R Larchee

Centre Hospitalier Universitaire de Poitiers, Poitiers, Poitou-Charentes, France

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Publications (2)14 Total impact

  • Source
    S Girerd · M Renaud · J Guilhot · C Giraud · R Larchee · I Jollet · F Guilhot
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    ABSTRACT: Acute corticosteroid refractory GVHD (aGVHD) remains a challenging problem after allogeneic hematopoietic SCT. Even though immunosuppressive therapies may achieve a response, unsatisfactory aGVHD control and toxicity of high cumulative doses of corticosteroids are frequent, notably with an increased infection rate. We report long-term follow-up of 33 consecutive patients who developed corticosteroid refractory aGVHD in our institution, treated homogeneously according to a unique algorithm combining an induction treatment (Inolimomab, 0.3 mg/kg per day), an associated immunosuppression (Mycophenolate Mofetil) and a predefined management of partial responses (PR) by the switch from Cyclosporin to Tacrolimus, together with an intensive infectious monitoring and supportive care. In this cohort, 17 patients (52%) achieved a complete response (CR) and 14 patients (42%) a PR, which converted to CR for 12 patients after Tacrolimus introduction. Transplant related mortality (TRM) was 15.5% and 29.7% at 1 and 3 years, respectively. OS was 54.5% at 3 years. Multivariate analysis identified CR after Inolimomab therapy as the unique prognostic factor on OS. Among the 30 evaluable patients, 19 (63%) developed extensive chronic GVHD. This Inolimomab-based algorithm allows for an efficient control of corticosteroid refractory aGVHD in a high proportion of patients with low toxicity, and deserves further investigation.Bone Marrow Transplantation advance online publication, 18 March 2013; doi:10.1038/bmt.2013.16.
    Full-text · Article · Mar 2013 · Bone marrow transplantation
  • Source
    L Roy · J Guilhot · G Martineau · R Larchée · F Guilhot

    Preview · Article · Oct 2005 · Leukemia

Publication Stats

36 Citations
14.00 Total Impact Points

Top Journals


  • 2013
    • Centre Hospitalier Universitaire de Poitiers
      Poitiers, Poitou-Charentes, France