Zygmunt Chodorowski

Medical University of Gdansk, Danzig, Pomeranian Voivodeship, Poland

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Publications (124)45.34 Total impact

  • Zygmunt Chodorowski · Krystian Kaletha · Marek Wiśniewski · Jacek Sein Anand
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    ABSTRACT: We have described three physicians aged 65-70 years, who had noticed during their insulintherapy significant, periodically recurrent variations of insulin requirement (max. 50 i.u./24h vs 25 i.u./24h) in the periods of 4-16 weeks. They had been characterized by similar diet and physical activity, stable normal body mass (av. BMI 24.6) and normal glycosylated hemoglobin (av. HbA1c 5.9%). The hypothesis was put forward that the cause of this phenomenon may be periodical changes in the incretin system activity or increased proliferation of pancreatic beta cells leading to decrease of insulin requirement.
    No preview · Article · Jan 2009 · Przegla̧d lekarski
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    ABSTRACT: The strong positive relationship between cholesterolaemia and ischaemic heart disease is unquestioned and comes from several lines of evidence. In this paper results of questionnaire studies concerning cholesterolemia performed among patients of the Cardiology Ward of a Regional Hospital in Wejherowo are presented.
    No preview · Article · Jan 2009 · Przegla̧d lekarski
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    ABSTRACT: Left ventricular pseudoaneurysm from myocardial infarction is rare but is associated with a high risk of rapid enlargement and rupture. This report describes a 57 year old woman with left ventricular pseudoaneurysm and delayed surgical repair. Seven weeks after myocardial infarction control transthoracic echocardiography revealed a inferolateral left ventricular pseudoaneurysm. Early surgical intervention was recommended but the patient refused hospitalization and surgical repair and continued every day home activity. The symptoms and signs were so mild that she was qualified to 1st class of NYHA classification and 1st class of CCS classification. Six weeks later-ventriculography confirmed the primary diagnosis. During heart surgery the pseudoaneurysm was incised, its fibrous wall with thrombus was resected and the ruptured left ventricular myocardium was satured. She had an uneventful postoperative course. Definitive diagnosis of the pseudoaneurysm was confirmed by histopathological evaluation of the excised left ventricular wall.
    No preview · Article · Jan 2009 · Przegla̧d lekarski
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    ABSTRACT: The main target of acetaminophen application is bifunctional enzyme--prostaglandin endoperoxide H2 synthase (PGHS)--which has cyclo-oxygenase and peroxidase activities and synthesizes initial intermediates in prostanoid synthesis. The reaction catalyzed by PGHS is radical-based and it is initiated and then maintained by the constant presence of peroxides especially peroxynitrate, which generate so-called "peroxide tone" in the enzyme surrounding. Currently it is known that inhibitory effect of acetaminophen on PGHS activity is directly connected with the elimination of "peroxide tone". High concentrations of reactive compounds (e.g. peroxynitrate and lipid peroxides)--produced by cellular defending mechanism at inflammatory sites--significantly decrease inhibitory impact of acetaminophen on PGHS activity. Such observation allows explanation of weak antiinflammatory effect of acetaminophen together with its strong analgesic and antipyretic properties.
    No preview · Article · Jan 2009 · Przegla̧d lekarski
  • Zygmunt Chodorowski · Iwona Rybakowska · Jacek Sein Anand · Krystian Kaletha
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    ABSTRACT: Daily heart consumption of energy (about 6 kg of ATP) exceeds significantly energy consumption of other organs. Deprivation of energy is considered as one of the main factors in development of heart failure. Currently available research methods permit not only to evaluate more precisely the role of impaired energy metabolism in the heart failure, but also give a hope for the future metabolic therapy.
    No preview · Article · Jan 2009 · Przegla̧d lekarski
  • Zygmunt Chodorowski · Robert Ciechanowicz · Jacek Sein Anand
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    ABSTRACT: The reduction of suicide death index in 1981 year and 1989 year, that is in the period of temporary and definitive "Solidarity" victory confirms Emile Durkheim theory that revolution processes increase social integration and prevent suicide decisions. In the years 1991-1994 the number of suicide deaths in Poland was distinctly lower than in other countries of the Soviet Block and republics of the Soviet Union.
    No preview · Article · Jan 2009 · Przegla̧d lekarski
  • Zygmunt Chodorowski · Jacek Sein Anand · Adam Hajduk · Marek Wiśniewski
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    ABSTRACT: Insulin-treated diabetes influences motor vehicle driving mainly through the possibility to induce hypoglycemia in patients. However, there has never been any consistent evidence to suggest that patients with insulin-treated diabetes cause significantly more accidents than the general population. Diabetes and its complications have very various individual courses in patients, because of that candidates for driver's license should always be qualified individually. Drivers with diabetes complications, especially the elderly, quite often themselves limit driving. The programme facilitating the diagnosis of early hypoglycemic symptoms--Blood Glucose Awareness Training--decreases road traffic collision number.
    No preview · Article · Jan 2009 · Przegla̧d lekarski
  • Source
    Jacek Sein Anand · Zygmunt Chodorowski · Marek Wiśniewski

