Zunyao Wang

Nanjing University, Nan-ching, Jiangsu, China

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Publications (88)251.82 Total impact

  • Chenguang Li · Li Qin · Ruijuan Qu · Ping Sun · Zunyao Wang
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    ABSTRACT: In this study, we evaluated the toxicity of ten polyfluorinated dibenzo-p-dioxins (PFDDs) congeners to freshwater fish Carassius auratus, by determining the antioxidative responses and lipid peroxidation in the liver after the fish were injected with two different concentrations (10 and 100µmol/kg) of individual PFDDs for 3 and 14 days. The results showed that oxidative stress was obviously induced in some PFDDs-treated groups, as implied by the significantly inhibited antioxidants levels (superoxide dismutase, catalase, reduced glutathione, and glutathione S-transferase) and elevated malondialdehyde content. In addition, the oxidative stress inducing ability was variable for different PFDDs congeners, which was related with the substitution number and position of fluorine atom. Based on the calculated integrated biomarker response (IBR) values, the toxicity was ranked as 2,3,7,8-FDD>Octa-FDD>1,2,3,4,7-FDD>1,3,6,8-FDD>1,2,3,4,6,7-FDD>1,2,6,7-FDD>1,2,7-FDD>DD>2,7-FDD>2-FDD. This study can enhance the general understanding of the PFDDs induced oxidative stress in aquatic organisms.
    No preview · Article · Apr 2016 · Ecotoxicology and Environmental Safety
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    ABSTRACT: The occurrence of benzophenone-4 (BP-4) in water environments may pose a serious public health hazard due to its potential endocrine disrupting effects. In this work, the intermediates, probable degradation pathways and toxicity changes during ozonation of BP-4 in aqueous solution were systematically investigated. Results revealed that alkaline conditions favored the oxidation of BP-4. However, inorganic anions (Cl(-), NO3(-), SO4(2-)), cations (K(+), Ca(2+), Mg(2+)) and humic acid had no remarkable effect on BP-4 removal within the tested concentrations. Ozonation was also effective for the fast removal of BP-4 in real waters. The TOC suggested a low mineralization rate, even after the complete BP-4 removal. Meanwhile, the treated mixtures exhibited an obvious inhibition to the bioluminescent bacteria Photobacterium phosphoreum, indicating the formation of transformation products with higher toxicities. Furthermore, fourteen products were identified by means of liquid chromatography-mass spectrometry. Notably, seven of them have not been reported previously. The quenching test indicated that the degradation processes probably were dominated by OH. Next, possible degradation pathways were proposed and further justified by theoretical calculations of frontier electron densities. This investigation will contribute to the systematic elucidation of the ozonation process of UV filters in aquatic environments.
    No preview · Article · Apr 2016 · Chemosphere
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    ABSTRACT: With the increasing applications of carbon nanotubes (CNTs) worldwide, considerable concerns have been raised regarding their inevitable releases into natural waters and ecotoxicity. It was supposed that CNTs may interact with some existing pollutants like zinc in aquatic systems and exhibit different effects when compared with their single treatments. However, data on their possible combined toxicity on aquatic species are still lacking. Moreover, the interactions of Zn with different functionalized CNTs may be distinct and thereby lead to diverse results. It is like that functional groups play a vital role in illustrating the differences in toxicity among various CNTs. In this study, the single and joint effects of multi-walled carbon nanotubes (MWCNTs) and two MWCNTs functionalized with carboxylation (COOH-MWCNTs) or hydroxylation (OH-MWCNTs) in the absence or presence of zinc (Zn) on antioxidant status and histopathological changes in Carassius auratus were evaluated. Synergistic effect was tentatively proposed for joint-toxicity action, which was supported by apparently observed oxidative stress and histopathological changes in joint exposure groups. The integrated biomarker response index was calculated to rank the toxicity order, from which the conclusion of synergistic effect was strengthened. Regarding differences among various CNTs, our data showed that OH-MWCNTs and COOH-MWCNTs were more stressful to fish than raw MWCNTs. This finding sustained that functionalization is an important factor in nanotoxicity, which may serve as clues for future design and application of CNTs. Overall, these results provided some valuable toxicological data on the joint effects of CNTs and heavy metals on aquatic species, which can facilitate further understanding on the potential impacts of other coexisting pollutants in the culture of freshwater fish.
