Dae Sik Kim

Kyonggi University, Sŏul, Seoul, South Korea

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Publications (87)224.43 Total impact

  • [Show abstract] [Hide abstract] ABSTRACT: Background/aims: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed, and a substantial number of patients need alternative treatment strategies. Methods: We have evaluated the effects of deferasirox, an orally active iron chelator, and imatinib on K562 and KU812 human CML cell lines. Imatinib-resistant CML cell lines were created by exposing cells to gradually increasing concentrations of imatinib. Results: Co-treatment of cells with deferasirox and imatinib induced a synergistic dose-dependent inhibition of proliferation of both CML cell lines. Cell cycle analysis showed an accumulation of cells in the subG1 phase. Western blot analysis of apoptotic proteins showed that co-treatment with deferasirox and imatinib induced an increased expression of apoptotic proteins. These tendencies were clearly identified in imatinib-resistant CML cell lines. The results also showed that co-treatment with deferasirox and imatinib reduced the expression of BcrAbl, phosphorylated Bcr-Abl, nuclear factor-κB (NF-κB) and β-catenin. Conclusions: We observed synergistic effects of deferasirox and imatinib on both imatinib-resistant and imatinib-sensitive cell lines. These effects were due to induction of apoptosis and cell cycle arrest by down-regulated expression of NF-κB and β-catenin levels. Based on these results, we suggest that a combination treatment of deferasirox and imatinib could be considered as an alternative treatment option for imatinib-resistant CML.
    No preview · Article · Feb 2016 · The Korean Journal of Internal Medicine
  • [Show abstract] [Hide abstract] ABSTRACT: Developing a parameter to predict bone marrow invasion by non-Hodgkin's lymphoma is an important unmet medical need for treatment decisions. This study aimed to confirm the validity of the hypothesis that bone marrow plasma vascular endothelial growth factor level might be correlated with the risk of bone marrow involvement and the prognosis of patients with diffuse large B-cell non-Hodgkin's lymphoma. Forty-nine diffuse large B-cell lymphoma patients treated with rituximab, cyclophosphamide, daunorubicin, vincristine and prednisolone regimen were enrolled. Vascular endothelial growth factor level was measured with enzyme-linked immunosorbent assay. The validity of bone marrow plasma vascular endothelial growth factor level and bone marrow vascular endothelial growth factor level per platelet count for predicting treatment response and survival after initial rituximab, cyclophosphamide, daunorubicin, vincristine and prednisolone combined chemotherapy was assessed. Bone marrow plasma vascular endothelial growth factor level per platelet count was significantly associated with old age (≥65 years), poor performance score (≥2), high International prognosis index (≥3) and bone marrow invasion. The patients with high bone marrow plasma vascular endothelial growth factor level per platelet count (≥3.01) showed a significantly lower complete response rate than the others. On Kaplan-Meier survival curves, the patients with high bone marrow plasma vascular endothelial growth factor levels (≥655 pg/ml) or high bone marrow plasma vascular endothelial growth factor level per platelet count (≥3.01) demonstrated a significantly shorter overall survival and progression-free survival than the others. In the patients without bone marrow involvement, bone marrow plasma vascular endothelial growth factor level per platelet count had a significant relationship with overall survival and progression-free survival. Multivariate analysis revealed that the patients without BM invasion showing high level of bone marrow plasma vascular endothelial growth factor per platelet count had significantly shorter progression-free survival and overall survival. Bone marrow plasma vascular endothelial growth factor level per platelet count might be associated with bone marrow invasion by diffuse large B-cell lymphoma and is correlated with clinical outcomes after treatment. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
    No preview · Article · Jul 2015 · Japanese Journal of Clinical Oncology
  • [Show abstract] [Hide abstract] ABSTRACT: We compared the efficacy of high-dose cytarabine alone to that of intermediate-dose cytarabine combined with anthracyclines as consolidation therapy. Patients enrolled in the Korea University acute myeloid leukemia (AML) registry received remission induction chemotherapy with the same standard induction regimen (idarubicin and cytarabine 3 + 7). Postremission therapy was performed for three or four cycles according to one of the following regimens: high-dose cytarabine (3 g/m(2)) or combination of intermediate-dose cytarabine (1 g/m(2)) with anthracyclines (idarubicin or mitoxantrone). Among the 443 AML patients enrolled in the registry, 145 patients received consolidation chemotherapy. The median overall survival (OS) and relapse-free survival (RFS) in the high-dose cytarabine group were significantly longer than those in the anthracycline combination group (OS, not reached vs. 16.6 months, p = 0.045; RFS, 38.6 months vs. 11.0 months, p = 0.011). The median duration of neutropenia was longer in the anthracycline combination group than in the high-dose cytarabine group (8 vs. 10 days, p = 0.001). This study suggests that high-dose cytarabine consolidation may produce superior outcomes than combination treatment with intermediate-dose cytarabine and anthracyclines and that the addition of anthracyclines during AML consolidation has limited value as compared to cytarabine intensification.
