[Show abstract][Hide abstract] ABSTRACT: Thunder god vine, the dried roots of Tripterygium wilfordii, is a widely used traditional Chinese medicine. More than 200 bioactive complex natural products have been isolated from this herb. Inspired by the diversity of chemical structures and bioactivities of the components of this herb, the investigation to mine new chemical entities as potential drug leads led to the identification of 36 nitrogen-containing compounds. Among them, 18 new dihydro-β-agarofuran alkaloids (tripterygiumines A-L (1-12), M-Q (22-26), and R (33)) were identified from the spectroscopic data and chemical degradation studies. Tripterygiumine Q (26) exhibited immunosuppressive activity against human peripheral mononuclear cells with an IC50 value of 8.67 μM and showed no cytotoxicity, even at 100 μM, indicating that 26 may represent a novel scaffold for the development of new immunosuppressants.
Full-text · Article · Jun 2014 · Journal of Natural Products
[Show abstract][Hide abstract] ABSTRACT: Three new steryl esters and a new phenylethanol ester, together with 22 known compounds were isolated from the aqueous ethanolic extract of the whole plants of Syringa komarowii. The new compounds were elucidated as stigmastane-3beta,6alpha-diol 3-O-tetradecanoate (1), stigmastane-3beta,6alpha-diol 3-O-palmitate (2), stigmastane-3beta,6alpha-diol 3-O-stearate (3), and 2-(4-hydroxyphenyl)-ethyl dotriacontanoate (4) on the basis of extensive spectral data and chemical evidences.
[Show abstract][Hide abstract] ABSTRACT: Three new compounds, goldfussins A (1) and B (2) and goldfussinol (3), and sixteen known compounds were isolated from the ethanolic extract of the whole plants of Goldfussia psilostachys. The structures of the new compounds were elucidated as a novel cadinane sesquiterpene, 1,8-dimethyl-5-hydroxymethyl-9-oxo-6,7,8,9-tetrahydronaphtho[2,1- b]furan (1), a novel norcadinane sesquiterpene, 4-acetyl-3-hydroxy-1-hydroxymethyl-6-methyl-5-oxo-5,6,7,8-tetrahydronaphthalene (2) and methyl 3-hydroxy-2-(3,5-dimethoxy-4-hydroxyphenyl)-propanoate (3) on the basis of spectral data.
[Show abstract][Hide abstract] ABSTRACT: A new glucoceramide named pellioniareside (1) was isolated from the aqueous ethanolic extract of whole plants of Pellionia repens, together with lupeol (2), uracil (3), (22E,20S,24R)-5alpha,8alpha-epidioxyergosta-6,22-dien-3-beta-ol (4), and daucosterol (5). The structure and relative configurations of pellioniareside were identified as (2S,3S,4R,6E,8E)-1-O-beta-D-glucopyranosyl-2-[(2 R)-2-hydroxytetracosanoylamino]-1,3,4-octadecanetriol-6,8-diene by analysis of spectral data and by chemical evidence.