[Show abstract][Hide abstract] ABSTRACT: Prognostic value of p53 and PCNA expression in non-small cell lung cancer (NSCLC) remains controversial. In this study we determined the relevance of these abnormalities in terms of overall survival and disease-free survival in 95 NSCLC patients who underwent curative pulmonary resection. Expression of p53 was found in 44 samples (45%), expression of PCNA-in 79 samples (83%), and expression of both markers-in 35 samples (36%). There was no relationship between expression of either protein and major clinicopathological characteristics. Median survival for patients with and without p53 expression was 36 and 33 months, respectively and 5-year survival probability-29 and 37%, respectively (P=0.73). Median survival for patients with and without PCNA expression was 36 and 27 months, respectively and 5-year survival probability-35 and 25%, respectively (P=0.60). There was no significant difference in overall survival between particular groups of patients with tumors carrying four possible p53/PCNA phenotypes. In multivariate analysis including patient age, sex, tumor stage, tumor type and differentiation, p53 and PCNA expression, the only variable important for survival was stage of disease. These results suggest the lack of prognostic relevance of p53 and PCNA expression in surgically treated NSCLC patients.
[Show abstract][Hide abstract] ABSTRACT: An association between cigarette smoking and lung cancer carcinogenesis is reviewed. It is highly possible, that "individual susceptibility" for tumor development exists and is related to polymorphic variants of genes encoding for enzymes, which are employed in metabolism of xenobiotic substances. The gathering of highly reactive molecules due to modified metabolic processes results in DNA adducts forming and increased tendency for mutations. Group of genes, responsible for proliferation, cell cycle arrest, apoptosis and DNA damage repair are frequently altered.
No preview · Article · Jul 2001 · Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego
[Show abstract][Hide abstract] ABSTRACT: The prevalence of cigarette smoking in Poland is one of the highest in Europe.
To compare the frequency of smoking among Polish pupils during a school year and the summer holidays.
A questionnaire including personal and demographic data and information on smoking behaviour was distributed among 598 school pupils: 357 girls and 241 boys aged 8-19 years, with a mean age of 14.4.
Among the entire group of school pupils, 18.6% were cigarette smokers. Half of the smokers smoked occasionally and the remainder smoked every day; of these, 9.9% smoked more than 10 cigarettes daily. The frequency of smoking among these teenagers increased with age. The average age of smoking initiation was 13 years for boys and 15 years for girls. The majority smoked more during the summer holidays than during the school year. The most frequently reported reasons for increasing cigarette smoking during the summer holidays were: feeling more free, having more money to spend, the influence of new friends, and smoking to pass the time when they felt bored.
Young people in this study still started smoking early, most frequently between the ages of 13 and 15. High rates of daily smokers among teenagers were observed. In some groups of teenagers the summer holidays may be a time of increased cigarette smoking.
No preview · Article · Dec 2000 · The International Journal of Tuberculosis and Lung Disease
[Show abstract][Hide abstract] ABSTRACT: The aim of the study was to evaluate the prognostic relevance of p53 protein in non-small cell lung cancer. The 95 surgically treated patients were included (53 patients with squamous cell carcinoma, 29--with adenocarcinoma, 5--with large cell carcinoma, and 8--with mixed type). The protein was assessed immunohistochemically with the use of monoclonal antibodies DO7, DAKO. Positive staining was present in 44 patients. There was no survival difference between groups with and without protein (median survival--36 and 33 months, respectively; p = 0.86). In the multivariate analysis the only characteristics with prognostic impact in the entire group was stage of the disease. There was no correlation between the expression of p53 protein and disease-free survival. These results indicate that there is no prognostic relevance of p53 protein in non-small cell lung cancer.
No preview · Article · Feb 2000 · Pneumonologia i alergologia polska: organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruzlicy i Chorob Pluc
[Show abstract][Hide abstract] ABSTRACT: Chronic Obstructive Pulmonary Disease (COPD) is defined as a disease state characterised by the presence of chronic bronchitis and/or emphysema, associated with chronic airflow limitation. Chronic airflow obstruction is slowly progressive, may be accompanied by airways hyperreactivity, and may be partially reversible. Airflow limitation is characterised by a decrease in forced expiratory volume in one second FEV1. Simple spirometry remains the most clinically relevant test for routine use. There is established evidence supporting smoking, severe hereditary alfa-1-antytrypsin deficiency, and occupational and environmental exposure to dusts and gases as risk factors for COPD. The role of respiratory infections is under active investigation at present. The aim of the study was to assess the possibility of early detection of COPD in Gdańsk urban area. Cross-sectional study was planned and 779 persons were examined (378 women and 401 men, mean age 54.4 years). The protocol of the study included smoking habit history, clinical symptoms analysis, questionnaire devoted infections exacerbations and spirmetric studies (Pneomscreen Jeager). As a basal spirometric parameters FEV1 and FEV1/VC were assessed. Abnormalities in spirometric tests were observed in 379 persons (48.6%). Among them 304 were smokers. 315 persons had typical chronic bronchitis features and 60% of them demonstrated obstructive changes in spirometry. In 442 people, who had frequent acute infective episodes, airflow limitation was found in 49.3%. There were no differences in comparison with the whole assessed population. Conclusions: Screening spirometric assessment is an effective method for early detection of COPD. Smoking habit is the most important risk factor for airflow limitation development.
No preview · Article · Jan 2000 · Annales Academiae Medicae Gedanensis
[Show abstract][Hide abstract] ABSTRACT: Cigarette smoking by teenagers is conditioned by many factors with psychosocial ones among them. The aim of our study was to define the reasons for cigarette smoking by juveniles in Poland nowadays. The analysis was performed on the basis of questionnaire given to 598 school pupils resting in the summer camps in the Tricity of three neighbouring towns of Gdańsk, Sopot and Gdynia. The study group included 357 females and 241 males, with an age of 8-19 years, on average 14.4. Out of the hole group 111 (18.6%) were smokers. This subgroup, 58 boys and 53 girls (age: 12-19 yrs.; on average 15.4), answered to several questions concerning cigarette smoking. Among remaining 487 non-smokers the prevalence of cigarette smoking among their parents was only assessed. As the main reason for smoking the majority (69.4%) of smokers reported the stress reduction. Pleasure was another frequently reported (29.7%) reason for cigarette smoking. Peers smoking was an important reason for cigarette smoking for 28.8% of school pupils. We found that the example of smoking parents significantly influenced the prevalence of smoking cigarettes among teenagers. The majority (73.9%) of smoking pupils knew the cigarette were harmful. Obtained results show the multiplicity of reasons for cigarette smoking by juveniles resulting mainly from psychosocial factors. There is a great necessity of antismoking programs for school pupils adjusted to specificity of psychology of adolescence as well as the exemplary role of adults creating a life style without cigarette.
No preview · Article · Feb 1999 · Pneumonologia i alergologia polska: organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruzlicy i Chorob Pluc
[Show abstract][Hide abstract] ABSTRACT: A case of eosinophilic granuloma of the lung in a 24 years old male is presented. The initial manifestations were hemoptysis and cough. During hospitalization the bronchoscopy was performed, which revealed granuloma in the right bronchus. Computer tomography showed tumour in the right bronchus, without pulmonary changes characteristic for histiocytosis X. The granuloma was removed by bronchoscopy, but control examination performed after three months showed the residue. Once again residual tumor was removed by bronchoscopy and oral steroids were ordered. Unfortunately the next local residue was observed and the residual tumour was finally removed by thoracotomy. Now patient is free of symptoms.
No preview · Article · Feb 1998 · Pneumonologia i alergologia polska: organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruzlicy i Chorob Pluc