Alpaslan Terzi

Harran University, Charan, Şanlıurfa, Turkey

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Publications (29)31.67 Total impact

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    ABSTRACT: Background: We aimed to retrospectively analyze patients who underwent surgical treatment in our clinic for hydatid cysts in terms of the surgical methods implemented and their results. Methods: Archival records of the patients who underwent surgery for the treatment of hydatid cysts between 2007 and 2014 were analyzed retrospectively. Results: The records of 425 patients who underwent surgery with varying ages of 16 to 88 years (mean: 44.5) were obtained. Among the patients, 33.9% (n=144) were male and 66.1% (n=281) were female. The most frequent symptoms were abdominal pain (46.4%) and dyspepsia (30.9%). About 79.5% of the patients had hydatid cysts in their livers, and 66.8% of these cysts were on the right lobe of the liver. Surgical intervention was performed on 513 cysts. The average diameter of these cysts was 8.3 cm. About 85.5% (n= 438) of the interventions implemented were partial cystectomy. Laparotomy was performed through the right subcostal incision on 81% (n=345) of the patients who underwent conventional surgery. The most frequently encountered complication was biliary fistula. The mortality rate was 0%. Conclusions: The results showed that most of the cases were uncomplicated isolated hepatic hydatid cysts frequently found on the right lobe of the liver. The most frequently implemented surgical procedure was partial cystectomy. This procedure was simple, fast and applicable for uncomplicated hepatic hydatid cysts. Key words: Hepatic hydatid cyst, Mortality, Partial cystectomy.
    No preview · Article · Nov 2015

  • No preview · Article · Aug 2015
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    Orhan Gozeneli · Alpaslan Terzi · Yusuf Yucel · Ahmet Seker

    Preview · Article · Jul 2015
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    Full-text · Article · Jun 2015
  • F Yildiz · S Coban · A Terzi · N Aksoy · M Bitiren
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    ABSTRACT: Flavonoids have been subjected to considerable investigation because of its antioxidant and anti-inflammatory properties. However, there is no previously reported study about its effect on hepatic ischemia/reperfusion (I/R). We investigated the effects of micronized purified flavonoid fraction (MPFF) on hepatic I/R injury in rats. Thirty rats were recruited in the study as follows: group A, sham operation (n = 10); group B, I/R (n = 10); and group C, I/R+MPFF (n = 10). In group C, rats received (80 mg/kg/day) MPFF by gavage for 3 days before surgery, 30 minutes before ischemia and just before the reperfusion. Blood samples were taken, and serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were measured to assess liver functions. Liver tissues were taken for histological evaluation and to determine the total antioxidant capacity (TAC), catalase (CAT), total oxidant status (TOS), oxidative stress index (OSI), and myeloperoxidase (MPO). The present data showed a decrease in AST, ALT, and LDH levels in the MPFF-treated rats when compared with I/R group rats (P < .001 for all). In the MPFF-treated rats, tissue levels of TOS, OSI, and MPO were significantly lower than those in the I/R group (P < .01, P < .001, and P < .05, respectively). Increases in TAC and CAT levels were statistically significant in the MPFF-treated rats compared with the I/R group (P = .01 for both). On the other hand, MPFF attenuated histological alterations that were induced by I/R. The present study demonstrates that MPFF ameliorates I/R-induced liver damage, probably through antioxidant and anti-inflammatory properties. Copyright © 2015 Elsevier Inc. All rights reserved.
