Y.L. Park

Kangbuk Samsung Hospital, Sŏul, Seoul, South Korea

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Publications (57)27.93 Total impact

  • Y.S. Kim · K.O. Kim · J.H. Oh · S.Y. Lee · S.H. Lee · Y.L. Park
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    ABSTRACT: Erythema nodosum is considered to be a hypersensitivity reaction to various conditions. Vaccination-related erythema nodosum is uncommon but cases associated with hepatitis B virus, human papillomavirus, tetanus, diphtheria and pertussis, rabies, smallpox, typhoid and cholera, and Bacille-Calmette-Guerin vaccinations have beenreported. A 33-year-old Korean woman presented with a 3-day history of painful erythematous plaques on both lower legs and knees. Prior to the development of the skin rash, she had received the pneumococcal polysaccharide conjugate vaccine Prevenar13® Histological examination of the left lower leg lesion revealed septal panniculitis without vasculitis. To the best of our knowledge, erythema nodosum caused by pneumococcal vaccination has not previously been reported. It is important for clinicians to be aware of this rare, yet potential, adverse effect to the pneumococcal vaccine.
    No preview · Article · Sep 2015
  • J.Y. Kim · E.H. Chung · H.J. Kim · Y.L. Park · K.U. Whang · J.S. Lee · S.Y. Lee
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    ABSTRACT: Background: Various Q-switched (QS) lasers, such as ruby, alexandrite or neodymium:YAG (Nd:YAG) lasers, are used to remove tattoos and permanent makeup. To our knowledge, there has been no indication or guideline published for the optimal time for laser-mediated tattoo removal. Objective: To set a guideline for me optimal irradiation time for tattoo and permanent makeup removal via 1064 nm QS Nd:YAG (QSND) laser, we compared the degree of tattoo removal and skin histologic changes when the irradiation was employed at different time points. Methods: Rat skin was marked with 54 artificial permanent makeup marks with black ink using a permanent makeup machine. The marks were irradiated with a 1064 nm QSND laser on the application day, and 3 days, 5 days, 1 week, 2 weeks, and 3 weeks after application. Pigmentation changes were checked over time using a Mexameter and skin biopsy. Results: There was no significant difference in the degree of pigment removal as examined by Mexameter on the day of makeup application compared to 3 days, 5 days, 1 week, 2 weeks, and 3 weeks after application. Histopamologically, the permanent makeup pigments seemed to move from epidermis to superficial and mid dermis with time. The pigments were relatively well removed throughout the epidermis and dermis when the laser was employed 7 days after tattoo application, compared to laser irradiation on the day of application, as viewed histologically. Conclusion: Laser removal of permanent makeup is effective on the day of application, as determined by testing pigment levels. However, based on histopathology, it is recommended to use lasers to remove permanent makeup about a week after application, since the wound repair process is almost complete at that time.
    No preview · Article · Jul 2015 · Korean Journal of Dermatology
  • K.O. Kim · S.H. Lee · S.Y. Lee · K.U. Whang · Y.L. Park
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    ABSTRACT: Background: Psoriasis is a chronic, relapsing inflammatory disease that affects approximately 2∼3% of the population worldwide and often requires, lifelong care. Recent advances in understanding, the immunogenesis of psoriasis has led to the development of biological/agents that target specific immunological pathways. Ustekinumab is a human monoclonal antibody that binds to the p40 subunit common to interleukin-12 and 23, key cytokines in the pathogenesis of psoriasis. Objective: This study aims to address the efficacy aiid safety of ustekinumab in Korean patients with moderate-to-severe psoriasis. Methods: The clinical records of 32 consecutive patients treated with ustekinumab were reviewed retrospectively. Treatment effectiveness was estimated based on reported Psoriasis Area and Severity Index (PASI) 50, 75, and 90 response rates, defined as a ≥50%, ≥75%, or ≥90% reduction from baseline PASI scores, respectively. A stereotyped questionnaire was completed by the physician, and information about adverse events and quality of life was collected. Results: The average baseline PASI score was 25.7. Overall 38%, 56%, and 80% patients achieved PASI 75 response rates at weeks 4, 16, and 52 respectively. Thirteen patients (41%) experienced a mild adverse event such as upper respiratory infection, pruritus, urticaria, nasopharyngitis, headache, hyperglycemia, abnormal hepatic function, or arthralgia. Conclusion: Ustekinumab provides an effective, safe, and well-tolerated alternative for the symptomatic treatment of Korean patients with moderate-to-severe psoriasis.
    No preview · Article · Jun 2015 · Korean Journal of Dermatology
  • Y.S. Kim · G.H. Jung · K.U. Whang · Y.L. Park · H.J. Lee · J.S. Lee · S.Y. Lee

