Se Jin Kim

Korea Advanced Institute of Science and Technology, Sŏul, Seoul, South Korea

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Publications (14)19.49 Total impact

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    ABSTRACT: Organizing pneumonia is an inflammatory lung disease involving the distal bronchioles, respiratory bronchioles, bronchiolar ducts, and alveoli. A number of viral and bacterial organisms have been identified as causative agents of organizing pneumonia. However, M ycobacterium tuberculosis has rarely been reported as a causative agent. Herein, we report our experience with two patients diagnosed with pulmonary tuberculosis, whose biopsies showed patterns associated with organizing pneumonia. Both patients showed positive results for bacteriological tests and presence of acid fast bacilli. Hence, we could successfully treat both patients with anti-tuberculosis medications. Our report suggests that M . tuberculosis infection could be added to the list of infectious conditions associated with organizing pneumonia.
    No preview · Article · Dec 2015
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    ABSTRACT: This study examined the prevalence of cerebral palsy (CP) in South Korea, and the attributable lifetime medical cost according to physiological types and extent of involvement. The number of medical service use and medical cost of CP were obtained from the national health insurance review and assessment (HIRA) service. The prevalence was calculated from the number of five-year-old patients who used medical services between 2004 and 2008. The lifetime medical cost of CP was calculated from the data and discount rate of 3%. The prevalence of CP in South Korea was 2.6 per 1000 children. The attributable lifetime medical cost of CP in South Korea was calculated to be 26,383 US dollars, which is 1.8 times the basic lifetime medical cost of the general population (14,579 US dollars). Spastic CP showed the highest attributable medical cost, followed by dyskinetic and ataxic CP. Spastic diplegia showed 1.4 times of the attributable lifetime medical cost of spastic hemiplegia. The prevalence of CP in South Korea is comparable to that in other countries. CP is a disease with wide range of clinical features, and the medical cost according to the physiological types and extent of involvement should be considered.
    No preview · Article · Oct 2010 · Health Policy
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    ABSTRACT: Inflammation plays a role in the response to metabolic stress in type 2 diabetes. However, the effects of rosiglitazone on inflammation of skeletal muscle have not been fully examined in type 2 diabetes. We investigated the effects of the insulin-sensitizing anti-diabetic agent, rosiglitazone, on the progression of skeletal muscle inflammation in Otsuka Long-Evans Tokushima Fatty (OLETF) type 2 diabetic rats. We examined the expression of serologic markers (serum glucose, insulin and free fatty acid) and inflammatory cytokines (tumor-necrosis factor-alpha, interleukin [IL]-1beta and IL-6) in OLETF rats from early to advanced diabetic stage (from 28 to 40 weeks of age). Serum glucose and insulin concentrations were significantly decreased in rosiglitazone-treated OLETF rats compared to untreated OLETF rats. Rosiglitazone treatment significantly decreased the concentrations of serum inflammatory cytokines from 28 to 40 weeks of age. The mRNA expression of various cytokines in skeletal muscle was reduced in rosiglitazone-treated OLETF rats compared with untreated OLETF rats. Furthermore, rosiglitazone treatment resulted in the downregulation of ERK1/2 phosphorylation and NF-kappaB expression in the skeletal muscle of OLETF rats. These results suggest that rosiglitazone may improve insulin sensitivity with its anti-inflammatory effects on skeletal muscle.
    Full-text · Article · Jun 2010 · Korean Diabetes Journal
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    ABSTRACT: Here we present telomerase activity screening using a capillary electrophoretic (CE) microdevice for human cancer diagnostics. The telomerase enzyme, a contributor to the maintenance of telomere length in cancer cells, was extracted from various human cells including MCF-7 (Human breast cancer cells), A549 (Human lung cancer cells), and SK-N-SH (Human neuroblastoma cells), and then telomeric repeat amplification protocol (TRAP)-based genetic analysis was performed to evaluate the activity of telomerase enzyme. The resultant 6-bp tandem repeat PCR amplicons derived from cancer cells were separated and detected on the 6 cm-long CE microdevice within 5 min. A limit of detection of 5 cells was achieved to analyze the telomerase activity on a CE microchip. In comparison with a conventional PAGE method, micro-fabricated CE-based analysis has many advantages in terms of high speed, low sample consumption, and high sensitive detection. The successful demonstration of telomerase activity screening on a chip implies great potential of a complete integration of a sample preparation and PCR unit in a single format for high-performance cancer diagnostics in a clinical arena. KeywordsTelomerase-Telomeric repeat amplification-Polymerase chain reaction-Capillary electrophoretic microdevice-Cancer diagnostics
