Qiang Li

Tianjin Medical University Cancer Institute and Hospital, T’ien-ching-shih, Tianjin Shi, China

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Publications (107)209.56 Total impact

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    ABSTRACT: We previously found that a low dose of Sorafenib had a pro-metastatic effect on hepatocellular carcinoma (HCC), which was caused by down-regulation of TIP30 expression. More recently, Metformin has been shown the potential as a preventive and therapeutic agent for different cancers, including hepatocellular carcinoma. The present study is conducted to evaluate whether the combination of Sorafenib and Metformin is sufficient to revert the expression of TIP30, by which reducing the lung metastasis and improving the survival simultaneously. Our data show that the combination of Sorafenib and Metformin inhibits proliferation and invasion in vitro, prolongs the median survival and reduces lung metastasis of HCC in vivo. This effect is closely associated with the up-regulation of TIP30, partly through activating AMPK. Thioredoxin, a pro-metastasis factor, is negatively regulated by TIP30 and plays an essential role during the process of HCC metastasis. Overall, our results suggest that Metformin might be a potent enhancer for the treatment of HCC by using Sorafenib. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Cancer Science
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    ABSTRACT: Background & aims: Many patients with hepatocellular carcinoma (HCC) have multiple lesions (primary tumors, intrahepatic metastases, multiple occurrences, satellite nodules, and tumor thrombi); these have been associated with a poor prognosis and tumor recurrence after surgery. We investigated the clonal relationship among these lesions on the basis of genetic features. Methods: We collected 43 lesions and 10 matched control samples (blood or non-tumorous liver) from 10 patients with hepatitis B virus (HBV)-associated HCC treated at Tianjin Cancer Hospital (China) from January 2013 through May 2014. We performed exome and low-depth whole genome sequencing on these samples. Genomic aberrations, including somatic mutations and copy number variations, were identified using germline DNA as control. We compared the genetic features of different lesions from each patient and constructed phylogenetic trees to depict their evolutionary histories. Results: In each patient, mutations shared by all the lesions were called ubiquitous mutations. The percentage of ubiquitous mutations varied from 8% to 97% among patients, indicating variation in the extent of intra-tumor heterogeneity. Branched evolution was evident, with somatic mutations, HBV integrations, and copy number variations identified on both the trunks and branches of the phylogenetic trees. Intra-hepatic metastases and tumor thrombi contained some, but not all, of the mutations detected in their matched primary lesions. By contrast, satellite nodules shared approximately 90% of mutations detected in primary lesions. In a patient with multi-centric tumors, 6 lesions were assigned to 2 distinct groups, based on significant differences in genetic features. In another patient with combined hepatocellular and intrahepatic cholangiocarcinoma, the physically separate HCC and cholangiocarcinoma lesions shared 102 mutations. Conclusions: The extent of intra-tumor heterogeneity varies considerably among patients with HCC. Therefore, sequence analysis of a single lesion cannot completely characterize the genomic features of HCC in some patients. Genomic comparisons of multiple lesions associated with HCCs will provide important information on the genetic changes associated with tumor progression.
    No preview · Article · Jan 2016 · Gastroenterology

  • No preview · Article · Jan 2016 · IEEE Transactions on Wireless Communications
  • Xiaohu Ge · Junliang Ye · Yang Yang · Qiang Li
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    ABSTRACT: With small cell networks becoming core parts of the fifth generation (5G) cellular networks, it is an important problem to evaluate the impact of user mobility on 5G small cell networks. However, the tendency and clustering habits in human activities have not been considered in traditional user mobility models. In this paper, human tendency and clustering behaviors are first considered to evaluate the user mobility performance for 5G small cell networks based on individual mobility model (IMM). As key contributions, user pause probability, user arrival and departure probabilities are derived in this paper for evaluat-ing the user mobility performance in a hotspot-type 5G small cell network. Furthermore, coverage probabilities of small cell and macro cell BSs are derived for all users in 5G small cell networks, respectively. Compared with the traditional random waypoint (RWP) model, IMM provides a different viewpoint to investigate the impact of human tendency and clustering behaviors on the performance of 5G small cell networks.
