evaluated how to control MRSA otorrhea before and after ear surgery. Twenty-six patients having MRSA otorrhea were enrolled in the present study and randomly divided into 2 groups, namely, mupirocin ointment therapy for 16 patients and ofloxacin ear drops for 10 patients. Approximately 0.6 mg of mupirocin ointment was administered locally to the tympanic membrane and the promontory around and through the perforation with its adjacent external ear canal 1 to 4 times for 2 or 3 weeks at the clinic. On the other hand, ofloxacin ear drops were administered daily by the patients for 2 or 3 weeks at home. Complete elimination of MRSA from the ear was obtained in all patients of the mupirocin group. This showed a significant improvement (p < 0.001) as compared with the ofloxacin group (improvement + cure rate, 40%). Local application of mupirocin did not aggravate hearing acuity of any patients who were evaluated by pure-tone audiometry before and after treatment. The present findings first indicate that minimally essential application of mupirocin ointment is an extremely useful ototopical agent against MRSA otorrhea without ototoxicity.
    No preview · Article · Sep 2008 · Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [Show abstract] [Hide abstract]
    ABSTRACT: Epidermolysis bullosa dystrophica is a rare hereditary skin disease of infancy in which minor trauma causes blister formation. We report a rare case of epidermolysis bullosa dystrophica (recessive) with a stenosis of the larynx due to epiglottic deformity. We performed a tracheotomy, and we detained a trachea aperture in the long term this time. In a characteristic of a disease though stimulation to the trachea causes the erosion on a trachea mucous membrane, postoperative course was uneventful and we are going to observe it in future.
    No preview · Article · Jun 2008 · Auris, nasus, larynx
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This study was designed to evaluate the concomitant use of weekly docetaxel and hyperfractionated radiotherapy for the treatment of head and neck cancer (HNC). Twenty-five patients with advanced squamous cell HNC were treated with hyperfractionated radiotherapy (72 Gy at 1.2 Gy twice per day) and weekly chemotherapy with docetaxel (10 mg/m2). Toxicity was significant, with grade 2 to 4 mucositis observed in 100% and lymphopenia in 84%. Seventeen patients (68%) received the full chemotherapy regimen as planned. The initial overall response rate was 88.0%, while the complete response rate was 68.0%. At a median follow-up period of 10 months, the 2-year Kaplan-Meier projected overall survival was 47.3%, and the cause-specific survival was 81.8%. This study demonstrated that hyperfractionated radiotherapy with weekly docetaxel achieved better initial response than conventional radiotherapy. In addition, the acute toxicity of this regimen was within the acceptable limits of severity.
    Preview · Article · Sep 2006 · Anticancer research