Yatsuji Ito

Gifu University, Gihu, Gifu, Japan

Are you Yatsuji Ito?

Claim your profile

Publications (123)71.83 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Invasive aspergillosis is a life-threatening infection in immunocompromised hosts and occurs most frequently in the lungs. Invasive laryngeal aspergillosis is extremely rare. Due to the potential progression of invasive aspergillosis, antifungal therapy must be started immediately in cases involving clinical suspicion of the disease. A 65-year-old male with agranulocytosis complained of sore throat and dysphagia. His epiglottis was covered with caseating granulomatous lesions and the tissue was easily disrupted. A histopathological examination showed an aggressive invasion of Aspergillus species and cartilage destruction. Therefore, we made a diagnosis of primary invasive epiglottic aspergillosis. The invasive aspergillosis resolved with antifungal therapy and an increase in neutrophils. It is therefore necessary to include invasive laryngeal aspergillosis in the differential diagnosis when encountering immunocompromised patients presenting with laryngeal granulomatous lesions and laryngitis-like symptoms. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    No preview · Article · May 2015 · Auris, nasus, larynx
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A carotid body tumor is pathologically a kind of paraganglioma. It is reported that the rate of malignancy is 5-7%. Pathologically, it is difficult to diagnose a malignant carotid body tumor. In most cases, the malignant potential is decided whether the metastasis is occured. Here, we report on a very rare case of a 25-year-old male with a malignant bilateral carotid body tumor discovered by liver metastasis. An abdominal CT revealed that the patient had a tumor of the liver. He underwent an operation to remove the tumor. Pathologically, the tumor was a metastasis of paraganglioma. He was administered FDG-PET, and pointed out the left neck high density area. The HDA was thought to be the primary tumor-a, malignant carotid body tumor. After assessment by MIBG scintigraphy and a balloon occlusion test, we operated to remove the tumor. We exfoliated the capsular adventitial plane by using irrigator bipolar and microscopy. We removed the tumor with the wall of the artery and closed it with a suture. After the operation, the patient is doing very well but we have to watch carefully in case the tumor relapses.
    Full-text · Article · Jan 2015
  • [Show abstract] [Hide abstract]
    ABSTRACT: Superficial siderosis of the central nervous system (CNS) is a progressive disease of the CNS associated with persistent or chronic subarachnoid hemorrhage. The classic symptoms are bilateral sensorineural hearing loss, cerebellar ataxia and myelopathy. Sensorineural hearing loss is a particularly important symptom which occurs early in the disease and ultimately affects 95% of cases. The failure site associated with hearing loss due to the disease is retrocochlear, and peripheral or both of them coexist. However, the detailed mechanism is not known. We describe herein a 57-year-old woman with superficial siderosis who underwent cochlear implantation for bilateral profound hearing loss. The performance score on the word recognition test was 72%. However, the speech perception started to worsen at 18 months after the operation. Prolonged follow-up may be therefore required to evaluate the benefit of cochlear implantation for profound hearing loss associated with superficial siderosis.
    No preview · Article · Jan 2015 · Practica Otologica
  • [Show abstract] [Hide abstract]
    ABSTRACT: Bleeding from parathyroid cysts is rare. The retropharyngeal space has a very soft structure and if bleeding spreads to this space, airway obstruction can easily occur. We report on a 50-year-old female case with idiopathic neck bleeding from a left parathyroid cyst without any episode of injury. The patient complained of neck swelling after exercise and went to a nearby hospital. At the hospital, the doctor thought this swelling was caused by retropharyngeal bleeding from a tumor behind the left thyroid gland. Embolization of the left thyroid artery was performed. However, the next day, airway obstruction.was occurred and she was brought to our hospital. An emergency operation was performed to open the left neck swelling region. The operation findings and pathological examination showed that the bleeding was caused by a parathyroid cyst and airway obstruction had occurred because of retropharyngeal edema. In this case, the bleeding may have been caused by torsion of the neck when the patient exercised. The retropharyngeal edema probably resulted from the delay of delivery of the lymphatic and venous return and the arterial embolization. 1 year after the operation, the patient is very well and there has been no recurrence.
    No preview · Article · Sep 2014 · Nippon Jibiinkoka Gakkai Kaiho