    No preview · Article · Dec 2015
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    ABSTRACT: Large scale hydraulic fracturing is the primary industrial technique for obtaining shale gas. Previous studies indicated that research on the fracture network forming principles, geological controls, and fracability of the shale reservoir should be performed before hydraulic fracturing. This paper reports a detailed study of the controlling factors of continental shale reservoirs from the Triassic Yanchang Formation, Ordos Basin, China. First, the fracture network formation mechanisms of hydraulic fracturing are discussed systematically with related schematic diagrams. Second, mineralogical factors, lithomechanics factors, in-situ stress and natural fractures are discussed as the controlling factors of the formation of a complex fracture network according to previous research and field fracturing experience; further analysis is based on these factors. Third, the Young's modulus, Poisson ratio (PR), brittle mineral content, quartz content, clay content, differential horizontal stress, fracture development condition and other factors are normalized and given corresponding weights based on a judgment matrix. Then, a quantitative method (fracability index) is used to characterize the fracability of continental shale based on analytic hierarchy process (AHP) mathematical modeling. Finally, under the control of the same evaluation parameters and weight values, different evaluation indices of continental shale in the Ordos Basin and marine shale in the Sichuan Basin are calculated, and with the help of two indices, the fracability of continental shale is intuitively analyzed. The results show that the continental shale in the Yanchang Formation in the Ordos Basin has good fracability and is suitable for hydraulic fracturing to form a complex fracture network.
    No preview · Article · Sep 2015 · Journal of Natural Gas Science and Engineering
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    ABSTRACT: As important indicators of conditions that affect the occurrence of shale gas reservoirs, pore structures are systematically studied for their significance in shale gas exploration and development. To date, research on the controlling factors of pore structure development in lacustrine shale remains lacking. In this paper, the authors used lacustrine shale samples of the Mesozoic Yanchang Formation in the Ordos Basin, Block X, to investigate the factors that influence the development of pore structure. The qualitative and quantitative study of pore type and size distribution in lacustrine shale was performed using scanning electron microscopy (SEM) on surfaces polished via argon beam milling imaging, nano-computed tomography (CT), nitrogen adsorption isotherm experiments and low-field nuclear magnetic resonance (NMR) imaging. In addition, the main controlling factors for the development of pore structure in lacustrine shale are discussed in detail. This research shows that a variety of pore types develop in lacustrine shale reservoirs, all having different geological significance in the evolution of shale gas accumulation. The results also show that the pore and throat structures are dispersed in three-dimensional space with spherical, tubular and irregular shapes. Both micropores (<2 nm) and mesopores (2–50 nm) provide the main specific surface areas of pores, whereas mesopores provide the primary pore volume. The total organic carbon content, mineral components, and thermal maturity are the main factors that control the development and evolution of pore structure in lacustrine shale.
    No preview · Article · Jul 2015 · Journal of Natural Gas Science and Engineering
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    ABSTRACT: Currently there is no predictor for survival after adjuvant sorafenib in patients with hepatocellular carcinoma (HCC) who have undergone curative resection. Thirty-eight patients who underwent curative resection of HCC received adjuvant sorafenib therapy between August 2009 and March 2012. Clinicopathological parameters including patient factors, tumor factors, liver background, and inflammatory factors (before surgery and dynamic changes after sorafenib therapy) were evaluated to identify predictors for overall survival (OS) and recurrence-free survival (RFS). The recurrence rate, mortality rate, and clinicopathological data were also compared. Increased NLR after sorafenib (HR = 3.199, 95 % CI 1.365-7.545, P = 0.008), increased GGT after sorafenib (HR = 3.204, 95 % CI 1.333-7.700, P = 0.009), and the presence of portal vein thrombosis (HR = 2.381, 95 % CI 1.064-5.328, P = 0.035) were risk factors related to RFS. By contrast, increased NLR after sorafenib was the only independent risk factor related to OS (HR = 4.647, 95 % CI 1.266-17.053, P = 0.021). Patients with increased NLR or increased GGT after sorafenib had a higher incidence of recurrence and death. Patients who had increased NLR tended to have higher preoperative levels of NLR and GGT. There were no differences in clinicopathological factors in patients with increased GGT and decreased GGT. In conclusion, increased NLR predicted a worse OS and RFS in patients with HCC who underwent curative resection with adjuvant sorafenib therapy. Increased GGT predicted a worse OS. NLR and GGT can be monitored dynamically before and after sorafenib therapy.