    No preview · Article · May 2015 · Annals of Hematology
  • [Show abstract] [Hide abstract] ABSTRACT: Background: Despite the advances in acute myeloid leukemia (AML) treatment, the prognosis of elderly patients remains poor and no definitive treatment guideline has been established. In the present study, we aimed to evaluate the effectiveness of intensive chemotherapy in elderly AML patients and to determine which subgroup of patients would be most responsive to the therapy. Methods: We retrospectively analyzed 84 elderly patients: 35, 19, and 30 patients were administered intensive chemotherapy, low-dose chemotherapy, and supportive care, respectively. Results: Among those who received intensive chemotherapy, there were 17 cases of remission after induction chemotherapy; treatment-related mortality was 22.9%. The median overall survival was 7.9 months. Multivariate analysis indicated that the significant prognostic factors for overall survival were performance status, fever before treatment, platelet count, blast count, cytogenetic risk category, and intensive chemotherapy. Subgroup analysis showed that intensive chemotherapy was markedly effective in the relatively younger patients (65-70 years) and those with de novo AML, better-to-intermediate cytogenetic risk, no fever before treatment, high albumin levels, and high lactate dehydrogenase levels. Conclusions: Elderly AML patients had better outcomes with intensive chemotherapy than with low-intensity chemotherapy. Thus, appropriate subgroup selection for intensive chemotherapy is likely to improve therapeutic outcome.
    No preview · Article · Dec 2014 · Acta Haematologica
  • Dae Sik Kim · Seuk Buom Kim
    [Show abstract] [Hide abstract] ABSTRACT: This article describes the electrochemical performance of an air electrode employing a CNF/Co3O4 composite. A polydopamine layer was coated on the surface of the composite to increase its wettability toward the electrolyte used. In addition, a dissolved catalyst (LiI) was introduced to facilitate the dissociation of reaction products. The polydopamine-coated CNF/Co3O4 composite showed better charge capacity and cyclic performance than a pristine CNF/Co3O4 composite. Moreover, the use of LiI effectively decreased the overpotential and increased the cyclic performance of Li-air cells. Thus, the combined use of a polydopamine-coated CNF/Co3O4 composite and a dissolved catalyst (LiI) was very effective for enhancing the electrochemical properties of Li-air cells.
    No preview · Article · Dec 2014 · Journal of Electroceramics
  • No preview · Article · Oct 2014 · Cancer Research
  • [Show abstract] [Hide abstract] ABSTRACT: Polycarbonate (PC) and acrylonitrile-butadiene-styrene (ABS) blends were prepared using a high shear extruder to investigate their thermal decomposition and mechanical properties with shear rate and shear time. In this experiment, high shear rate, from 1000 to 3000 rpm, in blending process was applied for 10 to 40 sec, respectively. At high shear rate over than 2000 rpm, the initial decomposition temperature was dropped significantly compared to a compounded sample because of thermal decomposition of the blend by high shear. Consequently, high shear processing gave an important effect on the mechanical and thermal properties of the PC/ABS blend. In particular, elongation of the blend decreased significantly with shear rate.