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The statistical properties of the center of pressure (COP) change over time, and time-invariant methods of the COP analysis is not sufficient to monitor the changes. Therefore, dynamic temporal information of the COP signals has been important in assessing the postural stability. The purpose of this study was to evaluate the characteristic pattern of time-frequency dynamics during the upright stance in patients with unilateral vestibular dysfunction (UVD) This study included 20 dizzy patients with UVD and age-matched 20control subjects without any vestibular disorder. The COP signals were collected using a single standard force platform and a spectral analysis including the time-frequency dynamics was carried out on the basis of the maximum entropy method (MEM) by using a segment time series analysis. The power spectral density (PSD) analysis exhibited an exponential decreasing shape (1/f −β) when plotted on a double logarithmic scale. The average value of β in the low frequency range of less than 1 Hz in the UVD group was significantly lower than that in the control group (p < 0.05) in the medial-lateral (ML) direction under eyes closed condition. In the segment time series analysis, the peak frequency of the COP signals in the patients with UVD gradually converged to the frequency range of 0.1 to 0.2 Hz in the ML direction under EC condition. Our results suggest that the segment time series analysis of the COP signals can derive a characteristic pattern related to the UVD. It may indicate an increased reflexivity of the COP fluctuation by the UVD, resulting in inducing the instability.
    Full-text · Article · Jul 2014 · Gait & Posture
  • [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to determine the diagnostic value of preoperative computed tomography (CT) and magnetic resonance imaging (MRI) in predicting the respectability. Fourteen patients with neck metastasis with clinical suspicion of carotid artery invasion from head and neck cancer were evaluated. Neck dissection was performed in all 14 patients. In 4 patients, the lymph node metastases could be dissected radically from the wall of the carotid artery (dissection group). In 10 patients, the carotid artery was invaded and resected (resection group). Eleven patients out of these patients underwent further evaluation with preoperative MRI. Both preoperative MRI and histopathological examination after surgery were obtained for 7 cases out of 10 patients with resection of the carotid artery.Patients in the resection group had tumors more than 180° around the carotid artery in enhanced CT scans. All patients with attachments of more than 270° to the carotid artery required resection of the carotid artery. In MRI, we focused attention on the signal intensity around the carotid artery on T2-weighted images. In the resection group, all patients had some obscure part of the low signal intensity band around the carotid artery. We considered that a carotid artery was possibly involved when any part of this low signal band around the carotid artery was obscure and broken. Our study of histopathological findings of the carotid artery compared with MRI results revealed that the degrees of microscopic invasion into the outer layer of the carotid artery corresponded with those of the obscure part of the low signal band around the carotid artery.
    No preview · Article · Jan 2014 · Japanese Journal of Head and Neck Cancer
  • [Show abstract] [Hide abstract]
    ABSTRACT: There are several reports showing the effect of a somatostatin analog in postoperative chylous leakage after gastrointestinal surgery and thoracic surgery. We treated a case with a postoperative refractory chylous leakage with a somatostatin analog. The patient was a 63-year-old man. We performed lymph node resection including the venous angle for metastatic cervical lymph node recurrence from tongue cancer. We performed conservative treatment with a ban on food and drink per os, total parenteral nutrition and applied local pressure to the neck chylous leakage. Because the neck chylous leak reached 1321 ml per day, we carried out thoracic duct ligation on the 3rd day after surgery. The chylous leak decreased temporarily after surgery, but increased again to 925 ml per day. Chylous leakage was stopped after the administration of a somatostatin analog for 5 days. We considered that the use of the somatostatin analog in addition to conservative conventional treatment and surgical treatment is one possible strategy to deal with postoperative refractory chylous leakage.
    No preview · Article · Jan 2014 · Practica Otologica
  • [Show abstract] [Hide abstract]
    ABSTRACT: There are few studies about the association between tinnitus and sleep disorders in the general population worldwide. This study assessed this association in a Japanese community. A total of 14,027 participants 45 to 79 years of age who were in the Takayama Study responded to a self-administered questionnaire about tinnitus and sleep disorders. Of this population, 13.3% of men and 10.6% of women had current tinnitus. The percentages of insomnia, respectively, among individuals with and without tinnitus were 28.1% in men and 36.1% in women and 18.8% in men and 21.5% in women. There were 1.7-fold (95% confidence interval [CI], 1.4 to 2.1) and 1.8-fold (95% CI, 1.5 to 2.2) increases in the odds ratios (ORs) of insomnia for those with tinnitus compared with those without tinnitus in men and women, respectively. Loud or very loud tinnitus was associated with 2.8-fold (95% CI, 1.8 to 4.3) and 3.3-fold (95% CI, 1.9 to 5.6) increases in the OR of insomnia in men and women, respectively. Even low (ie, quiet) or moderate tinnitus was significantly associated with insomnia. Difficulty initiating sleep, difficulty maintaining sleep, and a poor perceived quality of sleep were also significantly associated with tinnitus. Insomnia and other sleep disorders were significantly associated with tinnitus in Japanese adults.
