Bin Wang

Second Military Medical University, Shanghai, Shanghai, Shanghai Shi, China

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Publications (6)8.47 Total impact

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    ABSTRACT: Poorer prognosis is seen in patients with hepatocellular carcinoma (HCC) after curative hepatic resection with early recurrence (<or=1 year) than in those with late recurrence (>1 year). This study aimed to identify risk factors for postoperative early recurrence of small HCC (<or=3 cm in diameter). The study population consisted of 158 patients who underwent curative resection for small HCC between January 2002 and July 2004. Risk factors for early recurrence were analyzed. Thirty-three (20.8%) patients developed early recurrence after surgery. Univariate analysis showed the following significant risk factors for early recurrence in small HCC: serum alpha-fetoprotein (AFP) level >100 ng/ml, lack of tumor capsule formation, microscopic vascular invasion, high Edmonson-Steiner grades, and cytokeratin-19 (CK-19) expression (P<0.05). Multivariate stepwise logistic regression analysis showed that serum AFP level >100 ng/ml (odds ratio 2.561, 95% confidence interval 1.057 to 6.206, P=0.037) and microscopic vascular invasion (odds ratio 4.549, 95% confidence interval 1.865 to 11.097, P=0.001) were independent factors. Postoperative early recurrence is related to serum AFP level >100 ng/ml and microscopic vascular invasion in patients with small HCC. Adjuvant therapy and careful follow-up are required for patients with these risk factors.
    No preview · Article · Feb 2010 · Hepatobiliary & pancreatic diseases international: HBPD INT
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    ABSTRACT: Primary hepatic angiosarcoma is an uncommon but aggressive malignancy with poor prognosis. The purpose of this study was to evaluate surgical outcomes of patients with the disease. Medical records of 6 patients who underwent surgical resection for primary hepatic angiosarcoma at our institution between 1998 and 2006 were reviewed retrospectively. There were 5 men and 1 woman who ranged in age from 44 to 77 years, with a mean of 55.5 years. The most common symptoms at diagnosis were pain in the right upper quadrant, abdominal distension, weakness and weight loss. None of these patients presented with intra-abdominal hemorrhage from tumor rupture. Right hepatectomy was performed in 3 cases, extended right hepatectomy in 1 case, and left hepatectomy in the remaining 2 cases. All 6 patients had solitary masses. One patient died of perioperative complication, and another patient with microscopic tumor residuals died of disease recurrence at 6 months. Of the other 4 patients with pathological free margins, 3 died of disease recurrence at 10, 14 and 17 months, and the remaining 1 has been alive without recurrence for 29 months. Although the overall outcome of surgical resection remains unsatisfactory, complete surgical resection may prolong survival of patients with solitary primary hepatic angiosarcoma without spontaneous rupture.
    No preview · Article · Feb 2010 · Medical science monitor: international medical journal of experimental and clinical research
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    ABSTRACT: Solitary necrotic nodule of the liver is a rare nonmalignant lesion. The present study aimed to clarify the clinical features of the disease. The medical records of 51 patients with histologically confirmed solitary necrotic nodule of the liver who received surgical resection at our institution were retrospectively reviewed. Solitary necrotic nodule of the liver was found mainly in males (68.6%, 35/51), and patients ranged in age from 5 to 69 years with a mean of 45.3. Most of the patients (72.5%) had no significant symptoms, with negative results for the serum tumor markers alpha-fetoprotein, carbohydrate antigen 19-9 and carcinoembryonic antigen. The mean diameter of the nodule was 23 mm (range 10-55 mm). Compared with ultrasonographic and computed tomography findings, the specific features of magnetic resonance imaging were more helpful for differential diagnosis of the disease. Solitary necrotic nodule of the liver is a rare nonmalignant lesion, showing no notable symptoms and potential complications. The pathological change of the disease is not significant over a lifetime. Conservative treatment and clinical follow-up are recommended.
    No preview · Article · Nov 2008 · Hepatobiliary & pancreatic diseases international: HBPD INT
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    ABSTRACT: Hepatic angiomyolipoma (HAML) is a rare hepatic mesenchymal tumor. This study was designed to explore its clinical features. Clinical data from 26 patients who had been pathologically confirmed with HAML and had received surgical resection at our hospital were analyzed retrospectively. HAML was seen more frequently in females (18/26) in this series, and most of the patients presented no significant symptoms except for one who had a spontaneous rupture hemorrhage. Serum alpha-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) were negative in all patients. Imaging presentations were diverse. Pre-operative diagnosis was made in only 3 patients. Pathological study showed that the tumor was composed of adipose tissue, smooth muscle and blood vessels in different proportions. One patient showed hepatic vessel invasion. HMB-45 immunohistochemical staining was positive in all tumors. All patients underwent surgical resection without significant complications. Except for one patient who died 14 months after operation because of recurrent disease, no tumor recurrence was observed in the remaining 25 patients during a 2-3 years follow-up. Pre-operative diagnosis of HAML is difficult. There are potential risks of spontaneous rupture and malignant transformation. Surgical resection is the treatment of choice for HAML.
    No preview · Article · Jun 2008 · Hepatobiliary & pancreatic diseases international: HBPD INT
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    ABSTRACT: To explore clinicopathologic characteristics of intrahepatic cholangiocarcinoma (ICC) in patients with positive serum a-fetoprotein (AFP). One hundred and thirty one patients who underwent surgical dissection for pathologically confirmed ICC were divided into a positive AFP (> 20 ng/mL) group (n = 32) and a negative AFP group (n = 99), whose clinicopathologic features were analyzed and compared. The positive rate of HBsAg and liver cirrhosis of the positive AFP group was higher than that of the negative AFP group, while the positive rate of CA19-9 (> 37 U/mL) and the lymph node metastasis rate was lower. ICC patients with positive AFP share many clinicopathologic similarities with hepatocellular carcinoma.
    Full-text · Article · May 2008 · World Journal of Gastroenterology
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    ABSTRACT: Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is a rare histopathologic form of primary liver cancer. We report a case of cHCC-CC and review the literature. The clinicopathological features of a 61-year-old male were retrospectively analyzed. Hepatocellular carcinoma (HCC) was preoperatively considered on the basis of clinical findings resembling those associated with HCC. Hepatectomy was therefore performed. Microscopically, the specimen displayed histological features of cHCC-CC. The patient has remained alive after follow-up for 3 months without evidence of recurrence and metastasis. It is difficult to make a correct preoperative diagnosis of cHCC-CC and hepatic resection is the treatment of choice.
    No preview · Article · Jan 2008 · Hepatobiliary & pancreatic diseases international: HBPD INT