[Show abstract][Hide abstract] ABSTRACT: Introduction: Chronic obstructive pulmonary disease (COPD) is characterised by chronic airway inflammation with increased numbers of neutrophils in the airway lumen. Inhaled corticosteroids are widely used for the treatment of COPD despite of controversial statements concerning their efficiency. N-acetylcysteine is a mucolytic drug with antioxidant properties, counteracting the oxidant/antioxidant imbalance in COPD. Objectives: The aim of the present study is to evaluate whether treatment of COPD patients with inhaled corticosteroid or N-acetylcysteine will change indices of inflammation and oxidative stress. Material and Methods: Twenty COPD patients are treated for two times 10 weeks with fluticasone dipropionate (1000 μg/day) or N-acetylcysteine (600 mg/day) in a randomised crossover setting. Induced sputum and blood samples were collected every 10 weeks. Results: Protective markers for oxidative stress, glutathione peroxidase (47.5±5.3 vs. 57.6±7.8 U/g Hb, P<0.05) and trolox-equivalent antioxidant capacity (1.41±0.05 vs. 1.50±0.06 mM, P<0.05) were increased by steroid treatment. N-acetylcysteine decreased significantly sputum eosinophil cationic protein (266±61 vs. 136±27 ng/ml, P<0.02), sputum interleukin-8 (403±65 vs. 326±62 ng/ml, P=0.05), and sputum tryptase, a serine protease (1.80±0.29 vs. 1.33±0.16 ng/ml, P<0.01). Conclusions: These results suggest inhaled steroids have no action on inflammatory indices in the treatment of COPD, while N-acetylcysteine has some anti-inflammatory actions. Furthermore, steroids seem to have a positive influence on oxidant/antioxidant imbalance that is thought to be important in the pathogenesis of COPD.
No preview · Article · Jan 2008 · Central-European Journal of Immunology
[Show abstract][Hide abstract] ABSTRACT: Four patients with alpha-1 antitrypsin (alpha-1 AT) deficiency are presented: one woman with severe (phenotype PiZ) and 3 men with moderate (phenotype PiMZ) deficiency of alpha-1 AT. The variability of clinical presentation of hereditary emphysema is described. In all patients tobacco smoking history, spirometric and 6-minutes walking tests as well as HRCT of the lung were performed and compared. The influence of smoking on the functional status is underlined.
No preview · Article · Feb 2004 · Pneumonologia i alergologia polska: organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruzlicy i Chorob Pluc
[Show abstract][Hide abstract] ABSTRACT: Spirometric screening for airflow obstruction in smokers is easy in large cities. However, 38% of the population of Poland live in villages. The aim of the study was to assess feasibility of such screening in people attending Sunday mass using parochial church facilities in small remote communities. Study was performed in a small town and a village near Warsaw. Attendance was higher in town (9% of believers attending holy mass as compared 5% in the village). However, airflow obstruction was found in 38% of farmers as compared to 21% of the town dwellers. In conclusion spirometric screening in small communities performed in the parochial facility on Sunday morning is feasible, easy and fruitful.
No preview · Article · Feb 2002 · Pneumonologia i alergologia polska: organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruzlicy i Chorob Pluc
[Show abstract][Hide abstract] ABSTRACT: The aim of the study was to evaluate factors that could predict smoking cessation after a minimal antismoking counseling during spirometric screening for COPD. Every subject filled-in a simple questionnaire on clinical signs of COPD and tobacco habit, had a spirometry performed according to ATS standards and received a short antitobacco counseling together with a booklet on how to quit smoking. Out of 800 smokers over 40 years of age, smoking history of more than 10 packyears, screened for COPD in 1999, four hundred were invited a year later for a follow-up spirometry and evaluation of anti-smoking intervention. Of 383 patients, who responded to the invitation (208 M and 175 F, mean age 56.6 +/- 10.7 yrs), 52 (13.6%) quit smoking for one year and another 48 (12.5%) quit smoking temporarily and than resumed smoking. Smokers who permanently succeeded in quitting smoking were older (60.5 vs 55.9 years p < 0.01), started smoking later (age at starting smoking 22 vs 19.5 years p < 0.001), had a shorter tobacco exposition (28.8 vs 34.3 packyears p < 0.05), had lower lung function (FEV1%pred 80.5 vs 89.2% p < 0.05) and were less nicotine dependent (FTQ score 1 vs 4.8 p < 0.00001).
No preview · Article · Jan 2001 · Pneumonologia i alergologia polska: organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruzlicy i Chorob Pluc