    No preview · Article · Mar 2015 · Korean Journal of Dermatology
  • K.O. Kim · Y.S. Kim · Y.I. Bae · Y.L. Park · M.K. Cho · S.H. Lee

    No preview · Article · Nov 2014 · Korean Journal of Dermatology
  • K.O. Kim · Y.S. Kim · Y.L. Park · S.H. Lee · Y.I. Bae

    No preview · Article · Oct 2014 · Korean Journal of Dermatology
  • B.J. Ko · G.H. Jung · Y.L. Park · J.S. Lee · K.U. Whang · S.Y. Lee

    No preview · Article · Oct 2014
  • H.J. Kim · G.M. Lee · Y.L. Park · J.S. Lee · K.U. Whang · S.Y. Lee
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    ABSTRACT: Background: Laser therapy for various skin conditions is one of the most common procedures in dermatology. Recently, several articles described the use of 1064 nm Q-switched Nd:YAG lasers for the treatment of benign skin lesions. Such treatment is known to trigger its therapeutic effect through a photoacoustic effect and selective photothermolysis effect. However, only a limited number of articles have dealt with the theoretical base of the photoacoustic effect of the 1064 nm Q-switched Nd:YAG laser. Objective: To compare the wound repair process and nonselective tissue heat damage induced by three different laser modalities: the CO2 laser, Er:YAG laser, and 1064 nm Q-switched Nd:YAG laser. Methods: We irradiated the skin of an albino rat (Sprague Dawley®, 200 ̃ 250 g) with CO2, Er:YAG, and 1064 nm Q-switched Nd:YAG lasers. Skin biopsy specimens of the irradiated areas were collected on the first, fifth, and tenth day after laser exposure. For histologic analysis, the specimens were stained with the H&E, Verhoff-Van Gieson, and Masson's trichrome protocols. Results: Compared with other laser modalities, rat skin irradiated by the 1064 nm Q-switched Nd:YAG laser showed the least amount of heat damage and the quickest tissue repair response to the damage. Conclusion: A 1064 nm Q-switched Nd:YAG laser with a photoacoustic effect capable of ablating the epidermis and dermis can be a proper treatment modality for the removal of benign skin lesions. The 1064 nm Q-switched Nd:YAG laser may be considered as an alternative treatment option for the treatment of benign skin lesions.
    No preview · Article · Apr 2014 · Korean Journal of Dermatology
  • B.J. Ko · M.K. Cho · Y.L. Park · J.S. Lee · J.H. Lee · K.U. Whang
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    ABSTRACT: Background: c-Jun along with JunB, JunD, and the Fos group proteins comprise the core members of the activator protein 1 (APl) family of transcription factors. Recently, many studies have demonstrated the key roles of APl in regulating a wide spectrum of biological processes, including tumorigenesis. We therefore hypothesized that c-Jun and JunB influence the differentiation and malignant change of various skin tumors. Objective: We measured the expression levels of c-Jun and JunB in different skin tumors. Methods: The expressions of c-Jun and JunB were examined by performing the immunohistochemical staining of 55 specimens of skin tumors, including 13 cases of seborrheic keratosis, 4 cases of keratoacanthoma, 9 cases of actinic keratosis, 4 cases of Bowen's disease, 4 cases of basal cell carcinoma, 16 cases of squamous cell carcinoma, and 5 cases of malignant melanoma. Results: Immunohistochemical analysis of the skin tumor tissue samples revealed a significantly higher expression of c-Jun in malignant skin tumors (basal cell carcinoma, squamous cell carcinoma, malignant melanoma) than in benign (seborrheic keratosis, keratoacanthoma) or premalignant skin tumors (actinic keratosis, Bowen's disease). The expression of JunB, however, was significantly lower in malignant skin tumors than in benign skin tumors. Conclusion: These findings showed that c-Jun has a positive association with skin malignancies, while JunB has a negative association with skin malignancies. The role of APl as key regulators of cell proliferation and epidermal tumor progression is suggested.
    No preview · Article · Apr 2014 · Korean Journal of Dermatology
  • Y.S. Kim · G.M. Lee · Y.I. Bae · Y.L. Park · S.H. Lee