    Full-text · Article · Mar 2016 · Ecotoxicology and Environmental Safety
  • Xiaolan Zeng · Xiaoling Zhang · Zunyao Wang
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    ABSTRACT: Density functional theory (DFT) calculations at the B3LYP/6-311++G(2df,p) level of theory have been carried out to investigate the atmospheric oxidation mechanisms of some polyfluorinated dibenzo-p-dioxins (PFDDs), initiated by OH radical. The computed results show that all OH addition reactions of PFDDs are thermodynamically spontaneous processes and the branch ratio of the PFDD-OH adducts is determined by the magnitude of the Gibbs free energies of activation (ΔrG(≠)) and hence rate constants (k) for addition reactions. The OH reactions with all studied PFDDs are dominated by Cγ-addition and the total rate constants for OH addition decrease with increasing the number of fluorine atom substituting at α positions. Under the atmospheric conditions, the subsequent O2 addition reactions of PFDD-OH adducts occur hardly thermodynamically and are slow kinetically. For PFDD-α(β)-OH adducts without F atom at same positions the main reaction pathway is H abstraction by O2, while PFDD-γ-OH adducts will undergo fused-ring C-O bond cleavage, affording the substituted phenoxy radicals.
    No preview · Article · Feb 2016 · Chemosphere
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    ABSTRACT: By using CNTs functionalized by oxygenic functional groups (COOH or OH) as the carbon source, novel catalysts of nitrogen (N) and sulfur (S) co-doped multi-walled carbon nanotubes (CNTs) were prepared for the first time by thermal decomposition. The obtained CNTs were characterized by SEM, TEM, BET, XPS, XRD, FT-IR and Raman spectroscopy. Additionally, the new material was used as a catalyst for the activation of peroxymonosulfate (PMS) for the degradation of benzophenone-4 (BP-4). Results indicated that the COOH group plays an important role in the S doping process. Moreover, binary (N and S)-doped CNT-COOH (NS-CNT-COOH) exhibited a notably enhanced catalytic activity towards PMS for degrading BP-4. This activity level was approximately five-fold greater than that of singly (N)-doped CNT-COOH and binary (N and S)-doped CNT, and it even exceeded that of the metal catalyst CuFe2O4. The enhanced catalytic performance was attributed to the active sites generated by the introduced pyridinic and pyrrolic N atoms and thiophenic S atoms. The effects of various factors on the catalytic activity of NS-CNT-COOH were studied. Results revealed that the degradation efficiency of BP-4 increased with catalyst load, oxidant concentration and reaction temperature. In contrast, NS-CNT-COOH exhibited no remarkable catalytic activity towards peroxodisulfate (PDS) and H2O2. In the case of the NS-CNT-COOH/PMS system, a possible pathway for BP-4 degradation was proposed and based on detected intermediates. The mechanism was justified by theoretical calculations of the frontier electron densities, which have not been reported previously. Furthermore, mineralization, toxicity, stability and reusability tests suggested that the developed catalyst, NS-CNT-COOH, holds promise for practical application.