    No preview · Article · Jun 2015 · Transplantation Proceedings
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    Full-text · Article · Apr 2015
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    ABSTRACT: Aim: The aim of present study was to evaluate the diagnostic value of mean platelet volume in the diagnosis of patients either with acute or chronic cholecystitis. Material and method: The study included 33 patients with acute cholecystitis and 32 patients with chronic cholecystitis who were scheduled to surgical intervention at General Surgery Department of Harran University, Medicine School between January, 2010 and November, 2012. Twenty eight healthy individuals without a chronic disease or history of medication who presented to our clinic for routine controls were employed as control group. Patients with chronic diseases such as peripheral vascular disease, coronary artery disease, diabetes mellitus or hypertension and those on anticoagulant or non-steroidal anti-inflammatory medication were excluded as these medications can affect platelet functions. In all patients and controls, white blood cell (WBC) count, platelet count and mean platelet volume (MPV) in complete blood count as well as C-reactive protein values were assessed. Results: MPV values were found to be significantly lower in acute cholecystitis group when compared to those in chronic cholecystitis and control groups (p<0.05). MPV values were negatively correlated to WBC and CRP values, whereas it was positively correlated to platelet counts. WBC and CRP values were found to be significantly higher in acute cholecystitis group than those in chronic cholecystitis and control groups (p<0.05). Conclusion: It is known that early diagnosis decreases morbidity and mortality in patients with acute cholecystitis. Thus, in patients with acute cholecystitis, use of MPV in addition to available laboratory studies and imaging modalities could be helpful in making diagnosis. Although there is a slight decrease in MPV values in patients with chronic cholecystitis, this doesn't provide additional benefit in making diagnosis.
    Full-text · Article · Apr 2013 · Acta Medica Mediterranea
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    ABSTRACT: Pneumobilia is described as occurrence of free air in the gallbladder or biliary tree. There are a number of causes of pneumobilia, including surgically created biliary enteric fistula, instrumentation of the bile duct on endoscopic retrograde cholangiopancreatography, emphysematous cholecystitis, and pyogenic cholangitis. Pneumobilia has also occurred following blunt abdominal trauma, but to date, no more than five cases of such injury have been reported in the literature. In this report, we present a patient struck by a motor vehicle with traumatic pneumobilia following blunt trauma to the abdomen, which was managed conservatively.
    Full-text · Article · Jul 2011 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES
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    ABSTRACT: Aim: In the present study, the relationship between D2-40 immunoreactivity and tumor grade, clinic phase and lymph node metastase in colon adenocarcinomas were examined. Method: Sixty cases diagnosed with colon adenocarcinoma in our department between 2002 and 2009 were included in the study. Sections from appropriate paraffin blocks belonging to the cases were examined by D2-40 antibody immunohistochemical method. Findings: On the immunohistochemical examination, positive immunoreactivity with D2-40 was found in 18 of 60 cases (30%). In the statistical analysis, no significant correlation was determined between histologic grade (p:0,78), clinic phase (p:0,91), lymph node metastasis (p:0,56) and D2-40 immunoreactivity. Conclusion: No correlation was found between immunoreactivity with D2-40 and prognostic parameters. Yet, due to the fact that there are few studies in literature on immunoreactivity with D2-40 in tumor cells in colon adenocarcinomas, we believe that further studies are needed in this subject.
    No preview · Article · Jan 2011 · Duzce Medical Journal
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    ABSTRACT: Among appendicitis patients pregnant ones occupy only a small proportion. Still there are difficulties in the diagnosis and management of the acute appendicitis in pregnant population. We tried to find answers to these difficulties with our acute appendicitis cases in pregnant patients. This study involved 46 pregnant patients who received an operation following diagnosis of acute appendicitis in our clinic from 2006 to 2009. Data were collected retrospectively from medical records. Age, time delay to diagnosis, leukocyte count (WBC), gestational age, gestational history, morbidity-mortality and pathology results were evaluated. The mean age of patients, gestational age and number of prior pregnancies were 26, 21 and 2.6, respectively. The amount of time spent in the hospital, from presentation of first symptom to admission, was approximately 40 hours (range 6-120). The mean time from admission to operation was 5.89 (range 1-32) hours. The perforation rate among our cases was 21%. The negative appendectomy rate was 13%. The perforation rate was associated with advanced gestational age and delayed admission to the hospital (p ≤ 0.001 and p = 0.027, respectively). The diagnosis of appendicitis in pregnancy is difficult, and the perforation rate is high. Particularly in term pregnancies, we recommend performing appendectomy immediately after cesarean section.