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    ABSTRACT: Recent studies recommend pegylated interferon alpha2a as the first choice treatment for chronic hepatitis B, especially when the patient is negative for HBeAg. Pegylated interferon alpha is known to show variable side effects including skin symptoms, with alopecia as the most common dermatologic side effect experienced for 10% up to 36%. pcc) Most alopecia cases related to pegylated interferon alpha were presented with telogen effluvium pattern, but alopecia areata cases are reported rarely. In this case, typically localized alopecia areata was presented with pegylated interferon alpha2a treatment in hepatitis B patient, and the course of alopecia areata seemed to be related with administration and discontinuation of pegylated interferon alpha2a.
    No preview · Article · Jan 2014 · Korean Journal of Dermatology
  • B.J. Ko · G.M. Lee · I.H. Choi · Y.L. Park · S.Y. Lee · K.U. Whang
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    ABSTRACT: Amyloidosis is a group of disorders resulting from the extracellular deposition of amyloid fibrils in tissues and organs. Primary systemic amyloidosis may be myeloma-associated or idiopathic. It involves the kidney, heart, liver, peripheral nerves, autonomic nervous system and skin. We report a case of a 76 year-old woman with primary systemic amyloidosis who suffered from ecchymotic purpura on the periorbital, flexural area with hemorrhagic bulla, and macroglossia for two years. She showed typical symptoms of AL amyloidosis, and while primary systemic amyloidosis was suspected from electrophoresis results, no amyloid was found in the skin, tongue, and bone marrow. Upon her admission due to panperitonitis from diverticulitis, she was diagnosed with primary systemic amyloidosis after amyloid deposition was confirmed in the skin and colon biopsy. She had been treated with bortezomib, but she expired from methicillin-resistant Staphylococcus aureus septic shock.
    No preview · Article · Sep 2013 · Korean Journal of Dermatology
  • H.K. Cho · K.U. Whang · Y.L. Park · J.S. Lee
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    ABSTRACT: Among antimicrobial peptides produced by keratinocytes, β-defensins and LL-37 are the major human antimicrobial peptides. Because β-defensins have recently received great attention for its roles associated with host defense and cancer development, we hypothesized that β-defensin 1 has an influence on the differentiation and malignant changes of various skin tumors originating from keratinocytes and malignant melanomas. Objective: This study was conducted to measure the expression of β -defensin 1 in different skin tumors. Methods: The expression of β -defensin 1 was examined by immunohistochemical staining of 57 specimens of skin tumors including 12 cases of seborrheic keratosis, 4 cases of keratoacanthoma, 12 cases of actinic keratosis, 10 cases of basal cell carcinoma, 16 cases of squamous cell carcinoma and 3 cases of malignant melanoma. Results: Immunohistochemical analysis of skin tumor tissue samples revealed significantly higher expression of βdefensin 1 in benign skin tumors (seborrheic keratoses, keratoacanthomas) and premalignant lesions (actinic keratoses) than in malignant tumors (squamous cell carcinomas, basal cell carcinomas, and malignant melanomas). Among malignant tumors, basal cell carcinomas and malignant melanomas showed lower expression of β-defensin 1 than squamous cell carcinomas, in which their expression was shown to be decreased with increased dysplasia of the tumor cells. Conclusion: These findings showed that β-defensin 1 has a negative association with malignancies of skin tumors. The role of β-defensin 1 is suggested in the protection of malignant changes including loss of differentiation and dysplasia in skin tumors.
    No preview · Article · Aug 2013 · Korean Journal of Dermatology
  • G.M. Lee · J.H. Sim · Y.I. Bae · S.Y. Lee · Y.L. Park · S.H. Lee
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    ABSTRACT: Keratosis follicularis squamosa (Dohi) is a keratinizing disorder which is a separate clinical entity from keratosis follicularis (Darier's disease). It occurs predominantly in Japanese and appears clinically as scaly patches of 3 ∼ 10 mm in diameter with brownish follicular plugs in the center, which are symmetrically scattered on the trunks and thighs. Scales on the margin, slightly detached from the underlying epidermis, look like 'lotus leaves on the water'. The efficacy of minocycline has already been confirmed in many cases. In this report, we describe a case of using 1% of pimecrolimus cream for keratosis follicularis squamosa (Dohi) instead of minocycline.
    No preview · Article · Jul 2013 · Korean Journal of Dermatology
  • H.E. Lee · H.K. Cho · S.Y. Lee · J.S. Lee · Y.L. Park · K.U. Whang