    Full-text · Article · Oct 2008 · Clinical Toxicology

  • No preview · Article · Jun 2008 · Clinical Toxicology

  • No preview · Article · Jun 2008 · Clinical Toxicology
  • Jacek Sein Anand · Zygmunt Chodorowski
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    ABSTRACT: Drug-induced liver injury might be responsible for 1 of 600 to 3500 of all hospital admissions. About 2-3% of all drug adverse effects may be connected with the liver. There could be pure injury of heaptic cells or impairment of hepatocellular bile secretion. In our case there was cholestatic liver injury after the use of thiamazole with the complete regression after the discontinuation of the drug. For two years' the patient was treated with methyltiouracyl without any side effects. After 19 years, because of thyreotoxicosis, the methimazole was used. The acute cholestatic liver injury with the high serum bilirubin level (41.4 mg/dl) was observed. Despite the discontinuation of the drug the patient was deceased. CONCLUSIONS: There are possible cross reactions among imidazolines in patients who are predispose to develop drug-induced liver failure. The doctors should pay much more attention to possible drug side effects.
    No preview · Article · Feb 2007 · Przegla̧d lekarski
  • Jacek Sein Anand · Zygmunt Chodorowski
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    ABSTRACT: A case of a 16-year-old schoolgirl who had admitted a demonstrative suicide attempt against her school teacher thus trying to make the teacher leave the school has been presented. During the observation period in the Emergency Department the nurse taking care of the patient overheard that during her talks with the friends, the girl had been continuously urging them to swallow the same set of tablets, call the ambulance and get admitted to the hospital. The anamnesis revealed that three schoolmates decided to get rid of one of the teacher from their school by accusing her of mental cruelty which had led them to suicidal attempts. It was done mainly because of the bad marks they had got from the teacher. The idea was undertaken by our patient due to many news transmitted in the newspapers and television during last months in which the teachers were blamed for a lot of incidents which had taken place in different schools in Poland. Despite the fact that in many of these events the teachers were both physically and mentally tormented by the pupils the opinions presented by mass-medias were always against them. Our patient said that in such circumstances it was supposed to be an easy way to solve all the problems with unlike teacher. CONCLUSIONS: The physicians should pay more attention on suicidal attempts causes specially in adolescents. Adolescents possess poor knowledge of the lethal potential of drugs, specially over-the-counter medications. The media have to take more responsibility for transmitting news concerning youth which should be more honest and verified.
    No preview · Article · Feb 2007 · Przegla̧d lekarski
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    ABSTRACT: The aim of the study was to evaluate the impact of smoking, verified by the measurement of cotinine levels, on life satisfaction of patients with coronary artery disease. The questionnaire was answered by 36 patients (26 men and 10 women) aged from 48 to 7.6 (mean 63.5) years. The questions regarded the current attitude toward smoking, subjective self-assessment of health and life satisfaction while smoking and after cessation. Cantril's ladder has been used among others to assess life satisfaction. In order to verify the answers regarding current smoking cotinine (nicotine metabolite) serum, urine and saliva levels have been measured. There were 38.8% of current smokers in the studied group of patients after PTCA. The fact of current smoking was negated by 19.4% of smokers during medical exam. Objective verification of smoking is necessary in questionnaire studies on tobacco consumption. Measurement of cotinine in body fluids (serum, urine, saliva) may be useful in these cases. After cessation of smoking 93.9% respondents reported major subjective improvement in self-assessment of health. 54.5% of smokers admitted having been ashamed of the habit, and 60.6% the feeling of disturbing others while smoking. The increase of general life satisfaction measured by Cantril's ladder was observed in 94.7% of responders after cessation of smoking.
    No preview · Article · Feb 2007 · Przegla̧d lekarski
  • Piotr Burda · Jacek Sein Anand · Zygmunt Chodorowski · Barbara Groszek
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    ABSTRACT: Twelve hospitals--five form Warsaw, three from Kraków, and four from Gdańsk and Gdynia were randomized for the study. The logistic preparedness of hospitals during massive chemical accidents has been investigated. There were 146 probands (9 managers, 31 ward heads, 75 assistants and 31 ward nurses) included in the study. In statistical analysis the generalized linear model extended by random factors, particularly the Poisson's regression has been used. No hospital in the three big cities in the country was prepared for any logistic action in case of massive chemical disaster. There were no stationary and mobile decontamination units in the investigated hospitals. There was no individual protective equipment in any of the analyzed hospitals. There were serious deficits in assortment and amount of antidotes which can be used in the treatment of contaminated patients. As much as 97.2% of respondents pointed the poison information centers as a main source of information in case of chemical accidents.