    No preview · Article · Dec 2010 · Wiener klinische Wochenschrift
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    ABSTRACT: Ischemia-reperfusion, commonly seen in the fields of trauma surgery and renal transplantation, is a major cause of acute kidney injury and is associated with significant morbidity and mortality. The protective effects of Nigella sativa against ischemia-perfusion damage to various organs have been previously documented. However, its protective effects on kidney tissue against ischemia-reperfusion injury are unclear. In this study, we aimed to examine the effect of Nigella sativa in modulating inflammation and apoptosis after renal I/R injury. Thirty male Wistar-albino rats were divided into three groups: sham-operated, ischemia-reperfusion, and ischemia-reperfusion + Nigella sativa. Rats in the third group were given Nigella sativa 6 h prior to ischemia-reperfusion and at the beginning of reperfusion. All rats except those in the sham-operated group underwent 45 min of bilateral renal ischemia followed by 45 min of reperfusion. Blood samples and liver tissues were harvested from the rats, and then rats were sacrificed. Serum urea and creatinine levels were determined. Total antioxidant capacity (TAC), catalase (CAT), total oxidant status (TOS), oxidative stress index (OSI), and myeloperoxidase (MPO) in kidney tissue and blood were measured. Kidney tissue histopathology was also evaluated. Results. Nigella sativa was effective in reducing serum urea and creatinine levels as well as decreasing the tubular necrosis score. Nigella sativa treatment significantly reduced OSI and TOS levels and increased TAC levels in both kidney tissue and blood. The observed differences seem to demonstrate the protective effect of Nigella sativa against renal I/R injury in rat kidneys.
    No preview · Article · Feb 2010 · Renal Failure
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    ABSTRACT: In previous studies, it has been demonstrated that Nigella Sativa (NS) has protective effects against ischemia reperfusion injury on various organs. However, its protective effects on intestinal tissue against ischemia reperfusion injury are unclear. We aimed to determine whether NS prevents intestinal ischemia-reperfusion injury in rats. Thirty rats were divided into three groups as sham (group 1), control (group 2), and NS-treatment group (group 3). All rats underwent intestinal ischemia for 60 min followed by a 60-min period of reperfusion. Rats were intraperitoneally infused only 0.9% saline solutions in group 2. Rats in the group 3 received NS (0,2 mL/kg) intraperitoneally, before ischemia and before reperfusion. Total antioxidant capacity (TAC), catalase (CAT), total oxidative status (TOS), oxidative stress index (OSI), and myeloperoxidase (MPO) in ileum tissue were measured. Also, ileum tissue histopathology was evaluated by a light microscope. The levels of liver enzymes in group 3 were significantly lower than those in group 2 (p <.01). TAC and CAT activity levels in ileum tissue were significantly higher in group 3 than in group 2. TOS, OSI, and MPO in ileum tissue were significantly lower in group 3 than group 2 (p <.05 for TOS and MPO; p < .01 for OSI). Histological tissue damage was milder in the NS treatment group than in the control group. Our results suggest that NS treatment protected the rat's intestinal tissue against intestinal ischemia-reperfusion injury.
    No preview · Article · Feb 2010 · Journal of Investigative Surgery
  • A. Terzi · S. Çoban · F. Yildiz · S. Aksoy · H. Toy · A. Uzunkoy
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    ABSTRACT: Gastric cancer during pregnancy is extremely rare and there are problems in its diagnosis and treatment due to the presence of fetus. Beside the difficulties in diagnosis owing to the common symptoms of pregnancy, there are different practices during treatment procedure. Major concern in these cases is the situation of the fetus. There are different views on whether terminate the pregnancy or keep it until the term. It is undisputable that there must be not only medical but also ethical, social, cultural and religious considerations during decision making process. In this report, we planned to present our treatment process, medical outcomes, ethical issues and family involvement in a 23 weeks pregnant woman with gastric cancer. We performed total gastrectomy to the patient before the termination of pregnancy. There was no problem either in the mother or in the fetus at post-op stage. After 3 months, the patient gave birth to a healthy child in term. There was no recurrence or metastasis in post-op 9th month control. This information suggests us to be more sensitive on trying to keep fetuses alive until the term and re-evaluate our 'reflexive' attitude on terminating the pregnancy. Furthermore, we believe that terminating the pregnancy may -and will- cause biological and psychological trauma on mother which may -and will- affect the prognosis negatively.