    No preview · Article · Nov 2013 · The Annals of otology, rhinology, and laryngology
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The activation of oncogenic signaling pathways induces the reprogramming of glucose metabolism in tumor cells and increases lactic acid secretion into the tumor microenvironment. This is a well-known characteristic of tumor cells, termed the Warburg effect, and is a candidate target for anti-tumor therapy. Previous reports show that lactic acid secreted by tumor cells is a proinflammatory mediator that activates the IL-23/IL-17 pathway, thereby inducing inflammation, angiogenesis and tissue remodeling. Here, we show that lactic acid, or more specifically the acidification is causes, increases arginase I (ARG1) expression in macrophages to inhibit T cell proliferation and activation. Accordingly, we hypothesized that counteraction of the immune effects by lactic acid might suppress tumor development. We show that dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinases, targets macrophages to suppress activation of the IL-23/IL-17 pathway and the expression of ARG1 by lactic acid. Furthermore, lactic acid-pretreated macrophages inhibited CD8(+) T cell proliferation, but CD8(+) T cell proliferation was restored when macrophages were pretreated with lactic acid and DCA. DCA treatment decreased ARG1 expression in tumor-infiltrating immune cells and increased the number of IFN-γ-producing CD8(+) T cells and NK cells in tumor-bearing mouse spleen. Although DCA treatment alone did not suppress tumor growth, it increased anti-tumor immunotherapeutic activity of Poly(I:C) in both CD8(+) T cell- and NK cell-sensitive tumor models. Therefore, DCA acts not only on tumor cells to suppress glycolysis, but also on immune cells to improve the immune status modulated by lactic acid and to increase the effectiveness of anti-tumor immunotherapy. © 2013 Wiley Periodicals, Inc.
    Full-text · Article · Sep 2013 · International Journal of Cancer
  • [Show abstract] [Hide abstract]
    ABSTRACT: Peritonsillar abscesses are the most common deep neck infection in adults. However, pediatric cases are very rare. Pediatric patients have a small anatomy which often impedes cooperation with examination and treatment. In this article, we examine four cases of pediatric peritonsillar abscess, and discussed its treatment, concentrating in particular on abscess tonsillectomy. We performed abscess tonsillectomy in one of our cases. This method allows complete drainage of the abscess, and can decrease the recurrence rate.
    No preview · Article · Jul 2013 · Practica Otologica
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The morbidity of orthostatic hypotension (OH) increases with aging and the elderly often complain of dizziness associated with OH, which is implicated in white matter lesions (WMLs) on MRI. However little is known how WMLs are contributed to the development of dizziness in elderly patients. We evaluated the involvement of cerebral WMLs in the vertical perception in the elderly with OH.METHODS: This study consisted of 71 dizzy patients who underwent the examinations including the Schellong orthostatic test and subjective visual vertical (SVV) test. The male patients aged ⩾ 65 years with OH (1.9 ± 0.9°) showed a significantly higher magnitude of variance of SVV, which reflects an impaired vertical perception, in comparison with the male patients aged ⩾ 65 years without OH and the male patients aged < 65 years with OH (1.0 ± 0.4°, 0.9 ± 0.4°, p < 0.05). The variance of SVV significantly correlated with the volume of WMLs in both sides on MRI in the male, but not female patients (p < 0.01). Our results suggest that severe WMLs in the elderly with OH are involved in impaired perception of verticality, resulting in inducing subjective dizziness.
    Full-text · Article · Jun 2013 · Journal of Vestibular Research
  • [Show abstract] [Hide abstract]
    ABSTRACT: The inner ear is constituted by complicated cochlear and vestibular compartments, which are derived from the otic vesicle, an embryonic structure of ectodermal origin. Although the inner ear development has been analyzed using various techniques, the developmental events have not been fully elucidated because of the intricate structure. We previously developed a Sox10-IRES-Venus mouse designed to express green fluorescent protein under the control of the Sox10 promoter. In the present study, we showed that the Sox10-IRES-Venus mouse enabled the non-destructive visualization and understanding of the morphogenesis during the development of the inner ear. The expression of the transcription factor Sox10 was first observed in the invaginating otic placodal epithelium, and continued to be expressed in the mature inner ear epithelium except for the hair cells and mesenchymal cells. We found that Sox10 was expressed in immature hair cells in the developing inner ear, suggesting that hair cells were generated from the Sox10-expressing prosensory cells. Furthermore, we demonstrated that scattered Sox10-expressing cells existed around the developing inner ear, some of which differentiated into pigmented melanocytes in the stria vascularis, suggesting that they were neural crest cells. Further analyzing the Sox10-IRES-Venus mice would provide important information to better understand the development of the inner ear.
    No preview · Article · May 2013 · Hearing research