    No preview · Article · Apr 2015 · Medical Oncology
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    ABSTRACT: Aims: This study was conducted in order to investigate the indications for hepatecomy for multinodular hepatocellular carcinoma (MNHCC) in single institution. Methods: We retrospectively analyzed the medical records from 55 MNHCC patients, mainly with Child-Pugh A liver function, who underwent hepatectomy from January 2006 to December 2008. Both short- and long-term outcomes were analyzed. In addition, the prognostic significance of clinicopathological factors on overall survival (OS) was investigated by univariate analysis using the log-rank test. A Cox proportional hazards model was used in a subsequent multivariate analysis. Results: The perioperative morbidity rate (grade II or higher) was 18.2% (n = 10), and the in-hospital mortality rate was 3.6%. The median OS was 23.9 months (range, 2.5-84 months), whereas the median disease-free survival was 8.75 months (range, 1-65 months). Independent prognostic risk factors of 5-year OS included the number of tumors >2 (p = 0.032) and gross morphology indicating multiple tumor nodules scattered throughout the liver (p = 0.009). Conclusions: The postoperative morbidity and mortality rates were acceptable. The number of tumors >2 and gross morphology indicating multiple tumor nodules scattered throughout the liver were independent prognostic risk factors for patients with MNHCC after hepatectomy. Patients with both of these features had a very poor prognosis and were not considered suitable for surgery.
    No preview · Article · Feb 2015 · Digestive Surgery
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    ABSTRACT: PPE68 is a Mycobacterium tuberculosis-specific protein which is absent from the vaccine strains of BCG. A panel of 14 PPE68-derived peptides predicted to bind to HLA-A*0201 was synthesized. The HLA-A*0201 restriction of these peptides was determined in T2 cell line and HLA-A*0201 transgenic mice. The specificity of peptides was assessed in pulmonary tuberculosis (TB) patients using IFN-γ enzyme-linked immunospot (ELISPOT) assay, and immunodominant peptides were further used to evaluate their diagnostic potential in HLA-A*0201-positive pulmonary TB patients. 13 out of 14 peptides were identified as high-affinity binders. Of these peptides, 12 peptides induced significant IFN-γ-secreting T cell response in transgenic mice and 9 peptides were efficiently recognized by peripheral blood mononuclear cells of 10 HLA-A*0201-positive TB patients. Four immunodominant HLA-A*0201-restricted epitopes (PPE68126-134, PPE68133-141, PPE68140-148, and PPE68148-156) were recognized by the most of 80 HLA-A*0201-positive TB patients (81, 86, 74, and 84 %, respectively). These epitopes may be used for a potential diagnosis of M. tuberculosis infection.
    No preview · Article · Feb 2015 · Current Microbiology
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    ABSTRACT: Radical lymph node dissection in surgery for advanced gallbladder cancer is controversial. The purpose of this study is to evaluate the different extent of lymph node dissection for N2 stage gallbladder cancer patients. A retrospective analysis was made of 60 patients with N2 stage who underwent standard regional lymphadenectomy (SRLN) and extended regional lymphadenectomy (ERLN). Between September 2000 and June 2011, 60 advanced gallbladder cancer patients with N2 stage of lymph node metastasis were included in this study. The curative effects with different extent of lymphadenctomy for lymph node N2 stage of gallbladder cancer patients were compared. The median survival time was 34.83 months in the SRLN group and 30.28 months in the ERLN group. There was no significant difference of survival rate between SRLN and ERLN group (P=0.51). Postoperative major morbidity and mortality rates were 64.3% and 7.14% in the SRLN group, 81.3% and 9.34% in the ERLN group, respectively. Moreover, the number of positive lymph nodes and chemotherapy were found to correlate with survival on univariate analyses (P<0.05). For advanced gallbladder patients with N2 stage lymph node metastasis, ERLN cannot provide a significant survival benefit over SRLN and the rate of morbidity and mortality in ERLN is exceptionally high. ERLN therefore should not be considered in the advanced gallbladder cancers with N2 stage.
    No preview · Article · Feb 2015 · American Journal of Clinical Oncology
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    ABSTRACT: This paper investigates the energy efficiency of base station sleep scheduling strategies in 1-D infrastructure-based wireless communication networks formed by vehicles traveling on a highway. In certain scenarios, vehicular speeds and locations can be measured with a high degree of accuracy, and this information can be exploited to reduce the energy consumption of base stations. This paper considers cooperative base station scheduling strategies where base stations can switch between sleep and active modes to reduce the average energy consumption, while guaranteeing the connectivity of every vehicle. Analytical results on the expected amount of energy saving for a base stations are derived, which reveals for the first time the existence of a threshold parameter, determined by both the vehicular density and mobility, below which base stations can switch off and save energy, but above which no energy saving can be achieved.
