S El'Gaddal

Imperial College London, Londinium, England, United Kingdom

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Publications (1)4.57 Total impact

  • Source
    R Rai · E Tuddenham · M Backos · S Jivraj · S El'Gaddal · S Choy · B Cork · L Regan
    [Show abstract] [Hide abstract]
    ABSTRACT: Some cases of recurrent miscarriage have a thrombotic basis. Thromboelastography is a rapid, reproducible test of whole-blood haemostasis. Thromboelastography was performed in 494 consecutive, non-pregnant women (median age 35 years; range 21-48) with a history of miscarriages at <12 weeks gestation (median 4; range 3-12) and 55 parous women (median age 33 years; range 20-41) with no history of pregnancy loss. The prospective outcome of untreated pregnancies amongst 108 women with recurrent miscarriage was studied. The maximum clot amplitude (MA) (median 66.0 mm; range 48.0-76.0) was significantly higher and the rate of clot lysis (LY30) (median 2.5%; range 0.5-7.8) significantly lower amongst women with recurrent miscarriage compared with controls (MA 61.5 mm; range 50.0-67.0; P = 0.01; LY30 4.9%; range 2.9-9.7; P = 0.01). The pre-pregnancy MA was significantly higher amongst women who subsequently miscarried (median 66.0 mm; range 54.0-73.0) compared with those whose had a live birth (median 61.7 mm; 48.0-71.5; P < 0.01). A pre-pregnancy MA >or=64 mm has a sensitivity of 68% and specificity of 82% to predict miscarriage. Thromboelastography identifies a subgroup of women with recurrent miscarriage to be in a prothrombotic state outside of pregnancy. Women in such a state are at increased risk of miscarriage in future untreated pregnancies.
    Full-text · Article · Dec 2003 · Human Reproduction

Publication Stats

57 Citations
4.57 Total Impact Points

Top Journals


  • 2003
    • Imperial College London
      • Clinical Institute of Obstetrics and Gynaecology (CIOG)
      Londinium, England, United Kingdom