Gholam Reza Karimi

Mashhad University of Medical Sciences, Mashad, Razavi Khorasan, Iran

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Publications (2)1.84 Total impact

  • H. Hosseinzadeh · G. Karimi · M. Niapoor
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    ABSTRACT: The effects of aqueous and ethanolic extracts of Crocus sativus L. stigma and their constituents safranal and crocin were studied for the antidepressant activity using forced swimming test in mice. The extracts and constituents were injected intraperitoneally to mice. The aqueous and ethanolic extracts of stigma (0.2-0.8 g/kg) decreased immobility time in comparison to normal saline. Safranal (0.15-0.5 ml kg) and crocin (50-600 mg/kg) also reduced immobility time. Swimming time was increased by fluoxetine and both extracts. Safranal increased swimming time. Climbing time was increased by imipramine and both extracts. Safranal with a higher dose (0.5 mg/kg) and crocin at doses 50 and 600 increased climbing time. In the open field activity test, the ethanolic extract and safranal increased stereotypic activities. On the basis of these results, the antidepressant effect of C. sativus stigma extracts may be mediated via safranal and crocin. Crocin may act via the uptake inhibition of dopamine and norepinephrine, and safranal via serotonin.
    No preview · Article · May 2004 · Acta horticulturae
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    Hossein Hosseinzadeh · Gholam Reza Karimi · Maryam Ameri
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    ABSTRACT: As a folk remedy, Anethum graveolens seed (dill) is used for some gastrointestinal ailments. We aimed to evaluate aqueous and ethanolic extracts of anti-ulcer and acute toxicity effects of the Anethum graveolens in mice. Gastric mucosal lesions were induced by oral administration of HCl (1 N) and absolute ethanol in mice. The acidity and total acid content of gastric juice were measured in pylorus-ligated mice. LD50 values of the aqueous and ethanolic extracts were 3.04 g/kg, i.p., (1.5, 6.16) and 6.98 g/kg, i.p., (5.69, 8.56), respectively. The efficacy of high dose of extracts (p.o.) was similar to sucralfate. The acidity and total acid content were reduced by the orally or intraperitoneally administration of the extracts. The results suggest that A. graveolens seed extracts have significant mucosal protective and antisecretory effects of the gastric mucosa in mice.
    Preview · Article · Jan 2003 · BMC Pharmacology

Publication Stats

93 Citations
1.84 Total Impact Points

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  • 2003
    • Mashhad University of Medical Sciences
      • Department of Pharmacodynamics & Toxicology
      Mashad, Razavi Khorasan, Iran