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Publications (2)0 Total impact

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    ABSTRACT: In anesthetized guinea-pigs previously sensitized to ovalbumin by intratracheal immunization, the intravenous administration of propranolol (3.1 mg/kg) produced an increase in the respiratory insufflation pressure induced by ovalbumin. Atropine (2 mg/kg), zolertine (1 mg/kg) and indomethacin (3.1 mg/kg) did not antagonize the propranolol-induced airway hyperreactivity. Indomethacin at higher dose (10 mg/kg) and BW755c (10 mg/kg) decreased the potentiation of the respiratory insufflation pressure to ovalbumin. Our results suggest that besides the beta-blockade, propranolol-induced bronchial hyperreactivity to ovalbumin in sensitized guinea-pigs could be mediated by leukotrienes.
    No preview · Article · Jan 1988 · Pharmacological Research Communications
  • M.H. Vargas · L.M. Montano · I. Paramo · M.E. Selman
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    ABSTRACT: Experimental asthma models in guinea pigs usually produce bronchoconstriction as part of a systemic anaphylactic reaction. Since immunization in asthmatic patients is through airborne allergens and the human crisis is localized to the airways, we developed a new model that satisfied these two criteria. Twenty-four guinea pigs were nebulized with ovalbumin (300 mg) as antigen and Bordetella pertussis vaccine as adjuvant. One week later they were nebulized with ovalbumin daily for 2 weeks and then challenged with intravenous ovalbumin at three different doses. We found the animals developed a dose-dependent bronchoconstriction without acute systemic hypotension or other signs due to an anaphylactic reaction. As control group five guinea pigs nebulized with ovalbumin alone for 3 weeks were used and only presented a small and low reproducible bronchoconstriction. We conclude that this model presents greater similarities to the human disease and has the advantage of causing localized, reproducible and graduated bronchoconstrictive response.
    No preview · Article · Jan 1987