J. Horáček

Charles University in Prague, Praha, Praha, Czech Republic

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Publications (227)306.23 Total impact

  • B J He · G Nolte · K Nagata · D Takano · T Yamazaki · Y Fujimaki · T Maeda · Y Satoh · S Heckers · M S George · [...] · R Hashimoto · K Watanabe · Y Kawasaki · K Laimböck · L J Koorenhof · S J Swithenby · A Martins-Mourao · K W Song · J F Knebel · K Laimboeck ·

    No preview · Dataset · Jan 2016
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    B J He · G Nolte · K Nagata · D Takano · T Yamazaki · Y Fujimaki · T Maeda · Y Satoh · S Heckers · M S George · [...] · R Hashimoto · K Watanabe · Y Kawasaki · K Laimböck · L J Koorenhof · S J Swithenby · A Martins-Mourao · K W Song · J F Knebel · K Laimboeck ·

    Full-text · Dataset · Jan 2016
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    ABSTRACT: Comorbidities associated with depression have been researched in a number of contexts. However, the epidemiological situation in clinical practice is understudied, especially in the post-Communist Central and Eastern Europe region. The aim of this study was to assess physical comorbidities in depression, and to identify whether there are increased odds of physical comorbidities associated with co-occurring depressive and anxiety disorders. Data on 4264 patients aged 18–98 were collected among medical doctors in the Czech Republic between 2010 and 2011. Descriptive statistics were calculated and multiple logistic regressions were performed to assess comorbidities among patients with depressive disorder. There were 51.29% of those who have a physical comorbidity, and 45.5% of those who have a comorbid anxiety disorders among patients treated with depression in Czech primary care. Results of logistic regressions show that odds of having pain, hypertension or diabetes mellitus are particularly elevated at those who have co-occurring depressive and anxiety disorder. Our findings demonstrate that comorbidities associated with depressive disorders are highly prevalent in primary health care practice, and that physical comorbidities are particularly frequent among those with co-occurring depressive and anxiety disorders.
    Full-text · Article · Dec 2015 · International Journal of Environmental Research and Public Health
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    ABSTRACT: Psilocybin has recently attracted a great deal of attention as a clinical research and therapeutic tool. The aim of this paper is to bridge two major knowledge gaps regarding its behavioural pharmacology - sex differences and the underlying receptor mechanisms. We used psilocin (0.25, 1 and 4 mg/kg), an active metabolite of psilocybin, in two behavioural paradigms - the open-field test and prepulse inhibition (PPI) of the acoustic startle reaction. Sex differences were evaluated with respect to the phase of the female cycle. The contribution of serotonin receptors in the behavioural action was tested in male rats with selective serotonin receptor antagonists: 5-HT1A receptor antagonist (WAY100635 1 mg/kg), 5-HT2A receptor antagonist (MDL100907 0.5 mg/kg), 5-HT2B receptor antagonist (SB215505 1 mg/kg) and 5-HT2C receptor antagonist (SB242084 1 mg/kg). Psilocin induced dose-dependent inhibition of locomotion and suppression of normal behaviour in rats (behavioural serotonin syndrome, impaired PPI). The effects were more pronounced in male rats than in females. The inhibition of locomotion was normalized by 5-HT1A and 5-HT2B/C antagonists; however, PPI was not affected significantly by these antagonists. Our findings highlight an important issue of sex-specific reactions to psilocin and that apart from 5-HT2A-mediated effects 5-HT1A and 5-HT2C/B receptors also play an important role. These findings have implications for recent clinical trials.
    No preview · Article · Oct 2015 · Behavioural pharmacology
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    Full-text · Conference Paper · Sep 2015
  • A. Šípek · V. Gregor · J. Horacek · P. Calda