    No preview · Article · Mar 2010 · BioChip journal
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    ABSTRACT: Rapid and simple analysis for the multiple target pathogens is critical for patient management. CE-SSCP analysis on a microchip provides high speed, high sensitivity, and a portable genetic analysis platform in molecular diagnostic fields. The capability of separating ssDNA molecules in a capillary electrophoretic microchannel with high resolution is a critical issue to perform the precise interpretation in the electropherogram. In this study, we explored the potential of poly(ethyleneoxide)-poly(propyleneoxide)-poly(ethyleneoxide) (PEO-PPO-PEO) triblock copolymer as a sieving matrix for CE-SSCP analysis on a microdevice. To demonstrate the superior resolving power of PEO-PPO-PEO copolymers, 255-bp PCR amplicons obtained from 16S ribosomal RNA genes of four bacterial species, namely Proteus mirabilis, Haemophilus ducreyi, Pseudomonas aeruginosa, and Neisseria meningitidis, were analyzed in the PEO-PPO-PEO matrix in comparison with 5% linear polyacrylamide and commercial GeneScan gel. Due to enhanced dynamic coating and sieving ability, PEO-PPO-PEO copolymer displayed fourfold enhancement of resolving power in the CE-SSCP to separate same-sized DNA molecules. Fivefold input of genomic DNA of P. aeruginosa and/or N. meningitidis produced proportionally increased corresponding amplicon peaks, enabling correct quantitative analysis in the pathogen detection. Besides the high-resolution sieving capability, a facile loading and replenishment of gel in the microchannel due to thermally reversible gelation property makes PEO-PPO-PEO triblock copolymer an excellent matrix in the CE-SSCP analysis on the microdevice.
    Preview · Article · Mar 2010 · Electrophoresis
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    ABSTRACT: Aspergillus tracheobronchitis is one form of invasive pulmonary aspergillosis which is characterized by ulcers and pseudomembrane formation in tracheobronchial tree. In Aspergillus tracheobronchitis, the infection is often limited to the mucosa and it accounts for less than 10 percents of invasive disease. Invasive aspergillosis mainly occurs in immunocompromized patients with prolonged neutropenia, advanced AIDS, organ transplantation, high-dose glucocorticoid therapy or cytotoxic therapy although it can occur in less immunocompromised patients, such as after influenza, COPD, old age, and diabetes. We report a case of Aspergillus tracheobronchitis in a 61 year-old patient with diabetes and Child Pugh class A liver cirrhosis. He presented with cough and purulent sputum for 10 days. He was diagnosed by bronchoscopy and successfully treated with antifungal therapy.
    Full-text · Article · Jan 2010
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    ABSTRACT: Background: Bronchiectasis (BE) remains a rare respiratory disease in Korea. This retrospective study was done to investigate the potential pathogenic microorganisms (PPMs) that cause in patients with BE, through the use of sputum specimens. Methods: One hundred eleven adult patients, who had undergone chest computed tomography (CT), sputum gram stain/culture, and BE detected by chest CT, were included in this study. Sputum adequacy was determined by using Murray-Washington classification. Results: The mean (±SD) age of patients was 60.9 (±14.0). The number of PPMs was 167 (67%) in the total 248 isolated organisms. The most frequent PPMs were P. aeruginosa (23.4%), K. pneumoniae (10.5%), and S. aureus (8.4%). The proportion of adequate sputum (AS) was 25.8% in the total sputum specimens. The patients with AS were 41 (37%) and the patients with inadequate sputum (IS) were 70 (63%). The proportion of P. aeruginosa was higher in AS compared to that of IS (44% vs. 19%, p=0.004). The BE score was also higher in P. aeruginosa (+) patients compared to that of P. aeruginosa (-) patients (10.8 vs. 7.6, p=0.001). Conclusion: Although the proportion of AS in the total sputum was low, PPMs were isolated in most patients with BE. It is likely that P. aeruginosa was isolated in AS and AS patients had higher BE scores. Copyright©2009. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.