    No preview · Article · Jan 2015
  • Tao Han · Guoqiang Mao · Qiang Li · Lijun Wang · Jing Zhang
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    ABSTRACT: In this paper, we focus on one of the representative 5G network scenarios, namely multi-tier heterogeneous cellular networks. User association is investigated in order to reduce the down-link co-channel interference. Firstly, in order to analyze the multi-tier heterogeneous cellular networks where the base stations in different tiers usually adopt different transmission powers, we propose a Transmission Power Normalization Model (TPNM), which is able to convert a multi-tier cellular network into a single-tier network, such that all base stations have the same normalized transmission power. Then using TPNM, the signal and interference received at any point in the complex multi-tier environment can be analyzed by considering the same point in the equivalent single-tier cellular network model, thus significantly simplifying the analysis. On this basis, we propose a new user association scheme in heterogeneous cellular networks, where the base station that leads to the smallest interference to other co-channel mobile stations is chosen from a set of candidate base stations that satisfy the quality-of-service (QoS) constraint for an intended mobile station. Numerical results show that the proposed user association scheme is able to significantly reduce the down-link interference compared with existing schemes while maintaining a reasonably good QoS.
    No preview · Article · Jan 2015 · Mobile Networks and Applications
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    ABSTRACT: It is widely recognized that, in addition to the quality-of-service (QoS), energy efficiency is also a key parameter in designing and evaluating mobile multimedia communication systems, which has catalyzed great interest in recent literature. In this paper, an energy-efficiency model is first proposed for multiple-input–multiple-output orthogonal frequency-division multiplexing (MIMO-OFDM) mobile multimedia communication systems with statistical QoS constraints. Employing the channel-matrix singular value decomposition (SVD) method, all subchannels are classified by their channel characteristics. Furthermore, the multichannel joint optimization problem in conventional MIMO-OFDM communication systems is transformed into a multitarget single-channel optimization problem by grouping all subchannels. Therefore, a closed-form solution of the energy-efficiency optimization is derived for MIMO-OFDM mobile multimedia communication systems. As a consequence, an energy-efficiency optimized power allocation (EEOPA) algorithm is proposed to improve the energy efficiency of MIMO-OFDM mobile multimedia communication systems. Simulation comparisons validate that the proposed EEOPA algorithm can guarantee the required QoS with high energy efficiency in MIMO-OFDM mobile multimedia communication systems.
    Full-text · Article · Dec 2014 · IEEE Transactions on Vehicular Technology
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    ABSTRACT: Adjuvant therapy after resection of hepatocellular carcinoma (HCC) is limited. Here, we evaluated the effects of postoperative sorafenib on recurrence and survival in HCC patients. Recurrence-free survival and overall survival were analyzed as the main endpoint, recurrence rate, and mortality rate were analyzed as second endpoint. Furthermore, post-recurrence survival was also analyzed. Clinicopathological factors were compared between sorafenib and control groups. Seventy-eight patients were eligible for final data analysis (46 in control group; 32 in sorafenib group). Sorafenib did not significantly prolong recurrence-free survival (11.0 months in the control group vs. 11.7 months in the sorafenib group, p = 0.702), but significantly prolonged overall survival (32.4 vs. 25.0 months, p = 0.046). Sorafenib did not reduce recurrence rate (67.7% vs. 78.3%, p = 0.737), but significantly reduced mortality rate (28.1% vs. 60.9%, p = 0.004). The increased post-recurrence survival (22.2 vs. 4.4 months, p = 0.003) may have contributed to the survival benefit after recurrence in the sorafenib group. Adjuvant sorafenib did not decrease tumor recurrence, but significantly reduced mortality and prolonged overall survival of HCC patients after curative resection, probably by inhibiting tumor growth after tumor recurrence.
    Full-text · Article · Dec 2014 · Bioscience trends
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    ABSTRACT: Adjuvant interferon (IFN) therapy following curative treatment for hepatocellular carcinoma (HCC) has been extensively investigated; however, the clinical benefits with different hepatitis backgrounds remain unclear. Medline, Embase, PubMed and the Cochrane Library databases were searched to identify randomized trials and cohort studies that enrolled HCC patients who received curative surgery or ablation therapy followed by IFN and control subjects; the studies were required to include data on early or late recurrence and mortality rates of HCC. Hepatitis B virus (HBV) associated with HCC (HBV-HCC) and hepatitis C virus (HCV) associated with HCC (HCV-HCC) were separately analyzed and recurrence, mortality and clinicopathological factors were compared. A total of 14 studies (9 randomized trials and 5 cohort studies, including 1,385 patients in total) were eligible for meta-analysis. IFN was found to decrease mortality and early recurrence rates, but exerted no effect on late recurrence rate. The effect of IFN differed between HBV-HCC and HCV-HCC cases. In HCV-HCC, IFN significantly reduced mortality as well as recurrence rates. However, in HBV-HCC patients, IFN reduced mortality rather than recurrence rates, although it also reduced the recurrence rate in certain subgroups. In conclusion, the effect of adjuvant IFN on postoperative recurrence differed between HBV-HCC and HCV-HCC cases; therefore, different strategies with adjuvant IFN should be used to treat HCC with different hepatitis backgrounds.