    No preview · Article · Sep 2015 · Ultrasound in Obstetrics and Gynecology
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    ABSTRACT: Introduction: The surveillance of congenital anomalies in the Czech Republic has a long tradition. The official country-wide regis- tration started in 1964 and the Czech (Czechoslovak) Registry was one of the founding members of the ICBDMS Clearinghouse in 1974. The data collection on prenatal diagnosis officially started in 1985. The Registry serves up to now as an important source of repro- ductive health information for the local health authorities, medical professionals and general public. Methods: A retrospective analysis of the incidence of selected diagnoses of congenital anomalies in the Czech Republic in the 1994–2013 time period. Official data from the National Registry of Congenital Anomalies stored in the Institute of Health Information and Statistics of the Czech Republic were used. The incidences (in livebirths and in prenatally diagnosed cases) for the following diag- noses were analyzed: Down syndrome, Anencephaly, Spina Bifida, Omphalocele, Gastroschisis. Results: The incidence in livebirths (1 per 10.000 livebirths) for the years 1994/2013 for the selected diagnoses were as fol- lows: Down syndrome: 7.79/4.03, Anencephaly: 0.09/0.28, Spina Bifida: 2.35/0.66, Omphalocele: 0.94/0.66, Gastroschisis: 0.84/0.66. For the prenatally diagnosed cases (and the same years) the incidences were as follows: Down syndrome: 5.35/23.61, Anen- cephaly: 3.19/3.00, Spina Bifida: 3.66/4.68, Omphalocele: 1.88/4.31 Gastroschisis: 1.97/3.47. Conclusions: During the last 20 years (1994–2013 time period) the incidences of several diagnoses of congenital anomalies have changed significantly, mainly because of the continuing improve- ment of the screening and prenatal diagnostics methods. This trend can be mainly observed for the Down syndrome – where the current incidence of prenatally diagnosed cases is nearly 4.5 times higher than the initial value. The other factor influencing the increase of total incidence of the Down syndrome in the Czech Republic is the demographic change in the Czech population: while in 1994 there were only 4.36% of the pregnant women 35 years old or older – in 2013 this number increased to 22.84%.
    Full-text · Article · Sep 2015 · Reproductive Toxicology
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    ABSTRACT: No abstract available
    No preview · Article · Jun 2015 · Casopís lékar̆ů c̆eských
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    ABSTRACT: Introduction: Down syndrome is the most common autosomal aneuploidy syndrome. Total incidence (including prenatally and postnatally diagnosed cases) of the Down syndrome in the Czech Republic is increasing during the last two decades. The two mainly discussed causal factors are the improvement of the prenatal screening/diagnostics methods and the eminent increase of the average maternal age. Methods: Retrospective population-based analysis of the prenatally diagnosed cases of the Down syndrome in the Czech Republic (1998 - 2011 time period). Total number of 2 110 cases were analysed. Results: The relative number of the prenatally diagnosed cases of the Down syndrome has increased from 10.82 per 10 000 (in 1998) to 20.24 per 10 000 (in 2011), while the incidence in births has decreased from 6.41 (in 1998) to 3.50 (in 2011, relative numbers per 10 000 are given). The average gestation week at the time of prenatal diagnosis of the Down syndrome has decreased from 19.98 (in 1998) to 15.55 (in 2011). In 1998 the majority of Down syndrome cases were diagnosed in 20-22th week of gestation, while in 2011 the diagnosis was made mainly in 12-13th week of gestation. Conclusion: We have found significant changes in the prenatal diagnostics of the Down syndrome. While in 1998-2003 time period the Down syndrome was diagnosed early in elder women (women aged 35 years or over - who chose karyotyping because of advanced maternal age indication) we have not found this connection in the 2004-2011 time period. This change represents the increasing role of the first trimester prenatal screening in the Czech Republic.
    No preview · Article · Jun 2015 · European journal of human genetics: EJHG
  • A Šípek · V Gregor · J Horáček · J Klaschka · M Malý
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    ABSTRACT: Analysis of the prevalence of selected congenital anomalies in the Czech Republic in 1994-2009. Retrospective epidemiological analysis of the postnatal and overall (including prenatally diagnosed cases) prevalence of congenital anomalies from the database of the National Registry of Congenital Anomalies of the Czech Republic. Data from the National Registry of Congenital Anomalies (NRCA) maintained by the Institute of Health Information and Statistics of the Czech Republic (IHIS CR) were used. The analysis was carried out for the entire Czech Republic, based on the data from 1994 to 2009. Additional data on prenatally diagnosed anomalies were obtained from medical genetics centres and laboratories in the Czech Republic. This study analyzed the postnatal and overall (including prenatally diagnosed cases) prevalence of congenital anomalies. More detailed analysis was carried out for the following diagnoses: anencephaly, spina bifida, encephalocoele, congenital hydrocephalus, omphalocoele, gastroschisis, oesophageal atresia and stenosis, anorectal anomalies, and diaphragmatic hernia. Prevalence trends were analysed using Poisson regression. In 2009, a total of 118 348 live births were recorded in the Czech Republic, 60 368 boys and 57 980 girls. Of this total, 4 653, i.e. 2 745 boys and 1 908 girls, were diagnosed with congenital anomalies. In 2007-2009, the total of life births with congenital anomalies ranged between 4.6 and 4.8 thousand per year. The respective ranges in this three-year period were in the order of 2.7 and 2.8 thousand per year for boys and 1.9 thousand per year for girls. The prevalence of postnatally diagnosed anencephaly was minimal, as most cases were diagnosed prenatally, and the data did not vary significantly. The prevalence of postnatally diagnosed cases remained at the same level. The effectiveness of the prenatal diagnosis of spina bifida increased and thus the prevalence of postnatally diagnosed cases decreased. The prevalence of prenatally diagnosed encephalocoele increased and that of postnatally diagnosed cases varied between years, with no clear trend. The prevalence of omphalocoele varied for both prenatally and postnatally diagnosed cases; nevertheless, the effectiveness of prenatal diagnosis of this defect increases. The prevalence of gastroschisis remained unchanged, but the number of live births with this diagnosis showed a non-significant upward trend. If the trend reflects the real situation, it could be a result of a changed approach to prenatal diagnosis due to advances in corrective surgery of this defect. The prevalence of live births with congenital hydrocephalus showed a downward trend in the second half of the period 1994-2009 thanks to the improved diagnosis. The prevalence rates of live births with congenital esophageal and anorectal anomalies were slightly increasing. The prevalence of congenital diaphragmatic hernia varied between years but the overall prevalence appeared to be slightly increasing. The prevalence of some congenital anomalies (spina bifida, omphalocoele, and congenital hydrocephalus) showed a downward trend over the study period 1994-2009, mainly as a result of effective prenatal diagnosis. The prevalence of other congenital anomalies such as anencephaly or encephalocoele remained unchanged in live births. As for anencephaly, postnatally diagnosed cases were rare as the prenatal diagnosis was close to 100 %. The trend in encephalocoele is explained by the low incidence of this diagnosis in the population. The third group of postnatally diagnosed congenital anomalies such as gastroschisis or esophageal and anorectal anomalies were on the rise. As for gastroschisis, the reason was the changed approach to prenatal diagnosis due to good prognosis of this operable defect. The prevalence of congenital esophageal and anorectal anomalies varied between years, with a slowly increasing trend, similarly to diaphragmatic hernia.Key words: neural tube anomalies - congenital hydrocehalus - abdominal wall anomalies - congenital esophageal anomalies - anorectal anomalies - congenital diaphragmatic hernia.