    No preview · Article · Feb 2007 · Przegla̧d lekarski
  • Zygmunt Chodorowski · Jacek Sein Anand · Marek Wiśniewski · Adam Hajduk
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    ABSTRACT: A case of the patient who underwent by bilateral adrenalectomy at the age of 37 and 56 years due to recurrent pheochromocytoma has been described. The authors stress that follow-up of patients after adrenalectomy is mandatory on lifetime basis.
    No preview · Article · Feb 2007 · Przegla̧d lekarski
  • Jacek Sein Anand · Zygmunt Chodorowski · Adam Hajduk
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    ABSTRACT: There has been little data in the medical literature about intoxication with a new hypnotic agent zaleplon. The zaleplon, chemically N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamid, is a selective agonist of the benzodiazepine omega 1 receptor subtype. The case of a 15-year-old female who eat 60 mg of zaleplon (1.2 mg/kg) because of suicidal attempt was described. At the admission to the hospital the somnolence, blurred speech, slowdown, ataxia, tachycardia and hypokalaemia were observed. The child was treated symptomatically, and discharged from the hospital for further psychologic treatment after 36 hours. CONCLUSIONS: Acute intoxication with zaleplon had mild clinical course. The signs of intoxications were drowsiness, blurred speech, ataxia, tachycardia, dizziness, confusion and vomiting. The described case required only symptomatic treatment.
    No preview · Article · Feb 2007 · Przegla̧d lekarski
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    ABSTRACT: Pharmaceutical counterfeiting and purchasing medicines from illegal distribution channels have become more and more common problem in our country. Different medicines, especially erectile dysfunction drugs are involved. The aim of this study was the qualitative analysis of fake Levitra tablets and the estimation of the risk they bear to potential users. Tablets were secured by the police and delivered to Bayer office in 2006. RESULTS: Trace amount of sildenafil (the active ingredient of Viagra) and not vardenafil (the active ingredient of Levitra) was found in tablets described as "Levitra" (vardenafil). The presence of this substance was discovered by NIR--and Raman spectroscopy. The appearance of tablets and blisters corresponded to the original product. There were no paper boxes and patient information leaflets attached. As prescription medicines erectile dysfunction drugs should be purchased from a pharmacy only. They need to be used under strict medical control.
    No preview · Article · Feb 2007 · Przegla̧d lekarski
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    ABSTRACT: In the result of liver detoxification, xenobiotics change into more water soluble and thus easier for excretion from the body. It is convenient to consider this process as occurring in two phases. In phase I, the major reactions involved are hydroxylation, catalyzed by monoxygenases. In phase II, the preliminary modified xenobiotics after conjugation with some specific metabolites are transformed into less toxic and more soluble end-products. Recently, antiporter activity of MDR1 (MultiDrug Resistence) gene products in enterocytes was recognized as important stage in detoxification of xenobiotics, and definied as phase III of this process.
    No preview · Article · Feb 2007 · Przegla̧d lekarski
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    ABSTRACT: Age-standardised cancer incidence rates in reproductive system, digestive system and respiratory system were analyzed taking into account the statistics for 38 States of USA (1996-2001), European Union (2006) and Europe (2006). Age-standardized incidence rate in the reproductive system was higher in comparison with the corresponding rates for digestive and respiratory systems. The authors put under discussion a hypothesis of this phenomenon.
    No preview · Article · Feb 2007 · Przegla̧d lekarski
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    Jacek Sein Anand · Zygmunt Chodorowski · Roman P Korolkiewicz
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    ABSTRACT: Heat stroke may appear as a result of exposure to high environmental temperature or strenuous exercise. It represents a medical emergency characterized by an elevated core body temperature and multi-organ failure. We have described a case of a 41 year-old female after sun exposure, who was admitted to the hospital with the temperature of 42 degrees C. Because of high plasma bilirubin level the Molecular Adsorbent Recirculating System (MARS) was started. Three sessions of MARS, which lasted for eight hours each, were conducted on 15h, 18th, and 23rd day of hospitalization. The procedure was well tolerated by the patient and resulted in a sustained decline of plasma bilirubin from 33.5 to 14.7 mg/dl. The female was discharged from the hospital in good general condition. The two months follow up showed that the patient felt very well, and the plasma bilirubin was reduced to 2.2 mg/dl.
    Full-text · Article · Feb 2007 · Przegla̧d lekarski

Publication Stats

343 Citations
45.34 Total Impact Points

Institutions

  • 2002-2008
    • Medical University of Gdansk
      • Department of Pharmacology
      Danzig, Pomeranian Voivodeship, Poland
  • 2007
    • Szpital Kliniczny Przemienienia Panskiego
      Warszawa, Masovian Voivodeship, Poland
    • University of Gdansk
      • Faculty of Chemistry
      Danzig, Pomeranian Voivodeship, Poland