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    ABSTRACT: Washboard nail is a dystrophy that presents as a series of ridges that extends across the nail. It is often accompanied by a central depression that extends from the cuticle to the free edge. Washboard nail is often a result of frequently repeated trauma, but sometimes predisposing factors cannot be found. When habitual tic is the cause of the lesions, restraining the habit is the most important treatment. Here, we report a case of a 6-year-old male with washboard nails on both thumbnails and was treated with topical 0.1% tacrolimus ointment. Significant improvement was observed after 4 months of application. This case suggests that topical tacrolimus can be considered as a primary therapy in the treatment of washboard nails in the absence of trauma.
    No preview · Article · Dec 2012 · Korean Journal of Dermatology
  • J.H. Sim · Y.J. Kim · Y.I. Bae · K.U. Whang · Y.L. Park · S. Lee
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    ABSTRACT: Neonatal lupus erythematosus (NLE) is an autoimmune disease associated with the maternal anti-SSA/Ro and anti-SSB/La antibodies. NLE is characterized by cutaneous erythema, congenital heart block (CHB), hepatic dysfunction and hematological abnormalities. The characteristic cutaneous lesion is an annular or polycyclic erythematous patch or plaque. Individual annular lesions are often about 1 cm in diameter. We report a case of NLE in a 7-day-old female infant, born of a clinically asymptomatic mother, presenting "eye mask" shape rash and telangiectasia on her face. Periorbital rash with "eye mask" appearance presents in a few of NLE cases, and this cutaneous sign has been emphasized as a diagnostic clue to NLE. Her serological tests revealed high titers of anti-SSA/Ro, anti-SSB/La and antinuclear antibody. Based on these clinical and serological findings, the patient was diagnosed as NLE with characteristic periorbital skin findings.
    No preview · Article · Nov 2012 · Korean Journal of Dermatology
  • S.I. Choi · J.H. Yang · Y.L. Park · J.S. Lee · K.U. Whang · S.H. Lee
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    ABSTRACT: Parry and Romberg described progressive facial hemiatrophy, characterized by progressive unilateral wasting of the skin, fat, muscle and bone in 1825 and 1846, respectively. Involvement of the central nervous system, with impairment of neurologic function, occurs infrequently. Linear scleroderma on frontal and parietal scalp, named 'en coup de sabre', is considered an overlapping condition. An 11 year-old girl was presented to our office with left facial hemiatrophy and transverse linear band-like alopecia on her posterior parietal scalp. Histopathologically, there was a sclerotic change of the collagen fibers and dermal lymphocytic infiltrations around the skin appendages. Her skin lesion has improved by intralesional corticosteroid injection. Linear scleroderma frequently coexists with Parry-Romberg syndrome. But in this case, she had a unique pattern of scleroderma, which is distinct from the previously reported cases.
    No preview · Article · May 2012 · Korean Journal of Dermatology
  • J.H. Yang · Y.I. Bae · S.Y. Lee · J.S. Lee · Y.L. Park · K.U. Whang
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    ABSTRACT: Background: Pilomatncoma is a benign appendageal tumor characterized by basaloid and shadow cells. Differentiation towards normal hair follicles is often observed in this condition. Objective: The purpose of this study was to analyze the clinical and histopathological features of pilomatricoma and to confirm diverse types of differentiation towards normal hair follicles, and its origin. Methods: We retrospectively reviewed medical records and histopathological findings of 64 patients who had visited our hospital in the last 7 years. The evolutional stages of tumor and differentiation were analyzed through histopathological findings. Results: The majority of the rumors occurred in the first two decades (69.8%). Unlike previous reports, the male to female ratio was 1.1 : 1. The mean duration was 11.8 months. The predilection sites were the upper extremities ! (40.8%), face (33.8%), neck (15.5%), back (2.8%), scalp (2.8%), and thigh (2.8%) in that order. Histopathologically, 1 most of the tumors were located in the lower dermis (76%) and enclosed by pseudocapsules. The evolution of tumor was divided