    No preview · Article · Apr 2015 · Epidemiologie, mikrobiologie, imunologie: casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne
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    ABSTRACT: OBJECTIVE: Analysis of the prevalence of selected congenital anomalies in the Czech Republic in 1994-2009. DESIGN: Retrospective epidemiological analysis of the postnatal and overall (including prenatally diagnosed cases) prevalence of congenital anomalies from the database of the National Registry of Congenital Anomalies of the Czech Republic. MATERIAL AND METHODS: Data from the National Registry of Congenital Anomalies (NRCA) maintained by the Institute of Health Information and Statistics of the Czech Republic (IHIS CR) were used. The analysis was carried out for the entire Czech Republic, based on the data from 1994 to 2009. Additional data on prenatally diagnosed anomalies were obtained from medical genetics centres and laboratories in the Czech Republic. This study analyzed the postnatal and overall (including prenatally diagnosed cases) prevalence of congenital anomalies. More detailed analysis was carried out for the following diagnoses: anencephaly, spina bifida, encephalocoele, congenital hydrocephalus, omphalocoele, gastroschisis, oesophageal atresia and stenosis, anorectal anomalies, and diaphragmatic hernia. Prevalence trends were analysed using Poisson regression. RESULTS: In 2009, a total of 118 348 live births were recorded in the Czech Republic, 60 368 boys and 57 980 girls. Of this total, 4 653, i.e. 2 745 boys and 1 908 girls, were diagnosed with congenital anomalies. In 2007-2009, the total of life births with congenital anomalies ranged between 4.6 and 4.8 thousand per year. The respective ranges in this three-year period were in the order of 2.7 and 2.8 thousand per year for boys and 1.9 thousand per year for girls. The prevalence of postnatally diagnosed anencephaly was minimal, as most cases were diagnosed prenatally, and the data did not vary significantly. The prevalence of postnatally diagnosed cases remained at the same level. The effectiveness of the prenatal diagnosis of spina bifida increased and thus the prevalence of postnatally diagnosed cases decreased. The prevalence of prenatally diagnosed encephalocoele increased and that of postnatally diagnosed cases varied between years, with no clear trend. The prevalence of omphalocoele varied for both prenatally and postnatally diagnosed cases; nevertheless, the effectiveness of prenatal diagnosis of this defect increases. The prevalence of gastroschisis remained unchanged, but the number of live births with this diagnosis showed a non-significant upward trend. If the trend reflects the real situation, it could be a result of a changed approach to prenatal diagnosis due to advances in corrective surgery of this defect. The prevalence of live births with congenital hydrocephalus showed a downward trend in the second half of the period 1994-2009 thanks to the improved diagnosis. The prevalence rates of live births with congenital esophageal and anorectal anomalies were slightly increasing. The prevalence of congenital diaphragmatic hernia varied between years but the overall prevalence appeared to be slightly increasing. CONCLUSION: The prevalence of some congenital anomalies (spina bifida, omphalocoele, and congenital hydrocephalus) showed a downward trend over the study period 1994-2009, mainly as a result of effective prenatal diagnosis. The prevalence of other congenital anomalies such as anencephaly or encephalocoele remained unchanged in live births. As for anencephaly, postnatally diagnosed cases were rare as the prenatal diagnosis was close to 100 %. The trend in encephalocoele is explained by the low incidence of this diagnosis in the population. The third group of postnatally diagnosed congenital anomalies such as gastroschisis or esophageal and anorectal anomalies were on the rise. As for gastroschisis, the reason was the changed approach to prenatal diagnosis due to good prognosis of this operable defect. The prevalence of congenital esophageal and anorectal anomalies varied between years, with a slowly increasing trend, similarly to diaphragmatic hernia.Key words: neural tube anomalies - congenital hydrocehalus - abdominal wall anomalies - congenital esophageal anomalies - anorectal anomalies - congenital diaphragmatic hernia.
    Full-text · Article · Apr 2015 · Epidemiologie, mikrobiologie, imunologie: casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne
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    ABSTRACT: Article in Czech
    Full-text · Article · Mar 2015
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    Full-text · Article · Mar 2015 · European Psychiatry
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    ABSTRACT: Background: White matter abnormality has been recently proposed as a pathophysiological feature of schizophrenia (SZ). However, most of the data available has been gathered from chronic patients, and was therefore possibly confounded by factors such as duration of the disease, and treatment received. The extent and localization of these changes is also not clear. Methods: We examined a population of early stage SZ patients using diffusion tensor imaging (DTI). 77 SZ patients and 60 healthy controls (HCs) were included in the analysis using Tract-Based Spatial Statistics (TBSS). We have also analyzed 250 randomly created subsets of the original cohort, to investigate the relation between the result of TBSS analysis, and the size of the sample studied. Results: We have found a significant decrease in fractional anisotropy (FA) in the patient group. This change is present in most major white matter (WM) tracts including the corpus callosum, superior and inferior longitudinal fasciculi, inferior fronto-occipital fasciculus, and posterior thalamic radiation. Furthermore, we identified a clear trend towards an increase in the number and spatial extent of significant voxels reported, with an increasing number of subjects included in the analysis. Conclusion: Our study shows that FA is significantly decreased in patients at an early stage of schizophrenia, and that the extent of this finding is dependent on the size of studied sample; therefore underpowered studies might produce results with false spatial localization.
    Full-text · Article · Feb 2015 · Schizophrenia Research
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    P. Sos · M. Klirova · T. Novak · M. Brunovsky · J. Horacek · C. Hoschl