    Full-text · Article · Jan 2016 · Applied Catalysis B Environmental
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    ABSTRACT: As one of the first generation of fluoroquinolone antibiotics, flumequine (FLU) has been detected ubiquitously in surface waters and municipal wastewaters. In light of FLU's possible adverse effects on aquatic species, the removal of this antibiotic has received worldwide attention. In this study, the kinetics, transformation products, mechanisms and toxicity variations of the ozonation process for FLU were systematically determined. The possible effects of solution pH, addition of inorganic ions, dissolved organic matter, and tert-butyl-alcohol (a radical scavenger), as well as the type of water matrices on FLU removal by ozonation, were studied from the perspective of the degradation kinetics. The data obtained suggested that ozone can be used as an effective oxidant for the fast removal of FLU from natural waters. Using liquid chromatography-mass spectrometry, a total of thirteen transformation products of FLU during ozonation were identified, and their specific reaction mechanisms were also proposed. The degradation pathways involving the hydroxylation, decarboxylation and defluorination were tentatively proposed. Meanwhile, the generation of three low-molecular-weight carboxylic acids was also observed. In addition, the potential toxicity of the transformation mixtures of FLU by ozone was evaluated. Overall, this paper can be a unique contribution to the systematic elucidation of the ozonation process of this antibiotic in water.
    Full-text · Article · Jan 2016 · Science of The Total Environment
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    ABSTRACT: The occurrence of antibacterial agents in natural environment was of scientific concern in recent years. As endocrine disrupting chemicals, they had potential risk on ecology system and human beings. In the present study, the photodegradation kinetics and pathways of florfenicol were investigated under solar and xenon lamp irradiation in aquatic systems. Direct photolysis half-lives of florfenicol were determined as 187.29 h under solar irradiation and 22.43 h under xenon lamp irradiation, respectively. Reactive oxygen species (ROS), such as hydroxyl radical (·OH) and singlet oxygen ((1)O2) were found to play an important role in indirect photolysis process. The presence of nitrate and dissolved organic matters (DOMs) could affect photolysis of florfenicol in solutions through light screening effect, quenching effect, and photoinduced oxidization process. Photoproducts of florfenicol in DOMs solutions were identified by solid phase extraction-liquid chromatography-mass spectrometry (SPE-LC-MS) analysis techniques, and degradation pathways were proposed, including photoinduced hydrolysis, oxidation by (1)O2 and ·OH, dechlorination, and cleavage of the side chain.
    No preview · Article · Dec 2015 · Environmental Science and Pollution Research
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    Ya Zhang · Lei Zhou · Chao Zeng · Qi Wang · Zunyao Wang · Shixiang Gao · Yuefei Ji · Xi Yang

    Full-text · Dataset · Dec 2015
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    ABSTRACT: Aquatic oligochaete Limnodrilus hoffmeisteri (L. hoffmeisteri) has been commonly used as a lethal and/or sub-lethal toxicological model organism in ecological risk assessments in contaminated water environments. In this study, experiments were conducted to investigate the potential toxic effects of copper (Cu(II)) with or without perfluorooctane sulfonate (PFOS) under different pH values (6.0, 7.0 and 8.0) on LC50, bioaccumulation, and oxidative stress biomarkers in L. hoffmeisteri after 3 and 7 days. The LC50 values of Cu(II) decreased with the increasing pH and the addition of PFOS. After each exposure, increasing bioaccumulation of Cu(II) in L. hoffmeisteri was observed in the combined exposure treatments, whereas the bioaccumulation of PFOS decreased. Moreover, the activity of superoxide dismutase, the level of glutathione, and the content of malondialdehyde were significantly altered after these exposures, possibly indicating that the bioaccumulation of Cu(II) and PFOS caused adverse effects on antioxidant defenses of L. hoffmeisteri. The integrated biomarker response index, indicates that the combined effect was proposed as synergism, which is coincided with the results of toxic unit. Moreover, this work showed that aquatic environment may become more livable when water conditions changed from acidic to near-neutral or alkaline.