    No preview · Article · Jul 2014 · Polymer Korea
  • Dae Sik Kim · Yong Joon Park
    [Show abstract] [Hide abstract] ABSTRACT: We demonstrate a simple method for enhancing the electrochemical performance of air electrodes of Li–air batteries using a polydopamine coating on the surface of carbon. A thin polydopamine layer on Ketjen black carbon clearly modified the surface properties of the air electrode, in turn resulting in improved electrolyte filling. The coating also passivates surface carbon defects, which may be helpful in suppressing parasitic reactions during cycling. Electrochemical tests of the electrode indicate that the introduction of the polydopamine layer is beneficial in that it increases the capacity, lowers the overpotential, and improves the cyclic performance of Li–air cells. These effects may be associated with the increased active catalytic area of the electrode, mostly resulting from the improved wetting characteristics. The suppression of parasitic reactions due to the passivation of carbon defects also contributes to the enhanced cyclic performance of the polydopamine-treated electrode.
    No preview · Article · Jun 2014 · Electrochimica Acta
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    [Show abstract] [Hide abstract] ABSTRACT: Colorectal cancer (CRC) has a high risk for postoperative thromboembolic complications such as venous thromboembolism (VTE) compared to other surgical diseases, but the relationship between VTE and CRC in Asian patients remains poorly understood. The present study examined the incidence of symptomatic VTE in Korean patients who underwent surgery for CRC. We also identified risk factors, incidence and survival rate for VTE in these patients. The patients were identified from the CRC database treated from January 2011 to December 2012 in a single institution. These patients were classified into VTE and non-VTE groups, their demographic features were compared, and the factors which had significant effects on VTE and mortality between the two groups were analyzed. We analyzed retrospectively a total of 840 patients and the incidence of VTE was 3.7% (31 patients) during the follow-up period (mean, 17.2 months). Histologic subtype (mucinous adenocarcinoma) and previous history of VTE affected the incidence of VTE on multivariate analysis. There was a statistically significant difference in survival rate between the VTE and non-VTE group, but VTE wasn't the factor affecting survival rate on multivariate analysis. Comparing differences in survival rate for each pathologic stage, there was only a significant difference in stage II patients. Among CRC patients after surgery, the incidence of VTE was approximately 3% within 1 year and development of VTE wasn't a significant risk factor for death in our study but these findings are not conclusive due to our small sample size.
    Preview · Article · Jun 2014
  • Dae Sik Kim · Yong Joon Park
    [Show abstract] [Hide abstract] ABSTRACT: Oxide catalysts such as MnO2 and Co3O4 are effective in improving the electrochemical performance of the air electrode of a Li–air cell. However, it is difficult to bring the oxide catalyst into homogeneous contact with the reaction products formed during the discharge process. To overcome this problem and to enhance the performance of Li–air cells, an oxide catalyst and an additionally dissolved catalyst (LiI) were used in combination. LiI dissolved in an electrolyte can freely access and react with solid reaction products, thereby facilitating their catalytic decomposition. In this study, the electrochemical performance of an air electrode in combination with a pristine and a LiI-dissolved electrolyte system was characterized and compared. Analysis of the surface morphology of the air electrode before and after cycling along with the phases of the reaction products was conducted.
    No preview · Article · Apr 2014 · Journal of Alloys and Compounds
  • Dae Sik Kim · Yong Joon Park
    [Show abstract] [Hide abstract] ABSTRACT: In general, air electrodes are fabricated by mixing an oxide catalyst, carbon, and a binder. However, a nanosized oxide catalyst may not disperse homogeneously; instead, it easily aggregates, thus limiting its full catalytic activity. In order to solve this problem, a carbon nanofiber (CNF)/Co3O4 composite was prepared and characterized in this work. A polydopamine layer was used as a binding agent for the CNFs and Co3O4. The polydopamine-assisted CNF/Co3O4 composite was characterized by homogeneously dispersed nanosized Co3O4 particles, resulting in a wide catalytic active area. The electrode containing the CNF/Co3O4 composite was prepared via the buckypaper method and exhibited superior capacity, lower overpotential, and better cyclic performance than an electrode containing commercial Co3O4 nanoparticles and CNFs. This result indicates that the CNF/Co3O4 composite is an effective catalyst for air electrodes of lithium-air cells.