    No preview · Article · Jan 2010 · European Journal of General Medicine
  • A. Terzi · F. Yildiz · S. Çoban · M. Gencer
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    ABSTRACT: Hemorrhoid is a frequently seen benign anorectal disease. Although its diagnosis is simple, it is frequently misdiagnosed. Our patient was 55 years old female who had been diagnosed as hemorrhoid and using steroid pomades and suppozituars for 5 years. The patient had also dyspnea complaints and those medications had help to relieve the symptoms. The patient had applied to our clinic for the repetition of her hemorrhoid prescription. Anal examination was performed since it was thought from her story that she does not suffer from hemorrhoid. There was no sign of hemorrhoid in the anal examination. As the patient had dyspnea complains, she was referred to Chest Diseases Clinic and she was diagnosed as asthma. The importance of anorectal examination is well established. But it still sometimes neglected and wrong and unnecessary treatments are given to the patients. In our case, there was an unnecessary treatment for hemorrhoid, but the medication helped the treatment of asthma despite its late diagnosis. This case is presented as it has made an interesting contribution to the diagnosis of asthma.
    No preview · Article · Jan 2010 · Duzce Medical Journal
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    ABSTRACT: Nigella sativa (NS) has been shown to have antioxidant and antiinflammatory activities in different conditions. The goal of this study was to evaluate the effects of NS on cholestatic liver injury in rats. Thirty rats were recruited in the study as follows: Group 1, Bile duct ligation (BDL) (n = 10); Group 2, BDL plus NS (n = 10); and Group 3, Sham (n = 10). Bile duct ligated group received 0.2 mL kg(-1) dose of NS intraperitoneally daily throughout 14 days. Liver damage and cholestasis were determined by the biochemical and the pathologic examination. Data showed a decrease in gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) activities of the NS treated rats when compared with BDL group (p < 0.001 for GGT and p < 0.05 for others). The NS treated rats' tissue levels of total oxidant status (TOS), oxidative stress index (OSI), and myeloperoxidase (MPO) were significantly lower than that of the BDL group (p < 0.01 for all). Increases in total antioxidant capacity (TAC) and catalase (CAT) levels were statistically significant in the NS treated rats compared to BDL group (p < 0.01 for both). On the other hand, administration of NS in the rats with biliary obstruction resulted in inhibition of necro-inflammation. These results indicate that NS exerts a therapeutic effect on cholestatic liver injury in bile duct ligated rats possibly through attenuation of enhanced neutrophil infiltration and oxidative stress in the liver tissue.
    No preview · Article · Jan 2010 · Cell Biochemistry and Function
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    ABSTRACT: Background: This study was designed to investigate the effects of Urtica dioica on liver ischemia reperfusion injury in rats. Methods: Thirty male Wistar-albino rats were used in this experimental study. Animals were divided into three groups as sham operated (group 1), control (group 2), and Urtica dioica treatment group (group 3). Urtica dioica 2ml/kg were administered intraperitoneally before ischemia and immediately after the reperfusion. The levels of total antioxidant capacity, total free sulfidril group, Total oxidant status, Oxidative stress index, and myeloperoxidase in liver tissues were measured. The serum levels of ALT, AST and LDH were also measured Results: Total antioxidant capacity and total free sulfidril group in liver tissue were significantly higher in group 3 than in group 2. Oxidative stress index and myeloperoxidase in liver tissue were significantly lower in group 3 than the group 2. The levels of liver enzymes in treatment group were significantly lower than those in the control group. Histological tissue damage was milder in the treatment group than that in the control group. Conclusion: It is concluded that Urtica dioica increase the antioxidant capacity and decrease oxidative stress and liver enzymes in the hepatic ischemi reperfusion injury of rats.
    No preview · Article · Jan 2010 · Duzce Medical Journal
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    ABSTRACT: The prevalence of sexual dysfunction is high among women; however, sexual dysfunction secondary to anatomical deformity in women is rare. In addition, primary retroperitoneal leiomyomas are very rare clinical conditions. To present a case with sexual dysfunction secondary to anatomical deformity. In this article, we report the case of a large retroperitoneal leiomyoma causing sexual dysfunction. After the surgical removal of the large retroperitoneal mass, previous intercourse difficulties had been resolved. Retroperitoneal tumors may obstruct the vagina by congesting the pelvic area and may be considered as a possible cause of female sexual dysfunction.