    Full-text · Article · Dec 2015 · Journal of hazardous materials
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    Mingbao Feng · Hao Jin · Ruijuan Qu · Bingzhe Xu · Zunyao Wang
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    ABSTRACT: In this study, five different congeners of polyfluorinated dibenzo-P-dioxins (PFDDs) (1,8-di-FDD, 1,3,8-tri-FDD, 1,3,6,8-tetra-FDD, 2,3,7,8-tetra-FDD and 1,2,3,4,5,6,7,8-octa-FDD), representing different numbers and positions of fluorine substituents of all 75 PFDD congeners, were synthesized and purified to evaluate their potential environmental impact on living organisms. Their toxicity was evaluated by determining the impact on the organo-somatic indices (OSI) and ethoxyresorufin-O-deethylase (EROD) activity in mice (Mus musculus) after intragastric administration with different doses (0.5-100 μg/kg body weight) for 3 days. The results showed that these PFDDs significantly inhibited the growth and changed the OSI in mouse tissues. Notably, hepatic EROD activity was markedly induced in mice after exposure to these PFDDs, probably indicating a high affinity of binding to the aryl hydrocarbon receptor. Overall, these findings provided some preliminary but alarming toxicity data of PFDDs, and filled information gaps in the toxicological databases for living organisms.
    Full-text · Article · Nov 2015 · Journal of Environmental Science and Health Part A
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    ABSTRACT: In recent years, flumequine (FLU) has been ubiquitously detected in surface waters and municipal wastewaters. In light of its potential negative impacts to aquatic species, growing concern has been arisen for the removal of this antibiotic from natural waters. In this study, the kinetics, degradation mechanisms and pathways of aqueous FLU by persulfate (PS) oxidation were systematically determined. Three common activation methods, including heat, Fe(2+) and Cu(2+), and a novel heterogeneous catalyst, namely, polyhydroquinone-coated magnetite/multi-walled carbon nanotubes (Fe3O4/MWCNTs/PHQ), were investigated to activate PS for FLU removal. It was found that these three common activators enhanced FLU degradation obviously, while several influencing factors, such as solution pH, inorganic ions (especially HCO3(-) at 5 mmol/L) and dissolved organic matter extracts, exerted their different effects on FLU removal. The catalysts were characterized, and an efficient catalytic degradation performance, high stability and excellent reusability were observed. The measured total organic carbon levels suggested that FLU can be effectively mineralized by using the catalysts. Radical mechanism was studied by combination of the quenching tests and electron paramagnetic resonance analysis. It was assumed that sulfate radicals predominated in the activation of PS with Fe3O4/MWCNTs/PHQ for FLU removal, while hydroxyl radicals also contributed to the catalytic oxidation process. In addition, a total of fifteen reaction intermediates of FLU were identified, from which two possible pathways were proposed involving hydroxylation, decarbonylation and ring opening. Overall, this study represented a systematical evaluation regarding the transformation process of FLU by PS, and showed that the heterogeneous catalysts can efficiently activate PS for FLU removal from the water environment. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Full-text · Article · Nov 2015 · Water Research
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    ABSTRACT: Experiments were conducted to investigate the effect of four different carbon nanotubes single- and multi-walled carbon nanotubes (SWCNTs and MWCNTs) and hydroxylated and carboxylated multi-walled carbon nanotubes (OH-MWCNTs and COOH-MWCNTs) on Cd toxicity to the aquatic organism Daphnia magna. The acute toxicity results indicated that all CNTs could enhance the toxicity of Cd to D. magna. Furthermore, the filtrate toxicity and adsorption tests showed that the toxicity-increasing effect of SWCNTs and MWCNTs in the overall system was mainly caused by catalysts impurities from the pristine CNTs, whereas the greater adsorption of Cd onto OH-MWCNTs (30.52 mg/g) and COOH-MWCNTs (24.93 mg/g) was the key factor contributing to the enhanced toxicity. This result raised a concern that the metal catalyst impurities, adsorption capacities, and accumulation of waterborne CNTs were responsible for the toxicity of Cd to aquatic organism.