into four groups- early, fully developed, early regressive, and late regressive stage, as previously reported. Our 71 cases were classified as: 2 early, 16 fully developed, 34 early regressive, and 19 late regressive stage. Calcification (60.5%) and ossification (8.4%) were observed, and the ratio increased as the tumor aged. Inflammatory cell infiltration and multinucleated giant cells were observed disorderly. Differentiation to normal hair follicles was observed: 14 cases to infundibulum, 10 isthmus, 17 outer root sheath, and 11 inner root sheath. Conclusion: Pilomatricoma is a benign tumor that differentiates toward the hair cortex. Basaloid and shadow cells correspond to hair matrix cells and immature hair cortex cells, respectively. Basaloid cell can also differentiate to \normal hair follicles.
    No preview · Article · Mar 2012 · Korean Journal of Dermatology
  • Y.I. Bae · G.M. Lee · J.E. Kim · S. Lee · S.Y. Lee · Y.-L. Park
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    ABSTRACT: Vitiligo universalis is an uncommon variant that is rarely seen. Interestingly, vitiligo universalis often accompanies systemic diseases such as endocrinopathies. A 43-year-old man presented with whole body depigmentation and poliosis affecting most of his scalp and body hair. He had undergone a liver transplant 2 years ago due to liver cirrhosis from a chronic hepatitis B infection and has been treated for diabetes mellitus for several years. Histopathology showed no melanocytes and an absence of epidermal pigmentation on the skin. We herein report a rare case of vitiligo universalis associated with chronic viral hepatitis B.
    No preview · Article · Dec 2011 · Korean Journal of Dermatology
  • J.H. Sim · G.H. Lee · H.D. Kim · S.Y. Lee · Y.L. Park · K.U. Whang
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    ABSTRACT: Carcinoid tumors are derived from enterochromaffin cells that are capable of producing a wide range of neuroendocrine mediators including serotonin or 5-hydroxytryptamine. Carcinoid syndrome occurs when mediators produced by the tumor and normally metabolized by the liver escape into the systemic circulation. The syndrome classically involves the gastrointestinal tract, respiratory system, cardiovascular system and the skin. Flushing is almost universal in the syndrome. A 23-year-old woman came to our hospital presenting with flushing on face and trunk. The patient had experienced flushing for 2 years and it was aggravated by emotional change, stress, exercise, and eating spicy food. The patient also had abdominal pain, diarrhea, weight loss and hepatomegaly. Urinary 5-hydroxyindoleacetic acid was elevated (81.5 mg/day). Abdominal computed tomography scans showed multiple hepatic masses diagnosed as a carcinoid tumor by computed tomography-guided needle biopsy. Physicians should consider carcinoid syndrome when patients present with flushing and systemic symptoms.
    No preview · Article · Nov 2011 · Korean Journal of Dermatology
  • J.H. Sim · J.W. Shin · H.D. Kim · Y.L. Park · J.S. Lee · K.U. Whang
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    ABSTRACT: Angiosarcoma Is A Rare Malignant Tum. of An Endothelial Cell Derivation and It Acco. for Less Than 2% of All Sarcomas. It Is A Highly Aggressive Neoplasm with A Poor Prognosis and Most Patients Die Within A Short Period after Presentation. although Angiosarcoma May Occur in Any Location on the Body, It Rarely Arises from Major Vessels but Has A Decided Predilection for the Skin and Superficial Soft Tissue. A 39-Yr.-old Man Was Referred to Our Dept. with An Asymptomatic, Firm, Ulcerative Nodule on His Scalp That Was Noticed Almost 2 Months Previously. He Had Been Diagnosed with Lung Angiosarcoma 9 Month Earlier. Histopathologically, the Skin Specimen Showed Angiosarcoma. the Histological Findings of the Metastatic Skin Cancer Are Usually the Same As That of the Prim. Cancer. Metastatic Cutaneous Angiosarcoma Is Uncommon. Based on These Clin. and Histopathological Findings, Our Case Seems to Be Skin Metastasis at the Scalp from the Lung Angiosarcoma.
    No preview · Article · Jun 2011 · Korean Journal of Dermatology

Publication Stats

55 Citations
27.93 Total Impact Points

Institutions

  • 2011
    • Kangbuk Samsung Hospital
      Sŏul, Seoul, South Korea
  • 2010
    • Sungkyunkwan University
      Sŏul, Seoul, South Korea
  • 2007
    • Soonchunhyang University
      Onyang, South Chungcheong, South Korea