    Preview · Article · Dec 2009 · Tuberculosis and Respiratory Diseases
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    ABSTRACT: Common causes of acquired tracheoesophageal (T-E) fistula are blunt trauma on the neck or chest, malignancy, long-term mechanical ventilation, and post-intubation injury. Most of the cases are fatal due to severe respiratory infection. We experienced two cases of post-intubation T-E fistula in patients with a history of tracheostomy that developed earlier than usual. One case was caused by excessive cuff pressure and the other by avulsion injury during endotracheal intubation. We can get instructions from these cases that how to prevent T-E fistula because it is hard to treat and causes severe outcomes.
    Full-text · Article · Jan 2009
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    ABSTRACT: Streptozotocin-induced diabetic animals are characterized by hyperphagia due to deficiencies of insulin and leptin. Forkhead box-containing protein of the O subfamily-1 (FoxO1) regulates energy homeostasis by regulating energy expenditure and food intake as well as mediating insulin and leptin signals in the hypothalamus. To identify the mediator of diabetic hyperphagia, we examined the effects of insulin or leptin on hypothalamic FoxO1 expression in a diabetic animal model.
    Full-text · Article · Jan 2009 · Korean Diabetes Journal
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    ABSTRACT: Cisplatin causes the impairment of inner ear functions, including hearing and balance, through the involvement of a number of mechanisms. However, no laboratory studies have been performed on involvement of inflammation-related events in cisplatin-mediated vestibular dysfunction. We evaluated the secretion of proinflammatory cytokines and nuclear factor-κB (NF-κB) activation in cisplatin-treated UB/UE-1 utricular epithelial cells. We also employed immunohistochemistry to detect proinflammatory cytokines and NF-κB expression in cisplatin-injected mice. Productions of proinflammatory cytokines significantly caused the death of UB/UE1 cells by cisplatin. Pharmacologic inhibition of mitogen-activated protein (MAP) kinase/ERK kinase-1 (MEK1) or extracellular signal-regulated kinase (ERK) significantly attenuated the death of UB/UE1 cells caused by cisplatin and proinflammatory cytokines. Immunohistochemical studies revealed an increase in the expression of proinflammatory cytokines and NF-κB in both the cristae ampullae and utricle of cisplatin-injected mice. These results suggest that proinflammatory cytokines may play an important role in the pathogenesis of cisplatin-mediated vestibulotoxicity. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
    Full-text · Article · Nov 2008 · Head & Neck
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    Eun Kyung Kim · Eun Bae Yang · Se Jin Kim
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    ABSTRACT: Purpose: Medical students are exposed to various interpersonal relationships with patients, fac-ulty and colleagues. Therefore, a clear understanding of their personality types and interpersonal problems is vital in creating an appropriate educational program for medical students. This study intends to explore the characteristics of interpersonal problems based on medical students' per-sonality types. Results: The personality types focusing on the interpersonal domain showed that the medical students could be categorized into four types: analytical type (47.2%), driving type (30.3%), ami-able type (12.4%), and expressive type (10.1%). The characteristics of interpersonal problems data were within normal range. The relationship between the personality indicator and the character-istics of interpersonal problems is statistically significant in extraversion-introversion. Conclusion: Our results demonstrate that the personality factors of medical students are corre-lated to the interpersonal problems they face. Thus, educational programs that take into account personality types and characteristics of interpersonal problems are crucial in providing high-qual-ity medical education.
    Preview · Article · Jun 2007 · Korean Journal of Medical Education
