[Show abstract][Hide abstract]ABSTRACT: HIV is not usually transmitted by saliva from HIV-1-infected individuals. Antiviral substances in saliva responsible for this may include HIV-1-specific antibody-dependent cell-mediated cytotoxicity (ADCC). We evaluated saliva ADCC titers of 62 HIV-1-infected women from the Women's Interagency HIV Study (WIHS) and 55 uninfected individuals. HIV-1-infected women were less likely to have ADCC activity in saliva than in serum or cervical lavage fluid (CVL). 24% of HIV-1-positive women and a similar percentage of uninfected women had HIV-1-specific saliva ADCC activity. A significant amount of saliva ADCC activity in infected women was HIV-gp120-specific. These studies demonstrate that HIV-specific ADCC activity can be present in saliva. This activity may contribute to host defence against initial infection with HIV.
Full-text · Article · Dec 2006 · FEMS Immunology & Medical Microbiology
[Show abstract][Hide abstract]ABSTRACT: Antibodies that mediate human immunodeficiency virus (HIV)-specific antibody-dependent cell-mediated cytotoxicity (ADCC) are
present in the cervical fluid of many HIV-positive women; however, the role that these antibodies play in host defense against
HIV is not known. To understand the contribution of ADCC in cervical secretions as a protective mechanism against HIV, we
evaluated ADCC titers in paired serum and cervical-lavage (CVL) samples from >300 HIV-1-positive women who participated in
the multicenter Division of AIDS Treatment Research Initiative Study 009. The present study demonstrates that women with CVL
ADCC activity had lower genital viral loads than did women with serum ADCC activity only. Women with CVL ADCC activity were
likely to have HIV-1 gp120-specific immunoglobulin (Ig) G, but not IgA, in their cervical fluid. This finding suggests that
specific IgG in cervical fluid can mediate ADCC activity that inversely correlates with genital viral load.
Full-text · Article · Dec 2004 · The Journal of Infectious Diseases