Omana P Nainan

Centers for Disease Control and Prevention, Atlanta, Michigan, United States

Are you Omana P Nainan?

Claim your profile

Publications (1)4.85 Total impact

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The highest incidence of hepatitis B virus (HBV)-associated vasculitis in the world has been reported in Alaska Natives. We examined the incidence of HBV-associated vasculitis before and after mass HBV vaccine immunization and the association between HBV genotype and vasculitis in a population-based cohort study in Alaska natives chronically infected with HBV. Genotyping was performed in vasculitis cases and 644 hepatitis B-positive controls without vasculitis using polymerase chain reaction and sequencing of the S gene. Occurrence of HBV vasculitis from 1974 to 2004 was calculated. HBV vasculitis patients and controls were also tested for basal core promoter and precore mutations. Fifteen cases of HBV-associated vasculitis were identified: 13 (86%) had genotype D and one each genotype A and F. Genotype D was more commonly found in patients with vasculitis than controls [odd ratio (OR)=5.9, confidence interval (95% CI) 1.2, 21.8; P<0.015). HBV-associated vasculitis was associated with genotype D.
    Full-text · Article · Jun 2007 · Liver international: official journal of the International Association for the Study of the Liver