    No preview · Article · Mar 2014 · Solid State Ionics
  • [Show abstract] [Hide abstract] ABSTRACT: Despite several reports on clinical aspects of anemia and malignancy, little is known of male patients with iron-deficiency anemia (IDA) and malignancy in Korea. We examined the cause of anemia, prevalence of and factors associated with malignancy, and treatment response to iron therapy in male IDA patients.
    No preview · Article · Jan 2014
  • Dae Sik Kim · Yong Joon Park
    [Show abstract] [Hide abstract] ABSTRACT: A Ketjen black/Co3O4 catalyst nanocomposite was fabricated for use in an enhanced air electrode for Li/air batteries. Polydopamine was used as a coating on Ketjen black to act as a reaction agent, for ensuring homogeneous reaction and adequate distribution of the catalyst nanoparticles on the surface. The results of various characterization analyses indicated successful immobilization of Co3O4 via the polydopamine layer. An electrode prepared using the polydopamine-assisted Ketjen black/Co3O4 nanocomposite exhibited a low overpotential and excellent capacity and cyclic performance, demonstrating the suitability of this novel nanocomposite for use in the air electrode of a Li/air cell.
    No preview · Article · Oct 2013 · Journal of Alloys and Compounds
  • Dae Sik Kim · Dong Gyu Na
    [Show abstract] [Hide abstract] ABSTRACT: PURPOSE ‘FNA tract sign’ was defined as a linear hypoechoic needle tract transiently created by to and fro motion of a FNA needle during the FNA procedure. This study was performed to retrospectively determine if the ‘FNA tract sign’ is predictive of a benign follicular thyroid nodule. METHOD AND MATERIALS FNA was performed for 3866 nodules of 2961 patients for 26 months. One experienced radiologist prospectively evaluated the presence of the FNA tract sign during each FNA procedure. This study included 102 (2.6%) nodules of 100 (3.4%) patients that showed FNA tract signs during FNA procedures. Final diagnoses of thyroid nodules were made by surgery for follicular neoplasm or malignancy and by at least two times of FNA or core-needle biopsy for benign thyroid nodules. We retrospectively evaluated US features of nodules and also assessed the FNA cytology results and final diagnoses of positive tract sign nodules. We evaluated the malignancy risk of positive tract sign nodules based on final diagnoses. RESULTS The FNA cytology results of 102 thyroid nodules with FNA tract signs were nondiagnositc 6 nodule (6%), benign 79 (77%), atypical of undetermined significance 13 (13%), and follicular neoplasm 4 (4%). The final diagnosis was made in 49 (48%) of 102 nodules; 48 benign nodules (nodular hyperplasia or benign follicular nodule 47, follicular adenoma 1) and one malignant nodule (minimally invasive follicular carcinoma). The initial FNA cytology results of finally diagnosed thyroid nodules with FNA tract signs were nodiagnostic 1 (2%), benign 43 (88%), AUS 4(8%), and follicular neoplasm 1 (2%). The most common sonographic feature of nodules with FNA tract sign nodules were solid (97%), ovoid to round shape (99%), well-defined smooth margin (71%), isoechogenicity (84%), absence of calcification (91%), central and peripheral vascularity (67%), hypoechoic halo (87%), and absence of spongiform appearance (96%). The malignant risk of nodules with FNA tract sign was 2%. The malignant risk of isoechoic nodules with FNA tract sign was 0% (0/45) and that of hypoechoic nodules with FNA tract sign was 25% (1/4). CONCLUSION FNA tract sign is highly predictive of a benign follicular nodule and isoechoic thyroid nodule with FNA tract sign may be considered as a benign follicular nodule. CLINICAL RELEVANCE/APPLICATION Although FNA tract sign is uncommon, it will be helpful in the management of thyroid nodules.