    No preview · Article · Oct 2009 · Journal of Sexual Medicine
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    ABSTRACT: Flavonoids have been subjected to considerable investigations due to their antioxidant and anti-inflammatory properties. Yet the effects of flavonoids on the ileum and spleen against hepatic ischemia-reperfusion injury have so far not been addressed. We aimed to investigate whether micronized purified flavonoid fraction (MPFF) protects the ileum and spleen against hepatic ischemia-reperfusion injury. Rats were subjected to hepatic ischemia by clamping the hilar area of the rats for 60 min, followed by 60 min of reperfusion. Rats in the treatment group were treated with MPFF (80 mg/kg/day) by gavage for 3 days before surgery, 30 min prior to ischemia and just before the reperfusion. After the reperfusion period, all rats were sacrificed. Ileal and splenic tissues were taken for histological evaluation and determination of the total antioxidant capacity (TAC), catalase, total oxidant status (TOS), oxidative stress index (OSI) and myeloperoxidase (MPO) levels. TAC levels in the splenic tissue and intestinal tissue were significantly higher in the treatment group than in the control group (P < 0.01 for both). TOS, OSI, and MPO in splenic tissue (P < 0.01, P < 0.05, and P < 0.05, respectively) and intestinal tissue (P < 0.01, P < 0.01, and P < 0.001, respectively) were significantly lower in the treatment group than in the control group. Histological tissue damage of intestinal tissue was milder in the treatment group than in the control group. The results of this study indicated that MPFF pretreatment significantly limited the injury to the small intestine and spleen induced by hepatic ischemia-reperfusion in rats.
    No preview · Article · Oct 2009 · Digestive Diseases and Sciences
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    ABSTRACT: The aim of this study was to determine whether resveratrol could prevent intestinal tissue injury induced by ischemia-reperfusion (I/R). Intestinal I/R was induced in rats' intestines by 60-min occlusion of the superior mesenteric artery, followed by a 60-min reperfusion. Thirty rats were divided into three groups as follows: sham (group 1), control (group 2), and the treatment groups (group 3). The rats in the treatment group received resveratrol both before ischemia and before reperfusion. In all groups, serum aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase levels were determined. Total antioxidant capacity (TAC), catalase, total oxidative status (TOS), oxidative stress index (OSI), and myeloperoxidase (MPO) in the intestinal tissue were measured. Intestinal tissue histopathology was also evaluated by light microscopy. The levels of liver enzymes in group 3 were significantly lower than those in group 2 (P < 0.05). TAC in the intestinal tissue was significantly higher in group 3 than in group 2 (P < 0.05). TOS, OSI, and MPO in the intestinal tissue were significantly lower in group 3 than in group 2 (P < 0.05 for all). Histological tissue damage was milder in the resveratrol treatment group than in the control group. The results of this study indicated that resveratrol treatment limits the oxidative injury of the small intestine induced by I/R in rats. However, more precise investigations are required to evaluate the antioxidative effect of resveratrol on small intestine tissue damage in clinical and experimental models.
    No preview · Article · Sep 2009 · Journal of Gastroenterology and Hepatology
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    ABSTRACT: The study was planned to evaluate the depth of natal cleft in patients with pilonidal sinus disease and in healthy persons. The study included 50 patients with pilonidal sinus disease and 51 volunteers. Data including body mass index and natal cleft depth were recorded. Natal cleft depth was measured in millimeters by using a caliper instrument. Data were evaluated with the use of the statistical package program (SPSS) with a chi-squared test analysis. P < 0.01 was evaluated as significant. There was no discernable difference in age, occupation, and sex between the groups. The mean natal cleft depth was 27.06 mm in the pilonidal sinus group and 21.07 in the nonpilonidal sinus group. The differences between the two groups were statistically significant (P < 0.01) for natal cleft depth. The mean body mass index was 25.71 in the pilonidal sinus group and 25.28 in the nonpilonidal sinus group. The difference between groups was statistically insignificant for body mass index. The natal cleft of patients with pilonidal sinus disease is deeper than the natal cleft of members of the volunteer group.
    No preview · Article · May 2009 · Diseases of the Colon & Rectum