    Preview · Article · Nov 2014 · Molecular and Clinical Oncology
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    ABSTRACT: Unlabelled: Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the third most common cancer in Asia. HCC has heterogeneous etiologic and molecular profiles and a varied response to therapeutics. The high recurrence rate and curtailed survival in this cancer are attributed to its resistance to therapy. The ultimate goal is to develop a more effective personalized therapeutic strategy for HCC, but the first step is to develop a system for classifying the disease on the basis of molecular biomarkers. To that end, we performed mRNA and microRNA (miRNA) expression profiling in 100 HCC tissues. Clustering analysis of informative genes identified two robust subtypes, which were validated by an independent dataset. The subtype characterized by a cancer stem cell-like signature was clinically aggressive and associated with poor survival. Integrated analysis of miRNA and mRNA expression in this subtype showed that miR-148a was expressed at a significantly lower level in these tumors than in the other subtype. MiR-148a has been shown to directly suppress the expression of activin A receptor type 1 (ACVR1), a key receptor in the signaling pathway of the bone morphogenetic proteins (BMPs), which regulate many stem cell markers as well as the clinically important cytokine interleukin-8 (IL-8). Increased expression of ACVR1 and its downstream genes EPCAM, CD24, CD90, and IL-8 was associated with shorter survival in a larger cohort of 227 HCC cases. Introduction of miR-148a resulted in suppressed tumor phenotypes both in vitro and in vivo. Conclusion: We identified a clinically aggressive stem cell-like subtype of HCC that is characterized by an miR-148a-ACVR1-BMP-Wnt circuit. We propose that miR-148a may serve as a prognostic biomarker and therapeutic target for this subtype of HCC.
    No preview · Article · Oct 2014 · Hepatology
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    ABSTRACT: This study aimed to investigate the clinical utility of simultaneous measurement of alphafetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) for hepatocellular carcinoma (HCC) diagnosis in Chinese patients predominantly caused by hepatitis B virus infection by a multi-center case-controlled study. Subjects were 1,153 individuals from three major hospitals in China, including 550 cases in HCC group, 164 in Malignant disease group, 182 in Benign disease group, 85 in Chronic liver disease group, and 173 in Normal group. Serum levels of AFP and DCP were measured and clinicopathological features were determined for all subjects. Results showed that the levels of DCP and AFP were significantly higher in HCC group (550 patients, 74.18% with HBV infection) than that in other four groups (P < 0.001). Receiver operating curves (ROC) indicated the optimal cut-off value was 86 mAU/mL for DCP with a sensitivity of 71.50% and specificity of 86.30%, and 21 ng/mL for AFP with a sensitivity of 68.00% and specificity of 93.20%. The area under ROC curve was 0.846 for DCP, 0.832 for AFP, and 0.890 for the combination of DCP and AFP. The combination of DCP and AFP resulted in a higher Youden index and a sensitivity of approximately 90%, even for small tumors. The simultaneous measurement of AFP and DCP could achieve a better sensitivity in diagnosing Chinese HCC patients, even for small tumors.
    No preview · Article · Oct 2014 · Bioscience trends
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    ABSTRACT: Background: Although there are many studies on the mechanism of chemoresistance in cancers, studies on the relations between WNT5A and chemoresistance in pancreatic cancer are rare. The present study was to examine the role of WNT5A in the regulation of cell cycle progression and in chemo-resistance in pancreatic cancer tissues and cell lines. Methods: Fresh pancreatic cancer and paracarcinoma tissues were obtained from 32 patients. The expressions of WNT5A, AKT/p-AKT and Cyclin D1 were detected by immunohistochemistry, and the correlation between WNT5A expression and clinicopathological characteristics was analyzed. The relationship between WNT5A expression and gemcitabine resistance was studied in PANC-1 and MIAPaCa2 cell lines. The effect of WNT5A on the regulation of cell cycle and gemcitabine cytotoxicity were investigated. The associations among the expressions of p-AKT, Cyclin D1 and WNT5A were also analyzed in cell lines and the effect of WNT5A on restriction-point (R-point) progression was evaluated. Results: WNT5A, p-AKT and Cyclin D1 were highly expressed in pancreatic cancer tissues, and the WNT5A expression was correlated with the TNM stages. In vitro, WNT5A expression was associated with gemcitabine chemoresistance. The percentage of cells was increased in G0/G1 phase and decreased in S phase after knockdown of WNT5A in PANC-1. WNT5A promoted Cyclin D1 expression through phosphorylation of AKT which consequently enhanced G1-S transition and gemcitabine resistance. Furthermore, WNT5A enhanced the cell cycle progression toward R-point through regulation of retinoblastoma protein (pRb) and pRb-E2F complex formation. Conclusions: WNT5A induced chemoresistance by regulation of G1-S transition in pancreatic cancer cells. WNT5A might serve as a predictor of gemcitabine response and as a potential target for tumor chemotherapy.