    No preview · Conference Paper · Nov 2012
  • [Show abstract] [Hide abstract] ABSTRACT: PURPOSE To investigate malignancy risk and US features of two subtypes of thyroid nodules diagnosed as atypia of undetermined significance (AUS) by FNA. METHOD AND MATERIALS The Bethesda System was used for US-guided FNA diagnoses. The study included 200 nodules (Group 1, n=159, Group 2, n=41) of consecutive 187 patients in which FNA showed AUS diagnosis. Group1 included nodules with various types of nuclear atypia. Group2 included nodules with frequent microfollicle formation or Hurthle cells. Final diagnoses were obtained in 82 nodules (33 malignant nodules and 49 benign nodules). Two thyroid radiologists retrospectively evaluated US characteristics of thyroid nodules, and compared the malignancy risk and US features between two groups. A χ2 test was used for statistical analysis. RESULTS Malignancy rate of Group1 was slightly higher than that of Group2, but not statistically significant (Group 1, 41.8% versus Group 2, 33.3%, P = .772). Papillary thyroid cancer was found in 26 (92.9%) of 28 carcinomas in Group1 and in 2 (40%) of 5 carcinomas in Group2. There was significant difference of US features only in the margin and orientation (taller than wide) of nodules between two groups. Smooth margin of a nodule was significantly more common in Group 2 than that in Group 1 (Group 1, 71.1% versus Group 2, 97.6%, P < .001) and spiculated margin was found only in Group 1 (Group 1, 12% versus Group 2, 0%, P = .016). Nonparallel orientation of a nodule was found only in Group 1 (Group 1, 10.7% versus Group 2, 0%, P = .026). There was no significant difference of other US features between the two Groups. Presence of any of 5 malignant US features (spiculated margin, nonparallel orientation, marked hypoechogencity, microcalcification, and macrocalcification) was predictive of malignancy in Group 1 (malignancy 64.2% vs. benign 33.3%, P = .015), but it was not predictive of malignancy in Group 2 (malignancy 20% vs. benign 20%, P = 1). CONCLUSION There was a tendency of higher malignancy risk and incidence of papillary thyroid cancer in Group 1 compared with Group 2. US features of nonparallel orientation and spiculated margin were found only in Group 1, and malignant US features was not predictive of malignancy in Group 2. CLINICAL RELEVANCE/APPLICATION The difference of clinical and US features between the two subtypes of AUS should be considered in the management of thyroid nodules with AUS FNA diagnosis.The difference of clinical and US features b
    No preview · Conference Paper · Nov 2012
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    [Show abstract] [Hide abstract] ABSTRACT: Bronchobiliary fistula (BBF), defined as an abnormal communication between the biliary duct and bronchial trees, is a very rare condition. Bilioptysis is a pathognomonic finding for BBF. We studied a 58-year-old man, who had a BBF complicated by liver biloma that occurred after radiofrequency ablation. The diagnosis was confirmed by the presence of bile-stained sputum and an Endoscopic Retrograde Cholangio-Pancreatography. BBF was treated successfully by endoscopic sphincterotomy and biliary drainage with insertion of a double pig-tail plastic stent into the biloma. We suggest that the optimal choice of treatment modality for BBF depends on the natural course of the underlying disease, and the status of the biliary stricture.