    No preview · Article · Nov 2015 · Environmental Pollution
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    Mingbao Feng · Qun He · Jiaqi Shi · Li Qin · Xuesheng Zhang · Ping Sun · Zunyao Wang
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    ABSTRACT: In the present study, the toxic effect of decabromodiphenyl ether (BDE-209), an important brominated fire retardant, on soil was evaluated by amending with different concentrations (0, 1, 10 and 500 mg/kg dry weight) for 40 d. The activities of three soil enzymes (urease, catalase and alkaline phosphatase) were measured as the principal assessment endpoints. Meanwhile, the effects of natural environmental factors, such as light conditions and soil biota, on BDE-209 intoxication were studied. For the latter, 30 earthworms (Metaphire guillelmi) with fully-matured clitella or ryegrass (Lolium perenne) with fully-matured leaves were exposed in soil amended with BDE-209. The activities of soil enzymes were adversely affected by BDE-209, especially for high-concentration treatments, with greater adverse effects in the dark than in the light. The presence of earthworms reduced toxicity to BDE-209, whereas ryegrass did not. The calculated integrated biomarker response index, which provides a general indicator of the "health status" of test species by combining different biomarker signals, further validated these findings. Moreover, the antioxidant status (oxidant-antioxidant balance) of these two biota was assessed. Results of this assessment indicated that BDE-209 significantly affected the activities of antioxidant enzymes (superoxide dismutase and catalase) and enhanced the levels of malondialdehyde in both species. The present study may facilitate a better understanding of the toxicity of BDE-209 toward the real soil environment. This article is protected by copyright. All rights reserved.
    Full-text · Article · Oct 2015 · Environmental Toxicology and Chemistry
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    ABSTRACT: Tetrabromobisphenol A (TBBPA) is one of the most widely used brominated flame retar-dants and has attracted more and more attention. In this work, the parent TBBPA with an initial concentration of 100 mg/L was completely removed after 6 min of ozonation at pH 8.0, and alkaline conditions favored a more rapid removal than acidic and neutral conditions. The presence of typical anions and humic acid did not significantly affect the degradation of TBBPA. The quenching test using isopropanol indicated that direct ozone oxidation played a dominant role during this process. Seventeen reaction intermediates and products were identified using an electrospray time-of-flight mass spectrometer. Notably, the generation of 2,4,6-tribromophenol was first observed in the degradation process of TBBPA. The evolution of reaction products showed that ozonation is an efficient treatment for removal of both TBBPA and intermediates. Sequential transformation of organic bromine to bromide and bromate was confirmed by ion chromatography analysis. Two primary reaction pathways that involve cleavage of central carbon atom and benzene ring cleavage concomitant with debromination were thus proposed and further justified by calculations of frontier electron densities. Furthermore, the total organic carbon data suggested a low mineralization rate, even after the complete removal of TBBPA. Meanwhile, the acute aqueous toxicity of reaction solutions to Photobacterium Phosphoreum and Daphnia magna was rapidly decreased during ozonation. In addition, no obvious difference in the attenuation of TBBPA was found by ozone oxidation using different water matrices, and the effectiveness in natural waters further demonstrates that ozonation can be adopted as a promising technique to treat TBBPA-contaminated waters.
    Full-text · Article · Oct 2015 · PLoS ONE
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    ABSTRACT: As widely used chemicals intended to protect human being from infection of microorganisms, disinfectants are ubiquitous in the environment. Among them chlorine-substituted phenol is a basic structure in many disinfectant molecules. Removal of these pollutants from wastewater is of great concern. The oxidative degradation of antimicrobial agents such as triclosan, chlorofene, and dichlorofene by a Fenton-like system Cu2+/H2O2 was examined. Reaction conditions such as temperature, initial concentrations of H2O2 and Cu2+, and pH were optimized using triclosan as a representative. The degradation kinetics of the above disinfectants followed pseudo-first-order kinetics under the investigated conditions. Fourteen chlorophenols (CPs) with different chlorine substitution were also studied to evaluate the influence of molecular structure on the degradation process in the Cu2+/H2O2 system. Fourteen structure-related parameters were calculated using Gaussian 09 program. A quantitative structure-activity relationship (QSAR) model was established using SPSS software with measured rate constant (k) as dependent variable and calculated molecular descriptors as independent variables. A three-parameter model including energy of HOMO (E homo), molar heat capacity at constant volume (C vθ), and the most positive net charge of hydrogen atoms (qH+) was selected for k prediction, with correlation coefficient R 2 = 0.878. Analyses of the model demonstrated that the C vθ was the most significant factor affecting the k of chlorophenols. Variance analysis and standard t-value test were used to validate the model.