    Full-text · Article · Dec 2014 · European Psychiatry
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    ABSTRACT: Pharmacological models of psychosis bring a unique tool for studying brain disconnection in humans as well as in animals. Even though several electrophysiological biomarkers have been already described in schizophrenia, little is known about EEG biomarkers in pharmacological models of psychosis and about the translational validity of these data. Studies on EEG brain connectivity in rodents under these circumstances are extremely rare. To elucidate the characteristic patterns of EEG connectivity in freely moving rats we have conducted a series of experiments in serotonergic and glutamatergic models of psychosis. Using multiple cortical electrodes, EEG spectral and connectivity analysis was performed on selected episodes of behavioral inactivity – a model of resting EEG. The analyses showed consistent changes that were specific for each of the models used. Glutamatergic models with ketamine and dizocilpin (MK-801) induced typical global increase in high frequency oscillations. On the contrary, in serotonergic models (psilocin, mescaline, LSD, DOB, 2C-B) a global power decrease was observed. A common denominator in both models was a global decrease in connectivity expressed as decreased coherence in most of the frequency bands. A translational validity of these findings is supported by findings in schizophrenia patients and by recent human studies with ketamine and psilocybin. Recently obtained results with drugs modulating serotonergic, dopaminergic and glutamatergic neurotransmission will be also discussed in the light of potential therapeutic implications.
    No preview · Article · Dec 2014 · European Psychiatry
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    Full-text · Article · Dec 2014 · Central European journal of public health

  • No preview · Article · Oct 2014

  • No preview · Article · Oct 2014 · European Neuropsychopharmacology
  • P. Sos · M. Klirova · T. Novak · M. Brunovsky · J. Horacek · C. Hoschl

    No preview · Article · Oct 2014 · European Neuropsychopharmacology

Publication Stats

707 Citations
306.23 Total Impact Points

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Institutions

  • 1999-2015
    • Charles University in Prague
      • 3rd Faculty of Medicine
      Praha, Praha, Czech Republic
  • 2005-2014
    • Prague Psychiatric Center
      Praha, Praha, Czech Republic
  • 2003-2014
    • The Police Academy of the Czech Republic in Prague
      Praha, Praha, Czech Republic
  • 1999-2013
    • Thomayerova nemocnice
      Praha, Praha, Czech Republic
  • 1998-2007
    • Ústav pro péči o matku a dítě
      Praha, Praha, Czech Republic