Colin Key

Brigham Young University - Provo Main Campus, Provo, Utah, United States

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Publications (6)13.44 Total impact

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    ABSTRACT: Depression and anxiety are common morbidities of critical illness. We assessed risk factors of depression and anxiety in Acute Respiratory Distress Syndrome (ARDS) survivors at 1 and 2 years post-hospital discharge. Risk factors for depression and anxiety at 1 and 2 years were assessed using stepwise multiple regression analyses, with and without 1-year outcomes. ARDS survivors had depression (16% and 23%) and anxiety (24% and 23%) at 1 and 2 years, respectively. Predictors of depression at 1 year were alcohol dependence, female gender and younger age (P=.006). Predictors of anxiety were ratio of arterial oxygen tension to inspired oxygen fraction and duration of mechanical ventilation (P<.005). Predictors of depression at 2 years were depression at 1 year and the presence of cognitive sequelae (P<.0001). Predictors of anxiety at 2 years was anxiety at 1 year (P<.0001). Medical variables that predicted depression or anxiety at 1 year no longer predicted depression and anxiety at 2 years. Medical variables appear to have a short-term effect on psychiatric outcomes. At 2 years lifestyle behaviors including history of smoking along with cognitive sequelae, depression and anxiety at 1 year predict depression and anxiety.
    No preview · Article · Mar 2010 · General hospital psychiatry

  • No preview · Article · Apr 2009
  • RO Hopkins · CW Key · MR Suchyta · JF Orme · LK Weaver

    No preview · Conference Paper · Apr 2009

  • No preview · Article · Feb 2009 · Brain Injury
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    ABSTRACT: Objective: Substance dependence disorders are common in hospitalized patients and are associated with poor recovery. We compared mortality and discharge disposition in critically ill patients with and without substance dependence and patients with and without psychiatric disorders. We also compared the prevalence of substance dependence and psychiatric disorders to population data. Methods: All medical records of shock trauma intensive care unit (ICU) patients (mixed medical and surgical) at LDS Hospital were reviewed for pre-critical illness alcohol dependence, drug dependence, and psychiatric disorders. Results: There were 742 critically ill patients of whom 54% were male, acute respiratory distress syndrome developed in 5.5% and hospital mortality was 21%. The mean acute physiology and chronic health evaluation II scores were 16.5 +/- 7.9, sequential organ failure assessment scores were 6.7 +/- 4.2, duration of mechanical ventilation was 5 +/- 6.2 days, ICU length of stay (LOS) was 7.3 +/- 10.1 days, hospital LOS was 12.3 +/- 12.9 days. Multivariable regression analyses found psychiatric disorders predicted higher hospital mortality (Odds ratio = 1.50), but was not statistically significant (p = 0.08); substance dependence predicted shorter hospital LOS (R ( 2 ) = 0.08, p = 0.01) after controlling for covariates. There was a higher prevalence of substance dependence compared to Utah (p < 0.001) and US population data (p < 0.001). The prevalence of psychiatric disorders was significantly lower in our patients compared to US population data (19 vs. 26%, p < 0.001). Conclusions: Our data suggest that substance dependence increases hospital LOS and that patients with drug or alcohol dependence are at higher risk for ICU admission compared to the general population.
    Preview · Article · Feb 2009 · Intensive Care Medicine
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    ABSTRACT: To assess cognitive sequelae, depression and anxiety following carbon monoxide (CO) poisoning. Prospective cohort study. This study prospectively followed 256 patients, 55 with less severe and 201 with more severe CO-poisoning. The prevalence of cognitive sequelae, depression and anxiety at 6 weeks, 6 months and 12 months was compared in patients with less severe and more severe CO-poisoning. Of the less severe CO-poisoned patients, 39% had cognitive sequelae, 21% depression and 30% anxiety at 6 weeks. Of the more severe CO-poisoned patients, 35% had cognitive sequelae, 16% depression and 11% anxiety at 6 weeks. There was no difference in the prevalence of cognitive sequelae at any time. The prevalence of depression was higher in patients with less compared with more severe CO-poisoning at 6 months (p = 0.04), but not 6 weeks or 12 months. The prevalence of anxiety was higher in patients with less compared to more severe CO-poisoning at 6 weeks (p = 0.008), but not 6 or 12 months. Anxiety decreased over time in the less severe group (p < 0.01). CO-related cognitive sequelae, depression and anxiety are common and may be independent of poisoning severity.
    No preview · Article · May 2008 · Brain Injury