Divya Sridhar

University of California, San Francisco, San Francisco, California, United States

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Publications (2)4.3 Total impact

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    ABSTRACT: The goals of this study were to derive a frequency–position function for the human cochlear spiral ganglion (SG) to correlate represented frequency along the organ of Corti (OC) to location along the SG, to determine the range of individual variability, and to calculate an “average” frequency map (based on the trajectories of the dendrites of the SG cells). For both OC and SG frequency maps, a potentially important limitation is that accurate estimates of cochlear place frequency based upon the Greenwood function require knowledge of the total OC or SG length, which cannot be determined in most temporal bone and imaging studies. Therefore, an additional goal of this study was to evaluate a simple metric, basal coil diameter that might be utilized to estimate OC and SG length. Cadaver cochleae (n = 9) were fixed
    Full-text · Article · Jun 2007 · Journal of the Association for Research in Otolaryngology
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    Divya Sridhar · Olga Stakhovskaya · Patricia A Leake
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    ABSTRACT: Greenwood's frequency-position function for the organ of Corti (OC) is commonly used to estimate represented frequencies for cochlear implant (CI) electrodes, both in temporal bone studies and in imaging studies of living CI recipients. However, many contemporary CIs position stimulating electrodes near the modiolus, directly targeting the spiral ganglion (SG) cells within Rosenthal's canal. At the extreme base and apex, the SG does not extend as far as the OC, and the radial nerve fibers take a tangential course into the modiolus resulting in a potential offset between the frequency maps of the OC and SG. In this investigation, human cadaveric cochleae (n = 7) were studied in surface preparations after osmium staining. The OC and SG lengths were measured and radial fiber trajectories traced to identify frequency-matched points on each structure. These data allowed derivation of a mathematical function correlating represented frequency along the OC to position along the SG. A cubic function fit the data with a very high intersubject correlation. Better knowledge of the human SG 'neural frequency map' may help to refine electrode design, and to more accurately map CI channel filter bands to the appropriate cochlear place along the SG, which may be advantageous for more sophisticated CI outcomes, such as music appreciation. These data also could be valuable for electroacoustic stimulation, by defining the insertion distance of a CI electrode required to reach specific frequencies (based upon preoperative imaging) in an individual subject, thus helping to avoid trauma to cochlear regions with residual hearing.
    Full-text · Article · Feb 2006 · Audiology and Neurotology

Publication Stats

113 Citations
4.30 Total Impact Points


  • 2006-2007
    • University of California, San Francisco
      • Department of Otolaryngology - Head and Neck Surgery
      San Francisco, California, United States