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Publications (3)1.99 Total impact

  • Ahmed Al-Ghamdi · Ingrid Hings · Robert E Turcotte
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    ABSTRACT: Bone metastases are frequently encountered in the management of cancer. The incidence of such events is increasing in the geriatric population and most often they can be managed conservatively. Surgery is sometimes unavoidable to address some of these lesions and will represent a significant challenge for both the patient and the medical team. Patients presenting with bone metastases are a heterogeneous group. Some present late in the course of their disease after failing all treatment modalities whereas others present without a known diagnosis of cancer. In addition, some metastatic cancers are responsive to treatment and prolonged survival may be expected (e.g., myeloma, breast prostate, kidney and thyroid) as compared with others where therapeutic options are limited with concomitant decrease in life expectancy (e.g., lung, bladder and pancreas). Patients will benefit if physicians can recognize lesions at risk of fracture or already fractured, and understand the advantages and the limitations of surgery. Patient selection and the type of procedure performed are of outmost importance. Chances for a satisfactory functional outcome and survival rates following surgery should be known in order to avoid unnecessary procedures that may be associated with significant rates of complication. Appropriate surgical intervention for bone metastases can provide the elderly cancer patient with meaningful palliation and contribute to their overall quality of life.
    No preview · Article · Jun 2009 · Aging Health
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    ABSTRACT: To assess the outcome of patients with extra-abdominal desmoid tumor treated with low dose chemotherapy (methotrexate and vinblastine) both for tumor response and treatment related toxicity. We retrospectively reviewed the outcome of 12 patients who underwent low dose chemotherapy for extra abdominal desmoid of different locations. The study took place in the McGill University Health Center, Montreal, Canada between 1996 and 2003. We evaluated the patients for their compliance, tumor response, complications of treatment, and impact of treatment on symptoms. There were 7 females and 5 males with a mean age of 46 years. Disease related morbidity included pain in 7 patients, functional limitation in 7 and cosmetic defects in 3. The mean tumor size was 11 cm (3-20 cm). The mean follow-up was 43 months (15-71 months). Chemotherapy was administered weekly. Complications were significant. Only 2 patients did not experience the toxicity. According to Response Evaluation Criteria in Solid Tumors, 6 tumors showed a partial response and 6 remained stable. None showed progression. Of the 7 patients who had painful tumors, 6 achieved significant symptom relief. Function was improved in 3 and restored to normal in 4. Cosmesis was improved in 2 of the 3. At latest follow-up, tumors remained stable in 8, one has markedly regressed and 3 exhibited progression at an average of 54 months. Only one patient required surgery. The only long term side effect was a sensory peripheral neuropathy. Low dose chemotherapy was found to be a valuable adjunct to prevent local progression and improve symptoms.
    Preview · Article · Jan 2009 · Saudi medical journal
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    ABSTRACT: Kaposi's sarcoma (KS) is a multicentric low-grade vascular malignancy. In North America, it is usually seen in AIDS and solid organ transplant populations. Classic KS is a subtype that traditionally occurs in elderly HIV-negative males of Mediterranean, Eastern European, and Jewish descent. Patients with classic KS characteristically present with skin lesions in the distal extremities. Involvement of the viscera is uncommon in classic KS, but may occur in the late stages of the disease. We report the first case of classic KS presenting in the gastrointestinal tract of an elderly HIV-negative Inuit male from Northern Quebec, Canada.
    Preview · Article · Feb 2006 · Pathology - Research and Practice