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    ABSTRACT: In the present study, crosslinked poly(vinyl alcohol) (PVA) membranes were prepared using poly(styrene sulfonic acid-co-maleic acid) (PSSA_MA) at different crosslinking temperatures. The crosslinked PVA membranes were prepared by varying the content of PSSA_MA (5–11 wt%). The PSSA_MA was used both as a crosslinking agent and as a donor of the hydrophilic group (–SO3H and/or –COOH). The crosslinked PVA/PSSA_MA membranes were characterized using FT-IR spectroscopy, thermogravimetric analysis (TGA) and investigated in relation to proton conductivity and methanol permeability. The proton and methanol transport decreased with increasing the PSSA_MA content. The effect of crosslinking may be more dominant than that of the increase of the number of ionic exchange sites in this system. The proton conductivities and the methanol permeabilities of all the membranes were in the range of 10−3 to 10−2 S/cm and 10−7 to 10−6 cm2/s, respectively, in the temperature range of 25–90 °C, depending on the crosslinking conditions.
    Full-text · Article · Sep 2006 · Journal of Membrane Science
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    ABSTRACT: Samul extract, containing Radix Rehmanniae, Radix Angelicae Gigantis, Radix Paeoniae, and Rhizoma Cnidii, has been traditionally used for treatment of ischemic heart and brain damages in Oriental medicine. However, little is known about the mechanism by which Samul rescues cells from cytotoxic damage. This study was designed to investigate the protective mechanisms of Samul on H(2)O(2)-induced death of H9c2 cells. Treatment with H(2)O(2) markedly decreased the viability of H9c2 cells in a dose- and time-dependent manner, which was significantly prevented by pre-treatment with Samul. The nature of death of H9c2 cells by H(2)O(2) was demonstrated by apoptotic features, including ladder-pattern fragmentation of genomic DNA and chromatin condensation, which were markedly abolished by pretreatment of Samul in H(2)O(2)-treated cells. We further demonstrated that MEK inhibitor, PD98059, dose-dependently attenuated the protective effects of Samul against H(2)O(2), whereas inhibitors of Jnk and p38 did not. Consistently, Samul induced the early phosphorylation of Erk, p44, in H(2)O(2)-treated cells. In addition, treatment with Samul also resulted in an increase of expression of anti-apotogenic Bcl2 protein, which was decreased by H(2)O(2). However, it inhibited the expression of apotogenic Bax protein in H(2)O(2)-treated cells. Taken together, these results suggest that the protective effects of Samul against oxidative damage may be achieved via activation of MAP kinase, Erk as well as Bcl2 family proteins.
    No preview · Article · Feb 2006 · The American Journal of Chinese Medicine
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    ABSTRACT: Polycyclic aromatic hydrocarbons, such as benzo(a)pyrene (BaP), are widespread in the environment and cause untoward effects, including carcinogenesis, in mammalian cells. However, the molecular mechanism of apoptosis by BaP is remained to be elusive. Pharmacological inhibition of p38 kinase markedly inhibited the BaP-induced cytotoxicity, which was proven as apoptosis characterized by an increase in sub-G(0)/G(1) fraction of DNA content, ladder-pattern fragmentation of genomic DNA, and catalytic activation of caspase-3 with PARP cleavage. Our data also demonstrated that activation of caspase-3 was accompanied with activation of caspase-9 and mitochondrial dysfunction, which was also apparently suppressed by pretreatment with p38 kinase inhibitors. Also, pharmacological inhibition of p38 markedly inhibited the phosphorylation, accumulated expression, and transactivation activity of p53 in BaP-treated cells. Adenoviral overexpression of human p53 (wild-type) further augmented in increase of PARP cleavage and the sub-G(0)/G(1) fraction of DNA content. Furthermore, p53 mediated apoptotic activity in BaP-treated cells was inhibited by p38 kinase inhibitor. The current data collectively indicate that BaP induces apoptosis of Hepa1c1c7 cells via activation of p53-related signaling, which was, in part, regulated by p38 kinase.
    No preview · Article · Jan 2006 · Archives of Biochemistry and Biophysics

Publication Stats

169 Citations
19.49 Total Impact Points

Institutions

  • 2010
    • Korea Advanced Institute of Science and Technology
      • Department of Chemical and Biomolecular Engineering
      Sŏul, Seoul, South Korea
    • University of Ulsan
      • College of Medicine
      Ulsan, Ulsan, South Korea
  • 2009-2010
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
    • Konkuk University
      • Department of Internal medicine
      Sŏul, Seoul, South Korea
  • 2007
    • Yonsei University
      • Department of Education
      Sŏul, Seoul, South Korea
  • 2006
    • Wonkwang University School of Medicine and Hospital
      Riri, North Jeolla, South Korea
    • Hannam University
      Eidō, North Chungcheong, South Korea