Nisreen K Mesiwala

University of Michigan, Ann Arbor, Michigan, United States

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Publications (4)6.32 Total impact

  • Nisreen K Mesiwala · Melike Pekmezci · Jehn-Yu Huang · Travis C Porco · Shan C Lin
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    ABSTRACT: To compare optic disc measurements between the new Fourier-domain optical coherence tomography (RTVue-100) and the confocal scanning laser ophthalmoscopy (Heidelberg retinal tomography, HRT-II) in clinical practice. Patients seen from the glaucoma service of an academic department of ophthalmology between August 2008 to August 2009 with good-quality RTVue-100 and HRT-II images within 6 months of each other were included (363 patients were included, 1 eye from each patient). The rim of the optic disc was drawn automatically by RTVue-100 and manually by a single experienced observer for HRT-II. Optic disc measurements from both imaging devices were compared using Bland-Altman plots and the Student t test to assess agreement. The main outcome measure was the agreement in optic disc parameters between the two imaging devices. Bland-Altman plots indicate significant differences between the RTVue-100 and HRT-II for all optic nerve parameters. The mean HRT-II values were consistently larger than RTVue-100 values for optic disc area and rim area. The RTVue-100 values were larger for the cup area, cup-to-disc area ratio, and vertical and horizontal cup-to-disc ratio. The Student t test showed P<0.001 for averages of all measurements between the two devices. We conclude that the disc parameters from these two imaging devices are not interchangeable.
    No preview · Article · Jun 2011 · Journal of glaucoma
  • Nisreen K Mesiwala · Melike Pekmezci · Travis C Porco · Shan C Lin
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    ABSTRACT: To compare optic disc parameters when using manual disc detection versus automated software on RTVue-100 Fourier-domain optical coherence tomography. Nonrandomized comparative study using images obtained from a tertiary-care Glaucoma Clinic from August, 2008 to May, 2009. Four hundred thirty-four patients with mean age of 67.1 years (±13.4) underwent OCT imaging with RTVue-100. Optic disc margins were manually defined by a single, trained operator and redefined with automated software that estimates the position of the retinal pigment epithelium edges. Bland-Altman plots and intraclass correlations measured agreement between the 2 detection methods for various optic disc parameters. Bland-Altman plots/intraclass correlations showed good agreement in the following optic disc parameters: optic disc area, cup area, rim area, cup-to-disc area ratio, cup-to-disc ratio, and retinal nerve fiber layer thickness. There was no significant difference in measurements when comparing hand versus automated disc contour determination (P>0.05). Automated determination of the disc margin was in high agreement with subjective, manual assessment and should be used in clinical practice as it can make optical coherence tomography scanning more efficient and standardized, as disc detection would only be done by the software and not biased by multiple operators.
    No preview · Article · Apr 2011 · Journal of glaucoma
  • Jehn-Yu Huang · Melike Pekmezci · Nisreen Mesiwala · Andrew Kao · Shan Lin
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    ABSTRACT: To evaluate the capability of the optic disc, peripapillary retinal nerve fiber layer (P-RNFL), macular inner retinal layer (M-IRL) parameters, and their combination obtained by Fourier-domain optical coherent tomography (OCT) in differentiating a glaucoma suspect from perimetric glaucoma. Two hundred and twenty eyes from 220 patients were enrolled in this study. The optic disc morphology, P-RNFL, and M-IRL were assessed by the Fourier-domain OCT (RTVue OCT, Model RT100, Optovue, Fremont, CA). A linear discriminant function was generated by stepwise linear discriminant analysis on the basis of OCT parameters and demographic factors. The diagnostic power of these parameters was evaluated with receiver operating characteristic (ROC) curve analysis. The diagnostic power in the clinically relevant range (specificity ≥ 80%) was presented as the partial area under the ROC curve (partial AROC). The individual OCT parameter with the largest AROC and partial AROC in the high specificity (≥ 80%) range were cup/disc vertical ratio (AROC = 0.854 and partial AROC = 0.142) for the optic disc parameters, average thickness (AROC = 0.919 and partial AROC = 0.147) for P-RNFL parameters, inferior hemisphere thickness (AROC = 0.871 and partial AROC = 0.138) for M-IRL parameters, respectively. The linear discriminant function further enhanced the ability in detecting perimetric glaucoma (AROC = 0.970 and partial AROC = 0.172). Average P-RNFL thickness is the optimal individual OCT parameter to detect perimetric glaucoma. Simultaneous evaluation on disc morphology, P-RNFL, and M-IRL thickness can improve the diagnostic accuracy in diagnosing glaucoma.
    No preview · Article · Feb 2011 · Journal of glaucoma
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    ABSTRACT: To test the hypothesis that histamine 3 receptor (H3R) activation during Helicobacter infection inhibits gastric acid secretion in vivo and in vitro. Helicobacter felis (H. felis) infected and uninfected C57Bl/6 mice were infused with either PBS or the H3 receptor antagonist thioperamide (THIO) for 12 wk. After treatment, mice were analyzed for morphological changes and gastric acid content. Total RNA was prepared from the stomachs of each group and analyzed for changes in somatostatin and gastrin mRNA abundance by real time-polymerase chain reaction (RT-PCR). Location of H3 receptors in the stomach was analyzed by co-localization using antibodies specific for the H3 receptor and parietal cell marker H(+), K(+)-ATPase β subunit. Inflammation and parietal cell atrophy was observed after 12 wk of H. felis infection. Interestingly, treatment with the H3R antagonist thioperamide (THIO) prior to and during infection prevented H. felis-induced inflammation and atrophy. Compared to the uninfected controls, infected mice also had significantly decreased gastric acid. After eradication of H. felis with THIO treatment, gastric acidity was restored. Compared to the control mice, somatostatin mRNA abundance was decreased while gastrin gene expression was elevated during infection. Despite elevated gastric acid levels, after eradication of H. felis with THIO, somatostatin mRNA was elevated whereas gastrin mRNA was suppressed. Immunofluorescence revealed the presence of H3 receptors on the parietal cells, somatostatin-secreting D-cells as well as the inflammatory cells. This study shows that during H. felis infection, gastric acidity is suppressed as a consequence of an inhibitory effect on the parietal cell by H3R activation. The stimulation of gastric mucosal H3Rs increases gastrin expression and release by inhibiting release of somatostatin.
    Full-text · Article · Dec 2010

Publication Stats

39 Citations
6.32 Total Impact Points

Top Journals


  • 2011
    • University of Michigan
      Ann Arbor, Michigan, United States
    • University of California, San Francisco
      • Department of Ophthalmology
      San Francisco, California, United States