  • No preview · Article · Jan 2013 · Nihon Kikan Shokudoka Gakkai Kaiho
  • [Show abstract] [Hide abstract]
    ABSTRACT: Surgery is not usually indicated for the involvement of cervical lymph node metastasis to the subclavian vein. Although surgery is indicated for the involvement of cervical lymph node metastasis to the venous angle, the usual visual field associated with cervical lymph node dissection cannot sufficiently visualize the subclavian vein, and the possibility exists of causing great vessel injury when involved lymph nodes are large and their mobility is restricted. In such cases, surgical excision may be avoided based on the expectation that ligating or cutting the internal jugular vein will be difficult. We examined 10 patients who underwent surgery for the adhesion or invasion of the primary tumor or involved lymph nodes to the venous angle or subclavian vein. The clavicle was removed or displaced to secure the visual field. The sternoclavicular joint was conserved and the clavicle, separated from the first rib, was lifted in 4 patients, while the medial two thirds of the clavicle was removed in 6 patients. Involved lymph nodes could be securely dissected without causing great vessel injury. A chylous leak occurred in one patient undergoing the procedure on the left side.
    No preview · Article · Oct 2012 · Nippon Jibiinkoka Gakkai Kaiho

  • No preview · Article · Jul 2012 · Plastic and Reconstructive Surgery
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Aims: A proportional-integral-derivative (PID) control has recently been used as a control algorithm of body balance. The purpose of this study was to elucidate an association of the proportional and derivative gain based on the PID control gain for balance for quiet standing with the risk factor for falls in the elderly. Methods: The movement of a marker on the back of 23 elderly participants (age 75.6±6.6 years) was measured by our developed device with a complementary metal oxide semiconductor video camera and the trunk sway speed in the medial/lateral (M/L) direction (TSSX) was calculated as absolute values of the whole time series. The PID control gain (proportional gain: K(P), integral gain: K(I), derivative gain: K(D)) was identified using the trunk sway data, and normalized by individual height and weight (K(P)n, K(D)n and K(I)n). Individual risk factor for falls was additionally assessed with the Tinetti Performance Oriented Mobility Assessment (POMA) and the fall risk questionnaire. Results: The score in the POMA and the K(D)n significantly decreased with age (P<0.01). The score in the POMA showed a positive correlation with the K(D)n, and negative correlations with the TSSX and K(P)/K(D) ratios (P<0.01). The average K(D)n and the score in the POMA of fallers were significantly lower than those of non-fallers (P<0.05). Conclusion: These results suggest that the decreased damping control by derivative gain for balance in the M/L direction is one of the risk factors for falls in the elderly.
    Full-text · Article · Jun 2012 · Geriatrics & Gerontology International
  • [Show abstract] [Hide abstract]
    ABSTRACT: We describe two cases of burn caused by the operating microscope illumination system during a tympanoplasty. Cumulative risk factors such as strong light intensity, a short working distance, and dryness of the irradiated area induced irreversible tissue injury on the circumferential skin. Although only a few reports have referred to this kind of iatrogenic injury, in the interest of patient safety even during routine medical procedures, we believe that recognition of all potential risks is an essential prerequisite for the prevention of iatrogenic events.
    No preview · Article · Jun 2012 · Practica Otologica