    No preview · Article · Oct 2014 · Hepatobiliary & pancreatic diseases international: HBPD INT
  • Jing Zhang · Yili Xin · Tao Han · Minho Jo · Qiang Li · Xiaohu Ge
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    ABSTRACT: It is of great importance for service providers to evaluate the impact of inter-cell co-channel interference on the achievable data rate in cellular networks. In this paper, the cumulative distribution function (CDF) of the inter-cell interference factor is derived. On this basis, closed-form expression of the maximum achievable rate subject to the interference from finite planar cells is analyzed over Nakagami-m fading uplink channels. Numerical results show that besides Nakagami-m fading severity parameters and path loss coefficient, the maximum achievable rate is also affected by the number of interference cells. According to the numerical results, with an increase in the number of interference cells, the maximum achievable rate is degraded.
    No preview · Conference Paper · Jun 2014
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    ABSTRACT: The fresh rejuvenated fruits of JUGLANS MANDSHURICA (QLY), known as a traditional Chinese medicine, has long been used in clinical practice for the treatment of cancer. Nevertheless, the existing quality control method seems insufficient to reflect the effective constituents of QLY and guarantee its quality, safety, and clinical efficacy. In this research, the cytotoxicities of different solvent fractions of QLY against human colon carcinoma cell line LS-174 T were estimated by MTT assay. Then, the efficacy-fingerprints of QLY with predominate cytotoxic activity were established by high performance liquid chromatography. In the fingerprints, fifteen peaks were selected as the common peaks to evaluate the similarities of 20 batches of samples from different sources. Relationships between cytotoxicity and chromatographic profiles were also investigated. The results indicated that the levels of peaks 4, 5, and 6 correlated closely with cytotoxicity. It is proposed that the efficacy-fingerprint with key biomarkers (peaks 4 and 5) should be adopted for improving the quality control of QLY. The developed method by having a combination of cytotoxicity screening and efficacy-fingerprint analysis could be an easy and fast analytical approach to find out effective components for quality control of QLY and its related traditional Chinese medicinal preparations.
    No preview · Article · Apr 2014 · Journal of Liquid Chromatography & Related Technologies

Publication Stats

1k Citations
209.56 Total Impact Points


  • 2004-2016
    • Tianjin Medical University Cancer Institute and Hospital
      T’ien-ching-shih, Tianjin Shi, China
  • 2013-2015
    • Huazhong University of Science and Technology
      Wu-han-shih, Hubei, China
    • Wenzhou People's Hospital
      Yung-chia, Zhejiang Sheng, China
  • 2011-2015
    • Wenzhou University
      Yung-chia, Zhejiang Sheng, China
  • 2005-2015
    • Tianjin Medical University
      T’ien-ching-shih, Tianjin Shi, China
  • 2013-2014
    • Heilongjiang University
      Charbin, Heilongjiang Sheng, China
  • 2012
    • Wenzhou Medical College
      Yung-chia, Zhejiang Sheng, China
  • 2009-2012
    • Tianjin University
      • School of Pharmaceutical Science and Technology
      T’ien-ching-shih, Tianjin Shi, China
  • 2006-2012
    • Nanyang Technological University
      • School of Electrical and Electronic Engineering
      Tumasik, Singapore
  • 2010
    • University of Electronic Science and Technology of China
      Hua-yang, Sichuan, China
  • 2007
    • Memorial University of Newfoundland
      • Division of Community Health and Humanities
      St. John's, Newfoundland and Labrador, Canada
  • 2002
    • Fuda Cancer Hospital
      Shengcheng, Guangdong, China