    No preview · Article · Sep 2015 · Environmental Science and Pollution Research
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    ABSTRACT: Perfluorooctane sulfonate (PFOS) and zinc have been detected in aquatic environment widely. In order to study the combined effects of PFOS and Zn, a series of experiments was conducted to explore the acute mortality, bioaccumulation and antioxidant status of Limnodrilus hoffmeisteri. The acute toxicity was evaluated by calculating 24h-EC50 values, and it was observed that 24h-EC50 values in single and joint treatments decreased with decreasing pH value or increasing exposure concentration. Toxic unit analysis suggested that the combined effects of the PFOS+Zn binary mixture were mostly simple addition, with 8 groups showing synergism and only one group showing antagonism. The analysis of internal Zn and PFOS concentration showed that the possible interaction between Zn and PFOS can affect the bioaccumulation of the two chemicals in L. hoffmeisteri. In addition, oxidative stress status was assessed by measuring oxidation-related biochemical parameters such as superoxide dismutase, glutathione peroxidase and malondialdehyde, and the integrated biomarker response index was estimated to rank the toxicity order. Exposures to Zn and PFOS were found to evoke some changes in the antioxidant defense system, and a strong self-adaptive ability was noticed for L. hoffmeisteri after 10 d exposure.
    No preview · Article · Sep 2015 · Journal of hazardous materials
  • Qun He · Ruijuan Qu · Xinghao Wang · Zhongbo Wei · Ping Sun · Zunyao Wang
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    ABSTRACT: Although it has been widely known that arsenic poses great threat to organisms and arsenic species account for the toxic effect of the metalloid, relatively little attention has been given to the arsenic toxicity to different organisms at different pH values. Three kinds of aquatic organisms including Photobacterium phosphoreum, Daphnia magna, and Danio rerio were used to study the effects of pH on the toxicity of arsenic. Toxicity test results were analyzed by calculating EC50 values and for arsenic species at five different pH values (5.0, 6.0, 7.0, 8.0, and 9.0). As a result, As(III) is more toxic to the tested organisms than As(V), and P. phosphoreum was more sensitive to the toxicity of arsenic than D. magna and D. rerio. The toxicity of As(III) species is different for different organisms: dihydrogen arsenite, H2AsO3-, is more toxic to P. phosphoreum and D. rerio than arsenous acid, H3AsO3, while H3AsO3 is more toxic to D. magna. As for As(V), arsenate, HAsO42-, is the most toxic to P. phosphoreum, whereas dihydrogen arsenate, H2AsO4-, may be responsible for the toxicity to D. magna and D. rerio. As(III) and As(V) are more toxic to P. phosphoreum in an alkaline environment, while for D. magna in an acidic environment and As(III) is more toxic to D. rerio in an alkaline environment and As(V) in an acidic environment.