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To assess the clinical outcomes of single or oligo-fractionated stereotactic radiotherapy (SRT) using dynamic conformal arcs (DCA) for head and neck tumors (HNTs). Thirty-four consecutive patients with 35 lesions treated between 2005 and 2009 were retrospectively evaluated, of whom 85.7 % had recurrent or metastatic disease, and 45.7 and 34.3 % had previous radiotherapy and surgery, respectively. The median SRT dose was 22.3 Gy (11.2-32.8) in 2-4 fractions with a median interval of 7 days and 10.4 Gy (9.2-12.4) in one fraction. SRT was combined with upfront conventionally fractionated RT in 48.6 % of patients. The median follow-up periods were 18.4 months (2-84.1) for the entire cohort and 49.6 months for the survivors. The 1- and 2-year local control (LC) rates were 84.3 and 70.5 %, with the 1- and 2-year overall survival (OS) rates of 78.6 and 51.6 %. LC was significantly better for tumor volumes <25.6 cm(3) (p = 0.001). OS was significantly longer in patients without any disease outside the SRT site (p < 0.001), whereas LC after the SRT did not affect the OS. Late adverse events occurred in 9 patients, including cranial nerve (CN) injury (grade 3/4) in 2, brain radionecrosis in 5 (grade 1), and fatal bleeding in 2 patients harboring uncontrolled lesions abutting the carotid artery. DCA-based SRT can confer relatively long-term LC with acceptable toxicity in selected patients with HNTs. The patients with CN involvement or tumor volume ≥25.6 cm(3) were deemed unsuitable for this treatment regimen.
    Full-text · Article · Apr 2012 · Journal of Cancer Research and Clinical Oncology
  • [Show abstract] [Hide abstract]
    ABSTRACT: We report the case of an 87-year-old woman with sternal bone metastasis and multiple lung metastases from thyroid cancer who underwent hemithyroidectomy, then noticed anterior chest swelling. Chest CT showed a mass destroying the upper sternum. As the anterior chest mass grew, CT showed an increasingly large tumor, suggesting expansion to the anterior mediastinum. The size of multiple lung nodules, however, was unchanged from the previous scan. Suspecting the tumor of causing the woman's discomfort, we partially resected the sternum and reconstructed the sternal defect using a major myocutaneous pectoral flap. She has had no physical or pulmonary impairment since.
    No preview · Article · Jan 2012
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: There is little definitive evidence of the clinical significance of the vestibular-cardiovascular reflex in humans, despite the fact that the vestibular system is known to contribute to cardiovascular control in animals. The present study involved 248 dizzy patients (127 male patients and 121 female patients) aged 65 years and younger. We classified all participants into three groups based on their vestibular evoked myogenic potential (VEMP) responses; absent VEMP, asymmetry VEMP and normal VEMP. To investigate the effect of the otolith disorder, which was estimated by the VEMP, on the orthostatic blood pressure responses, the subjects' systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate were monitored during the orthostatic test after they actively stood up. The male patients in the absent VEMP group had a significant drop in their DBP at 1 min after active standing up (P < 0.05) without any change in their SBP. Conversely, male patients in the asymmetry VEMP and normal VEMP groups showed a significant increase in the SBP at 1 min after active standing up (P < 0.05). Female patients in the absent VEMP group did not show any significant drop in their blood pressure after standing up (P > 0.05). In the entire group of participants, a total of 19.6% of the patients in the absent VEMP group fulfilled the criteria for orthostatic hypotension (OH), which was significantly > the 8.6% of patients in the normal VEMP group and the 7.2% in the asymmetry VEMP group (P < 0.05). Our results suggest that vestibular disorders due to the dysfunction of otolith organs provoke OH.
    Full-text · Article · Dec 2011 · Experimental Brain Research

Publication Stats

343 Citations
71.83 Total Impact Points

Institutions

  • 1996-2015
    • Gifu University
      • Department of Otolaryngology
      Gihu, Gifu, Japan
  • 1987-2007
    • Gifu University Hospital
      Gihu, Gifu, Japan
  • 2001
    • Ichinomiya Nishi Hospital
      Itinomiya, Aichi, Japan