    Preview · Article · Feb 2012 · Tuberculosis and Respiratory Diseases
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    [Show abstract] [Hide abstract] ABSTRACT: Propylthiouracil (PTU) is one of the most common drugs used in the treatment of Graves' disease. There are a number of side effects found with PTU use including fever, rash, arthralgia, and flu-like symptoms. Recently antineutrophil cytoplasmic antibodies (ANCA) positive vasculitis after PTU treatment was reported as a rare side effect, which can cause diffuse alveolar hemorrhage and glomerulonephritis. A 45-year-old woman with Graves' disease had been treated with PTU for five months, complained of hemoptysis due to pulmonary alveolar hemorrhage causing anemia, and also had hematuria. Simple chest X-ray and HRCT showed bilateral consolidation and bronchoalveolar lavage fluid revealed alveolar hemorrhage. A serologic test was positive for ANCA against myeloperoxidase and proteinase-3. Such findings suggested that the presence of PTU induced ANCA positive vasculitis. Cessation of PTU and the administration of high dose steroids improved the clinical manifestation, radiologic and serologic findings. We observed ANCA titer serially for 6 years. During the follow up period, ANCA titer decreased slowly and stayed within the acceptable upper normal limit.
    Preview · Article · Jan 2012 · Tuberculosis and Respiratory Diseases
  • [Show abstract] [Hide abstract] ABSTRACT: Leiomyoma of the tracheobroncheal tree is a very rare benign tumor of the lung. Airway obstructive symptoms can be similar to those of asthma; therefore, delayed or misdiagnosis is common. Although surgical resection with bronchoplastic reconstruction has long been the standard treatment, improvements in the technique have led to therapeutic bronchoscopy replacing surgery for treatment of benign tumors of the tracheobroncheal tree. We report a case of tracheal leiomyoma that was successfully resected under rigid bronchoscopy using an electrosurgical unit and bronchial snare.
    No preview · Article · Jan 2012
  • [Show abstract] [Hide abstract] ABSTRACT: Acute pancreatitis caused by primary hyperparathyroidism-induced hypercalcemia is a rare condition, as acute pancreatitis is typically associated with a decrease in serum calcium levels. If hypercalcemia is present in a patient with acute pancreatitis, the possibility of hyperparathyroidism should be considered, and parathyroid hormone levels should be evaluated and the parathyroid gland imaged. We present a case of a 48-year-old male with acute recurrent pancreatitis caused by hyperparathyroidism. Initially, the acute pancreatitis improved after conservative therapy. However, the patient relapsed 1 month later. The patient had hypercalcemia and was diagnosed with parathyroid adenoma. He underwent surgical resection of the parathyroid adenoma and recovered. After 24 months of the treatment, there was no recurrence of the hypercalcemia or pancreatitis.
    No preview · Article · Jan 2012
  • [Show abstract] [Hide abstract] ABSTRACT: An esophageal submucosal gland duct adenoma is a rare benign disease. We report a 58-year-old man who presented with an esophageal submucosal tumor on health screening endoscopy. The endoscopic examination showed a round elevated lesion with central depression at the mid-esophagus. On endoscopic ultrasonography, an anechoic lesion with some hyperechoic septal structures measuring 8 mm in the largest diameter was observed in the third layer. We resected the lesion endoscopically. Histologically, there were several dilated gland ducts, with proliferation of the inner epithelial and outer myoepithelial cell layers. These findings were compatible with a submucosal gland duct adenoma of the esophagus.
    No preview · Article · Jan 2012

Publication Stats

2k Citations
224.43 Total Impact Points


  • 2013-2014
    • Kyonggi University
      • Department of Advanced Materials Engineering
      Sŏul, Seoul, South Korea
  • 2012
    • Sungkyunkwan University
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2009-2012
    • Los Alamos National Laboratory
      • • Materials Physics and Applications Division
      • • Sensors and Electrochemical Devices Group
      Лос-Аламос, California, United States
  • 2008-2011
    • Seoul National University Hospital
      • Department of Radiology
      Sŏul, Seoul, South Korea
    • Korea University
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2006-2009
    • National Research Council Canada
      Ottawa, Ontario, Canada
  • 2001-2009
    • Seoul National University
      Sŏul, Seoul, South Korea
  • 2001-2005
    • Hanyang University
      • • Division of Chemical Engineering and Bioengineering
      • • Division of Mechanical Engineering
      Sŏul, Seoul, South Korea
  • 2000
    • Gyeongsang National University
      Shinshū, Gyeongsangnam-do, South Korea