    No preview · Article · Aug 2015 · CLEAN - Soil Air Water
  • Xiaolan Zeng · Xuesheng Zhang · Li Qin · Zunyao Wang
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    ABSTRACT: The tissue distribution, excretion, and metabolic pathway of 2,2',4,4',5-penta-chlorinated diphenylsulfide (CDPS-99) in ICR mice were investigated after oral perfusion at 10mg/kg body weight (b.w.). Biological samples were extracted and separated and, for the first time, were determined by a novel, sensitive, and specific GC-MS method under the full scan and selected ion monitoring (SIM) modes. The results showed that the concentrations of CDPS-99 in the liver, kidneys, and serum reached a maximum after a one-day exposure and that the CDPS-99 concentration in the liver was the highest (3.43μg/g). The increase in the concentration of CDPS-99 in muscle, skin, and adipose tissue was slower, and the concentrations of CDPS-99 achieved their highest levels after 3 days of exposure. It was observed that the CDPS-99 concentration in adipose tissue was still very high (0.71μg/g) after 21 days of exposure, which suggested that CDPS-99 was able to accumulate in adipose tissue. In addition, mouse feces accounted for approximately 75% of the total gavage dose, indicating that CDPS-99 was mainly excreted via mouse feces. Metabolism analysis demonstrated that there were three possible metabolic pathways of CDPS-99 in mice: dechlorination reactions with the formation of tetra-CDPS and hydroxylation and oxidation reactions with the formation of OH-CDPS-99 and chlorinated diphenylsulfone. The present study will help to develop a better understanding of mammalian metabolism of CDPS-99. Copyright © 2015 Elsevier B.V. All rights reserved.
    No preview · Article · Jul 2015 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
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    Junhe Lu · Juan Shao · Hui Liu · Zunyao Wang · Qingguo Huang
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    ABSTRACT: Laccases are a type of extracellular enzymes produced by fungi, bacteria, and plants. Laccase can catalyze one-electron oxidation of a variety of phenolic compounds using molecular oxygen as the electron acceptor. In this study, transformation of halophenols (XPs) in laccase-catalyzed oxidation processes was explored. We first examined the intrinsic reaction kinetics and found that the transformation of XPs appeared first order to the concentrations of both XPs and laccase. A numerical model was developed to describe the role of humic acid (HA) in this process. It was demonstrated that HA could reverse the oxidation of XPs by acting as the inner filtrator of XP radical intermediates formed upon reactions between the substrates and laccase. The extent of such reversion was proportional to HA concentration. MS analysis in combination with quantum chemistry computation suggested that coupling products were generated. XPs coupled to each via C-C or C-O-C pathways, generating hydroxyl polyhalogenated biphenyl ethers (OH-PCDEs) and hydroxyl polyhalogenated biphenyls, respectively. Many of these polyhalogenated products are known to be hazardous to the ecosystem and human health but their genesis are not fully understood. This study shed light on their occurrence in the environmental media.
    Full-text · Article · Jul 2015 · Environmental Science and Technology
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    ABSTRACT: Nafion 117 membrane (N117), an important polymer electrolyte membrane (PEM), has been widely used for numerous chemical technologies. Despite its increasing production and use, the toxicity data for N117 and its combustion products remain lacking. Toxicity studies are necessary to avoid problems related to waste disposal in landfills and incineration that may arise. In this study, we investigated the histopathological alterations, oxidative stress bio-marker responses, and transcriptome profiles in the liver of male mice exposed to N117 and its combustion products for 24 days. An ion-chromatography system and liquid chromatography system coupled to a hybrid quadrupole time-of-flight mass spectrometry were used to analyze the chemical compositions of these combustion products. The transcriptomics analysis identified several significantly altered molecular pathways, including the metabolism of xeno-biotics, carbohydrates and lipids; signal transduction; cellular processes; immune system; and signaling molecules and interaction. These studies provide preliminary data for the potential toxicity of N117 and its combustion products on living organisms and may fill the information gaps in the toxicity databases for the currently used PEMs.
    Full-text · Article · Jun 2015 · PLoS ONE

Publication Stats

412 Citations
251.82 Total Impact Points

Institutions

  • 2004-2016
    • Nanjing University
      • • School of Environment
      • • State Key Laboratory of Pollution Control and Resource Reuse
      Nan-ching, Jiangsu, China
  • 2005-2009
    • Jiaxing University
      Kashing, Zhejiang Sheng, China
    • Yancheng Institute of Technology
      Yen-ch’eng-chen, Jiangsu, China